GREMLIN Database
Ribophorin_I - Ribophorin I
PFAM: PF04597 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 439 (426)
Sequences: 605 (462)
Seq/√Len: 22.4
META: 0.182

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_N142_T7.5541.00
3_N36_Y7.0521.00
271_V285_L5.8451.00
36_Y142_T5.3851.00
217_A317_N4.8801.00
362_N412_K4.8521.00
377_E392_V4.5371.00
212_H411_Y4.4251.00
215_N317_N4.3371.00
119_E230_K4.2801.00
270_D317_N4.2631.00
208_I352_V3.4411.00
111_H348_D3.0561.00
209_E215_N2.9540.99
413_F421_K2.9210.99
338_F369_F2.8670.99
203_S349_E2.8440.99
324_L334_L2.7450.99
200_T227_T2.7180.99
279_N283_S2.6640.99
365_V391_V2.6610.99
273_Y280_I2.5580.98
272_Y315_G2.5440.98
201_V204_L2.5140.98
379_H390_V2.4990.98
39_A86_Y2.4500.98
6_V136_V2.4440.98
36_Y103_L2.4300.98
3_N6_V2.3380.97
226_H399_V2.3080.97
363_I389_P2.2220.96
210_V334_L2.2030.96
352_V407_F2.1860.96
335_K406_D2.1690.96
48_L109_L2.1610.95
38_L53_A2.1450.95
134_A188_I2.1300.95
240_Y256_A2.1030.95
25_V36_Y2.0730.94
384_D388_R2.0700.94
6_V23_I2.0350.94
121_T124_E1.9770.93
199_L257_L1.9560.92
226_H305_F1.9520.92
91_L103_L1.9510.92
349_E394_E1.9320.92
53_A89_V1.8840.91
280_I310_Y1.8820.91
130_Y224_L1.8650.90
195_N226_H1.8570.90
354_V407_F1.7800.88
226_H304_L1.7770.88
421_K424_L1.7650.88
358_E387_G1.7610.88
198_F228_G1.7480.87
414_P417_A1.7430.87
113_L192_Y1.7270.86
315_G358_E1.7240.86
231_L282_T1.7140.86
134_A162_L1.6870.85
199_L304_L1.6610.84
427_A431_L1.6530.84
239_D242_R1.6400.83
126_Q229_A1.6300.83
372_D407_F1.6190.83
127_L157_E1.6140.82
110_T346_V1.5990.82
395_K403_H1.5940.82
111_H200_T1.5790.81
38_L89_V1.5700.81
205_E351_T1.5540.80
134_A298_L1.5320.79
356_L409_V1.5200.78
96_A99_E1.5190.78
385_T424_L1.5080.78
165_P177_Y1.4830.77
128_V198_F1.4760.76
209_E217_A1.4690.76
10_I229_A1.4570.75
67_V71_L1.4570.75
262_T341_P1.4510.75
23_I136_V1.4500.75
426_V430_F1.4400.74
315_G387_G1.4280.74
3_N138_S1.4280.74
261_K295_E1.4210.73
120_I229_A1.4200.73
23_I36_Y1.4170.73
388_R433_F1.3900.72
290_D293_E1.3850.71
114_K131_T1.3690.70
335_K408_Q1.3650.70
116_L129_L1.3560.70
202_T348_D1.3480.69
125_K193_E1.3470.69
25_V103_L1.3460.69
125_K155_N1.3440.69
34_S90_T1.3430.69
260_L312_F1.3350.69
219_E272_Y1.3330.68
268_A318_L1.3310.68
216_I323_F1.3240.68
296_L391_V1.3150.67
391_V409_V1.3130.67
27_N97_P1.3080.67
128_V194_N1.3070.67
153_S398_L1.3050.67
49_A74_T1.2950.66
369_F403_H1.2910.66
135_Y180_V1.2860.66
432_L437_I1.2770.65
305_F399_V1.2720.65
3_N23_I1.2690.64
265_P319_P1.2670.64
285_L296_L1.2640.64
210_V356_L1.2630.64
384_D387_G1.2620.64
413_F418_M1.2600.64
215_N272_Y1.2500.63
278_G301_R1.2470.63
111_H346_V1.2360.62
123_S239_D1.2350.62
273_Y283_S1.2330.62
205_E221_R1.2280.62
228_G315_G1.2210.61
235_F303_P1.2190.61
220_E305_F1.2190.61
119_E232_K1.2180.61
303_P308_W1.2090.61
312_F339_L1.2070.61
280_I390_V1.2010.60
373_S394_E1.1890.59
353_K390_V1.1870.59
351_T394_E1.1840.59
208_I218_V1.1800.59
6_V21_T1.1700.58
144_K178_E1.1640.58
117_P308_W1.1560.57
415_K419_L1.1480.57
362_N379_H1.1460.56
372_D395_K1.1390.56
135_Y145_Q1.1370.56
339_L347_V1.1360.56
267_G337_P1.1350.56
353_K392_V1.1230.55
120_I214_G1.1210.55
115_P356_L1.1210.55
331_K410_T1.1200.55
21_T38_L1.1200.55
147_T177_Y1.1160.54
203_S223_D1.1130.54
200_T346_V1.1070.54
164_K167_K1.1020.53
209_E281_S1.0970.53
309_K314_I1.0930.53
6_V10_I1.0920.53
275_D301_R1.0920.53
236_S409_V1.0920.53
384_D421_K1.0790.52
418_M421_K1.0770.52
352_V393_L1.0680.51
114_K180_V1.0660.51
275_D278_G1.0650.51
203_S351_T1.0650.51
233_G368_P1.0630.51
23_I39_A1.0590.51
129_L189_T1.0530.50
2_E143_K1.0510.50
347_V350_L1.0510.50
12_L296_L1.0470.50
216_I320_L1.0460.50
361_T412_K1.0460.50
44_E47_H1.0460.50
17_V113_L1.0460.50
382_Y419_L1.0420.49
226_H301_R1.0420.49
206_R272_Y1.0410.49
119_E394_E1.0350.49
301_R357_P1.0280.48
27_N32_P1.0240.48
211_S384_D1.0230.48
39_A139_P1.0170.48
89_V350_L1.0170.48
17_V99_E1.0140.47
191_H274_R1.0140.47
35_E60_D1.0090.47
110_T348_D1.0080.47
213_W422_P1.0060.47
51_I391_V1.0050.47
431_L435_A1.0040.47
134_A186_S1.0040.47
220_E298_L0.9990.46
3_N25_V0.9920.46
310_Y337_P0.9890.46
335_K392_V0.9850.45
373_S376_D0.9850.45
32_P72_K0.9850.45
105_V438_V0.9820.45
93_K393_L0.9820.45
429_F433_F0.9820.45
282_T385_T0.9800.45
213_W387_G0.9780.45
29_G33_V0.9760.45
219_E315_G0.9740.45
297_E332_Y0.9740.45
321_S335_K0.9720.45
271_V348_D0.9710.44
214_G229_A0.9680.44
198_F304_L0.9670.44
11_D236_S0.9670.44
294_V310_Y0.9660.44
37_Y86_Y0.9590.44
427_A430_F0.9560.43
265_P383_L0.9520.43
428_A433_F0.9490.43
207_D379_H0.9490.43
161_K226_H0.9470.43
367_T370_P0.9470.43
226_H309_K0.9460.43
129_L318_L0.9450.43
312_F341_P0.9440.43
212_H281_S0.9430.43
153_S228_G0.9410.42
284_H414_P0.9340.42
212_H215_N0.9330.42
96_A189_T0.9300.42
235_F315_G0.9270.42
382_Y398_L0.9270.42
296_L314_I0.9230.41
315_G384_D0.9180.41
216_I262_T0.9150.41
299_R316_Y0.9130.41
209_E381_T0.9070.40
265_P368_P0.9030.40
194_N198_F0.9030.40
49_A110_T0.9020.40
225_R309_K0.9000.40
37_Y88_S0.8970.40
106_E222_Y0.8970.40
149_V190_V0.8940.39
382_Y387_G0.8910.39
217_A320_L0.8900.39
164_K177_Y0.8890.39
144_K188_I0.8880.39
294_V302_Y0.8840.39
25_V91_L0.8830.39
269_H317_N0.8820.39
71_L75_E0.8820.39
312_F343_E0.8790.38
27_N95_L0.8780.38
151_L172_I0.8780.38
170_S181_P0.8770.38
71_L349_E0.8770.38
8_R147_T0.8760.38
99_E144_K0.8740.38
122_Q388_R0.8710.38
136_V139_P0.8660.38
121_T253_G0.8650.37
203_S438_V0.8630.37
8_R145_Q0.8620.37
358_E382_Y0.8610.37
436_A439_Y0.8590.37
229_A399_V0.8580.37
96_A438_V0.8580.37
130_Y365_V0.8570.37
434_V438_V0.8550.37
79_D435_A0.8540.37
260_L393_L0.8530.37
28_T48_L0.8530.37
235_F308_W0.8520.37
272_Y358_E0.8520.37
135_Y159_Y0.8480.36
374_Q393_L0.8440.36
137_L184_S0.8440.36
280_I421_K0.8430.36
275_D357_P0.8420.36
282_T315_G0.8410.36
2_E5_N0.8410.36
279_N388_R0.8390.36
40_F49_A0.8380.36
112_A130_Y0.8370.36
109_L220_E0.8340.36
47_H180_V0.8270.35
360_A363_I0.8190.35
198_F226_H0.8180.35
158_S191_H0.8180.35
117_P300_P0.8150.34
54_K57_D0.8120.34
211_S315_G0.8120.34
122_Q283_S0.8050.34
366_S408_Q0.8050.34
34_S184_S0.8010.33
223_D309_K0.8010.33
403_H407_F0.7990.33
129_L377_E0.7970.33
172_I273_Y0.7950.33
48_L107_Y0.7950.33
105_V439_Y0.7920.33
143_K178_E0.7920.33
59_K192_Y0.7910.33
229_A274_R0.7910.33
214_G324_L0.7900.33
87_Y238_V0.7880.33
87_Y367_T0.7880.33
149_V178_E0.7880.33
56_K92_P0.7810.32
391_V425_V0.7800.32
268_A418_M0.7800.32
206_R313_T0.7800.32
206_R213_W0.7790.32
317_N320_L0.7770.32
406_D417_A0.7760.32
233_G389_P0.7750.32
195_N253_G0.7750.32
56_K60_D0.7740.32
6_V382_Y0.7730.32
105_V139_P0.7720.32
95_L344_D0.7710.32
14_S280_I0.7710.32
221_R314_I0.7690.32
272_Y422_P0.7690.32
271_V299_R0.7670.31
202_T309_K0.7620.31
83_D230_K0.7610.31
312_F337_P0.7600.31
149_V188_I0.7600.31
214_G407_F0.7590.31
122_Q286_R0.7590.31
172_I361_T0.7580.31
142_T180_V0.7570.31
130_Y174_Y0.7570.31
132_G404_N0.7570.31
83_D149_V0.7550.31
224_L409_V0.7550.31
313_T410_T0.7540.31
202_T323_F0.7530.31
267_G322_D0.7510.30
12_L130_Y0.7510.30
175_G315_G0.7500.30
258_K431_L0.7500.30
126_Q197_P0.7500.30
277_I306_G0.7490.30
78_V330_G0.7490.30
43_D71_L0.7480.30
21_T380_Y0.7470.30
215_N381_T0.7470.30
216_I336_V0.7460.30
238_V258_K0.7440.30
183_F202_T0.7400.30
27_N305_F0.7370.30
101_V182_P0.7370.30
7_V22_T0.7360.30
146_K168_S0.7350.30
93_K429_F0.7350.30
12_L196_K0.7340.30
277_I338_F0.7310.29
185_Y350_L0.7300.29
5_N26_E0.7290.29
112_A284_H0.7280.29
91_L302_Y0.7250.29
124_E348_D0.7230.29
256_A380_Y0.7230.29
90_T439_Y0.7230.29
66_E71_L0.7230.29
118_A154_S0.7200.29
66_E69_L0.7200.29
286_R297_E0.7200.29
271_V431_L0.7200.29
268_A316_Y0.7190.29
216_I324_L0.7170.29
164_K344_D0.7130.28
273_Y386_V0.7120.28
198_F421_K0.7120.28
196_K302_Y0.7090.28
210_V336_V0.7080.28
60_D190_V0.7080.28
272_Y387_G0.7080.28
182_P290_D0.7070.28
131_T189_T0.7050.28
332_Y335_K0.7050.28
262_T312_F0.7050.28
308_W357_P0.7020.28
8_R41_P0.7020.28
10_I354_V0.7020.28
21_T107_Y0.7000.28
226_H274_R0.6990.28
222_Y260_L0.6990.28
381_T385_T0.6980.27
224_L260_L0.6970.27
285_L294_V0.6960.27
316_Y342_F0.6960.27
41_P189_T0.6930.27
111_H228_G0.6920.27
214_G309_K0.6900.27
204_L297_E0.6890.27
206_R299_R0.6870.27
5_N22_T0.6870.27
299_R335_K0.6850.27
237_R308_W0.6850.27
213_W283_S0.6840.27
312_F411_Y0.6820.27
117_P126_Q0.6790.26
21_T146_K0.6780.26
141_P258_K0.6770.26
201_V225_R0.6770.26
130_Y309_K0.6760.26
25_V138_S0.6760.26
121_T431_L0.6750.26
4_T26_E0.6750.26
102_T109_L0.6740.26
71_L74_T0.6740.26
150_K224_L0.6730.26
43_D224_L0.6730.26
6_V407_F0.6710.26
23_I409_V0.6700.26
365_V374_Q0.6700.26
134_A277_I0.6660.26
211_S236_S0.6660.26
237_R384_D0.6640.26
128_V229_A0.6630.26
302_Y398_L0.6620.26
38_L51_I0.6620.26
281_S315_G0.6600.25
198_F373_S0.6580.25
262_T335_K0.6560.25
115_P231_L0.6560.25
218_V316_Y0.6560.25
20_T99_E0.6550.25
202_T225_R0.6540.25
281_S300_P0.6510.25
84_T137_L0.6500.25
423_L434_V0.6490.25
11_D415_K0.6490.25
117_P306_G0.6450.25
284_H360_A0.6420.25
16_Y27_N0.6410.24
174_Y188_I0.6400.24
316_Y421_K0.6400.24
20_T51_I0.6390.24
242_R260_L0.6370.24
130_Y180_V0.6370.24
226_H275_D0.6370.24
369_F395_K0.6360.24
211_S387_G0.6350.24
226_H278_G0.6340.24
45_A87_Y0.6330.24
351_T392_V0.6320.24
84_T302_Y0.6320.24
14_S17_V0.6320.24
220_E404_N0.6310.24
24_T330_G0.6300.24
206_R370_P0.6300.24
72_K75_E0.6270.24
25_V426_V0.6270.24
25_V35_E0.6270.24
152_P266_A0.6260.24
107_Y148_K0.6260.24
217_A381_T0.6250.24
133_S188_I0.6240.24
89_V205_E0.6240.24
73_V96_A0.6240.24
117_P356_L0.6230.24
265_P316_Y0.6230.24
148_K173_T0.6220.24
317_N381_T0.6220.24
169_G344_D0.6210.23
239_D355_I0.6190.23
117_P229_A0.6180.23
42_P46_D0.6180.23
95_L351_T0.6170.23
156_V172_I0.6160.23
37_Y208_I0.6150.23
127_L155_N0.6150.23
130_Y187_P0.6130.23
331_K409_V0.6120.23
145_Q159_Y0.6120.23
179_N241_Q0.6110.23
43_D416_L0.6110.23
8_R18_K0.6100.23
418_M439_Y0.6100.23
209_E214_G0.6100.23
376_D430_F0.6070.23
229_A397_N0.6060.23
355_I379_H0.6050.23
148_K171_T0.6050.23
311_S320_L0.6040.23
190_V361_T0.6040.23
173_T254_T0.6020.23
152_P192_Y0.6000.22
274_R316_Y0.5990.22
209_E212_H0.5980.22
383_L389_P0.5980.22
6_V32_P0.5960.22
310_Y340_D0.5950.22
322_D337_P0.5950.22
302_Y310_Y0.5950.22
283_S315_G0.5930.22
364_K378_L0.5920.22
70_V74_T0.5910.22
204_L350_L0.5900.22
84_T201_V0.5900.22
200_T348_D0.5890.22
35_E327_D0.5880.22
432_L438_V0.5880.22
25_V56_K0.5870.22
124_E399_V0.5870.22
220_E399_V0.5860.22
40_F92_P0.5850.22
342_F439_Y0.5830.22
312_F345_V0.5830.22
113_L177_Y0.5820.22
102_T169_G0.5820.22
302_Y380_Y0.5800.22
220_E337_P0.5800.22
282_T310_Y0.5800.22
9_T69_L0.5800.22
371_V398_L0.5790.21
236_S241_Q0.5790.21
272_Y305_F0.5790.21
87_Y184_S0.5780.21
262_T310_Y0.5780.21
205_E349_E0.5770.21
216_I311_S0.5760.21
216_I379_H0.5760.21
5_N144_K0.5760.21
134_A386_V0.5750.21
16_Y53_A0.5740.21
374_Q434_V0.5740.21
422_P433_F0.5720.21
98_G138_S0.5710.21
282_T358_E0.5710.21
82_S360_A0.5700.21
192_Y197_P0.5670.21
98_G190_V0.5670.21
129_L204_L0.5660.21
165_P182_P0.5660.21
59_K414_P0.5660.21
23_I142_T0.5660.21
155_N259_S0.5650.21
231_L382_Y0.5630.21
191_H316_Y0.5630.21
310_Y421_K0.5600.21
339_L398_L0.5580.21
89_V376_D0.5570.20
179_N370_P0.5550.20
220_E397_N0.5550.20
31_S124_E0.5540.20
162_L184_S0.5510.20
134_A160_T0.5500.20
21_T56_K0.5500.20
81_P103_L0.5490.20
122_Q279_N0.5490.20
127_L191_H0.5480.20
126_Q306_G0.5480.20
338_F395_K0.5480.20
272_Y281_S0.5470.20
195_N304_L0.5450.20
298_L430_F0.5450.20
211_S272_Y0.5430.20
397_N430_F0.5420.20
211_S388_R0.5420.20
237_R280_I0.5410.20
103_L325_R0.5410.20
201_V256_A0.5410.20
170_S204_L0.5410.20
338_F371_V0.5400.20
132_G337_P0.5400.20
117_P384_D0.5400.20
23_I105_V0.5390.20
158_S352_V0.5390.20
4_T100_T0.5390.20
208_I262_T0.5390.20
212_H283_S0.5390.20
152_P179_N0.5380.20
116_L210_V0.5370.20
354_V434_V0.5360.20
313_T391_V0.5350.20
127_L204_L0.5350.20
321_S337_P0.5350.20
405_Q414_P0.5340.19
185_Y210_V0.5330.19
430_F434_V0.5330.19
127_L325_R0.5300.19
205_E353_K0.5300.19
16_Y400_D0.5300.19
23_I50_Y0.5300.19
41_P44_E0.5290.19
42_P108_V0.5280.19
397_N413_F0.5280.19
138_S204_L0.5270.19
369_F392_V0.5270.19
79_D99_E0.5270.19
95_L101_V0.5270.19
132_G391_V0.5270.19
101_V391_V0.5250.19
96_A391_V0.5250.19
340_D404_N0.5250.19
280_I298_L0.5250.19
208_I350_L0.5240.19
337_P408_Q0.5240.19
312_F408_Q0.5240.19
192_Y332_Y0.5220.19
122_Q307_G0.5220.19
204_L239_D0.5210.19
114_K415_K0.5210.19
140_Y306_G0.5200.19
47_H112_A0.5200.19
274_R310_Y0.5200.19
46_D78_V0.5190.19
222_Y312_F0.5180.19
3_N204_L0.5170.19
395_K399_V0.5170.19
156_V343_E0.5150.19
3_N21_T0.5150.19
114_K439_Y0.5140.19
218_V268_A0.5140.19
212_H279_N0.5140.19
332_Y371_V0.5140.19
237_R303_P0.5140.19
371_V423_L0.5120.19
166_V188_I0.5120.19
33_V101_V0.5120.19
231_L306_G0.5100.18
209_E388_R0.5090.18
152_P414_P0.5080.18
344_D382_Y0.5080.18
250_S284_H0.5080.18
97_P220_E0.5080.18
358_E384_D0.5070.18
273_Y335_K0.5060.18
181_P184_S0.5060.18
119_E181_P0.5060.18
9_T30_K0.5050.18
132_G259_S0.5030.18
354_V416_L0.5020.18
14_S229_A0.5010.18
312_F417_A0.5010.18
320_L393_L0.5000.18
358_E381_T0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yewA 3 0.2984 24.8 0.974 Contact Map
4phzA 3 0.2984 19 0.976 Contact Map
2l9uA 2 0.0501 4.2 0.982 Contact Map
2m20A 2 0.0456 3.6 0.983 Contact Map
3hxlA 1 0.205 2.9 0.983 Contact Map
3lmlA 1 0.2346 2.7 0.984 Contact Map
2xl4A 1 0.1276 2.6 0.984 Contact Map
3pg7A 1 0.1595 2.6 0.984 Contact Map
1d8bA 1 0.1481 2.4 0.984 Contact Map
1wv9A 2 0.2005 2.1 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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