GREMLIN Database
MCU - Mitochondrial calcium uniporter
PFAM: PF04678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (172)
Sequences: 569 (365)
Seq/√Len: 27.8
META: 0.176

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_R116_E5.1141.00
134_F138_Y5.0561.00
80_K84_D4.8601.00
72_E175_R4.2351.00
109_L129_V3.5401.00
175_R178_E3.1571.00
161_K165_L2.8941.00
34_V38_P2.7941.00
74_E78_K2.6210.99
90_R93_R2.5760.99
122_M125_I2.5120.99
111_R115_W2.4860.99
149_S152_D2.4570.99
112_L116_E2.4380.99
128_F133_T1.9090.95
73_L77_E1.8000.93
6_Q21_I1.7790.93
11_A24_G1.7610.93
14_L25_T1.7260.92
120_D123_E1.7110.91
6_Q9_D1.6910.91
21_I129_V1.6760.91
4_E25_T1.6290.89
107_G126_T1.5360.86
89_K168_K1.5170.86
110_A114_F1.5090.85
4_E8_I1.4960.85
8_I135_M1.4580.83
76_L179_L1.4570.83
106_T109_L1.4420.82
108_A129_V1.4400.82
10_F13_I1.4360.82
114_F131_S1.4330.82
148_P162_Q1.4280.82
5_D8_I1.4060.81
16_E25_T1.4060.81
132_G136_A1.3940.80
109_L128_F1.3870.80
171_F179_L1.3810.80
172_D175_R1.3710.79
112_L115_W1.3650.79
42_V48_A1.3620.79
42_V49_L1.3430.78
71_E74_E1.3420.78
109_L153_F1.2930.75
5_D13_I1.2920.75
109_L113_T1.2740.74
11_A108_A1.2670.73
107_G156_R1.2610.73
126_T148_P1.2530.72
11_A15_D1.2470.72
72_E172_D1.2450.72
133_T156_R1.2400.72
84_D165_L1.2210.70
21_I150_Y1.2130.70
9_D17_D1.2090.70
36_L40_Q1.2020.69
94_E140_Y1.1830.68
93_R96_W1.1790.68
79_K130_T1.1790.68
79_K169_H1.1770.68
95_L104_V1.1610.67
102_L106_T1.1580.66
64_P67_E1.1360.65
44_A121_V1.1220.64
58_K61_E1.1190.64
3_N6_Q1.1100.63
115_W141_F1.1060.63
122_M126_T1.0990.62
79_K170_N1.0970.62
6_Q17_D1.0950.62
129_V137_G1.0860.61
99_L141_F1.0850.61
35_F41_V1.0760.60
173_V177_N1.0690.60
6_Q12_A1.0670.60
82_E85_R1.0620.59
61_E104_V1.0590.59
77_E135_M1.0570.59
115_W118_S1.0470.58
45_L75_P1.0400.58
77_E81_A1.0080.55
110_A127_Y0.9990.55
10_F17_D0.9990.55
76_L130_T0.9970.55
7_G22_V0.9930.54
4_E9_D0.9890.54
18_G25_T0.9870.54
176_Y179_L0.9800.53
167_K170_N0.9700.53
83_I169_H0.9650.52
110_A117_Y0.9640.52
114_F126_T0.9600.52
133_T141_F0.9560.51
135_M154_F0.9410.50
12_A74_E0.9390.50
140_Y143_R0.9360.50
42_V50_P0.9260.49
11_A14_L0.9240.49
73_L98_G0.9230.49
82_E86_K0.9210.49
9_D20_V0.9130.48
52_E82_E0.9080.48
17_D24_G0.9040.47
6_Q14_L0.8970.47
107_G128_F0.8910.47
113_T138_Y0.8790.46
109_L142_L0.8730.45
113_T142_L0.8720.45
69_L126_T0.8670.45
10_F21_I0.8640.44
158_F162_Q0.8640.44
12_A16_E0.8580.44
174_E178_E0.8580.44
39_K49_L0.8550.44
41_V81_A0.8480.43
20_V38_P0.8440.43
150_Y171_F0.8360.42
42_V101_L0.8350.42
55_Q58_K0.8310.42
90_R161_K0.8290.42
19_V168_K0.8140.41
7_G23_L0.8120.41
146_Q163_H0.8110.40
11_A22_V0.8100.40
113_T130_T0.8090.40
128_F156_R0.8090.40
114_F122_M0.8060.40
11_A142_L0.8060.40
106_T127_Y0.7890.39
4_E45_L0.7890.39
97_A164_K0.7860.39
115_W130_T0.7850.39
84_D162_Q0.7830.38
98_G141_F0.7720.38
117_Y127_Y0.7590.37
72_E87_A0.7560.37
58_K62_L0.7470.36
61_E64_P0.7460.36
33_K108_A0.7420.36
126_T140_Y0.7360.35
14_L48_A0.7340.35
138_Y141_F0.7330.35
5_D159_L0.7310.35
96_W139_A0.7310.35
17_D23_L0.7310.35
94_E157_R0.7260.34
118_S124_P0.7180.34
69_L114_F0.7180.34
3_N13_I0.7170.34
96_W144_T0.7160.34
83_I90_R0.7150.34
103_S159_L0.7090.33
17_D100_G0.7080.33
18_G21_I0.7070.33
16_E65_E0.6990.33
61_E142_L0.6980.33
56_L84_D0.6960.32
15_D22_V0.6950.32
21_I97_A0.6940.32
74_E178_E0.6940.32
15_D23_L0.6930.32
13_I173_V0.6860.32
140_Y161_K0.6820.31
44_A164_K0.6730.31
7_G21_I0.6660.30
14_L20_V0.6650.30
85_R173_V0.6610.30
80_K93_R0.6610.30
3_N20_V0.6600.30
71_E97_A0.6590.30
25_T160_S0.6500.29
9_D12_A0.6500.29
43_K48_A0.6460.29
13_I19_V0.6460.29
45_L96_W0.6450.29
36_L41_V0.6420.29
18_G72_E0.6360.28
13_I88_E0.6330.28
101_L104_V0.6290.28
14_L34_V0.6270.28
119_W123_E0.6250.28
51_L62_L0.6250.28
93_R161_K0.6210.28
19_V25_T0.6170.27
42_V45_L0.6160.27
3_N10_F0.6150.27
86_K104_V0.6150.27
7_G12_A0.6130.27
125_I133_T0.6100.27
64_P164_K0.6080.27
63_L75_P0.6060.27
162_Q166_A0.5990.26
94_E97_A0.5980.26
17_D20_V0.5940.26
15_D85_R0.5930.26
8_I14_L0.5920.26
17_D151_E0.5870.26
7_G10_F0.5860.25
25_T39_K0.5860.25
125_I128_F0.5860.25
75_P173_V0.5850.25
84_D87_A0.5840.25
84_D166_A0.5840.25
10_F23_L0.5840.25
43_K67_E0.5840.25
41_V52_E0.5830.25
97_A137_G0.5820.25
121_V150_Y0.5810.25
55_Q59_E0.5790.25
82_E169_H0.5780.25
49_L66_L0.5750.25
117_Y128_F0.5730.25
14_L23_L0.5710.25
113_T116_E0.5710.25
74_E176_Y0.5690.25
147_E159_L0.5690.25
135_M156_R0.5680.24
110_A113_T0.5680.24
96_W128_F0.5660.24
35_F38_P0.5620.24
113_T128_F0.5620.24
44_A147_E0.5620.24
6_Q19_V0.5590.24
110_A148_P0.5550.24
116_E176_Y0.5540.24
110_A130_T0.5510.23
105_Q125_I0.5500.23
41_V45_L0.5490.23
7_G136_A0.5460.23
11_A20_V0.5420.23
110_A126_T0.5400.23
4_E7_G0.5350.23
107_G146_Q0.5350.23
105_Q109_L0.5340.23
79_K82_E0.5320.22
3_N86_K0.5320.22
94_E175_R0.5310.22
105_Q133_T0.5310.22
149_S170_N0.5290.22
109_L148_P0.5290.22
118_S121_V0.5290.22
107_G132_G0.5280.22
15_D20_V0.5260.22
126_T143_R0.5240.22
4_E103_S0.5240.22
107_G139_A0.5240.22
20_V24_G0.5220.22
147_E155_D0.5210.22
90_R94_E0.5170.22
73_L79_K0.5160.22
32_A160_S0.5140.22
114_F165_L0.5100.21
33_K81_A0.5060.21
50_P133_T0.5060.21
98_G120_D0.5040.21
147_E173_V0.5030.21
116_E141_F0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m8rA 1 0.5978 40 0.928 Contact Map
3dptA 2 0.5363 26.5 0.935 Contact Map
4flaA 2 0.4749 25.4 0.935 Contact Map
4wnrA 1 0.5978 18.5 0.939 Contact Map
2yy0A 6 0.2961 14.1 0.942 Contact Map
3rrkA 1 0.9162 13.2 0.943 Contact Map
4qinA 2 0.838 12.2 0.944 Contact Map
3ljcA 1 0.4693 11.5 0.945 Contact Map
1gaxA 1 0.4637 10.6 0.946 Contact Map
4rsjA 2 0.4972 8 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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