GREMLIN Database
ETC_C1_NDUFA5 - ETC complex I subunit conserved region
PFAM: PF04716 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (54)
Sequences: 901 (674)
Seq/√Len: 91.7
META: 0.499

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K43_E3.2581.00
27_R31_E2.5691.00
44_E49_K2.0311.00
15_D18_K1.9821.00
18_K22_E1.9391.00
46_D49_K1.9341.00
40_I50_I1.9281.00
11_T42_E1.9171.00
7_I38_L1.8311.00
31_E35_K1.8291.00
43_E53_K1.7591.00
13_T34_T1.5201.00
11_T38_L1.4290.99
25_V28_Q1.3730.99
17_L30_T1.3470.99
3_R45_E1.2990.99
6_L10_Y1.2200.98
3_R7_I1.1840.98
25_V29_S1.1680.98
10_Y13_T1.1390.97
20_I24_S1.1050.97
37_R54_I1.1000.97
10_Y34_T1.0970.97
29_S32_A1.0900.96
46_D51_E1.0820.96
10_Y41_V1.0740.96
18_K31_E1.0540.96
48_E52_K1.0310.95
47_I51_E1.0060.94
23_D28_Q0.9810.94
10_Y37_R0.9650.93
40_I53_K0.9630.93
1_N4_E0.9400.92
28_Q32_A0.9260.92
7_I41_V0.9200.91
44_E50_I0.9010.90
26_Y30_T0.8850.90
22_E27_R0.8780.89
30_T34_T0.8460.87
5_T9_L0.8310.86
12_K16_K0.8030.84
50_I54_I0.8020.84
44_E53_K0.7980.84
49_K52_K0.7940.84
33_L37_R0.7720.82
36_H40_I0.7560.81
9_L12_K0.7550.81
35_K39_K0.7450.80
7_I42_E0.7390.79
35_K38_L0.7390.79
5_T8_K0.7340.79
17_L27_R0.7260.78
4_E8_K0.7230.78
22_E31_E0.7110.77
7_I11_T0.7020.76
39_K42_E0.6920.75
49_K53_K0.6850.74
8_K11_T0.6810.73
3_R50_I0.6490.70
6_L13_T0.6450.69
10_Y33_L0.6440.69
40_I54_I0.6430.69
2_P41_V0.6280.67
4_E7_I0.6270.67
4_E12_K0.6230.67
45_E49_K0.6100.65
6_L41_V0.6030.64
41_V47_I0.5990.64
20_I37_R0.5880.62
2_P30_T0.5830.62
38_L42_E0.5800.61
36_H54_I0.5580.58
16_K20_I0.5550.58
14_L34_T0.5530.58
20_I30_T0.5380.56
7_I35_K0.5300.54
45_E51_E0.5220.53
24_S29_S0.5180.53
41_V50_I0.5100.52
29_S33_L0.5020.51
28_Q39_K0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uv5A 1 1 29.7 0.806 Contact Map
3aadA 1 1 24.3 0.814 Contact Map
1s94A 1 0.6545 19.1 0.823 Contact Map
4xy8A 1 0.9455 13.2 0.835 Contact Map
1e6iA 1 0.9636 12 0.838 Contact Map
4uitA 1 0.9636 11.1 0.841 Contact Map
2i7kA 1 1 10.3 0.843 Contact Map
2dkwA 1 0.9273 8.1 0.85 Contact Map
4algA 2 0.9455 7.7 0.852 Contact Map
4i3hA 2 1 7.4 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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