GREMLIN Database
DUF568 - Protein of unknown function (DUF568)
PFAM: PF04526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (99)
Sequences: 518 (377)
Seq/√Len: 37.9
META: 0.085

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_L34_G4.2661.00
88_T93_L3.0781.00
66_T100_D2.9131.00
90_G93_L2.8641.00
30_S34_G2.7481.00
91_D94_Q2.4331.00
10_F78_V2.4141.00
85_K88_T2.3731.00
40_V56_A2.3671.00
79_S84_A2.3511.00
5_Q28_Y2.0690.99
70_Q97_G1.9580.98
17_S83_P1.8250.98
60_L80_G1.7880.97
90_G94_Q1.7600.97
24_N34_G1.6640.96
6_A25_I1.6360.95
93_L96_K1.6280.95
74_V92_N1.6110.95
77_S84_A1.6100.95
21_Y33_E1.5800.94
35_P39_D1.4950.92
68_V101_L1.4840.92
41_S59_K1.3960.90
36_L40_V1.3910.89
18_M45_A1.3640.88
89_S94_Q1.3040.86
5_Q37_S1.2480.83
49_G79_S1.2200.82
6_A58_L1.1950.81
69_N89_S1.1920.80
94_Q97_G1.1880.80
18_M52_M1.1780.80
78_V93_L1.1670.79
12_Q47_Y1.1620.79
68_V76_P1.1570.78
8_V83_P1.1370.77
22_T69_N1.0660.72
5_Q70_Q1.0510.71
50_G73_Q1.0250.69
2_V85_K1.0220.69
10_F97_G1.0150.69
37_S43_L1.0000.68
44_S53_T0.9970.67
5_Q25_I0.9950.67
15_S29_S0.9800.66
6_A53_T0.9450.63
40_V44_S0.9270.62
72_W75_G0.9250.61
73_Q92_N0.9220.61
41_S58_L0.9170.61
38_F73_Q0.9140.60
57_T61_P0.9110.60
15_S35_P0.9080.60
12_Q101_L0.9060.60
58_L100_D0.9040.60
7_L78_V0.9020.59
14_S87_P0.8860.58
23_Y101_L0.8850.58
47_Y57_T0.8820.58
46_E55_F0.8810.58
30_S50_G0.8800.58
2_V71_V0.8750.57
10_F18_M0.8570.56
60_L65_S0.8560.55
37_S44_S0.8540.55
37_S95_S0.8510.55
27_S56_A0.8480.55
78_V92_N0.8380.54
61_P74_V0.8380.54
39_D42_D0.8270.53
44_S55_F0.8230.52
12_Q18_M0.7980.50
7_L101_L0.7960.50
71_V95_S0.7900.50
56_A61_P0.7870.49
74_V87_P0.7860.49
68_V99_L0.7810.49
89_S96_K0.7790.49
43_L56_A0.7790.49
4_S8_V0.7780.48
21_Y24_N0.7740.48
77_S80_G0.7570.47
78_V99_L0.7440.45
13_N100_D0.7440.45
41_S47_Y0.7390.45
14_S81_G0.7360.45
22_T92_N0.7270.44
9_A45_A0.7200.43
41_S60_L0.7110.43
47_Y70_Q0.7090.42
76_P87_P0.7030.42
21_Y51_E0.6990.42
74_V81_G0.6970.41
63_G99_L0.6940.41
20_V69_N0.6930.41
38_F58_L0.6930.41
42_D59_K0.6880.41
25_I40_V0.6800.40
15_S56_A0.6790.40
53_T74_V0.6770.40
15_S51_E0.6730.39
20_V45_A0.6700.39
68_V96_K0.6690.39
67_T101_L0.6600.38
46_E50_G0.6520.37
54_I61_P0.6450.37
8_V89_S0.6430.37
26_T32_Q0.6350.36
25_I29_S0.6330.36
87_P96_K0.6320.36
57_T60_L0.6270.35
39_D59_K0.6160.35
28_Y53_T0.6150.34
4_S14_S0.6150.34
50_G81_G0.6120.34
29_S85_K0.6110.34
25_I48_S0.6090.34
3_G6_A0.6040.34
2_V10_F0.6030.33
35_P93_L0.6030.33
67_T98_T0.5980.33
57_T63_G0.5950.33
27_S30_S0.5910.33
43_L100_D0.5800.32
22_T25_I0.5790.32
38_F41_S0.5780.32
29_S101_L0.5770.31
26_T30_S0.5730.31
22_T38_F0.5660.31
27_S95_S0.5540.30
23_Y33_E0.5480.29
64_N100_D0.5470.29
93_L98_T0.5460.29
63_G70_Q0.5410.29
1_M9_A0.5370.28
16_G57_T0.5340.28
4_S71_V0.5260.28
55_F80_G0.5250.28
12_Q15_S0.5230.27
33_E52_M0.5230.27
18_M97_G0.5200.27
26_T83_P0.5110.27
26_T31_L0.5100.27
18_M64_N0.5080.26
9_A18_M0.5070.26
4_S30_S0.5050.26
56_A90_G0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d7bA 2 0.9109 17.1 0.922 Contact Map
2ygnA 2 0.7426 8 0.933 Contact Map
2ygoA 2 0.7327 4.8 0.939 Contact Map
2oxgY 1 0.3168 4 0.941 Contact Map
4uqdA 1 0.5941 3.2 0.944 Contact Map
1i2hA 1 0.8515 3 0.945 Contact Map
3wa1A 4 0.3267 3 0.945 Contact Map
4qi3A 2 0.901 2.6 0.947 Contact Map
2nt0A 4 0.5743 2.4 0.948 Contact Map
3bw8A 1 0.5842 2.2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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