GREMLIN Database
DUF594 - Protein of unknown function, DUF594
PFAM: PF04578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (52)
Sequences: 1419 (777)
Seq/√Len: 107.7
META: 0.127

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_V18_M2.2671.00
34_Q37_R2.1711.00
14_V17_E2.0861.00
10_V17_E2.0351.00
17_E20_C1.8821.00
26_C32_A1.8071.00
24_P27_R1.6731.00
46_W54_I1.6491.00
8_W44_H1.5721.00
3_D6_K1.4721.00
14_V52_A1.4401.00
27_R30_A1.3170.99
22_A42_I1.3040.99
30_A44_H1.2830.99
23_A42_I1.2410.99
7_R52_A1.2370.99
30_A36_S1.2350.99
10_V14_V1.2120.99
35_L41_L1.1840.99
23_A50_A1.1750.99
4_E9_E1.1660.99
42_I45_V1.1470.98
16_V32_A1.1470.98
9_E13_D1.1400.98
14_V20_C1.1310.98
7_R11_L1.1250.98
16_V20_C1.1200.98
29_E33_K1.0620.97
9_E12_A1.0600.97
28_A42_I1.0290.97
18_M22_A1.0280.97
12_A16_V1.0240.97
41_L50_A1.0040.96
21_Y37_R0.9740.96
19_L42_I0.9510.95
27_R46_W0.9330.95
44_H49_L0.9310.95
16_V33_K0.9120.94
28_A54_I0.9090.94
8_W53_G0.8730.92
14_V21_Y0.8710.92
10_V36_S0.8570.92
20_C29_E0.8540.92
13_D16_V0.8460.91
39_G44_H0.8360.91
10_V13_D0.8340.91
7_R35_L0.8190.90
34_Q50_A0.8100.89
34_Q44_H0.7930.88
4_E40_E0.7910.88
29_E34_Q0.7720.87
47_L50_A0.7480.85
46_W49_L0.7290.84
26_C33_K0.7280.84
18_M21_Y0.7190.83
8_W48_L0.7110.82
26_C50_A0.7070.82
12_A49_L0.6980.81
6_K33_K0.6960.81
47_L51_H0.6940.81
19_L45_V0.6920.80
7_R10_V0.6870.80
20_C49_L0.6560.77
27_R34_Q0.6420.75
18_M26_C0.6370.75
10_V48_L0.6110.72
11_L51_H0.6060.71
24_P54_I0.5950.70
6_K10_V0.5950.70
9_E54_I0.5910.69
5_E9_E0.5840.68
5_E19_L0.5500.64
28_A47_L0.5460.63
18_M32_A0.5440.63
27_R54_I0.5290.61
17_E25_S0.5170.59
11_L30_A0.5000.56
28_A36_S0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4okzA 1 1 4.7 0.895 Contact Map
3v1vA 2 1 4.4 0.896 Contact Map
4zq8A 2 1 3.7 0.9 Contact Map
1seiA 2 0.7963 3.6 0.901 Contact Map
1di1A 1 0.9444 3.6 0.901 Contact Map
3rf2A 1 0.7963 3.4 0.902 Contact Map
4pdbA 1 0.7963 3.4 0.902 Contact Map
4rb5H 1 0.7963 3.3 0.902 Contact Map
1s03H 1 0.7963 3 0.905 Contact Map
1i6uA 1 0.7963 2.9 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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