GREMLIN Database
PDDEXK_6 - PDDEXK-like family of unknown function
PFAM: PF04720 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 209 (204)
Sequences: 628 (435)
Seq/√Len: 30.4
META: 0.04

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_Y134_D4.3441.00
93_A115_D3.7751.00
28_S31_E3.6551.00
115_D130_R3.0001.00
13_E16_S2.8681.00
53_E167_R2.8071.00
146_P186_K2.5110.99
79_R113_Y2.3950.99
113_Y189_H2.2730.99
153_L175_M2.2420.99
12_N15_Q2.1190.98
94_A209_R2.0970.98
112_E182_S2.0460.98
100_W109_G2.0140.97
134_D137_F1.9960.97
195_K199_M1.9850.97
169_K200_Q1.9470.97
92_D95_I1.8390.95
111_Y176_C1.8080.95
103_S151_K1.7700.94
96_C145_R1.7680.94
172_V200_Q1.7650.94
83_M207_Y1.7030.93
96_C115_D1.6400.92
92_D105_S1.6080.91
198_Y201_A1.5880.90
153_L163_G1.5860.90
27_S30_D1.5730.90
27_S175_M1.5590.89
161_F168_L1.5590.89
119_E128_E1.5540.89
13_E17_S1.5420.89
42_L180_K1.5380.89
99_K207_Y1.5180.88
81_E113_Y1.5050.88
146_P191_P1.5010.87
138_R195_K1.4900.87
131_Y167_R1.4830.87
11_G17_S1.4790.87
63_A205_S1.4420.85
28_S33_D1.4400.85
83_M95_I1.4360.85
9_E82_V1.4330.85
172_V183_L1.4290.85
90_G150_Y1.4270.85
98_S197_R1.4190.84
82_V195_K1.4190.84
134_D140_E1.4150.84
97_K197_R1.4070.84
176_C187_G1.4060.84
142_E198_Y1.3810.83
60_V191_P1.3660.82
136_D171_I1.3650.82
188_M201_A1.3580.82
20_N139_S1.3490.81
77_C146_P1.3480.81
140_E165_P1.3410.81
56_L177_E1.3300.80
94_A115_D1.3190.80
23_N32_F1.3150.79
100_W198_Y1.3140.79
68_K95_I1.2920.78
96_C100_W1.2800.78
16_S19_S1.2540.76
137_F204_L1.2510.76
53_E131_Y1.2470.76
93_A182_S1.2420.75
111_Y184_K1.2330.75
100_W157_L1.2250.74
4_V7_F1.2200.74
58_A114_I1.2180.74
4_V9_E1.2100.73
42_L171_I1.2080.73
20_N23_N1.2050.73
98_S113_Y1.2010.73
29_D33_D1.1970.73
139_S178_A1.1900.72
50_S131_Y1.1820.72
104_G190_L1.1800.71
145_R198_Y1.1620.70
155_Q161_F1.1470.69
95_I167_R1.1450.69
197_R200_Q1.1410.69
82_V135_L1.1320.68
136_D139_S1.1290.68
87_R130_R1.1230.68
62_K111_Y1.1220.68
161_F167_R1.1100.67
18_S25_S1.1090.67
163_G168_L1.1070.66
55_N132_I1.1000.66
117_V179_A1.0960.66
194_R203_W1.0940.66
193_W203_W1.0940.66
192_P203_W1.0940.66
95_I137_F1.0920.65
15_Q19_S1.0900.65
99_K163_G1.0670.64
79_R112_E1.0650.63
100_W182_S1.0640.63
115_D198_Y1.0480.62
111_Y182_S1.0470.62
71_G132_I1.0430.62
85_R89_L1.0410.62
189_H199_M1.0380.61
57_L134_D1.0370.61
134_D191_P1.0330.61
79_R178_A1.0280.61
26_D33_D1.0250.60
56_L91_Y1.0230.60
109_G198_Y1.0110.59
5_Q8_L1.0080.59
5_Q15_Q1.0040.59
15_Q18_S0.9970.58
10_E132_I0.9950.58
91_Y134_D0.9910.58
173_R196_A0.9900.58
17_S23_N0.9860.57
130_R145_R0.9850.57
96_C130_R0.9850.57
98_S107_P0.9840.57
83_M87_R0.9810.57
95_I133_V0.9650.56
84_D170_Q0.9590.55
80_R83_M0.9580.55
83_M94_A0.9560.55
59_D91_Y0.9520.55
83_M111_Y0.9490.54
176_C200_Q0.9470.54
106_I138_R0.9440.54
79_R115_D0.9440.54
113_Y185_E0.9410.54
14_S18_S0.9390.54
21_C29_D0.9390.54
146_P204_L0.9360.53
172_V176_C0.9340.53
55_N134_D0.9300.53
163_G171_I0.9290.53
39_A42_L0.9280.53
24_G27_S0.9210.52
9_E25_S0.9210.52
8_L21_C0.9200.52
3_M50_S0.9190.52
115_D206_P0.9150.52
180_K198_Y0.9150.52
87_R94_A0.9090.51
53_E198_Y0.9020.51
135_L159_E0.9010.51
113_Y145_R0.9000.51
102_K166_E0.8970.50
130_R198_Y0.8970.50
131_Y169_K0.8950.50
138_R185_E0.8940.50
150_Y204_L0.8910.50
115_D209_R0.8900.50
73_G76_S0.8880.50
35_W38_Q0.8800.49
104_G161_F0.8740.48
3_M8_L0.8650.48
139_S142_E0.8510.47
11_G14_S0.8480.46
156_S188_M0.8400.46
77_C135_L0.8350.45
96_C198_Y0.8350.45
64_V99_K0.8290.45
45_L124_G0.8200.44
140_E183_L0.8160.44
187_G196_A0.8150.44
3_M9_E0.8110.43
60_V66_K0.8080.43
6_S140_E0.8050.43
8_L14_S0.8020.43
147_T191_P0.8010.43
191_P203_W0.7950.42
52_A113_Y0.7900.42
151_K154_L0.7900.42
169_K205_S0.7850.41
157_L179_A0.7820.41
75_R78_L0.7800.41
186_K195_K0.7710.40
79_R195_K0.7640.40
13_E19_S0.7630.40
23_N28_S0.7630.40
139_S198_Y0.7600.39
96_C109_G0.7590.39
109_G115_D0.7580.39
6_S91_Y0.7570.39
25_S30_D0.7410.38
161_F171_I0.7410.38
44_S120_G0.7410.38
172_V196_A0.7350.38
133_V205_S0.7330.37
91_Y117_V0.7320.37
8_L111_Y0.7270.37
58_A115_D0.7260.37
70_A98_S0.7250.37
178_A183_L0.7200.36
53_E201_A0.7160.36
4_V170_Q0.7080.36
130_R204_L0.7070.36
2_D6_S0.7050.35
184_K190_L0.7030.35
85_R91_Y0.7000.35
97_K111_Y0.7000.35
149_E155_Q0.6940.35
37_E190_L0.6940.35
34_F190_L0.6930.34
149_E164_K0.6910.34
56_L65_E0.6910.34
140_E199_M0.6900.34
29_D32_F0.6890.34
36_E116_V0.6820.34
118_V135_L0.6710.33
107_P138_R0.6690.33
107_P188_M0.6670.33
91_Y138_R0.6580.32
17_S43_K0.6570.32
100_W107_P0.6570.32
83_M104_G0.6550.32
110_E138_R0.6530.32
26_D29_D0.6530.32
174_I188_M0.6530.32
56_L60_V0.6500.31
79_R204_L0.6490.31
94_A173_R0.6480.31
25_S31_E0.6470.31
10_E13_E0.6460.31
109_G145_R0.6420.31
105_S197_R0.6420.31
147_T162_V0.6400.31
21_C28_S0.6320.30
55_N59_D0.6310.30
26_D31_E0.6300.30
24_G73_G0.6290.30
164_K195_K0.6290.30
91_Y132_I0.6270.30
114_I170_Q0.6240.30
128_E175_M0.6240.30
92_D130_R0.6220.30
23_N27_S0.6220.30
110_E189_H0.6180.29
52_A199_M0.6140.29
139_S175_M0.6140.29
70_A133_V0.6120.29
92_D169_K0.6100.29
77_C99_K0.6090.29
62_K182_S0.6070.29
14_S17_S0.6040.28
181_Q187_G0.6030.28
8_L15_Q0.6020.28
61_K65_E0.5970.28
99_K106_I0.5970.28
59_D161_F0.5960.28
68_K115_D0.5940.28
95_I169_K0.5940.28
57_L176_C0.5910.28
15_Q27_S0.5840.27
93_A113_Y0.5830.27
45_L120_G0.5810.27
25_S29_D0.5810.27
84_D188_M0.5770.27
103_S197_R0.5760.27
81_E174_I0.5750.27
33_D36_E0.5740.26
23_N82_V0.5700.26
137_F152_A0.5670.26
135_L165_P0.5590.26
168_L188_M0.5580.25
42_L168_L0.5570.25
80_R160_V0.5550.25
24_G28_S0.5530.25
140_E195_K0.5420.25
114_I136_D0.5410.24
2_D5_Q0.5390.24
14_S19_S0.5380.24
10_E155_Q0.5380.24
95_I114_I0.5350.24
12_N18_S0.5340.24
36_E41_L0.5290.24
38_Q191_P0.5260.24
194_R202_K0.5220.23
192_P202_K0.5220.23
193_W202_K0.5220.23
127_G149_E0.5190.23
75_R171_I0.5190.23
40_E43_K0.5180.23
35_W134_D0.5180.23
34_F37_E0.5170.23
13_E29_D0.5170.23
136_D186_K0.5150.23
42_L151_K0.5150.23
81_E118_V0.5120.23
42_L156_S0.5100.23
189_H200_Q0.5090.23
104_G169_K0.5090.23
3_M53_E0.5080.23
42_L174_I0.5080.23
24_G32_F0.5040.22
191_P207_Y0.5030.22
107_P201_A0.5030.22
161_F188_M0.5020.22
196_A200_Q0.5020.22
3_M138_R0.5010.22
74_C77_C0.5000.22
92_D195_K0.5000.22
37_E169_K0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e2tA 5 0.7703 31.8 0.955 Contact Map
4rcnA 6 0.6459 30.6 0.956 Contact Map
3hblA 4 0.6746 28 0.957 Contact Map
3i12A 2 0.7033 12.5 0.963 Contact Map
3n6rA 1 0.5885 11.8 0.963 Contact Map
4dmoA 1 0.8182 11.6 0.964 Contact Map
4qshA 4 0.622 11.3 0.964 Contact Map
4guzA 2 0.8373 11 0.964 Contact Map
4c5pA 1 0.8182 10.8 0.964 Contact Map
1w4tA 1 0.823 10.5 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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