Choline_transpo - PFAM28P - GREMLIN Contacts

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Choline_transpo - Plasma-membrane choline transporter

PFAM:	PF04515	Sequences: AIIFLIFAVILLLLLIFLRKRIPLAIALLKEASKALGANPSLLLVPLLTFLLLLAFSAYWVVVAVGLYLASGFVEFKSDGKVIYLIVYHLFGLLWTSQFIIAVQQVTIAGAVASWYFAKPKDIPSSPVLSSFKRALTYHLGSIAFGSLIVAIVQLIRLILEYLRRKLKGADNPVAKCLLCCLQCCLWCLEKFVKFLNRNAYIYIAIYGKSFCTSAKDAFELLKRNGLRAAVNDSLGDFVLFLGKLLVGLLTGLLGYLYLTHTLAVPVLLAFLIGYLIASIFFSVYEMAVDTIFVCFAEDPERN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	303 (301)
Sequences:	2016 (1547)
Seq/√Len:	89.2
META:	0.346

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_S	204_I	7.353	1.00
113_A	206_I	5.535	1.00
102_A	143_I	4.662	1.00
146_G	201_Y	3.932	1.00
148_L	152_I	3.624	1.00
106_V	143_I	3.488	1.00
209_K	214_S	3.487	1.00
153_V	193_V	3.332	1.00
190_E	194_K	3.301	1.00
99_F	144_A	3.253	1.00
2_I	6_I	3.079	1.00
200_A	215_A	3.010	1.00
252_G	271_F	2.907	1.00
102_A	201_Y	2.904	1.00
94_L	158_L	2.832	1.00
209_K	217_D	2.758	1.00
224_R	301_E	2.754	1.00
107_T	132_F	2.720	1.00
103_V	135_A	2.686	1.00
210_S	213_T	2.683	1.00
110_G	134_R	2.584	1.00
252_G	267_V	2.570	1.00
132_F	136_L	2.505	1.00
57_S	93_L	2.492	1.00
60_W	93_L	2.488	1.00
109_A	202_I	2.412	1.00
91_F	151_A	2.393	1.00
91_F	155_L	2.316	1.00
204_I	214_S	2.303	1.00
56_F	60_W	2.296	1.00
152_I	156_I	2.236	1.00
106_V	135_A	2.177	1.00
162_Y	166_K	2.174	1.00
106_V	204_I	2.101	1.00
160_L	186_L	2.027	1.00
248_G	271_F	1.987	1.00
159_I	163_L	1.977	1.00
103_V	107_T	1.966	1.00
102_A	147_S	1.938	1.00
145_F	212_C	1.916	1.00
112_V	288_A	1.892	1.00
177_C	181_C	1.885	1.00
270_A	274_G	1.843	1.00
49_T	104_Q	1.814	1.00
98_Q	154_Q	1.806	1.00
184_C	188_C	1.783	1.00
164_R	183_Q	1.768	1.00
151_A	155_L	1.750	1.00
203_Y	294_V	1.749	1.00
110_G	131_S	1.732	1.00
229_A	293_F	1.722	1.00
39_N	111_A	1.696	1.00
187_W	191_K	1.691	1.00
99_F	147_S	1.672	1.00
31_E	34_K	1.613	1.00
220_E	224_R	1.600	1.00
255_G	270_A	1.585	1.00
228_R	300_P	1.579	1.00
79_D	82_V	1.556	1.00
24_L	28_L	1.535	1.00
244_K	275_Y	1.534	1.00
35_A	112_V	1.522	1.00
5_L	9_V	1.520	1.00
14_L	18_L	1.519	1.00
59_Y	63_V	1.448	0.99
99_F	140_L	1.439	0.99
99_F	143_I	1.438	0.99
108_I	112_V	1.418	0.99
90_L	158_L	1.398	0.99
36_L	42_L	1.389	0.99
197_N	211_F	1.371	0.99
134_R	208_G	1.363	0.99
87_V	155_L	1.363	0.99
161_E	164_R	1.361	0.99
106_V	142_S	1.344	0.99
35_A	39_N	1.334	0.99
99_F	103_V	1.328	0.99
185_C	188_C	1.327	0.99
207_Y	298_E	1.320	0.99
94_L	151_A	1.308	0.99
135_A	143_I	1.304	0.99
19_R	23_P	1.302	0.99
89_H	92_G	1.300	0.99
42_L	108_I	1.296	0.99
252_G	274_G	1.271	0.99
110_G	208_G	1.270	0.99
117_F	295_C	1.270	0.99
32_A	288_A	1.260	0.98
215_A	218_A	1.257	0.98
161_E	183_Q	1.254	0.98
29_L	289_V	1.240	0.98
247_V	278_A	1.234	0.98
102_A	197_N	1.225	0.98
157_R	190_E	1.218	0.98
16_I	19_R	1.215	0.98
9_V	13_L	1.209	0.98
205_A	208_G	1.207	0.98
147_S	201_Y	1.204	0.98
155_L	159_I	1.197	0.98
105_Q	287_M	1.194	0.98
60_W	89_H	1.188	0.98
56_F	96_T	1.179	0.98
89_H	93_L	1.175	0.98
248_G	274_G	1.161	0.97
38_A	115_W	1.160	0.97
88_Y	92_G	1.144	0.97
268_L	272_L	1.140	0.97
115_W	292_I	1.138	0.97
131_S	134_R	1.116	0.97
186_L	189_L	1.115	0.97
119_K	122_D	1.101	0.96
218_A	294_V	1.099	0.96
298_E	302_R	1.097	0.96
121_K	125_S	1.086	0.96
28_L	292_I	1.085	0.96
56_F	59_Y	1.085	0.96
247_V	251_T	1.066	0.96
244_K	278_A	1.059	0.95
253_L	261_H	1.059	0.95
84_Y	87_V	1.054	0.95
92_G	96_T	1.047	0.95
28_L	116_Y	1.043	0.95
102_A	146_G	1.042	0.95
94_L	155_L	1.038	0.95
203_Y	214_S	1.037	0.95
182_L	186_L	1.036	0.95
12_L	16_I	1.034	0.95
25_A	29_L	1.031	0.95
133_K	136_L	1.027	0.95
13_L	17_F	1.016	0.94
42_L	112_V	1.012	0.94
254_L	257_L	1.012	0.94
203_Y	209_K	1.011	0.94
91_F	94_L	1.004	0.94
154_Q	190_E	1.002	0.94
95_W	211_F	0.998	0.94
133_K	137_T	0.987	0.93
64_A	89_H	0.986	0.93
228_R	232_N	0.985	0.93
244_K	279_S	0.984	0.93
244_K	248_G	0.980	0.93
198_R	290_D	0.977	0.93
171_D	175_A	0.972	0.93
232_N	293_F	0.970	0.93
202_I	291_T	0.969	0.93
198_R	202_I	0.963	0.92
123_I	127_P	0.956	0.92
156_I	186_L	0.953	0.92
270_A	277_I	0.948	0.92
254_L	258_Y	0.941	0.92
240_L	282_F	0.940	0.92
258_Y	261_H	0.934	0.91
160_L	190_E	0.928	0.91
21_R	228_R	0.927	0.91
180_C	191_K	0.927	0.91
6_I	9_V	0.925	0.91
55_A	59_Y	0.922	0.91
106_V	110_G	0.916	0.90
237_D	240_L	0.914	0.90
218_A	222_L	0.907	0.90
213_T	217_D	0.907	0.90
55_A	58_A	0.907	0.90
136_L	140_L	0.905	0.90
52_L	56_F	0.903	0.90
63_V	89_H	0.897	0.90
167_L	170_A	0.891	0.89
41_S	128_V	0.888	0.89
153_V	186_L	0.886	0.89
36_L	43_L	0.885	0.89
248_G	251_T	0.882	0.89
217_D	220_E	0.867	0.88
124_P	127_P	0.866	0.88
168_K	171_D	0.858	0.87
157_R	186_L	0.856	0.87
177_C	180_C	0.856	0.87
294_V	297_A	0.855	0.87
173_P	176_K	0.852	0.87
114_S	134_R	0.849	0.87
112_V	292_I	0.840	0.86
203_Y	217_D	0.839	0.86
109_A	218_A	0.838	0.86
103_V	132_F	0.831	0.86
179_L	183_Q	0.828	0.85
178_L	182_L	0.828	0.85
20_K	23_P	0.827	0.85
137_T	140_L	0.822	0.85
5_L	8_A	0.819	0.85
134_R	197_N	0.818	0.85
276_L	279_S	0.816	0.85
203_Y	218_A	0.816	0.85
93_L	96_T	0.814	0.84
264_A	268_L	0.812	0.84
11_L	15_L	0.811	0.84
45_V	49_T	0.806	0.84
4_F	7_F	0.806	0.84
227_L	233_D	0.806	0.84
192_F	196_L	0.801	0.83
32_A	57_S	0.795	0.83
106_V	207_Y	0.793	0.83
142_S	211_F	0.791	0.83
282_F	288_A	0.790	0.83
174_V	177_C	0.788	0.82
58_A	62_V	0.787	0.82
139_H	285_Y	0.781	0.82
21_R	227_L	0.777	0.82
271_F	274_G	0.770	0.81
39_N	127_P	0.769	0.81
120_P	123_I	0.769	0.81
255_G	259_L	0.767	0.81
285_Y	288_A	0.767	0.81
206_I	216_K	0.767	0.81
103_V	140_L	0.765	0.81
99_F	102_A	0.765	0.81
65_V	69_L	0.764	0.80
45_V	107_T	0.762	0.80
43_L	192_F	0.757	0.80
113_A	291_T	0.749	0.79
243_G	299_D	0.749	0.79
22_I	219_F	0.748	0.79
200_A	231_V	0.743	0.79
106_V	205_A	0.742	0.79
221_L	301_E	0.741	0.78
5_L	17_F	0.739	0.78
36_L	47_L	0.737	0.78
199_N	232_N	0.736	0.78
170_A	175_A	0.732	0.78
253_L	282_F	0.731	0.77
62_V	195_F	0.730	0.77
100_I	111_A	0.726	0.77
150_V	196_L	0.726	0.77
94_L	98_Q	0.725	0.77
221_L	297_A	0.724	0.77
94_L	154_Q	0.723	0.77
249_L	272_L	0.721	0.77
57_S	84_Y	0.718	0.76
277_I	291_T	0.717	0.76
129_L	133_K	0.717	0.76
21_R	225_N	0.714	0.76
49_T	53_L	0.713	0.76
122_D	125_S	0.710	0.75
195_F	231_V	0.708	0.75
225_N	228_R	0.705	0.75
206_I	227_L	0.702	0.75
231_V	234_S	0.701	0.74
42_L	284_V	0.700	0.74
275_Y	279_S	0.698	0.74
79_D	83_I	0.695	0.74
66_G	69_L	0.694	0.74
19_R	28_L	0.687	0.73
257_L	263_L	0.685	0.73
199_N	218_A	0.684	0.73
149_I	193_V	0.680	0.72
167_L	171_D	0.680	0.72
249_L	256_Y	0.677	0.72
72_G	90_L	0.675	0.72
237_D	286_E	0.675	0.72
35_A	288_A	0.674	0.72
274_G	278_A	0.673	0.71
98_Q	150_V	0.673	0.71
160_L	182_L	0.672	0.71
109_A	287_M	0.671	0.71
112_V	291_T	0.670	0.71
171_D	176_K	0.668	0.71
56_F	97_S	0.668	0.71
9_V	35_A	0.667	0.71
63_V	92_G	0.667	0.71
195_F	211_F	0.666	0.71
232_N	290_D	0.666	0.71
149_I	152_I	0.664	0.70
89_H	135_A	0.661	0.70
259_L	263_L	0.659	0.70
164_R	179_L	0.658	0.70
107_T	110_G	0.658	0.70
145_F	149_I	0.658	0.70
113_A	208_G	0.656	0.70
46_P	102_A	0.655	0.69
103_V	136_L	0.655	0.69
186_L	190_E	0.650	0.69
10_I	256_Y	0.650	0.69
46_P	50_F	0.650	0.69
225_N	299_D	0.650	0.69
164_R	167_L	0.649	0.69
16_I	22_I	0.649	0.69
199_N	225_N	0.647	0.68
12_L	22_I	0.647	0.68
286_E	290_D	0.646	0.68
227_L	231_V	0.644	0.68
193_V	212_C	0.642	0.68
256_Y	262_T	0.641	0.68
56_F	100_I	0.641	0.68
49_T	100_I	0.640	0.68
9_V	16_I	0.639	0.68
47_L	51_L	0.639	0.68
147_S	200_A	0.637	0.67
110_G	135_A	0.637	0.67
205_A	209_K	0.635	0.67
131_S	135_A	0.635	0.67
21_R	35_A	0.634	0.67
15_L	238_F	0.632	0.67
36_L	40_P	0.630	0.66
3_I	7_F	0.629	0.66
86_I	288_A	0.628	0.66
150_V	211_F	0.627	0.66
182_L	193_V	0.627	0.66
146_G	218_A	0.624	0.66
220_E	255_G	0.624	0.66
293_F	299_D	0.622	0.65
142_S	145_F	0.618	0.65
85_L	88_Y	0.617	0.65
43_L	47_L	0.615	0.65
180_C	184_C	0.615	0.65
18_L	22_I	0.614	0.64
172_N	175_A	0.613	0.64
13_L	16_I	0.612	0.64
73_F	76_F	0.612	0.64
99_F	106_V	0.611	0.64
11_L	149_I	0.611	0.64
107_T	128_V	0.609	0.64
198_R	286_E	0.608	0.64
60_W	96_T	0.605	0.63
70_A	149_I	0.604	0.63
83_I	87_V	0.604	0.63
26_I	29_L	0.603	0.63
14_L	287_M	0.602	0.63
98_Q	292_I	0.602	0.63
66_G	71_S	0.602	0.63
18_L	21_R	0.601	0.63
196_L	211_F	0.601	0.63
37_G	43_L	0.598	0.62
228_R	296_F	0.595	0.62
68_Y	259_L	0.595	0.62
95_W	146_G	0.595	0.62
257_L	261_H	0.594	0.62
9_V	54_L	0.593	0.62
253_L	257_L	0.590	0.61
85_L	283_S	0.589	0.61
140_L	144_A	0.588	0.61
157_R	161_E	0.588	0.61
42_L	71_S	0.587	0.61
40_P	94_L	0.586	0.61
55_A	62_V	0.586	0.61
29_L	45_V	0.586	0.61
181_C	184_C	0.585	0.61
117_F	298_E	0.582	0.60
149_I	215_A	0.582	0.60
274_G	277_I	0.579	0.60
30_K	64_A	0.577	0.60
121_K	124_P	0.577	0.60
162_Y	188_C	0.576	0.60
28_L	203_Y	0.576	0.60
232_N	236_G	0.576	0.60
124_P	128_V	0.575	0.59
169_G	175_A	0.575	0.59
110_G	143_I	0.574	0.59
248_G	278_A	0.573	0.59
130_S	255_G	0.573	0.59
156_I	202_I	0.571	0.59
175_A	178_L	0.571	0.59
14_L	25_A	0.569	0.59
228_R	231_V	0.568	0.59
184_C	212_C	0.566	0.58
93_L	97_S	0.566	0.58
12_L	47_L	0.562	0.58
229_A	233_D	0.560	0.57
229_A	232_N	0.560	0.57
42_L	288_A	0.558	0.57
172_N	176_K	0.556	0.57
117_F	204_I	0.554	0.57
95_W	144_A	0.554	0.57
290_D	293_F	0.553	0.56
106_V	139_H	0.553	0.56
155_L	193_V	0.553	0.56
27_A	292_I	0.553	0.56
284_V	295_C	0.553	0.56
41_S	44_L	0.552	0.56
298_E	301_E	0.552	0.56
116_Y	215_A	0.551	0.56
206_I	215_A	0.550	0.56
266_P	270_A	0.550	0.56
209_K	213_T	0.549	0.56
135_A	140_L	0.548	0.56
3_I	253_L	0.547	0.56
211_F	284_V	0.546	0.56
156_I	273_I	0.545	0.55
97_S	154_Q	0.545	0.55
109_A	222_L	0.543	0.55
198_R	237_D	0.543	0.55
35_A	111_A	0.542	0.55
105_Q	198_R	0.542	0.55
39_N	153_V	0.540	0.55
86_I	90_L	0.540	0.55
110_G	293_F	0.539	0.55
42_L	299_D	0.539	0.55
22_I	30_K	0.538	0.54
21_R	25_A	0.538	0.54
251_T	274_G	0.538	0.54
283_S	288_A	0.536	0.54
29_L	104_Q	0.536	0.54
13_L	35_A	0.536	0.54
204_I	231_V	0.536	0.54
294_V	300_P	0.536	0.54
189_L	196_L	0.535	0.54
134_R	207_Y	0.534	0.54
107_T	135_A	0.533	0.54
180_C	188_C	0.533	0.54
210_S	214_S	0.532	0.54
270_A	276_L	0.532	0.54
281_F	292_I	0.530	0.53
246_L	255_G	0.530	0.53
102_A	222_L	0.529	0.53
206_I	267_V	0.529	0.53
155_L	182_L	0.528	0.53
27_A	30_K	0.528	0.53
32_A	289_V	0.528	0.53
266_P	276_L	0.528	0.53
48_L	132_F	0.527	0.53
32_A	237_D	0.525	0.53
48_L	159_I	0.524	0.53
68_Y	174_V	0.524	0.53
108_I	299_D	0.524	0.53
91_F	146_G	0.523	0.52
126_S	250_L	0.523	0.52
55_A	103_V	0.522	0.52
42_L	280_I	0.522	0.52
96_T	100_I	0.522	0.52
142_S	146_G	0.520	0.52
80_G	121_K	0.520	0.52
159_I	177_C	0.519	0.52
196_L	239_V	0.519	0.52
132_F	149_I	0.519	0.52
87_V	254_L	0.519	0.52
147_S	247_V	0.518	0.52
256_Y	260_T	0.516	0.51
236_G	289_V	0.516	0.51
126_S	129_L	0.515	0.51
248_G	252_G	0.515	0.51
28_L	31_E	0.514	0.51
159_I	167_L	0.513	0.51
246_L	301_E	0.512	0.51
21_R	230_A	0.511	0.51
19_R	216_K	0.508	0.50
109_A	286_E	0.507	0.50
244_K	247_V	0.506	0.50
139_H	199_N	0.504	0.50
25_A	43_L	0.504	0.50
33_S	227_L	0.502	0.50
54_L	81_K	0.502	0.50
4_F	8_A	0.502	0.50
119_K	124_P	0.502	0.50
127_P	286_E	0.501	0.49
195_F	219_F	0.501	0.49
171_D	248_G	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jwaA	2	0.0792	3	0.962	Contact Map
2l2tA	2	0.0858	2.4	0.964	Contact Map
3dh4A	3	0.2112	1.7	0.967	Contact Map
2ks1B	1	0.0825	1.6	0.967	Contact Map
3wu2I	1	0.1023	1.6	0.967	Contact Map
4n6hA	1	0.396	1.3	0.969	Contact Map
2l6wA	2	0.0759	1.2	0.969	Contact Map
2k1kA	2	0.0693	1.1	0.97	Contact Map
3j2wE	1	0.0693	1	0.971	Contact Map
2llmA	1	0.0693	1	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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