GREMLIN Database
DUF573 - Protein of unknown function, DUF573
PFAM: PF04504 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (94)
Sequences: 542 (386)
Seq/√Len: 39.8
META: 0.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_L56_I3.2881.00
54_E57_R2.5241.00
48_S51_Q2.5091.00
74_K77_S2.3741.00
12_A18_I2.3701.00
4_L50_S2.3511.00
13_I52_L2.2000.99
24_K76_P2.0530.99
10_E82_H2.0460.99
35_F43_L1.9350.99
29_Y56_I1.8430.98
17_L93_I1.7090.97
5_W63_Y1.6610.96
4_L62_K1.5860.95
18_I93_I1.5320.94
69_K74_K1.5040.94
38_F44_S1.4500.92
6_S49_K1.4450.92
54_E58_R1.4420.92
13_I43_L1.4410.92
4_L37_D1.4300.92
24_K42_S1.4080.91
20_Y78_F1.4070.91
90_S94_W1.4050.91
5_W60_K1.3360.89
54_E63_Y1.3110.88
50_S53_V1.2970.87
3_R10_E1.2890.87
5_W18_I1.2520.85
73_G76_P1.2290.84
5_W39_I1.2200.84
88_E92_K1.1930.82
32_T60_K1.1930.82
36_Y77_S1.1800.81
52_L92_K1.1750.81
64_R80_K1.1650.81
15_Q43_L1.1640.81
59_L88_E1.1610.80
5_W10_E1.1560.80
3_R39_I1.1340.79
33_D41_G1.1130.78
30_P35_F1.1090.77
16_G39_I1.0920.76
22_A50_S1.0920.76
7_E11_I1.0880.76
13_I26_T1.0550.74
86_L93_I1.0330.72
55_K95_G1.0320.72
50_S62_K1.0260.71
6_S47_V0.9990.69
19_D90_S0.9910.69
7_E62_K0.9880.69
82_H86_L0.9840.68
3_R84_Q0.9830.68
64_R83_D0.9830.68
22_A92_K0.9720.67
15_Q93_I0.9680.67
19_D74_K0.9650.67
17_L87_F0.9640.67
17_L32_T0.9610.66
84_Q88_E0.9430.65
5_W73_G0.9350.64
33_D58_R0.9320.64
42_S95_G0.9220.63
7_E22_A0.9160.63
63_Y90_S0.9150.63
50_S57_R0.9100.62
36_Y64_R0.8810.60
79_S89_L0.8790.59
69_K90_S0.8650.58
58_R68_K0.8450.56
52_L86_L0.8390.56
36_Y88_E0.8380.56
16_G69_K0.8290.55
45_F52_L0.8200.54
5_W40_K0.8170.54
9_D87_F0.8100.53
79_S83_D0.8090.53
15_Q85_K0.8030.53
14_L89_L0.7880.51
6_S40_K0.7880.51
32_T47_V0.7870.51
49_K87_F0.7860.51
2_Q58_R0.7820.51
20_Y47_V0.7810.51
80_K90_S0.7770.50
18_I43_L0.7690.49
76_P83_D0.7660.49
14_L90_S0.7570.48
8_E79_S0.7540.48
13_I32_T0.7320.46
62_K88_E0.7280.46
31_D56_I0.7270.46
36_Y65_N0.7220.45
4_L45_F0.7200.45
40_K51_Q0.7150.45
57_R60_K0.7110.44
67_V73_G0.7070.44
33_D77_S0.7040.44
3_R66_N0.6960.43
65_N83_D0.6920.42
13_I86_L0.6870.42
61_K68_K0.6820.42
78_F81_P0.6740.41
41_G60_K0.6700.41
27_S51_Q0.6610.40
67_V84_Q0.6560.39
9_D35_F0.6530.39
7_E44_S0.6500.39
21_R84_Q0.6400.38
64_R95_G0.6190.36
61_K65_N0.6180.36
23_K84_Q0.6160.36
28_P41_G0.6110.35
13_I36_Y0.6050.35
35_F38_F0.6010.35
70_I89_L0.5970.34
14_L83_D0.5950.34
49_K53_V0.5850.33
39_I69_K0.5820.33
35_F93_I0.5810.33
36_Y83_D0.5800.33
16_G62_K0.5790.33
74_K95_G0.5710.32
19_D22_A0.5710.32
9_D40_K0.5680.32
10_E52_L0.5620.31
13_I21_R0.5620.31
46_D60_K0.5410.30
40_K91_K0.5310.29
66_N90_S0.5310.29
61_K75_D0.5270.29
2_Q7_E0.5260.29
52_L87_F0.5230.28
21_R47_V0.5210.28
23_K45_F0.5210.28
16_G20_Y0.5150.28
36_Y52_L0.5110.28
30_P89_L0.5060.27
35_F51_Q0.5030.27
60_K95_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ebiA 1 0.8526 86.5 0.822 Contact Map
2ckxA 1 0.8421 46.7 0.869 Contact Map
3osgA 1 0.5474 32.2 0.88 Contact Map
2yumA 1 0.7263 31.5 0.88 Contact Map
2yusA 1 0.6421 30.3 0.881 Contact Map
2elkA 1 0.5368 29.8 0.882 Contact Map
2k9nA 1 0.5895 28.4 0.883 Contact Map
3sjmA 1 0.5684 25.6 0.886 Contact Map
2lr8A 1 0.6105 24.9 0.887 Contact Map
1ug2A 1 0.6737 23.5 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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