GREMLIN Database
Extensin_2 - Extensin-like region
PFAM: PF04554 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (53)
Sequences: 622 (196)
Seq/√Len: 27.0
META: 0.051

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V51_V3.3151.00
18_Y50_Y2.2290.98
30_V51_V2.0100.96
22_S33_S1.8970.95
2_V30_V1.8460.94
2_V19_V1.8180.93
22_S43_S1.7200.91
33_S43_S1.6460.89
29_Y33_S1.6110.88
18_Y21_K1.5750.87
22_S25_P1.5630.86
5_S8_P1.4350.81
19_V30_V1.4080.80
21_K53_K1.4050.80
43_S46_P1.3710.78
11_Y15_S1.3650.78
33_S54_S1.3590.77
10_Y13_S1.3100.75
47_P50_Y1.2320.70
32_K53_K1.2150.69
54_S58_P1.2040.68
55_P58_P1.1160.62
32_K38_Y1.0820.60
4_K21_K1.0630.58
52_Y58_P1.0290.56
1_Y5_S1.0170.55
37_P53_K1.0140.55
45_P50_Y1.0130.55
25_P31_Y1.0030.54
21_K42_K0.9560.50
22_S54_S0.9470.50
10_Y38_Y0.9290.48
52_Y55_P0.9120.47
32_K39_Y0.9070.47
20_Y31_Y0.8860.45
4_K9_P0.8830.45
43_S54_S0.8720.44
13_S18_Y0.8660.44
39_Y53_K0.8560.43
5_S22_S0.8520.42
15_S34_P0.8470.42
5_S9_P0.8440.42
2_V51_V0.8440.42
38_Y45_P0.8400.42
31_Y37_P0.8380.41
5_S35_P0.8260.41
3_Y20_Y0.8200.40
22_S28_P0.8150.40
47_P53_K0.8070.39
24_P35_P0.8030.39
22_S31_Y0.7990.39
16_P20_Y0.7740.37
26_P57_P0.7690.37
1_Y4_K0.7480.35
39_Y42_K0.7400.35
9_P26_P0.7240.33
7_P16_P0.7120.33
11_Y39_Y0.7030.32
14_P37_P0.6960.32
1_Y8_P0.6770.30
15_S18_Y0.6770.30
38_Y42_K0.6650.30
26_P37_P0.6600.29
46_P51_V0.6340.28
29_Y50_Y0.6340.28
3_Y13_S0.6150.27
37_P52_Y0.6120.26
42_K45_P0.6110.26
12_S17_K0.6070.26
21_K29_Y0.6050.26
36_P55_P0.5740.24
4_K42_K0.5670.24
17_K28_P0.5430.23
4_K12_S0.5340.22
16_P36_P0.5310.22
24_P56_P0.5250.22
18_Y36_P0.5200.21
20_Y42_K0.5170.21
35_P50_Y0.5070.21
2_V17_K0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bn5B 1 0.2759 0.6 0.895 Contact Map
1twfA 1 0 0.5 0.904 Contact Map
1ozjA 1 0.1379 0.4 0.906 Contact Map
1rxtA 1 0.3448 0.3 0.916 Contact Map
4hd4A 1 0.1207 0.3 0.921 Contact Map
3iu1A 1 0.3448 0.3 0.921 Contact Map
4c68A 1 0.3448 0.3 0.921 Contact Map
4c7iA 1 0.3448 0.3 0.921 Contact Map
4irgA 2 0.2586 0.2 0.926 Contact Map
4irhA 2 0.2759 0.2 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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