GREMLIN Database
CwfJ_C_2 - Protein similar to CwfJ C-terminus 2
PFAM: PF04676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (96)
Sequences: 816 (531)
Seq/√Len: 54.2
META: 0.289

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_P57_E3.5441.00
83_K87_E3.2941.00
28_F55_G2.9881.00
78_K82_K2.7571.00
22_P41_A2.5731.00
57_E71_R2.4341.00
22_P25_F2.0131.00
17_L31_E1.8850.99
75_R85_V1.8840.99
90_K93_K1.8820.99
77_S80_E1.8180.99
86_E89_K1.7630.99
11_T29_H1.7580.99
17_L41_A1.7180.99
39_G44_I1.6910.99
41_A45_E1.6640.99
17_L21_I1.6570.99
5_H9_I1.6500.99
79_E82_K1.6420.99
77_S95_F1.6120.98
11_T20_S1.5860.98
14_K19_R1.5340.98
82_K86_E1.5150.97
87_E91_R1.4890.97
76_E81_E1.4850.97
79_E90_K1.3800.96
12_S36_G1.3490.95
3_S6_K1.3420.95
1_E7_K1.3110.94
88_F92_W1.2880.94
21_I41_A1.2870.94
57_E60_A1.2710.93
21_I25_F1.2380.92
39_G42_H1.2380.92
27_Y75_R1.2360.92
83_K86_E1.2180.92
39_G43_V1.1930.91
9_I20_S1.1880.91
64_D83_K1.1770.90
51_P70_W1.1530.89
30_V40_F1.1480.89
28_F50_F1.1370.89
70_W73_P1.1310.88
12_S15_K1.1070.87
21_I39_G1.0950.87
76_E84_R1.0520.84
51_P54_F1.0260.83
16_G19_R1.0150.82
57_E73_P1.0140.82
90_K94_P0.9870.80
42_H61_G0.9790.80
53_Q58_V0.9770.80
23_K26_P0.9440.77
88_F94_P0.9400.77
87_E90_K0.9290.76
36_G82_K0.9280.76
40_F44_I0.9020.74
4_Q20_S0.8950.73
28_F88_F0.8880.73
53_Q70_W0.8870.73
10_D13_A0.8830.72
5_H72_K0.8830.72
89_K92_W0.8780.72
46_D63_L0.8730.71
7_K95_F0.8570.70
51_P71_R0.8530.70
51_P65_L0.8440.69
27_Y98_T0.8400.69
25_F30_V0.8390.68
40_F47_E0.8370.68
4_Q56_R0.8340.68
15_K44_I0.8170.66
15_K20_S0.8160.66
83_K95_F0.8030.65
86_E93_K0.7830.63
15_K69_V0.7780.63
34_L97_W0.7680.62
2_W6_K0.7570.60
53_Q57_E0.7530.60
51_P55_G0.7410.59
31_E81_E0.7400.59
78_K86_E0.7330.58
60_A67_P0.7180.56
22_P50_F0.7180.56
17_L29_H0.7160.56
53_Q73_P0.7160.56
39_G97_W0.7060.55
60_A66_P0.7040.55
65_L74_C0.6970.54
51_P61_G0.6880.53
5_H56_R0.6880.53
13_A83_K0.6840.53
26_P97_W0.6830.53
62_M88_F0.6800.52
86_E90_K0.6780.52
48_K80_E0.6770.52
60_A70_W0.6720.52
30_V39_G0.6650.51
33_G36_G0.6590.50
25_F41_A0.6580.50
80_E93_K0.6500.49
8_L19_R0.6420.48
57_E70_W0.6410.48
35_D48_K0.6310.47
5_H8_L0.6290.47
7_K40_F0.6290.47
59_I68_R0.6280.47
6_K63_L0.6210.46
30_V96_D0.6160.46
60_A69_V0.6150.45
77_S92_W0.6010.44
31_E35_D0.6000.44
52_L56_R0.5980.44
32_F40_F0.5920.43
22_P27_Y0.5920.43
51_P67_P0.5860.42
60_A65_L0.5820.42
19_R89_K0.5800.42
59_I82_K0.5790.42
66_P69_V0.5740.41
64_D72_K0.5720.41
12_S35_D0.5710.41
36_G60_A0.5710.41
20_S30_V0.5700.41
10_D14_K0.5700.41
4_Q8_L0.5670.40
52_L70_W0.5650.40
32_F39_G0.5560.39
17_L24_G0.5550.39
57_E84_R0.5400.38
56_R89_K0.5380.37
78_K87_E0.5270.36
10_D15_K0.5260.36
27_Y39_G0.5220.36
19_R24_G0.5210.36
9_I43_V0.5090.35
21_I59_I0.5080.35
3_S82_K0.5050.34
61_G85_V0.5050.34
64_D92_W0.5030.34
31_E34_L0.5030.34
29_H34_L0.5030.34
20_S43_V0.5020.34
40_F91_R0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l1lA 1 0.9184 11.3 0.918 Contact Map
3j20L 1 0.3878 7.4 0.925 Contact Map
5aj3J 1 0.5612 5.2 0.93 Contact Map
3qsvA 1 0.4184 3.3 0.936 Contact Map
1dquA 4 0.9388 3.1 0.937 Contact Map
4wrtB 1 0.8469 2.9 0.939 Contact Map
2zp1A 2 0.9592 2.8 0.939 Contact Map
2ts1A 2 0.9796 2.7 0.939 Contact Map
2cyaA 2 0.9184 2.7 0.939 Contact Map
3c26A 2 0.6122 2.7 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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