GREMLIN Database
DUF588 - Domain of unknown function (DUF588)
PFAM: PF04535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 149 (148)
Sequences: 1664 (1030)
Seq/√Len: 84.7
META: 0.022

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_Y101_S5.0121.00
126_C133_C4.2651.00
19_L23_V3.4701.00
22_A26_A3.4381.00
28_N136_V3.1161.00
93_Q97_Y3.1021.00
138_A142_L2.9241.00
18_A59_A2.7641.00
59_A95_M2.5701.00
89_F93_Q2.3821.00
54_A58_I2.2461.00
8_L12_L2.0091.00
100_L104_S1.9921.00
109_I112_L1.9761.00
56_N143_S1.9631.00
114_K134_D1.8691.00
59_A99_L1.8161.00
49_F136_V1.8071.00
66_Q88_L1.8011.00
113_A122_W1.7971.00
100_L147_F1.7751.00
17_F142_L1.7241.00
25_M139_S1.7241.00
25_M53_V1.6971.00
112_L116_G1.6571.00
107_A144_F1.6491.00
56_N99_L1.6411.00
30_Q116_G1.5291.00
20_A24_V1.5211.00
89_F97_Y1.4910.99
19_L60_A1.4280.99
28_N46_Y1.4090.99
52_L56_N1.3870.99
7_D70_S1.3540.99
57_A60_A1.3250.99
124_K127_N1.3250.99
55_A98_L1.3230.99
110_T114_K1.3000.98
103_A107_A1.2950.98
57_A61_A1.2850.98
9_V76_R1.2810.98
15_F19_L1.2760.98
15_F64_L1.2740.98
103_A144_F1.2710.98
18_A60_A1.2610.98
68_L138_A1.2600.98
87_L91_G1.2550.98
20_A142_L1.2520.98
113_A116_G1.2370.98
23_V27_T1.2160.98
5_I27_T1.2040.97
32_L35_F1.1950.97
122_W129_F1.1900.97
25_M52_L1.1620.97
43_F47_P1.1620.97
26_A43_F1.1420.97
131_K135_R1.1320.96
87_L94_V1.1300.96
86_W89_F1.1290.96
24_V138_A1.1000.96
116_G126_C1.0960.96
62_Y92_D1.0770.95
144_F147_F1.0710.95
50_R54_A1.0700.95
130_G134_D1.0620.95
23_V60_A1.0540.95
141_A145_L1.0460.94
58_I98_L1.0340.94
49_F110_T1.0260.94
3_L20_A1.0260.94
84_L148_V1.0230.94
120_A136_V1.0210.94
18_A146_A1.0210.94
13_L17_F1.0070.93
28_N125_I1.0040.93
30_Q133_C1.0000.93
107_A112_L0.9950.93
23_V54_A0.9860.92
13_L18_A0.9850.92
60_A142_L0.9730.92
21_A73_A0.9560.91
93_Q100_L0.9550.91
28_N135_R0.9490.91
108_A112_L0.9490.91
55_A102_A0.9460.91
116_G133_C0.9460.91
21_A143_S0.9350.90
5_I145_L0.9220.90
65_L138_A0.9110.89
53_V140_V0.9100.89
34_F39_F0.9020.89
13_L20_A0.8980.88
10_L43_F0.8950.88
48_A108_A0.8830.87
5_I9_V0.8710.87
85_A103_A0.8600.86
98_L125_I0.8530.86
22_A145_L0.8280.84
30_Q130_G0.8270.84
79_L82_P0.8210.83
8_L51_Y0.8170.83
28_N53_V0.8150.83
102_A107_A0.8130.83
48_A109_I0.8100.83
27_T64_L0.7880.81
89_F104_S0.7880.81
16_A82_P0.7830.80
60_A64_L0.7820.80
101_S108_A0.7750.80
10_L19_L0.7720.79
16_A148_V0.7680.79
18_A99_L0.7640.79
28_N109_I0.7630.79
85_A104_S0.7610.78
13_L60_A0.7590.78
57_A135_R0.7520.78
66_Q97_Y0.7500.77
114_K124_K0.7490.77
26_A121_G0.7480.77
52_L143_S0.7400.76
22_A60_A0.7390.76
17_F146_A0.7390.76
88_L98_L0.7250.75
6_A139_S0.7210.75
52_L106_A0.7140.74
106_A140_V0.7110.74
34_F128_Q0.7080.73
34_F147_F0.7060.73
51_Y55_A0.7050.73
27_T32_L0.6970.72
68_L72_Y0.6930.72
32_L38_Q0.6910.71
118_S127_N0.6900.71
31_T38_Q0.6860.71
56_N146_A0.6860.71
34_F42_K0.6840.71
83_G87_L0.6830.71
9_V12_L0.6810.70
76_R83_G0.6810.70
52_L101_S0.6810.70
86_W93_Q0.6760.70
112_L126_C0.6730.69
83_G105_A0.6710.69
29_K48_A0.6690.69
66_Q143_S0.6640.68
8_L29_K0.6610.68
29_K40_K0.6550.67
90_I126_C0.6530.67
41_A45_D0.6490.67
84_L93_Q0.6470.66
103_A129_F0.6460.66
127_N130_G0.6450.66
97_Y104_S0.6450.66
110_T113_A0.6430.66
31_T41_A0.6410.66
29_K44_S0.6400.66
105_A110_T0.6390.65
31_T138_A0.6380.65
68_L145_L0.6340.65
20_A57_A0.6340.65
25_M144_F0.6340.65
60_A95_M0.6330.65
30_Q129_F0.6300.64
96_A143_S0.6290.64
6_A145_L0.6250.64
42_K91_G0.6230.63
43_F54_A0.6200.63
37_I41_A0.6180.63
30_Q98_L0.6170.63
48_A105_A0.6150.62
52_L102_A0.6020.61
19_L65_L0.5980.60
62_Y96_A0.5960.60
5_I139_S0.5950.60
46_Y112_L0.5950.60
106_A125_I0.5880.59
9_V57_A0.5880.59
122_W125_I0.5830.58
80_R94_V0.5810.58
114_K127_N0.5800.58
13_L68_L0.5770.58
112_L133_C0.5730.57
18_A54_A0.5710.57
117_N120_A0.5710.57
54_A141_A0.5670.56
94_V99_L0.5610.56
27_T63_S0.5570.55
16_A87_L0.5560.55
29_K132_F0.5560.55
72_Y76_R0.5560.55
54_A83_G0.5560.55
95_M99_L0.5500.54
54_A119_H0.5480.54
120_A124_K0.5480.54
61_A90_I0.5470.54
50_R87_L0.5470.54
62_Y65_L0.5400.53
135_R142_L0.5380.52
88_L124_K0.5370.52
95_M119_H0.5360.52
13_L104_S0.5350.52
6_A65_L0.5330.52
66_Q96_A0.5300.51
66_Q110_T0.5280.51
16_A144_F0.5270.51
12_L69_L0.5260.51
79_L83_G0.5240.51
44_S133_C0.5220.50
43_F50_R0.5170.50
32_L39_F0.5130.49
9_V83_G0.5120.49
133_C143_S0.5120.49
67_L98_L0.5100.49
55_A66_Q0.5100.49
64_L76_R0.5090.49
18_A102_A0.5080.48
10_L120_A0.5080.48
67_L106_A0.5060.48
50_R130_G0.5040.48
6_A55_A0.5020.48
131_K134_D0.5010.48
53_V106_A0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x01A 4 0.2081 6.4 0.929 Contact Map
4o6yA 2 0.8725 2.1 0.944 Contact Map
1fftA 1 0.1611 1.5 0.949 Contact Map
4us3A 1 0.3221 0.9 0.956 Contact Map
4p79A 1 0.4698 0.9 0.956 Contact Map
4izzA 2 0.3423 0.8 0.957 Contact Map
4phuA 1 0.6779 0.8 0.957 Contact Map
2pjvA 1 0.0872 0.7 0.959 Contact Map
2k1vA 1 0.1409 0.6 0.96 Contact Map
3rlfG 1 0.5369 0.6 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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