GREMLIN Database
zf-FLZ - zinc-finger of the FCS-type, C2-C2
PFAM: PF04570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (48)
Sequences: 800 (383)
Seq/√Len: 55.2
META: 0.058

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_Q48_L4.6541.00
46_Q50_D3.2021.00
10_H21_K2.1901.00
17_L46_Q1.7350.99
16_F35_K1.6680.99
30_M43_R1.6360.99
47_I51_E1.5340.98
15_C42_C1.5260.98
27_D31_Y1.4160.96
23_G52_E1.4130.96
10_H35_K1.3580.95
28_I31_Y1.3350.95
27_D43_R1.3210.95
40_E49_M1.2710.94
11_F43_R1.2660.93
13_S49_M1.2350.93
26_K52_E1.1730.90
5_S8_S1.1540.90
11_F41_E1.1060.88
10_H45_Q1.0960.87
26_K51_E1.0890.87
32_R51_E1.0730.86
26_K29_Y1.0050.82
17_L30_M0.9970.82
45_Q48_L0.9920.81
12_L19_K0.9870.81
17_L34_D0.9790.80
34_D50_D0.9530.79
32_R35_K0.9460.78
13_S52_E0.9450.78
17_L33_G0.9390.78
13_S35_K0.9230.76
5_S24_P0.9030.75
16_F51_E0.8800.73
8_S45_Q0.8780.73
34_D40_E0.8570.71
7_P45_Q0.8410.69
10_H52_E0.8300.68
25_G51_E0.8150.67
18_C38_C0.8050.66
10_H48_L0.7870.64
40_E48_L0.7770.63
16_F21_K0.7460.60
28_I35_K0.7380.59
22_L39_S0.7360.59
23_G32_R0.7210.57
14_S23_G0.7160.57
21_K45_Q0.6880.54
39_S47_I0.6880.54
11_F19_K0.6580.51
33_G39_S0.6430.49
41_E45_Q0.6180.46
22_L27_D0.6150.46
22_L33_G0.6130.46
14_S21_K0.6100.46
11_F24_P0.6100.46
17_L41_E0.6100.46
7_P16_F0.6070.45
15_C38_C0.5970.44
22_L28_I0.5960.44
15_C18_C0.5920.44
29_Y47_I0.5890.43
24_P40_E0.5880.43
7_P49_M0.5870.43
6_Y52_E0.5860.43
23_G34_D0.5690.41
12_L39_S0.5610.40
22_L29_Y0.5380.38
11_F31_Y0.5310.37
8_S13_S0.5300.37
27_D39_S0.5290.37
6_Y19_K0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j65p 1 0.8302 42.5 0.824 Contact Map
4w20W 1 0.8302 40.5 0.826 Contact Map
3j39W 1 0.8302 39.1 0.828 Contact Map
4ujrJ 1 0.8302 38.7 0.828 Contact Map
4a17T 1 0.8491 35.2 0.832 Contact Map
3j61W 1 0.8679 34.3 0.833 Contact Map
2iybE 1 0.8113 32 0.835 Contact Map
1vx70 1 0.8302 31.1 0.837 Contact Map
1vq8U 1 0.7736 28.7 0.839 Contact Map
3zf7Y 1 0.8302 26.4 0.843 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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