GREMLIN Database
CD225 - Interferon-induced transmembrane protein
PFAM: PF04505 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (70)
Sequences: 6420 (4788)
Seq/√Len: 572.3
META: 0.797

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_D50_G2.9071.00
60_K64_I2.2131.00
53_R57_K2.1631.00
63_I67_G2.1581.00
15_V19_L1.9161.00
42_K50_G1.8631.00
35_Y57_K1.6481.00
35_Y38_Q1.6091.00
52_Q56_K1.5771.00
32_A62_A1.5281.00
30_I34_V1.5181.00
9_P40_N1.5021.00
42_K54_A1.4931.00
20_V62_A1.4351.00
28_L65_S1.4281.00
39_V55_S1.3951.00
9_P43_W1.3781.00
38_Q42_K1.3771.00
42_K47_D1.3461.00
12_N40_N1.3321.00
48_Y52_Q1.3201.00
17_A32_A1.3161.00
59_K63_I1.2941.00
21_T33_I1.2861.00
16_W62_A1.2831.00
43_W48_Y1.2731.00
67_G71_V1.2731.00
56_K60_K1.2701.00
38_Q54_A1.2351.00
40_N44_A1.2011.00
49_A52_Q1.1981.00
19_L23_F1.1971.00
10_P43_W1.1881.00
20_V65_S1.1711.00
41_S45_A1.1591.00
57_K61_W1.1411.00
13_Y16_W1.1321.00
28_L61_W1.1131.00
64_I68_L1.0951.00
13_Y55_S1.0911.00
13_Y62_A1.0821.00
69_G73_I1.0811.00
16_W66_F1.0121.00
49_A53_R0.9951.00
62_A66_F0.9921.00
11_K16_W0.9831.00
31_V35_Y0.9821.00
57_K60_K0.9291.00
35_Y54_A0.9291.00
7_P52_Q0.9191.00
50_G54_A0.9181.00
14_L18_I0.9121.00
16_W63_I0.9081.00
31_V61_W0.9061.00
68_L72_V0.8851.00
58_A62_A0.8661.00
21_T29_G0.8621.00
9_P44_A0.8541.00
42_K45_A0.8251.00
17_A62_A0.8241.00
16_W20_V0.8221.00
13_Y59_K0.8201.00
39_V58_A0.8141.00
7_P48_Y0.8081.00
14_L37_A0.8051.00
37_A41_S0.7841.00
28_L68_L0.7711.00
27_P31_V0.7601.00
63_I66_F0.7581.00
33_I37_A0.7081.00
13_Y17_A0.6961.00
14_L33_I0.6841.00
53_R56_K0.6671.00
20_V66_F0.6581.00
39_V43_W0.6531.00
39_V54_A0.6521.00
28_L31_V0.6511.00
34_V38_Q0.6501.00
32_A65_S0.6471.00
25_C28_L0.6451.00
7_P43_W0.6411.00
54_A57_K0.6291.00
36_A58_A0.5991.00
16_W59_K0.5921.00
56_K59_K0.5831.00
28_L64_I0.5711.00
8_P43_W0.5700.99
26_L31_V0.5700.99
17_A36_A0.5640.99
66_F70_L0.5640.99
25_C68_L0.5580.99
68_L71_V0.5570.99
11_K55_S0.5470.99
34_V37_A0.5450.99
51_A55_S0.5430.99
35_Y61_W0.5420.99
70_L73_I0.5380.99
16_W19_L0.5380.99
17_A20_V0.5330.99
13_Y58_A0.5290.99
68_L73_I0.5240.99
18_I22_L0.5220.99
43_W51_A0.5040.99
65_S69_G0.5030.99
60_K67_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftB 1 1 32.9 0.832 Contact Map
4yayA 1 0.8026 22.3 0.845 Contact Map
3ayfA 2 0.9605 17.7 0.852 Contact Map
4n6hA 1 0.9868 13.3 0.86 Contact Map
4ea3A 2 0.9868 12.9 0.861 Contact Map
3v2yA 1 0.9342 11.7 0.864 Contact Map
2j7aC 2 0.2237 11 0.865 Contact Map
4ldeA 1 0.9474 11 0.865 Contact Map
4grvA 1 1 10.7 0.866 Contact Map
4pxzA 1 1 10.4 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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