GREMLIN Database
DUF572 - Family of unknown function (DUF572)
PFAM: PF04502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 330 (315)
Sequences: 740 (577)
Seq/√Len: 32.5
META: 0.096

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_I106_A4.4081.00
47_T87_A3.7241.00
99_D108_R3.4471.00
237_K240_L3.1971.00
37_F60_A3.0821.00
27_A33_L3.0321.00
2_G6_V2.9451.00
15_F20_I2.9131.00
39_M43_I2.8921.00
64_K74_P2.8641.00
187_E191_E2.6521.00
17_P20_I2.6181.00
63_E77_R2.5531.00
238_K241_S2.4100.99
197_A201_K2.3920.99
235_K238_K2.3700.99
79_Y88_E2.2860.99
11_Y16_D2.1830.99
39_M52_I2.1580.99
11_Y19_K2.1440.99
77_R103_E2.1390.99
1_M4_R2.1200.98
77_R92_K2.0040.98
58_F83_T1.9240.97
236_P239_S1.9220.97
147_K151_E1.9190.97
277_S280_S1.9110.97
94_D97_N1.8920.97
234_S237_K1.8710.97
21_P26_R1.8620.96
21_P27_A1.8550.96
39_M80_M1.8110.96
90_E104_S1.8100.96
111_E114_R1.8050.96
155_R159_L1.7800.95
261_S264_R1.7690.95
80_M91_F1.7670.95
184_E188_R1.7640.95
235_K240_L1.7430.95
127_R131_E1.7390.95
9_K19_K1.6770.94
115_L119_E1.6720.94
20_I25_E1.6630.93
234_S238_K1.6620.93
69_T74_P1.6560.93
255_L262_L1.6480.93
1_M5_K1.6380.93
249_S253_E1.6340.93
289_K292_T1.6290.93
3_E6_V1.6240.93
183_E187_E1.6230.93
196_E199_K1.6150.92
253_E256_E1.6120.92
286_E289_K1.5840.92
255_L260_G1.5680.91
267_V270_K1.5340.90
321_L325_Y1.5330.90
79_Y90_E1.5220.90
142_R146_S1.5080.89
286_E290_T1.5010.89
87_A101_V1.4950.89
243_K246_S1.4820.89
273_A276_K1.4750.88
233_S240_L1.4710.88
16_D19_K1.4690.88
235_K239_S1.4470.87
125_K128_E1.4400.87
76_Y87_A1.4280.87
102_V170_D1.4140.86
35_V62_K1.4100.86
6_V15_F1.4020.86
77_R90_E1.4010.86
65_V92_K1.4000.86
68_E92_K1.3980.85
236_P242_P1.3950.85
28_R34_V1.3860.85
321_L326_S1.3810.85
295_S315_G1.3680.84
201_K204_L1.3660.84
20_I32_Q1.3650.84
94_D101_V1.3640.84
20_I27_A1.3540.84
320_S325_Y1.3460.83
281_K285_T1.3430.83
122_R128_E1.3340.83
258_S261_S1.3330.83
10_Y13_P1.3320.83
247_S255_L1.3100.81
58_F84_R1.3090.81
291_S296_A1.3070.81
320_S323_G1.3030.81
247_S251_K1.3020.81
232_S238_K1.2960.81
102_V106_A1.2910.80
288_S292_T1.2860.80
209_L213_D1.2850.80
268_R271_K1.2800.80
317_S321_L1.2760.80
3_E9_K1.2760.80
248_A253_E1.2700.79
285_T288_S1.2650.79
258_S263_T1.2610.79
278_S281_K1.2590.79
293_P314_P1.2550.79
233_S238_K1.2410.78
103_E175_L1.2250.77
313_T316_S1.2240.77
237_K241_S1.2230.77
291_S295_S1.2230.77
27_A31_G1.2210.77
255_L261_S1.2180.76
318_S323_G1.2110.76
284_T287_S1.2060.76
255_L263_T1.2040.76
312_A315_G1.2020.75
137_K141_N1.2020.75
260_G263_T1.1970.75
287_S291_S1.1890.75
290_T294_G1.1870.75
326_S329_D1.1760.74
189_E193_E1.1760.74
287_S297_P1.1730.74
63_E79_Y1.1720.74
60_A178_R1.1650.73
255_L258_S1.1640.73
296_A311_P1.1640.73
289_K293_P1.1630.73
34_V37_F1.1630.73
38_M57_K1.1620.73
123_E128_E1.1590.73
255_L265_K1.1420.72
284_T290_T1.1410.72
325_Y328_S1.1340.71
312_A317_S1.1330.71
295_S310_A1.1240.70
21_P33_L1.1210.70
286_E295_S1.1150.70
279_P290_T1.1130.70
64_K104_S1.1130.70
287_S293_P1.1080.69
143_T149_E1.1000.69
232_S237_K1.0970.68
21_P32_Q1.0950.68
319_L322_L1.0890.68
65_V81_K1.0880.68
291_S297_P1.0880.68
242_P245_T1.0870.68
293_P296_A1.0850.68
92_K156_L1.0840.68
281_K284_T1.0820.67
286_E292_T1.0820.67
251_K255_L1.0810.67
318_S321_L1.0710.67
292_T297_P1.0700.67
293_P297_P1.0640.66
250_S253_E1.0630.66
275_S280_S1.0630.66
128_E131_E1.0630.66
28_R33_L1.0570.66
98_T135_A1.0490.65
143_T146_S1.0480.65
198_L201_K1.0470.65
276_K280_S1.0330.64
317_S323_G1.0320.64
56_V80_M1.0320.64
37_F43_I1.0250.63
312_A326_S1.0250.63
108_R136_M1.0200.63
234_S239_S1.0110.62
235_K241_S1.0110.62
236_P240_L1.0070.62
282_K285_T1.0060.62
256_E262_L1.0020.61
284_T291_S0.9950.61
131_E141_N0.9880.60
21_P31_G0.9870.60
33_L37_F0.9860.60
124_E127_R0.9850.60
61_R79_Y0.9850.60
287_S290_T0.9830.60
108_R165_R0.9810.60
239_S242_P0.9780.59
311_P314_P0.9690.59
271_K274_S0.9660.58
2_G37_F0.9650.58
122_R126_E0.9650.58
282_K286_E0.9610.58
26_R33_L0.9530.57
62_K95_P0.9530.57
233_S239_S0.9530.57
321_L324_A0.9530.57
42_N86_S0.9490.57
99_D114_R0.9420.57
311_P317_S0.9390.56
118_E122_R0.9380.56
31_G34_V0.9370.56
50_E91_F0.9290.55
90_E102_V0.9270.55
33_L60_A0.9210.55
280_S285_T0.9210.55
60_A171_Y0.9190.55
259_L262_L0.9120.54
185_K189_E0.9080.54
282_K288_S0.9040.53
295_S313_T0.9030.53
2_G43_I0.9030.53
310_A314_P0.9010.53
280_S313_T0.9000.53
323_G326_S0.8950.53
51_Y82_C0.8920.52
100_Y106_A0.8920.52
43_I89_I0.8920.52
311_P315_G0.8910.52
147_K150_M0.8880.52
174_N178_R0.8860.52
231_E234_S0.8820.52
294_G311_P0.8800.51
92_K103_E0.8760.51
264_R268_R0.8740.51
152_A155_R0.8710.51
60_A74_P0.8690.51
74_P102_V0.8620.50
281_K310_A0.8570.50
231_E235_K0.8560.49
78_F85_C0.8520.49
282_K293_P0.8510.49
255_L259_L0.8480.49
294_G297_P0.8480.49
120_E123_E0.8410.48
141_N169_D0.8390.48
3_E8_N0.8370.48
318_S322_L0.8370.48
267_V271_K0.8370.48
64_K87_A0.8360.48
283_K287_S0.8330.48
146_S149_E0.8310.47
119_E126_E0.8310.47
258_S265_K0.8290.47
1_M8_N0.8270.47
30_N66_G0.8260.47
124_E128_E0.8240.47
37_F56_V0.8230.47
287_S292_T0.8230.47
127_R133_N0.8230.47
121_E125_K0.8200.46
273_A282_K0.8180.46
24_R66_G0.8110.46
290_T295_S0.8100.46
80_M89_I0.8030.45
283_K290_T0.7930.44
190_E193_E0.7920.44
144_K210_L0.7870.44
46_K92_K0.7870.44
279_P289_K0.7870.44
24_R33_L0.7850.44
164_Q168_K0.7840.44
283_K288_S0.7840.44
267_V272_K0.7780.43
235_K242_P0.7780.43
289_K294_G0.7730.43
313_T319_L0.7730.43
122_R125_K0.7720.43
283_K286_E0.7710.42
317_S324_A0.7640.42
282_K287_S0.7610.42
277_S285_T0.7610.42
115_L118_E0.7580.41
67_N75_I0.7550.41
292_T296_A0.7540.41
5_K77_R0.7530.41
145_D157_E0.7530.41
115_L161_E0.7510.41
248_A254_S0.7450.40
286_E297_P0.7450.40
35_V102_V0.7430.40
9_K15_F0.7430.40
279_P282_K0.7370.40
231_E241_S0.7370.40
256_E264_R0.7360.40
257_K261_S0.7310.39
316_S326_S0.7290.39
76_Y212_E0.7280.39
258_S264_R0.7220.39
289_K297_P0.7190.38
280_S283_K0.7190.38
89_I129_E0.7190.38
147_K152_A0.7190.38
310_A315_G0.7180.38
312_A316_S0.7180.38
286_E294_G0.7170.38
324_A327_D0.7150.38
67_N156_L0.7140.38
172_E175_L0.7140.38
37_F62_K0.7130.38
39_M91_F0.7130.38
181_F186_K0.7100.38
62_K75_I0.7070.37
119_E123_E0.7070.37
186_K189_E0.7060.37
196_E224_K0.7060.37
16_D82_C0.7040.37
207_I214_E0.7040.37
60_A102_V0.7040.37
288_S293_P0.7020.37
288_S314_P0.7000.37
31_G56_V0.6980.37
323_G328_S0.6970.37
279_P292_T0.6960.37
268_R273_A0.6950.36
196_E243_K0.6910.36
75_I158_E0.6910.36
231_E237_K0.6890.36
293_P311_P0.6880.36
8_N82_C0.6880.36
313_T329_D0.6870.36
34_V60_A0.6850.36
294_G313_T0.6850.36
130_E133_N0.6840.36
73_T96_K0.6840.36
2_G5_K0.6790.35
109_N113_E0.6780.35
95_P100_Y0.6780.35
1_M7_L0.6750.35
275_S278_S0.6720.35
289_K296_A0.6690.35
291_S294_G0.6670.34
121_E128_E0.6660.34
283_K289_K0.6660.34
285_T292_T0.6650.34
222_L225_G0.6630.34
128_E132_E0.6620.34
71_L96_K0.6610.34
43_I56_V0.6590.34
282_K296_A0.6580.34
95_P109_N0.6580.34
162_L166_Q0.6580.34
311_P329_D0.6560.34
53_Y99_D0.6560.34
136_M155_R0.6540.33
6_V20_I0.6530.33
21_P24_R0.6520.33
2_G18_S0.6520.33
279_P286_E0.6480.33
208_R212_E0.6470.33
170_D173_A0.6460.33
297_P310_A0.6460.33
37_F80_M0.6410.32
52_I89_I0.6410.32
124_E132_E0.6400.32
219_R223_V0.6400.32
37_F178_R0.6390.32
31_G43_I0.6390.32
129_E133_N0.6390.32
178_R185_K0.6380.32
31_G66_G0.6370.32
181_F185_K0.6360.32
50_E192_E0.6360.32
293_P310_A0.6350.32
149_E160_K0.6330.32
171_Y178_R0.6320.32
219_R222_L0.6300.32
57_K73_T0.6280.32
113_E116_E0.6270.31
230_F237_K0.6270.31
74_P171_Y0.6270.31
217_E220_A0.6260.31
157_E162_L0.6260.31
80_M141_N0.6250.31
280_S293_P0.6240.31
38_M73_T0.6210.31
274_S285_T0.6210.31
146_S158_E0.6210.31
50_E56_V0.6200.31
249_S255_L0.6200.31
313_T317_S0.6200.31
281_K291_S0.6180.31
86_S113_E0.6110.30
268_R272_K0.6100.30
285_T291_S0.6090.30
32_Q61_R0.6080.30
116_E120_E0.6060.30
284_T311_P0.6050.30
11_Y15_F0.6050.30
291_S314_P0.6030.30
39_M56_V0.6020.30
280_S296_A0.6010.30
321_L327_D0.6000.30
42_N51_Y0.6000.30
317_S320_S0.5960.29
233_S241_S0.5950.29
236_P241_S0.5950.29
279_P283_K0.5930.29
60_A80_M0.5920.29
209_L212_E0.5920.29
285_T293_P0.5920.29
280_S310_A0.5880.29
209_L214_E0.5870.29
200_A203_S0.5850.29
21_P28_R0.5840.28
27_A32_Q0.5810.28
234_S267_V0.5810.28
287_S296_A0.5800.28
311_P316_S0.5800.28
216_D219_R0.5790.28
257_K260_G0.5790.28
278_S283_K0.5780.28
264_R267_V0.5770.28
72_G107_T0.5770.28
216_D220_A0.5770.28
42_N111_E0.5760.28
250_S262_L0.5760.28
20_I54_K0.5750.28
290_T296_A0.5740.28
282_K292_T0.5730.28
141_N145_D0.5720.28
21_P142_R0.5700.28
109_N118_E0.5690.27
297_P312_A0.5690.27
291_S310_A0.5690.27
278_S282_K0.5690.27
171_Y185_K0.5690.27
285_T289_K0.5670.27
37_F57_K0.5660.27
82_C87_A0.5660.27
273_A293_P0.5650.27
287_S295_S0.5630.27
234_S260_G0.5610.27
237_K242_P0.5610.27
296_A315_G0.5590.27
290_T311_P0.5580.27
320_S326_S0.5560.27
283_K292_T0.5560.27
292_T314_P0.5550.27
278_S288_S0.5510.26
252_K257_K0.5490.26
266_V270_K0.5470.26
233_S245_T0.5460.26
294_G316_S0.5450.26
280_S287_S0.5430.26
277_S281_K0.5430.26
82_C85_C0.5410.26
277_S284_T0.5400.26
46_K96_K0.5370.25
278_S290_T0.5350.25
42_N112_A0.5340.25
142_R155_R0.5330.25
204_L207_I0.5320.25
232_S236_P0.5300.25
178_R182_R0.5300.25
278_S285_T0.5280.25
254_S261_S0.5280.25
50_E58_F0.5270.25
215_E219_R0.5270.25
58_F89_I0.5270.25
218_E222_L0.5270.25
63_E103_E0.5250.25
286_E293_P0.5230.25
224_K227_S0.5210.24
80_M138_K0.5180.24
1_M6_V0.5160.24
280_S290_T0.5130.24
271_K283_K0.5080.24
61_R88_E0.5070.24
310_A316_S0.5060.24
233_S237_K0.5060.24
2_G15_F0.5050.23
296_A314_P0.5050.23
33_L56_V0.5020.23
2_G39_M0.5010.23
253_E262_L0.5000.23
15_F19_K0.5000.23
268_R292_T0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iloA 3 0.2212 72.9 0.958 Contact Map
3na7A 1 0.2273 63.9 0.961 Contact Map
4qiwP 1 0.1273 37.1 0.967 Contact Map
2k2dA 1 0.1424 30.1 0.968 Contact Map
5aunA 1 0.2818 26.4 0.969 Contact Map
3m7kA 2 0.3212 25.4 0.97 Contact Map
1wiiA 1 0.2515 24.5 0.97 Contact Map
1vd4A 1 0.1727 21.3 0.971 Contact Map
3wwlA 1 0.1606 19.6 0.971 Contact Map
2kdxA 1 0.2394 17.9 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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