GREMLIN Database
Phi_1 - Phosphate-induced protein 1 conserved region
PFAM: PF04674 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 275 (260)
Sequences: 1171 (740)
Seq/√Len: 45.9
META: 0.61

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_C156_C5.2351.00
82_D86_S5.1911.00
85_Y119_D4.3641.00
210_D222_K3.8811.00
113_F192_L3.5911.00
213_G216_G3.2511.00
143_D204_D3.2441.00
131_G191_V2.9691.00
87_L95_D2.6551.00
7_P206_N2.5801.00
135_S143_D2.3411.00
59_N62_Y2.3361.00
34_F39_S2.3271.00
188_M192_L2.2981.00
56_W59_N2.2091.00
31_I35_L2.1941.00
58_I62_Y2.1881.00
85_Y120_V2.1821.00
115_L188_M2.1671.00
34_F189_V2.0821.00
195_E198_E2.0630.99
135_S204_D2.0430.99
30_I34_F2.0340.99
57_K72_G1.9940.99
93_D129_Y1.9930.99
14_N77_G1.9920.99
16_Y110_G1.9570.99
152_P191_V1.9130.99
30_I39_S1.9110.99
30_I33_D1.9050.99
33_D257_R1.9000.99
194_H198_E1.8780.99
76_L79_Q1.8520.99
4_H209_Y1.8500.99
147_A195_E1.8300.99
64_D68_A1.8280.99
113_F147_A1.8210.99
178_S181_G1.8130.99
31_I34_F1.8120.99
106_N142_S1.7760.98
63_Y69_N1.7480.98
90_S123_T1.6700.98
27_Q182_D1.6630.98
247_A250_N1.6490.97
56_W200_V1.6370.97
130_C160_C1.6350.97
35_L39_S1.6210.97
34_F193_A1.6140.97
35_L38_L1.6140.97
17_L35_L1.6070.97
85_Y117_S1.6040.97
50_P53_S1.5650.97
95_D99_I1.5590.96
34_F38_L1.5370.96
179_P182_D1.5360.96
178_S183_V1.5150.96
64_D67_G1.5140.96
16_Y78_G1.4940.95
14_N107_D1.4810.95
98_A102_K1.4720.95
17_L192_L1.4630.95
99_I114_V1.4560.95
121_A155_Q1.4550.95
92_T95_D1.4480.95
74_V113_F1.4400.94
56_W62_Y1.4110.94
25_P28_K1.4040.94
218_E223_C1.3920.93
246_G250_N1.3920.93
194_H221_D1.3900.93
39_S51_S1.3780.93
32_S35_L1.3740.93
31_I39_S1.3600.93
57_K60_T1.3510.92
126_C155_Q1.3470.92
16_Y112_Y1.3280.92
124_G127_T1.3230.91
96_I122_V1.3170.91
31_I189_V1.3160.91
85_Y88_G1.3110.91
52_V55_W1.2860.90
33_D37_S1.2750.90
197_A219_N1.2550.89
34_F51_S1.2420.89
53_S62_Y1.2360.88
107_D110_G1.2350.88
123_T129_Y1.2280.88
202_D218_E1.2270.88
9_L145_K1.2230.88
31_I36_S1.2170.88
96_I99_I1.2100.87
55_W58_I1.2070.87
249_Y252_N1.2070.87
55_W62_Y1.2070.87
201_T219_N1.2040.87
31_I188_M1.1780.86
15_V74_V1.1750.86
213_G217_L1.1450.84
87_L102_K1.1380.84
57_K62_Y1.1380.84
157_P161_A1.1270.83
24_T27_Q1.1210.83
245_T249_Y1.1150.83
28_K31_I1.1110.82
50_P55_W1.0950.81
113_F149_V1.0860.81
220_A264_L1.0840.81
100_V114_V1.0800.81
195_E221_D1.0760.80
85_Y89_K1.0750.80
124_G128_S1.0730.80
115_L192_L1.0730.80
229_T238_S1.0630.79
129_Y132_F1.0520.79
197_A220_A1.0500.79
8_V142_S1.0440.78
219_N264_L1.0430.78
236_A240_L1.0430.78
82_D87_L1.0430.78
87_L98_A1.0390.78
55_W59_N1.0360.78
115_L184_G1.0350.78
54_P62_Y1.0330.77
19_W189_V1.0200.77
10_T65_S1.0190.76
113_F196_L1.0160.76
93_D132_F1.0120.76
230_G233_P1.0060.76
16_Y104_I1.0020.75
14_N75_S0.9990.75
63_Y67_G0.9990.75
178_S182_D0.9970.75
104_I112_Y0.9890.74
261_L264_L0.9860.74
53_S56_W0.9830.74
111_I199_T0.9830.74
90_S121_A0.9790.74
251_A254_V0.9770.73
194_H262_Q0.9740.73
125_F148_F0.9710.73
237_G240_L0.9700.73
241_V244_T0.9680.73
179_P183_V0.9670.73
123_T127_T0.9640.72
38_L103_A0.9630.72
182_D201_T0.9630.72
251_A261_L0.9470.71
106_N140_G0.9340.70
194_H264_L0.9280.69
209_Y224_A0.9230.69
38_L196_L0.9210.69
205_L209_Y0.9110.68
103_A146_Y0.9100.68
10_T68_A0.9080.68
89_K119_D0.9080.68
116_T122_V0.9040.67
232_Y236_A0.9020.67
174_P183_V0.9020.67
32_S79_Q0.8990.67
149_V187_G0.8980.67
249_Y258_K0.8960.67
33_D39_S0.8950.67
157_P183_V0.8940.67
115_L131_G0.8870.66
53_S59_N0.8850.66
247_A251_A0.8800.65
28_K35_L0.8780.65
178_S187_G0.8780.65
53_S57_K0.8760.65
20_Y150_G0.8670.64
27_Q31_I0.8610.64
244_T247_A0.8570.63
130_C133_H0.8570.63
17_L31_I0.8560.63
246_G249_Y0.8520.63
185_A188_M0.8510.63
126_C187_G0.8480.62
126_C157_P0.8400.62
49_Q53_S0.8400.62
212_S217_L0.8400.62
91_L120_V0.8330.61
188_M193_A0.8320.61
242_D258_K0.8310.61
16_Y107_D0.8230.60
240_L247_A0.8130.59
191_V198_E0.8110.59
93_D97_Q0.8090.59
131_G195_E0.8060.58
47_A51_S0.8060.58
28_K81_T0.8020.58
150_G156_C0.7950.57
17_L113_F0.7920.57
50_P56_W0.7910.57
36_S39_S0.7900.57
86_S102_K0.7890.57
190_S227_F0.7870.57
20_Y91_L0.7840.56
31_I38_L0.7810.56
13_V111_I0.7790.56
27_Q185_A0.7780.56
65_S69_N0.7770.56
184_G187_G0.7730.55
122_V129_Y0.7680.55
134_G205_L0.7670.55
9_L13_V0.7660.55
54_P60_T0.7650.55
232_Y235_Y0.7600.54
58_I64_D0.7510.53
13_V72_G0.7490.53
112_Y144_I0.7460.53
55_W197_A0.7450.53
82_D88_G0.7410.52
151_N184_G0.7350.52
149_V192_L0.7340.51
209_Y212_S0.7330.51
53_S58_I0.7320.51
187_G191_V0.7320.51
28_K34_F0.7310.51
56_W60_T0.7260.51
263_A266_D0.7250.51
96_I132_F0.7180.50
30_I51_S0.7160.50
196_L201_T0.7130.49
149_V188_M0.7090.49
18_I112_Y0.7070.49
254_V259_Y0.7010.48
236_A241_V0.7010.48
60_T64_D0.7010.48
54_P58_I0.7000.48
124_G129_Y0.7000.48
59_N219_N0.7000.48
31_I51_S0.7000.48
81_T102_K0.6950.48
148_F152_P0.6940.48
16_Y20_Y0.6910.47
80_V103_A0.6890.47
56_W201_T0.6880.47
165_H168_I0.6840.47
240_L243_K0.6820.46
126_C150_G0.6790.46
73_S78_G0.6770.46
51_S62_Y0.6770.46
30_I38_L0.6760.46
32_S39_S0.6740.46
238_S241_V0.6730.46
49_Q52_V0.6690.45
97_Q146_Y0.6670.45
48_P51_S0.6660.45
210_D213_G0.6650.45
198_E202_D0.6640.45
221_D225_G0.6640.45
190_S198_E0.6630.45
65_S68_A0.6630.45
190_S226_T0.6520.43
264_L267_P0.6510.43
245_T250_N0.6470.43
59_N197_A0.6470.43
73_S76_L0.6430.43
235_Y238_S0.6420.43
57_K63_Y0.6400.42
177_V180_N0.6350.42
131_G187_G0.6340.42
18_I39_S0.6330.42
240_L244_T0.6320.42
29_A182_D0.6310.41
220_A223_C0.6270.41
106_N139_I0.6250.41
116_T125_F0.6250.41
156_C187_G0.6230.41
135_S205_L0.6230.41
18_I100_V0.6200.40
190_S225_G0.6180.40
47_A50_P0.6180.40
33_D158_G0.6160.40
96_I114_V0.6140.40
112_Y132_F0.6140.40
8_V207_A0.6130.40
248_S251_A0.6120.40
13_V200_V0.6120.40
238_S243_K0.6100.39
74_V196_L0.6060.39
218_E221_D0.6060.39
262_Q265_W0.6050.39
152_P159_Q0.6030.39
78_G265_W0.6020.39
248_S266_D0.6020.39
94_A99_I0.6010.39
233_P245_T0.6010.39
180_N183_V0.6000.39
132_F225_G0.6000.39
87_L96_I0.5970.38
32_S36_S0.5960.38
252_N258_K0.5960.38
236_A265_W0.5960.38
205_L208_W0.5940.38
154_T161_A0.5920.38
51_S55_W0.5890.38
14_N110_G0.5860.37
39_S50_P0.5850.37
210_D216_G0.5840.37
161_A187_G0.5840.37
257_R267_P0.5810.37
232_Y237_G0.5790.37
18_I110_G0.5790.37
34_F50_P0.5760.36
202_D207_A0.5750.36
75_S98_A0.5740.36
128_S159_Q0.5740.36
52_V56_W0.5740.36
37_S181_G0.5730.36
19_W79_Q0.5730.36
111_I152_P0.5720.36
127_T159_Q0.5710.36
209_Y225_G0.5710.36
197_A264_L0.5700.36
3_Y6_G0.5700.36
14_N109_N0.5690.36
100_V104_I0.5670.36
161_A183_V0.5670.36
10_T63_Y0.5660.35
234_G240_L0.5650.35
17_L115_L0.5650.35
30_I180_N0.5640.35
20_Y110_G0.5620.35
74_V111_I0.5600.35
15_V113_F0.5600.35
241_V250_N0.5590.35
58_I61_T0.5570.35
35_L76_L0.5570.35
128_S191_V0.5570.35
95_D98_A0.5560.35
131_G198_E0.5560.35
82_D85_Y0.5550.34
244_T259_Y0.5550.34
154_T157_P0.5550.34
20_Y23_W0.5540.34
178_S238_S0.5540.34
109_N118_S0.5540.34
9_L15_V0.5530.34
174_P177_V0.5530.34
192_L196_L0.5510.34
191_V195_E0.5510.34
92_T212_S0.5500.34
160_C163_P0.5490.34
88_G120_V0.5470.34
55_W64_D0.5460.34
126_C151_N0.5460.34
27_Q35_L0.5460.34
145_K204_D0.5440.33
64_D69_N0.5440.33
33_D155_Q0.5430.33
50_P149_V0.5420.33
108_P142_S0.5420.33
55_W61_T0.5410.33
91_L95_D0.5370.33
9_L14_N0.5370.33
16_Y103_A0.5370.33
130_C134_G0.5360.33
118_S151_N0.5350.33
176_L225_G0.5340.33
110_G149_V0.5340.33
80_V83_E0.5340.33
14_N206_N0.5310.32
50_P58_I0.5300.32
18_I109_N0.5300.32
15_V38_L0.5280.32
58_I193_A0.5270.32
125_F155_Q0.5250.32
232_Y240_L0.5240.32
51_S59_N0.5230.32
5_G207_A0.5210.31
198_E219_N0.5200.31
54_P59_N0.5160.31
242_D245_T0.5160.31
241_V248_S0.5150.31
162_W260_L0.5130.31
17_L189_V0.5110.31
55_W60_T0.5110.31
39_S79_Q0.5100.31
237_G241_V0.5090.30
20_Y99_I0.5080.30
255_N258_K0.5070.30
116_T150_G0.5060.30
146_Y179_P0.5060.30
9_L147_A0.5030.30
157_P187_G0.5030.30
244_T248_S0.5030.30
153_A156_C0.5020.30
234_G238_S0.5020.30
2_N10_T0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sqdA 1 0.2691 2.7 0.978 Contact Map
4hjzA 1 0.2182 2.2 0.979 Contact Map
3bqoB 1 0.0473 2.1 0.979 Contact Map
3ljmA 3 0.0436 1.8 0.98 Contact Map
4rwuA 1 0.2945 1.6 0.98 Contact Map
1wwhA 3 0.0945 1.4 0.981 Contact Map
3fbyA 3 0.2145 1.4 0.981 Contact Map
3c5nA 1 0.2182 1.1 0.982 Contact Map
4rwfB 1 0.0618 1.1 0.982 Contact Map
4f8bA 5 0.3418 1.1 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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