GREMLIN Database
Dickkopf_N - Dickkopf N-terminal cysteine-rich region
PFAM: PF04706 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (49)
Sequences: 1801 (1556)
Seq/√Len: 222.3
META: 0.82

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_L41_A3.4031.00
9_G12_L3.3871.00
28_K32_A2.9941.00
15_D25_V2.1131.00
12_L26_P1.9941.00
13_Y28_K1.7511.00
35_T39_E1.7021.00
24_C27_L1.6531.00
28_K39_E1.6211.00
27_L42_S1.5971.00
34_C46_C1.5201.00
41_A44_L1.3921.00
29_A32_A1.3451.00
13_Y31_G1.3171.00
48_N51_C1.3061.00
2_C7_D1.2671.00
5_D38_A1.1531.00
3_T16_A1.1411.00
47_V51_C1.1211.00
26_P30_A1.0941.00
12_L44_L1.0391.00
30_A44_L1.0231.00
5_D36_R1.0121.00
11_G27_L0.9911.00
13_Y27_L0.9461.00
2_C8_C0.9411.00
36_R39_E0.9371.00
3_T7_D0.9210.99
26_P29_A0.9190.99
13_Y25_V0.8880.99
31_G44_L0.8820.99
37_D40_C0.8640.99
13_Y39_E0.8550.99
20_G37_D0.8500.99
23_T50_V0.8470.99
17_G20_G0.8470.99
35_T50_V0.8450.99
3_T9_G0.8210.99
27_L38_A0.7840.98
7_D47_V0.7540.98
28_K41_A0.7530.98
18_T23_T0.7490.98
3_T45_V0.7430.98
4_S32_A0.7420.98
35_T42_S0.7370.98
23_T37_D0.7290.97
31_G48_N0.7120.97
11_G14_C0.7060.97
3_T6_S0.7060.97
45_V51_C0.7020.97
5_D13_Y0.6840.96
18_T32_A0.6760.96
19_G24_C0.6580.95
37_D47_V0.6470.95
16_A21_G0.6260.94
5_D9_G0.6250.94
17_G35_T0.6160.93
30_A47_V0.6150.93
16_A38_A0.6020.93
4_S12_L0.5910.92
18_T48_N0.5750.91
31_G41_A0.5630.90
15_D19_G0.5620.90
26_P33_A0.5570.89
42_S45_V0.5570.89
14_C51_C0.5560.89
2_C5_D0.5400.88
10_A42_S0.5370.88
32_A44_L0.5330.87
8_C11_G0.5260.86
6_S10_A0.5230.86
45_V50_V0.5140.85
23_T30_A0.5010.84
35_T49_G0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jtkA 1 0.9808 83.6 0.574 Contact Map
3s2kC 1 0.9808 78.1 0.597 Contact Map
2kraA 1 1 74.9 0.608 Contact Map
1imtA 1 1 67.6 0.629 Contact Map
1lpbA 1 0.9808 55.1 0.656 Contact Map
4tpvA 2 0.9231 32 0.701 Contact Map
1oigA 1 0.4231 31.3 0.704 Contact Map
4pmkA 1 0.0577 27 0.713 Contact Map
2l1qA 1 0.6538 25.6 0.715 Contact Map
4cpaI 1 0.5385 21.6 0.726 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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