GREMLIN Database
ERG2_Sigma1R - ERG2 and Sigma1 receptor like protein
PFAM: PF04622 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 208 (199)
Sequences: 624 (397)
Seq/√Len: 28.2
META: 0.481

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_W170_S3.0481.00
179_T189_L2.9271.00
130_Q134_E2.8261.00
124_W133_R2.7871.00
176_L193_V2.7541.00
180_L189_L2.7171.00
117_T141_V2.6470.99
75_N106_H2.5970.99
125_A142_H2.4760.99
137_R140_D2.3400.99
47_V96_I2.3270.99
61_H203_N2.3210.99
82_A159_W2.2940.99
178_D182_S2.2490.98
75_N183_T2.2230.98
79_A152_Y2.1850.98
113_D143_H2.1700.98
123_Q142_H2.1680.98
80_M106_H2.0690.97
34_R53_E2.0590.97
77_G174_F2.0400.97
144_L150_K1.9250.96
85_I196_Y1.9180.95
80_M174_F1.9050.95
116_F160_A1.8990.95
29_H141_V1.8680.95
75_N80_M1.8570.95
61_H87_H1.7810.93
10_Y14_D1.7410.92
142_H150_K1.7360.92
189_L193_V1.7040.92
88_A196_Y1.6800.91
118_I123_Q1.6720.91
197_G204_L1.6520.90
17_L20_F1.6400.90
116_F123_Q1.6270.90
82_A126_Y1.6120.89
51_V96_I1.6110.89
112_A167_W1.5740.88
35_A50_I1.5640.88
76_A97_F1.5410.87
51_V86_L1.5360.87
27_V57_R1.5360.87
50_I53_E1.5240.86
134_E150_K1.5180.86
118_I160_A1.5130.86
114_D152_Y1.4960.85
27_V58_Y1.4940.85
98_G159_W1.4900.85
114_D164_A1.4520.83
113_D146_R1.4490.83
114_D160_A1.4390.83
81_G97_F1.4130.82
124_W153_K1.3980.81
50_I119_L1.3970.81
74_N152_Y1.3410.78
122_E137_R1.3320.77
76_A174_F1.3190.77
111_T170_S1.3120.76
201_I205_L1.2970.76
35_A49_A1.2820.75
109_R149_A1.2780.74
10_Y13_L1.2770.74
11_Y15_T1.2670.74
123_Q160_A1.2620.73
24_D27_V1.2610.73
70_E198_R1.2580.73
10_Y16_W1.2450.72
30_E34_R1.2390.72
72_V195_I1.2370.72
154_M157_G1.2290.71
78_G178_D1.2230.71
94_L110_H1.2150.71
114_D123_Q1.2130.70
155_P158_C1.2050.70
197_G201_I1.1960.69
107_S142_H1.1880.69
27_V31_I1.1750.68
72_V85_I1.1740.68
145_P148_Q1.1720.68
196_Y200_M1.1670.67
12_L16_W1.1630.67
114_D142_H1.1530.66
124_W156_E1.1500.66
10_Y15_T1.1470.66
21_Y115_Y1.1450.66
29_H117_T1.1400.66
199_E203_N1.1310.65
114_D125_A1.1240.64
80_M183_T1.1210.64
12_L15_T1.1180.64
114_D171_M1.1130.64
54_L191_R1.1120.64
120_D157_G1.0840.62
88_A169_P1.0670.60
8_A12_L1.0620.60
8_A11_Y1.0560.60
81_G152_Y1.0500.59
35_A53_E1.0380.58
87_H182_S1.0310.58
101_I155_P1.0250.57
83_M95_I1.0180.57
47_V131_L1.0150.56
51_V84_Y1.0090.56
134_E142_H1.0060.56
116_F142_H1.0060.56
32_A36_I1.0010.55
164_A175_G0.9900.55
31_I53_E0.9830.54
114_D118_I0.9750.53
32_A94_L0.9730.53
8_A15_T0.9670.53
115_Y141_V0.9630.52
74_N103_T0.9620.52
22_V50_I0.9610.52
164_A171_M0.9600.52
31_I50_I0.9560.52
23_F73_F0.9420.51
118_I158_C0.9410.51
60_G128_E0.9390.51
99_T104_E0.9300.50
125_A171_M0.9230.49
52_D94_L0.9230.49
142_H160_A0.9180.49
190_W194_R0.9050.48
174_F183_T0.9020.48
110_H160_A0.9000.48
126_Y151_Q0.8990.48
46_M119_L0.8990.48
9_L16_W0.8970.47
9_L14_D0.8940.47
104_E126_Y0.8870.47
50_I94_L0.8830.46
74_N175_G0.8760.46
8_A40_P0.8760.46
105_G108_G0.8740.46
34_R49_A0.8730.46
171_M183_T0.8570.44
93_Y98_G0.8480.44
154_M160_A0.8370.43
194_R199_E0.8320.42
36_I138_P0.8310.42
70_E84_Y0.8280.42
79_A95_I0.8270.42
79_A171_M0.8220.42
110_H164_A0.8170.41
124_W155_P0.8170.41
85_I195_I0.8140.41
191_R194_R0.8070.41
112_A168_I0.8050.40
180_L187_P0.8030.40
82_A100_P0.8030.40
50_I54_L0.7920.39
9_L13_L0.7900.39
79_A103_T0.7900.39
136_Y183_T0.7850.39
154_M158_C0.7830.39
110_H114_D0.7830.39
82_A128_E0.7790.39
107_S144_L0.7760.38
60_G206_R0.7650.38
16_W20_F0.7640.37
172_L189_L0.7620.37
29_H33_K0.7610.37
13_L16_W0.7610.37
101_I151_Q0.7610.37
85_I88_A0.7600.37
74_N97_F0.7540.37
97_F103_T0.7510.37
176_L189_L0.7490.36
75_N188_T0.7360.35
81_G168_I0.7350.35
74_N178_D0.7340.35
186_F205_L0.7310.35
125_A134_E0.7290.35
202_R206_R0.7270.35
65_L163_Y0.7220.34
59_P63_I0.7130.34
28_L161_L0.7120.34
106_H125_A0.7090.34
33_K44_E0.7080.34
77_G183_T0.7070.33
48_D52_D0.7010.33
192_T196_Y0.7010.33
55_A60_G0.6980.33
52_D56_E0.6970.33
83_M192_T0.6920.32
86_L170_S0.6900.32
195_I198_R0.6890.32
76_A178_D0.6880.32
37_G200_M0.6850.32
127_T148_Q0.6850.32
196_Y199_E0.6810.32
200_M205_L0.6770.31
116_F125_A0.6720.31
182_S192_T0.6690.31
40_P44_E0.6590.30
15_T18_P0.6570.30
58_Y63_I0.6560.30
16_W100_P0.6530.30
82_A129_G0.6520.30
112_A164_A0.6520.30
30_E57_R0.6510.30
74_N192_T0.6510.30
90_I110_H0.6420.29
14_D58_Y0.6410.29
186_F190_W0.6390.29
125_A152_Y0.6370.29
85_I138_P0.6360.29
48_D94_L0.6350.29
90_I169_P0.6350.29
123_Q152_Y0.6340.29
150_K160_A0.6320.29
9_L18_P0.6310.28
55_A205_L0.6300.28
168_I171_M0.6290.28
107_S181_F0.6280.28
27_V32_A0.6280.28
75_N171_M0.6260.28
176_L192_T0.6210.28
90_I95_I0.6210.28
93_Y162_E0.6190.28
152_Y171_M0.6160.28
39_H42_P0.6160.28
8_A13_L0.6120.27
9_L12_L0.6100.27
73_F172_L0.6100.27
177_A183_T0.6090.27
95_I114_D0.6080.27
136_Y140_D0.6050.27
59_P96_I0.6000.27
194_R198_R0.5990.26
44_E69_E0.5960.26
74_N102_G0.5950.26
104_E124_W0.5940.26
174_F177_A0.5890.26
113_D145_P0.5880.26
13_L42_P0.5870.26
56_E59_P0.5870.26
31_I34_R0.5860.26
12_L17_L0.5840.26
96_I191_R0.5830.26
118_I142_H0.5830.26
24_D173_P0.5820.25
95_I152_Y0.5810.25
125_A160_A0.5800.25
87_H176_L0.5770.25
49_A53_E0.5770.25
171_M174_F0.5770.25
11_Y16_W0.5760.25
31_I49_A0.5730.25
16_W40_P0.5730.25
150_K203_N0.5690.25
116_F164_A0.5680.25
75_N87_H0.5680.25
180_L194_R0.5670.25
187_P194_R0.5640.24
188_T192_T0.5630.24
37_G43_T0.5580.24
25_P180_L0.5570.24
17_L133_R0.5520.24
106_H129_G0.5490.24
55_A67_T0.5470.23
112_A174_F0.5460.23
80_M112_A0.5450.23
72_V191_R0.5440.23
144_L152_Y0.5430.23
59_P202_R0.5430.23
80_M152_Y0.5390.23
76_A177_A0.5380.23
53_E57_R0.5380.23
174_F178_D0.5360.23
79_A104_E0.5360.23
41_L44_E0.5360.23
123_Q150_K0.5320.23
88_A167_W0.5310.23
171_M175_G0.5310.23
118_I144_L0.5300.23
136_Y175_G0.5260.22
87_H91_T0.5250.22
18_P100_P0.5250.22
9_L15_T0.5220.22
143_H146_R0.5220.22
15_T130_Q0.5220.22
75_N178_D0.5210.22
118_I154_M0.5200.22
186_F194_R0.5180.22
14_D146_R0.5180.22
197_G205_L0.5150.22
10_Y19_K0.5150.22
178_D188_T0.5140.22
15_T60_G0.5140.22
97_F152_Y0.5120.22
109_R187_P0.5100.22
86_L199_E0.5080.21
46_M120_D0.5060.21
83_M87_H0.5000.21
89_S99_T0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3balA 4 0.6779 95.5 0.92 Contact Map
2o1qA 4 0.6538 94.1 0.926 Contact Map
5bpxA 2 0.6827 88.7 0.936 Contact Map
4p9gA 2 0.649 83.3 0.941 Contact Map
3cjxA 6 0.7019 77.7 0.944 Contact Map
1yhfA 2 0.5481 76.2 0.945 Contact Map
3ebrA 4 0.6971 66.3 0.949 Contact Map
2cavA 3 0.726 66.1 0.949 Contact Map
2q1zB 1 0.6779 64.7 0.949 Contact Map
3s7iA 3 0.726 64 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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