GREMLIN Database
Choline_transpo - Plasma-membrane choline transporter
PFAM: PF04515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 303 (301)
Sequences: 2016 (1547)
Seq/√Len: 89.2
META: 0.346

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_S204_I7.3531.00
113_A206_I5.5351.00
102_A143_I4.6621.00
146_G201_Y3.9321.00
148_L152_I3.6241.00
106_V143_I3.4881.00
209_K214_S3.4871.00
153_V193_V3.3321.00
190_E194_K3.3011.00
99_F144_A3.2531.00
2_I6_I3.0791.00
200_A215_A3.0101.00
252_G271_F2.9071.00
102_A201_Y2.9041.00
94_L158_L2.8321.00
209_K217_D2.7581.00
224_R301_E2.7541.00
107_T132_F2.7201.00
103_V135_A2.6861.00
210_S213_T2.6831.00
110_G134_R2.5841.00
252_G267_V2.5701.00
132_F136_L2.5051.00
57_S93_L2.4921.00
60_W93_L2.4881.00
109_A202_I2.4121.00
91_F151_A2.3931.00
91_F155_L2.3161.00
204_I214_S2.3031.00
56_F60_W2.2961.00
152_I156_I2.2361.00
106_V135_A2.1771.00
162_Y166_K2.1741.00
106_V204_I2.1011.00
160_L186_L2.0271.00
248_G271_F1.9871.00
159_I163_L1.9771.00
103_V107_T1.9661.00
102_A147_S1.9381.00
145_F212_C1.9161.00
112_V288_A1.8921.00
177_C181_C1.8851.00
270_A274_G1.8431.00
49_T104_Q1.8141.00
98_Q154_Q1.8061.00
184_C188_C1.7831.00
164_R183_Q1.7681.00
151_A155_L1.7501.00
203_Y294_V1.7491.00
110_G131_S1.7321.00
229_A293_F1.7221.00
39_N111_A1.6961.00
187_W191_K1.6911.00
99_F147_S1.6721.00
31_E34_K1.6131.00
220_E224_R1.6001.00
255_G270_A1.5851.00
228_R300_P1.5791.00
79_D82_V1.5561.00
24_L28_L1.5351.00
244_K275_Y1.5341.00
35_A112_V1.5221.00
5_L9_V1.5201.00
14_L18_L1.5191.00
59_Y63_V1.4480.99
99_F140_L1.4390.99
99_F143_I1.4380.99
108_I112_V1.4180.99
90_L158_L1.3980.99
36_L42_L1.3890.99
197_N211_F1.3710.99
134_R208_G1.3630.99
87_V155_L1.3630.99
161_E164_R1.3610.99
106_V142_S1.3440.99
35_A39_N1.3340.99
99_F103_V1.3280.99
185_C188_C1.3270.99
207_Y298_E1.3200.99
94_L151_A1.3080.99
135_A143_I1.3040.99
19_R23_P1.3020.99
89_H92_G1.3000.99
42_L108_I1.2960.99
252_G274_G1.2710.99
110_G208_G1.2700.99
117_F295_C1.2700.99
32_A288_A1.2600.98
215_A218_A1.2570.98
161_E183_Q1.2540.98
29_L289_V1.2400.98
247_V278_A1.2340.98
102_A197_N1.2250.98
157_R190_E1.2180.98
16_I19_R1.2150.98
9_V13_L1.2090.98
205_A208_G1.2070.98
147_S201_Y1.2040.98
155_L159_I1.1970.98
105_Q287_M1.1940.98
60_W89_H1.1880.98
56_F96_T1.1790.98
89_H93_L1.1750.98
248_G274_G1.1610.97
38_A115_W1.1600.97
88_Y92_G1.1440.97
268_L272_L1.1400.97
115_W292_I1.1380.97
131_S134_R1.1160.97
186_L189_L1.1150.97
119_K122_D1.1010.96
218_A294_V1.0990.96
298_E302_R1.0970.96
121_K125_S1.0860.96
28_L292_I1.0850.96
56_F59_Y1.0850.96
247_V251_T1.0660.96
244_K278_A1.0590.95
253_L261_H1.0590.95
84_Y87_V1.0540.95
92_G96_T1.0470.95
28_L116_Y1.0430.95
102_A146_G1.0420.95
94_L155_L1.0380.95
203_Y214_S1.0370.95
182_L186_L1.0360.95
12_L16_I1.0340.95
25_A29_L1.0310.95
133_K136_L1.0270.95
13_L17_F1.0160.94
42_L112_V1.0120.94
254_L257_L1.0120.94
203_Y209_K1.0110.94
91_F94_L1.0040.94
154_Q190_E1.0020.94
95_W211_F0.9980.94
133_K137_T0.9870.93
64_A89_H0.9860.93
228_R232_N0.9850.93
244_K279_S0.9840.93
244_K248_G0.9800.93
198_R290_D0.9770.93
171_D175_A0.9720.93
232_N293_F0.9700.93
202_I291_T0.9690.93
198_R202_I0.9630.92
123_I127_P0.9560.92
156_I186_L0.9530.92
270_A277_I0.9480.92
254_L258_Y0.9410.92
240_L282_F0.9400.92
258_Y261_H0.9340.91
160_L190_E0.9280.91
21_R228_R0.9270.91
180_C191_K0.9270.91
6_I9_V0.9250.91
55_A59_Y0.9220.91
106_V110_G0.9160.90
237_D240_L0.9140.90
218_A222_L0.9070.90
213_T217_D0.9070.90
55_A58_A0.9070.90
136_L140_L0.9050.90
52_L56_F0.9030.90
63_V89_H0.8970.90
167_L170_A0.8910.89
41_S128_V0.8880.89
153_V186_L0.8860.89
36_L43_L0.8850.89
248_G251_T0.8820.89
217_D220_E0.8670.88
124_P127_P0.8660.88
168_K171_D0.8580.87
157_R186_L0.8560.87
177_C180_C0.8560.87
294_V297_A0.8550.87
173_P176_K0.8520.87
114_S134_R0.8490.87
112_V292_I0.8400.86
203_Y217_D0.8390.86
109_A218_A0.8380.86
103_V132_F0.8310.86
179_L183_Q0.8280.85
178_L182_L0.8280.85
20_K23_P0.8270.85
137_T140_L0.8220.85
5_L8_A0.8190.85
134_R197_N0.8180.85
276_L279_S0.8160.85
203_Y218_A0.8160.85
93_L96_T0.8140.84
264_A268_L0.8120.84
11_L15_L0.8110.84
45_V49_T0.8060.84
4_F7_F0.8060.84
227_L233_D0.8060.84
192_F196_L0.8010.83
32_A57_S0.7950.83
106_V207_Y0.7930.83
142_S211_F0.7910.83
282_F288_A0.7900.83
174_V177_C0.7880.82
58_A62_V0.7870.82
139_H285_Y0.7810.82
21_R227_L0.7770.82
271_F274_G0.7700.81
39_N127_P0.7690.81
120_P123_I0.7690.81
255_G259_L0.7670.81
285_Y288_A0.7670.81
206_I216_K0.7670.81
103_V140_L0.7650.81
99_F102_A0.7650.81
65_V69_L0.7640.80
45_V107_T0.7620.80
43_L192_F0.7570.80
113_A291_T0.7490.79
243_G299_D0.7490.79
22_I219_F0.7480.79
200_A231_V0.7430.79
106_V205_A0.7420.79
221_L301_E0.7410.78
5_L17_F0.7390.78
36_L47_L0.7370.78
199_N232_N0.7360.78
170_A175_A0.7320.78
253_L282_F0.7310.77
62_V195_F0.7300.77
100_I111_A0.7260.77
150_V196_L0.7260.77
94_L98_Q0.7250.77
221_L297_A0.7240.77
94_L154_Q0.7230.77
249_L272_L0.7210.77
57_S84_Y0.7180.76
277_I291_T0.7170.76
129_L133_K0.7170.76
21_R225_N0.7140.76
49_T53_L0.7130.76
122_D125_S0.7100.75
195_F231_V0.7080.75
225_N228_R0.7050.75
206_I227_L0.7020.75
231_V234_S0.7010.74
42_L284_V0.7000.74
275_Y279_S0.6980.74
79_D83_I0.6950.74
66_G69_L0.6940.74
19_R28_L0.6870.73
257_L263_L0.6850.73
199_N218_A0.6840.73
149_I193_V0.6800.72
167_L171_D0.6800.72
249_L256_Y0.6770.72
72_G90_L0.6750.72
237_D286_E0.6750.72
35_A288_A0.6740.72
274_G278_A0.6730.71
98_Q150_V0.6730.71
160_L182_L0.6720.71
109_A287_M0.6710.71
112_V291_T0.6700.71
171_D176_K0.6680.71
56_F97_S0.6680.71
9_V35_A0.6670.71
63_V92_G0.6670.71
195_F211_F0.6660.71
232_N290_D0.6660.71
149_I152_I0.6640.70
89_H135_A0.6610.70
259_L263_L0.6590.70
164_R179_L0.6580.70
107_T110_G0.6580.70
145_F149_I0.6580.70
113_A208_G0.6560.70
46_P102_A0.6550.69
103_V136_L0.6550.69
186_L190_E0.6500.69
10_I256_Y0.6500.69
46_P50_F0.6500.69
225_N299_D0.6500.69
164_R167_L0.6490.69
16_I22_I0.6490.69
199_N225_N0.6470.68
12_L22_I0.6470.68
286_E290_D0.6460.68
227_L231_V0.6440.68
193_V212_C0.6420.68
256_Y262_T0.6410.68
56_F100_I0.6410.68
49_T100_I0.6400.68
9_V16_I0.6390.68
47_L51_L0.6390.68
147_S200_A0.6370.67
110_G135_A0.6370.67
205_A209_K0.6350.67
131_S135_A0.6350.67
21_R35_A0.6340.67
15_L238_F0.6320.67
36_L40_P0.6300.66
3_I7_F0.6290.66
86_I288_A0.6280.66
150_V211_F0.6270.66
182_L193_V0.6270.66
146_G218_A0.6240.66
220_E255_G0.6240.66
293_F299_D0.6220.65
142_S145_F0.6180.65
85_L88_Y0.6170.65
43_L47_L0.6150.65
180_C184_C0.6150.65
18_L22_I0.6140.64
172_N175_A0.6130.64
13_L16_I0.6120.64
73_F76_F0.6120.64
99_F106_V0.6110.64
11_L149_I0.6110.64
107_T128_V0.6090.64
198_R286_E0.6080.64
60_W96_T0.6050.63
70_A149_I0.6040.63
83_I87_V0.6040.63
26_I29_L0.6030.63
14_L287_M0.6020.63
98_Q292_I0.6020.63
66_G71_S0.6020.63
18_L21_R0.6010.63
196_L211_F0.6010.63
37_G43_L0.5980.62
228_R296_F0.5950.62
68_Y259_L0.5950.62
95_W146_G0.5950.62
257_L261_H0.5940.62
9_V54_L0.5930.62
253_L257_L0.5900.61
85_L283_S0.5890.61
140_L144_A0.5880.61
157_R161_E0.5880.61
42_L71_S0.5870.61
40_P94_L0.5860.61
55_A62_V0.5860.61
29_L45_V0.5860.61
181_C184_C0.5850.61
117_F298_E0.5820.60
149_I215_A0.5820.60
274_G277_I0.5790.60
30_K64_A0.5770.60
121_K124_P0.5770.60
162_Y188_C0.5760.60
28_L203_Y0.5760.60
232_N236_G0.5760.60
124_P128_V0.5750.59
169_G175_A0.5750.59
110_G143_I0.5740.59
248_G278_A0.5730.59
130_S255_G0.5730.59
156_I202_I0.5710.59
175_A178_L0.5710.59
14_L25_A0.5690.59
228_R231_V0.5680.59
184_C212_C0.5660.58
93_L97_S0.5660.58
12_L47_L0.5620.58
229_A233_D0.5600.57
229_A232_N0.5600.57
42_L288_A0.5580.57
172_N176_K0.5560.57
117_F204_I0.5540.57
95_W144_A0.5540.57
290_D293_F0.5530.56
106_V139_H0.5530.56
155_L193_V0.5530.56
27_A292_I0.5530.56
284_V295_C0.5530.56
41_S44_L0.5520.56
298_E301_E0.5520.56
116_Y215_A0.5510.56
206_I215_A0.5500.56
266_P270_A0.5500.56
209_K213_T0.5490.56
135_A140_L0.5480.56
3_I253_L0.5470.56
211_F284_V0.5460.56
156_I273_I0.5450.55
97_S154_Q0.5450.55
109_A222_L0.5430.55
198_R237_D0.5430.55
35_A111_A0.5420.55
105_Q198_R0.5420.55
39_N153_V0.5400.55
86_I90_L0.5400.55
110_G293_F0.5390.55
42_L299_D0.5390.55
22_I30_K0.5380.54
21_R25_A0.5380.54
251_T274_G0.5380.54
283_S288_A0.5360.54
29_L104_Q0.5360.54
13_L35_A0.5360.54
204_I231_V0.5360.54
294_V300_P0.5360.54
189_L196_L0.5350.54
134_R207_Y0.5340.54
107_T135_A0.5330.54
180_C188_C0.5330.54
210_S214_S0.5320.54
270_A276_L0.5320.54
281_F292_I0.5300.53
246_L255_G0.5300.53
102_A222_L0.5290.53
206_I267_V0.5290.53
155_L182_L0.5280.53
27_A30_K0.5280.53
32_A289_V0.5280.53
266_P276_L0.5280.53
48_L132_F0.5270.53
32_A237_D0.5250.53
48_L159_I0.5240.53
68_Y174_V0.5240.53
108_I299_D0.5240.53
91_F146_G0.5230.52
126_S250_L0.5230.52
55_A103_V0.5220.52
42_L280_I0.5220.52
96_T100_I0.5220.52
142_S146_G0.5200.52
80_G121_K0.5200.52
159_I177_C0.5190.52
196_L239_V0.5190.52
132_F149_I0.5190.52
87_V254_L0.5190.52
147_S247_V0.5180.52
256_Y260_T0.5160.51
236_G289_V0.5160.51
126_S129_L0.5150.51
248_G252_G0.5150.51
28_L31_E0.5140.51
159_I167_L0.5130.51
246_L301_E0.5120.51
21_R230_A0.5110.51
19_R216_K0.5080.50
109_A286_E0.5070.50
244_K247_V0.5060.50
139_H199_N0.5040.50
25_A43_L0.5040.50
33_S227_L0.5020.50
54_L81_K0.5020.50
4_F8_A0.5020.50
119_K124_P0.5020.50
127_P286_E0.5010.49
195_F219_F0.5010.49
171_D248_G0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jwaA 2 0.0792 3 0.962 Contact Map
2l2tA 2 0.0858 2.4 0.964 Contact Map
3dh4A 3 0.2112 1.7 0.967 Contact Map
2ks1B 1 0.0825 1.6 0.967 Contact Map
3wu2I 1 0.1023 1.6 0.967 Contact Map
4n6hA 1 0.396 1.3 0.969 Contact Map
2l6wA 2 0.0759 1.2 0.969 Contact Map
2k1kA 2 0.0693 1.1 0.97 Contact Map
3j2wE 1 0.0693 1 0.971 Contact Map
2llmA 1 0.0693 1 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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