Phi_1 - PFAM28P - GREMLIN Contacts

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Phi_1 - Phosphate-induced protein 1 conserved region

PFAM:	PF04674	Sequences: LNYHGGPVLTGPVNVYLIWYGNWTPSQKAIISDFLSSLSSSSSSSSAPQPSVSPWWKINTTYYDSTGANVSGSVSLGGQVTDESYSLGKSLTDADIQAIVSKAITNDPNGIYFVLTSSDVAVTGFCTSYCGFHGSTFTIGGSDIKYAFVGNPATQCPGQCAWPFHQPIYGPQGPPLVSPNGDVGADGMVSVLAHELAETVTDPDLNAWYDGSGPAGLENADKCAGTFGTGAYPGYAGSLLVDKTTGASYNANGVNGRKYLLQALWDPSTSSCSTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	275 (260)
Sequences:	1171 (740)
Seq/√Len:	45.9
META:	0.61

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
126_C	156_C	5.235	1.00
82_D	86_S	5.191	1.00
85_Y	119_D	4.364	1.00
210_D	222_K	3.881	1.00
113_F	192_L	3.591	1.00
213_G	216_G	3.251	1.00
143_D	204_D	3.244	1.00
131_G	191_V	2.969	1.00
87_L	95_D	2.655	1.00
7_P	206_N	2.580	1.00
135_S	143_D	2.341	1.00
59_N	62_Y	2.336	1.00
34_F	39_S	2.327	1.00
188_M	192_L	2.298	1.00
56_W	59_N	2.209	1.00
31_I	35_L	2.194	1.00
58_I	62_Y	2.188	1.00
85_Y	120_V	2.182	1.00
115_L	188_M	2.167	1.00
34_F	189_V	2.082	1.00
195_E	198_E	2.063	0.99
135_S	204_D	2.043	0.99
30_I	34_F	2.034	0.99
57_K	72_G	1.994	0.99
93_D	129_Y	1.993	0.99
14_N	77_G	1.992	0.99
16_Y	110_G	1.957	0.99
152_P	191_V	1.913	0.99
30_I	39_S	1.911	0.99
30_I	33_D	1.905	0.99
33_D	257_R	1.900	0.99
194_H	198_E	1.878	0.99
76_L	79_Q	1.852	0.99
4_H	209_Y	1.850	0.99
147_A	195_E	1.830	0.99
64_D	68_A	1.828	0.99
113_F	147_A	1.821	0.99
178_S	181_G	1.813	0.99
31_I	34_F	1.812	0.99
106_N	142_S	1.776	0.98
63_Y	69_N	1.748	0.98
90_S	123_T	1.670	0.98
27_Q	182_D	1.663	0.98
247_A	250_N	1.649	0.97
56_W	200_V	1.637	0.97
130_C	160_C	1.635	0.97
35_L	39_S	1.621	0.97
34_F	193_A	1.614	0.97
35_L	38_L	1.614	0.97
17_L	35_L	1.607	0.97
85_Y	117_S	1.604	0.97
50_P	53_S	1.565	0.97
95_D	99_I	1.559	0.96
34_F	38_L	1.537	0.96
179_P	182_D	1.536	0.96
178_S	183_V	1.515	0.96
64_D	67_G	1.514	0.96
16_Y	78_G	1.494	0.95
14_N	107_D	1.481	0.95
98_A	102_K	1.472	0.95
17_L	192_L	1.463	0.95
99_I	114_V	1.456	0.95
121_A	155_Q	1.455	0.95
92_T	95_D	1.448	0.95
74_V	113_F	1.440	0.94
56_W	62_Y	1.411	0.94
25_P	28_K	1.404	0.94
218_E	223_C	1.392	0.93
246_G	250_N	1.392	0.93
194_H	221_D	1.390	0.93
39_S	51_S	1.378	0.93
32_S	35_L	1.374	0.93
31_I	39_S	1.360	0.93
57_K	60_T	1.351	0.92
126_C	155_Q	1.347	0.92
16_Y	112_Y	1.328	0.92
124_G	127_T	1.323	0.91
96_I	122_V	1.317	0.91
31_I	189_V	1.316	0.91
85_Y	88_G	1.311	0.91
52_V	55_W	1.286	0.90
33_D	37_S	1.275	0.90
197_A	219_N	1.255	0.89
34_F	51_S	1.242	0.89
53_S	62_Y	1.236	0.88
107_D	110_G	1.235	0.88
123_T	129_Y	1.228	0.88
202_D	218_E	1.227	0.88
9_L	145_K	1.223	0.88
31_I	36_S	1.217	0.88
96_I	99_I	1.210	0.87
55_W	58_I	1.207	0.87
249_Y	252_N	1.207	0.87
55_W	62_Y	1.207	0.87
201_T	219_N	1.204	0.87
31_I	188_M	1.178	0.86
15_V	74_V	1.175	0.86
213_G	217_L	1.145	0.84
87_L	102_K	1.138	0.84
57_K	62_Y	1.138	0.84
157_P	161_A	1.127	0.83
24_T	27_Q	1.121	0.83
245_T	249_Y	1.115	0.83
28_K	31_I	1.111	0.82
50_P	55_W	1.095	0.81
113_F	149_V	1.086	0.81
220_A	264_L	1.084	0.81
100_V	114_V	1.080	0.81
195_E	221_D	1.076	0.80
85_Y	89_K	1.075	0.80
124_G	128_S	1.073	0.80
115_L	192_L	1.073	0.80
229_T	238_S	1.063	0.79
129_Y	132_F	1.052	0.79
197_A	220_A	1.050	0.79
8_V	142_S	1.044	0.78
219_N	264_L	1.043	0.78
236_A	240_L	1.043	0.78
82_D	87_L	1.043	0.78
87_L	98_A	1.039	0.78
55_W	59_N	1.036	0.78
115_L	184_G	1.035	0.78
54_P	62_Y	1.033	0.77
19_W	189_V	1.020	0.77
10_T	65_S	1.019	0.76
113_F	196_L	1.016	0.76
93_D	132_F	1.012	0.76
230_G	233_P	1.006	0.76
16_Y	104_I	1.002	0.75
14_N	75_S	0.999	0.75
63_Y	67_G	0.999	0.75
178_S	182_D	0.997	0.75
104_I	112_Y	0.989	0.74
261_L	264_L	0.986	0.74
53_S	56_W	0.983	0.74
111_I	199_T	0.983	0.74
90_S	121_A	0.979	0.74
251_A	254_V	0.977	0.73
194_H	262_Q	0.974	0.73
125_F	148_F	0.971	0.73
237_G	240_L	0.970	0.73
241_V	244_T	0.968	0.73
179_P	183_V	0.967	0.73
123_T	127_T	0.964	0.72
38_L	103_A	0.963	0.72
182_D	201_T	0.963	0.72
251_A	261_L	0.947	0.71
106_N	140_G	0.934	0.70
194_H	264_L	0.928	0.69
209_Y	224_A	0.923	0.69
38_L	196_L	0.921	0.69
205_L	209_Y	0.911	0.68
103_A	146_Y	0.910	0.68
10_T	68_A	0.908	0.68
89_K	119_D	0.908	0.68
116_T	122_V	0.904	0.67
232_Y	236_A	0.902	0.67
174_P	183_V	0.902	0.67
32_S	79_Q	0.899	0.67
149_V	187_G	0.898	0.67
249_Y	258_K	0.896	0.67
33_D	39_S	0.895	0.67
157_P	183_V	0.894	0.67
115_L	131_G	0.887	0.66
53_S	59_N	0.885	0.66
247_A	251_A	0.880	0.65
28_K	35_L	0.878	0.65
178_S	187_G	0.878	0.65
53_S	57_K	0.876	0.65
20_Y	150_G	0.867	0.64
27_Q	31_I	0.861	0.64
244_T	247_A	0.857	0.63
130_C	133_H	0.857	0.63
17_L	31_I	0.856	0.63
246_G	249_Y	0.852	0.63
185_A	188_M	0.851	0.63
126_C	187_G	0.848	0.62
126_C	157_P	0.840	0.62
49_Q	53_S	0.840	0.62
212_S	217_L	0.840	0.62
91_L	120_V	0.833	0.61
188_M	193_A	0.832	0.61
242_D	258_K	0.831	0.61
16_Y	107_D	0.823	0.60
240_L	247_A	0.813	0.59
191_V	198_E	0.811	0.59
93_D	97_Q	0.809	0.59
131_G	195_E	0.806	0.58
47_A	51_S	0.806	0.58
28_K	81_T	0.802	0.58
150_G	156_C	0.795	0.57
17_L	113_F	0.792	0.57
50_P	56_W	0.791	0.57
36_S	39_S	0.790	0.57
86_S	102_K	0.789	0.57
190_S	227_F	0.787	0.57
20_Y	91_L	0.784	0.56
31_I	38_L	0.781	0.56
13_V	111_I	0.779	0.56
27_Q	185_A	0.778	0.56
65_S	69_N	0.777	0.56
184_G	187_G	0.773	0.55
122_V	129_Y	0.768	0.55
134_G	205_L	0.767	0.55
9_L	13_V	0.766	0.55
54_P	60_T	0.765	0.55
232_Y	235_Y	0.760	0.54
58_I	64_D	0.751	0.53
13_V	72_G	0.749	0.53
112_Y	144_I	0.746	0.53
55_W	197_A	0.745	0.53
82_D	88_G	0.741	0.52
151_N	184_G	0.735	0.52
149_V	192_L	0.734	0.51
209_Y	212_S	0.733	0.51
53_S	58_I	0.732	0.51
187_G	191_V	0.732	0.51
28_K	34_F	0.731	0.51
56_W	60_T	0.726	0.51
263_A	266_D	0.725	0.51
96_I	132_F	0.718	0.50
30_I	51_S	0.716	0.50
196_L	201_T	0.713	0.49
149_V	188_M	0.709	0.49
18_I	112_Y	0.707	0.49
254_V	259_Y	0.701	0.48
236_A	241_V	0.701	0.48
60_T	64_D	0.701	0.48
54_P	58_I	0.700	0.48
124_G	129_Y	0.700	0.48
59_N	219_N	0.700	0.48
31_I	51_S	0.700	0.48
81_T	102_K	0.695	0.48
148_F	152_P	0.694	0.48
16_Y	20_Y	0.691	0.47
80_V	103_A	0.689	0.47
56_W	201_T	0.688	0.47
165_H	168_I	0.684	0.47
240_L	243_K	0.682	0.46
126_C	150_G	0.679	0.46
73_S	78_G	0.677	0.46
51_S	62_Y	0.677	0.46
30_I	38_L	0.676	0.46
32_S	39_S	0.674	0.46
238_S	241_V	0.673	0.46
49_Q	52_V	0.669	0.45
97_Q	146_Y	0.667	0.45
48_P	51_S	0.666	0.45
210_D	213_G	0.665	0.45
198_E	202_D	0.664	0.45
221_D	225_G	0.664	0.45
190_S	198_E	0.663	0.45
65_S	68_A	0.663	0.45
190_S	226_T	0.652	0.43
264_L	267_P	0.651	0.43
245_T	250_N	0.647	0.43
59_N	197_A	0.647	0.43
73_S	76_L	0.643	0.43
235_Y	238_S	0.642	0.43
57_K	63_Y	0.640	0.42
177_V	180_N	0.635	0.42
131_G	187_G	0.634	0.42
18_I	39_S	0.633	0.42
240_L	244_T	0.632	0.42
29_A	182_D	0.631	0.41
220_A	223_C	0.627	0.41
106_N	139_I	0.625	0.41
116_T	125_F	0.625	0.41
156_C	187_G	0.623	0.41
135_S	205_L	0.623	0.41
18_I	100_V	0.620	0.40
190_S	225_G	0.618	0.40
47_A	50_P	0.618	0.40
33_D	158_G	0.616	0.40
96_I	114_V	0.614	0.40
112_Y	132_F	0.614	0.40
8_V	207_A	0.613	0.40
248_S	251_A	0.612	0.40
13_V	200_V	0.612	0.40
238_S	243_K	0.610	0.39
74_V	196_L	0.606	0.39
218_E	221_D	0.606	0.39
262_Q	265_W	0.605	0.39
152_P	159_Q	0.603	0.39
78_G	265_W	0.602	0.39
248_S	266_D	0.602	0.39
94_A	99_I	0.601	0.39
233_P	245_T	0.601	0.39
180_N	183_V	0.600	0.39
132_F	225_G	0.600	0.39
87_L	96_I	0.597	0.38
32_S	36_S	0.596	0.38
252_N	258_K	0.596	0.38
236_A	265_W	0.596	0.38
205_L	208_W	0.594	0.38
154_T	161_A	0.592	0.38
51_S	55_W	0.589	0.38
14_N	110_G	0.586	0.37
39_S	50_P	0.585	0.37
210_D	216_G	0.584	0.37
161_A	187_G	0.584	0.37
257_R	267_P	0.581	0.37
232_Y	237_G	0.579	0.37
18_I	110_G	0.579	0.37
34_F	50_P	0.576	0.36
202_D	207_A	0.575	0.36
75_S	98_A	0.574	0.36
128_S	159_Q	0.574	0.36
52_V	56_W	0.574	0.36
37_S	181_G	0.573	0.36
19_W	79_Q	0.573	0.36
111_I	152_P	0.572	0.36
127_T	159_Q	0.571	0.36
209_Y	225_G	0.571	0.36
197_A	264_L	0.570	0.36
3_Y	6_G	0.570	0.36
14_N	109_N	0.569	0.36
100_V	104_I	0.567	0.36
161_A	183_V	0.567	0.36
10_T	63_Y	0.566	0.35
234_G	240_L	0.565	0.35
17_L	115_L	0.565	0.35
30_I	180_N	0.564	0.35
20_Y	110_G	0.562	0.35
74_V	111_I	0.560	0.35
15_V	113_F	0.560	0.35
241_V	250_N	0.559	0.35
58_I	61_T	0.557	0.35
35_L	76_L	0.557	0.35
128_S	191_V	0.557	0.35
95_D	98_A	0.556	0.35
131_G	198_E	0.556	0.35
82_D	85_Y	0.555	0.34
244_T	259_Y	0.555	0.34
154_T	157_P	0.555	0.34
20_Y	23_W	0.554	0.34
178_S	238_S	0.554	0.34
109_N	118_S	0.554	0.34
9_L	15_V	0.553	0.34
174_P	177_V	0.553	0.34
192_L	196_L	0.551	0.34
191_V	195_E	0.551	0.34
92_T	212_S	0.550	0.34
160_C	163_P	0.549	0.34
88_G	120_V	0.547	0.34
55_W	64_D	0.546	0.34
126_C	151_N	0.546	0.34
27_Q	35_L	0.546	0.34
145_K	204_D	0.544	0.33
64_D	69_N	0.544	0.33
33_D	155_Q	0.543	0.33
50_P	149_V	0.542	0.33
108_P	142_S	0.542	0.33
55_W	61_T	0.541	0.33
91_L	95_D	0.537	0.33
9_L	14_N	0.537	0.33
16_Y	103_A	0.537	0.33
130_C	134_G	0.536	0.33
118_S	151_N	0.535	0.33
176_L	225_G	0.534	0.33
110_G	149_V	0.534	0.33
80_V	83_E	0.534	0.33
14_N	206_N	0.531	0.32
50_P	58_I	0.530	0.32
18_I	109_N	0.530	0.32
15_V	38_L	0.528	0.32
58_I	193_A	0.527	0.32
125_F	155_Q	0.525	0.32
232_Y	240_L	0.524	0.32
51_S	59_N	0.523	0.32
5_G	207_A	0.521	0.31
198_E	219_N	0.520	0.31
54_P	59_N	0.516	0.31
242_D	245_T	0.516	0.31
241_V	248_S	0.515	0.31
162_W	260_L	0.513	0.31
17_L	189_V	0.511	0.31
55_W	60_T	0.511	0.31
39_S	79_Q	0.510	0.31
237_G	241_V	0.509	0.30
20_Y	99_I	0.508	0.30
255_N	258_K	0.507	0.30
116_T	150_G	0.506	0.30
146_Y	179_P	0.506	0.30
9_L	147_A	0.503	0.30
157_P	187_G	0.503	0.30
244_T	248_S	0.503	0.30
153_A	156_C	0.502	0.30
234_G	238_S	0.502	0.30
2_N	10_T	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3sqdA	1	0.2691	2.7	0.978	Contact Map
4hjzA	1	0.2182	2.2	0.979	Contact Map
3bqoB	1	0.0473	2.1	0.979	Contact Map
3ljmA	3	0.0436	1.8	0.98	Contact Map
4rwuA	1	0.2945	1.6	0.98	Contact Map
1wwhA	3	0.0945	1.4	0.981	Contact Map
3fbyA	3	0.2145	1.4	0.981	Contact Map
3c5nA	1	0.2182	1.1	0.982	Contact Map
4rwfB	1	0.0618	1.1	0.982	Contact Map
4f8bA	5	0.3418	1.1	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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