GREMLIN Database
Arch_fla_DE - Archaeal flagella protein
PFAM: PF04659 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (91)
Sequences: 632 (442)
Seq/√Len: 46.3
META: 0.775

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_A59_L4.4241.00
22_L55_L4.1271.00
21_W85_S3.2481.00
48_S51_V3.2021.00
9_P14_S3.1251.00
12_Y15_E3.0261.00
40_Y44_I2.5531.00
47_I51_V2.3461.00
25_L37_A2.3011.00
38_L52_R2.0691.00
17_V92_L2.0090.99
29_V77_L1.8970.99
42_E52_R1.8260.99
30_G33_G1.5710.97
77_L81_D1.5450.96
18_V92_L1.4850.95
50_D54_E1.4760.95
59_L66_D1.4360.94
28_R81_D1.3490.92
17_V31_R1.3170.91
89_I93_A1.3110.91
4_Y93_A1.3010.91
23_E27_E1.2890.91
8_L40_Y1.2350.89
29_V37_A1.2130.88
78_T81_D1.1990.87
32_E69_K1.1880.87
51_V55_L1.1700.86
11_D14_S1.1560.85
11_D15_E1.1530.85
43_D48_S1.1510.85
19_L91_K1.1510.85
16_V20_E1.1450.84
33_G36_D1.1070.82
61_G86_L1.1000.82
7_T50_D1.0820.81
33_G77_L1.0800.81
80_D91_K1.0460.79
52_R71_D1.0070.76
22_L63_D1.0060.76
39_D52_R0.9860.74
52_R56_L0.9510.72
62_I86_L0.9460.71
39_D73_K0.9270.70
20_E88_Y0.9260.70
5_L89_I0.9120.68
82_H85_S0.9020.68
40_Y78_T0.8950.67
41_Y82_H0.8900.67
7_T45_G0.8870.66
66_D71_D0.8840.66
56_L59_L0.8820.66
63_D80_D0.8770.65
86_L90_A0.8640.64
27_E62_I0.8600.64
28_R61_G0.8340.61
87_L90_A0.8330.61
82_H92_L0.8290.61
23_E60_R0.8250.61
37_A59_L0.8220.60
33_G73_K0.8190.60
30_G71_D0.8170.60
19_L84_Q0.8060.59
11_D60_R0.8000.58
67_V70_D0.8000.58
8_L55_L0.7920.58
19_L88_Y0.7890.57
21_W82_H0.7770.56
19_L87_L0.7690.55
79_V90_A0.7670.55
35_A56_L0.7660.55
12_Y18_V0.7460.53
74_P79_V0.7460.53
35_A79_V0.7420.53
11_D16_V0.7420.53
87_L91_K0.7320.52
23_E68_E0.7260.51
24_F80_D0.7200.50
85_S88_Y0.7150.50
72_W75_S0.7140.50
17_V84_Q0.7110.50
16_V67_V0.6950.48
12_Y53_D0.6890.47
60_R76_D0.6780.46
31_R62_I0.6760.46
22_L77_L0.6730.46
10_D60_R0.6680.45
38_L56_L0.6680.45
17_V83_I0.6590.44
9_P71_D0.6530.44
58_Y61_G0.6520.44
36_D81_D0.6470.43
70_D80_D0.6460.43
44_I57_D0.6450.43
69_K72_W0.6410.43
13_A34_A0.6380.42
11_D20_E0.6320.42
77_L83_I0.6310.42
40_Y47_I0.6280.41
23_E86_L0.6270.41
39_D54_E0.6270.41
37_A77_L0.6260.41
9_P20_E0.6220.41
28_R38_L0.6190.41
35_A77_L0.6170.40
26_V30_G0.6130.40
49_E71_D0.6120.40
30_G37_A0.6060.39
37_A92_L0.6050.39
66_D70_D0.6040.39
20_E87_L0.5990.39
55_L70_D0.5980.39
49_E88_Y0.5950.38
57_D68_E0.5940.38
16_V79_V0.5910.38
7_T10_D0.5780.37
14_S20_E0.5760.37
84_Q90_A0.5700.36
26_V77_L0.5660.36
41_Y46_W0.5610.35
14_S91_K0.5590.35
88_Y92_L0.5490.34
90_A93_A0.5410.33
45_G68_E0.5380.33
13_A57_D0.5370.33
12_Y29_V0.5370.33
46_W82_H0.5360.33
19_L92_L0.5310.33
24_F70_D0.5280.32
39_D90_A0.5210.32
3_P80_D0.5140.31
56_L84_Q0.5140.31
19_L61_G0.5120.31
17_V26_V0.5060.30
79_V93_A0.5000.30
40_Y61_G0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aqeA 1 0.4574 12.6 0.902 Contact Map
2cujA 1 0.4681 12.3 0.903 Contact Map
3mkqA 2 0.4894 8 0.91 Contact Map
1q06A 2 0.5851 6.7 0.913 Contact Map
2fokA 1 0.9787 6.3 0.915 Contact Map
2eljA 1 0.4362 6.1 0.915 Contact Map
2dg6A 2 0.4894 5.5 0.917 Contact Map
3gp4A 4 0.5957 5.4 0.917 Contact Map
3zj0A 1 0.6702 5.2 0.918 Contact Map
1x3uA 1 0.5213 5 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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