DUF572 - PFAM28P - GREMLIN Contacts

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DUF572 - Family of unknown function (DUF572)

PFAM:	PF04502	Sequences: MGERKVLNKYYPPDFDPSKIPALRERARKNGQLVVRFMMPFNIWCKTCGEYIYKGVKFNARKEKVGNETYLGTPIYRFYMKCTRCSAEIEFKTDPKNTDYVVESGATRNFEAERLEEEEEEREEKEREEEEENDAMKKLENRTKDSKREMEALERLEELKELNQRQWKDDYEANLRLRREFREEKKEREEEEEDEEALKAKFSLEGIRLLPEDEEDEERAALVKGKSSEFESSSKPKKSLSPKPTSSASSKKESLEKSLGSLTRKVVRKKKKASSKSSPSKKKTTESSKTSTPGSAPSSSTSSKKESKPAPATPGSSSLSLLGAYSDSDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	330 (315)
Sequences:	740 (577)
Seq/√Len:	32.5
META:	0.096

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
43_I	106_A	4.408	1.00
47_T	87_A	3.724	1.00
99_D	108_R	3.447	1.00
237_K	240_L	3.197	1.00
37_F	60_A	3.082	1.00
27_A	33_L	3.032	1.00
2_G	6_V	2.945	1.00
15_F	20_I	2.913	1.00
39_M	43_I	2.892	1.00
64_K	74_P	2.864	1.00
187_E	191_E	2.652	1.00
17_P	20_I	2.618	1.00
63_E	77_R	2.553	1.00
238_K	241_S	2.410	0.99
197_A	201_K	2.392	0.99
235_K	238_K	2.370	0.99
79_Y	88_E	2.286	0.99
11_Y	16_D	2.183	0.99
39_M	52_I	2.158	0.99
11_Y	19_K	2.144	0.99
77_R	103_E	2.139	0.99
1_M	4_R	2.120	0.98
77_R	92_K	2.004	0.98
58_F	83_T	1.924	0.97
236_P	239_S	1.922	0.97
147_K	151_E	1.919	0.97
277_S	280_S	1.911	0.97
94_D	97_N	1.892	0.97
234_S	237_K	1.871	0.97
21_P	26_R	1.862	0.96
21_P	27_A	1.855	0.96
39_M	80_M	1.811	0.96
90_E	104_S	1.810	0.96
111_E	114_R	1.805	0.96
155_R	159_L	1.780	0.95
261_S	264_R	1.769	0.95
80_M	91_F	1.767	0.95
184_E	188_R	1.764	0.95
235_K	240_L	1.743	0.95
127_R	131_E	1.739	0.95
9_K	19_K	1.677	0.94
115_L	119_E	1.672	0.94
20_I	25_E	1.663	0.93
234_S	238_K	1.662	0.93
69_T	74_P	1.656	0.93
255_L	262_L	1.648	0.93
1_M	5_K	1.638	0.93
249_S	253_E	1.634	0.93
289_K	292_T	1.629	0.93
3_E	6_V	1.624	0.93
183_E	187_E	1.623	0.93
196_E	199_K	1.615	0.92
253_E	256_E	1.612	0.92
286_E	289_K	1.584	0.92
255_L	260_G	1.568	0.91
267_V	270_K	1.534	0.90
321_L	325_Y	1.533	0.90
79_Y	90_E	1.522	0.90
142_R	146_S	1.508	0.89
286_E	290_T	1.501	0.89
87_A	101_V	1.495	0.89
243_K	246_S	1.482	0.89
273_A	276_K	1.475	0.88
233_S	240_L	1.471	0.88
16_D	19_K	1.469	0.88
235_K	239_S	1.447	0.87
125_K	128_E	1.440	0.87
76_Y	87_A	1.428	0.87
102_V	170_D	1.414	0.86
35_V	62_K	1.410	0.86
6_V	15_F	1.402	0.86
77_R	90_E	1.401	0.86
65_V	92_K	1.400	0.86
68_E	92_K	1.398	0.85
236_P	242_P	1.395	0.85
28_R	34_V	1.386	0.85
321_L	326_S	1.381	0.85
295_S	315_G	1.368	0.84
201_K	204_L	1.366	0.84
20_I	32_Q	1.365	0.84
94_D	101_V	1.364	0.84
20_I	27_A	1.354	0.84
320_S	325_Y	1.346	0.83
281_K	285_T	1.343	0.83
122_R	128_E	1.334	0.83
258_S	261_S	1.333	0.83
10_Y	13_P	1.332	0.83
247_S	255_L	1.310	0.81
58_F	84_R	1.309	0.81
291_S	296_A	1.307	0.81
320_S	323_G	1.303	0.81
247_S	251_K	1.302	0.81
232_S	238_K	1.296	0.81
102_V	106_A	1.291	0.80
288_S	292_T	1.286	0.80
209_L	213_D	1.285	0.80
268_R	271_K	1.280	0.80
317_S	321_L	1.276	0.80
3_E	9_K	1.276	0.80
248_A	253_E	1.270	0.79
285_T	288_S	1.265	0.79
258_S	263_T	1.261	0.79
278_S	281_K	1.259	0.79
293_P	314_P	1.255	0.79
233_S	238_K	1.241	0.78
103_E	175_L	1.225	0.77
313_T	316_S	1.224	0.77
237_K	241_S	1.223	0.77
291_S	295_S	1.223	0.77
27_A	31_G	1.221	0.77
255_L	261_S	1.218	0.76
318_S	323_G	1.211	0.76
284_T	287_S	1.206	0.76
255_L	263_T	1.204	0.76
312_A	315_G	1.202	0.75
137_K	141_N	1.202	0.75
260_G	263_T	1.197	0.75
287_S	291_S	1.189	0.75
290_T	294_G	1.187	0.75
326_S	329_D	1.176	0.74
189_E	193_E	1.176	0.74
287_S	297_P	1.173	0.74
63_E	79_Y	1.172	0.74
60_A	178_R	1.165	0.73
255_L	258_S	1.164	0.73
296_A	311_P	1.164	0.73
289_K	293_P	1.163	0.73
34_V	37_F	1.163	0.73
38_M	57_K	1.162	0.73
123_E	128_E	1.159	0.73
255_L	265_K	1.142	0.72
284_T	290_T	1.141	0.72
325_Y	328_S	1.134	0.71
312_A	317_S	1.133	0.71
295_S	310_A	1.124	0.70
21_P	33_L	1.121	0.70
286_E	295_S	1.115	0.70
279_P	290_T	1.113	0.70
64_K	104_S	1.113	0.70
287_S	293_P	1.108	0.69
143_T	149_E	1.100	0.69
232_S	237_K	1.097	0.68
21_P	32_Q	1.095	0.68
319_L	322_L	1.089	0.68
65_V	81_K	1.088	0.68
291_S	297_P	1.088	0.68
242_P	245_T	1.087	0.68
293_P	296_A	1.085	0.68
92_K	156_L	1.084	0.68
281_K	284_T	1.082	0.67
286_E	292_T	1.082	0.67
251_K	255_L	1.081	0.67
318_S	321_L	1.071	0.67
292_T	297_P	1.070	0.67
293_P	297_P	1.064	0.66
250_S	253_E	1.063	0.66
275_S	280_S	1.063	0.66
128_E	131_E	1.063	0.66
28_R	33_L	1.057	0.66
98_T	135_A	1.049	0.65
143_T	146_S	1.048	0.65
198_L	201_K	1.047	0.65
276_K	280_S	1.033	0.64
317_S	323_G	1.032	0.64
56_V	80_M	1.032	0.64
37_F	43_I	1.025	0.63
312_A	326_S	1.025	0.63
108_R	136_M	1.020	0.63
234_S	239_S	1.011	0.62
235_K	241_S	1.011	0.62
236_P	240_L	1.007	0.62
282_K	285_T	1.006	0.62
256_E	262_L	1.002	0.61
284_T	291_S	0.995	0.61
131_E	141_N	0.988	0.60
21_P	31_G	0.987	0.60
33_L	37_F	0.986	0.60
124_E	127_R	0.985	0.60
61_R	79_Y	0.985	0.60
287_S	290_T	0.983	0.60
108_R	165_R	0.981	0.60
239_S	242_P	0.978	0.59
311_P	314_P	0.969	0.59
271_K	274_S	0.966	0.58
2_G	37_F	0.965	0.58
122_R	126_E	0.965	0.58
282_K	286_E	0.961	0.58
26_R	33_L	0.953	0.57
62_K	95_P	0.953	0.57
233_S	239_S	0.953	0.57
321_L	324_A	0.953	0.57
42_N	86_S	0.949	0.57
99_D	114_R	0.942	0.57
311_P	317_S	0.939	0.56
118_E	122_R	0.938	0.56
31_G	34_V	0.937	0.56
50_E	91_F	0.929	0.55
90_E	102_V	0.927	0.55
33_L	60_A	0.921	0.55
280_S	285_T	0.921	0.55
60_A	171_Y	0.919	0.55
259_L	262_L	0.912	0.54
185_K	189_E	0.908	0.54
282_K	288_S	0.904	0.53
295_S	313_T	0.903	0.53
2_G	43_I	0.903	0.53
310_A	314_P	0.901	0.53
280_S	313_T	0.900	0.53
323_G	326_S	0.895	0.53
51_Y	82_C	0.892	0.52
100_Y	106_A	0.892	0.52
43_I	89_I	0.892	0.52
311_P	315_G	0.891	0.52
147_K	150_M	0.888	0.52
174_N	178_R	0.886	0.52
231_E	234_S	0.882	0.52
294_G	311_P	0.880	0.51
92_K	103_E	0.876	0.51
264_R	268_R	0.874	0.51
152_A	155_R	0.871	0.51
60_A	74_P	0.869	0.51
74_P	102_V	0.862	0.50
281_K	310_A	0.857	0.50
231_E	235_K	0.856	0.49
78_F	85_C	0.852	0.49
282_K	293_P	0.851	0.49
255_L	259_L	0.848	0.49
294_G	297_P	0.848	0.49
120_E	123_E	0.841	0.48
141_N	169_D	0.839	0.48
3_E	8_N	0.837	0.48
318_S	322_L	0.837	0.48
267_V	271_K	0.837	0.48
64_K	87_A	0.836	0.48
283_K	287_S	0.833	0.48
146_S	149_E	0.831	0.47
119_E	126_E	0.831	0.47
258_S	265_K	0.829	0.47
1_M	8_N	0.827	0.47
30_N	66_G	0.826	0.47
124_E	128_E	0.824	0.47
37_F	56_V	0.823	0.47
287_S	292_T	0.823	0.47
127_R	133_N	0.823	0.47
121_E	125_K	0.820	0.46
273_A	282_K	0.818	0.46
24_R	66_G	0.811	0.46
290_T	295_S	0.810	0.46
80_M	89_I	0.803	0.45
283_K	290_T	0.793	0.44
190_E	193_E	0.792	0.44
144_K	210_L	0.787	0.44
46_K	92_K	0.787	0.44
279_P	289_K	0.787	0.44
24_R	33_L	0.785	0.44
164_Q	168_K	0.784	0.44
283_K	288_S	0.784	0.44
267_V	272_K	0.778	0.43
235_K	242_P	0.778	0.43
289_K	294_G	0.773	0.43
313_T	319_L	0.773	0.43
122_R	125_K	0.772	0.43
283_K	286_E	0.771	0.42
317_S	324_A	0.764	0.42
282_K	287_S	0.761	0.42
277_S	285_T	0.761	0.42
115_L	118_E	0.758	0.41
67_N	75_I	0.755	0.41
292_T	296_A	0.754	0.41
5_K	77_R	0.753	0.41
145_D	157_E	0.753	0.41
115_L	161_E	0.751	0.41
248_A	254_S	0.745	0.40
286_E	297_P	0.745	0.40
35_V	102_V	0.743	0.40
9_K	15_F	0.743	0.40
279_P	282_K	0.737	0.40
231_E	241_S	0.737	0.40
256_E	264_R	0.736	0.40
257_K	261_S	0.731	0.39
316_S	326_S	0.729	0.39
76_Y	212_E	0.728	0.39
258_S	264_R	0.722	0.39
289_K	297_P	0.719	0.38
280_S	283_K	0.719	0.38
89_I	129_E	0.719	0.38
147_K	152_A	0.719	0.38
310_A	315_G	0.718	0.38
312_A	316_S	0.718	0.38
286_E	294_G	0.717	0.38
324_A	327_D	0.715	0.38
67_N	156_L	0.714	0.38
172_E	175_L	0.714	0.38
37_F	62_K	0.713	0.38
39_M	91_F	0.713	0.38
181_F	186_K	0.710	0.38
62_K	75_I	0.707	0.37
119_E	123_E	0.707	0.37
186_K	189_E	0.706	0.37
196_E	224_K	0.706	0.37
16_D	82_C	0.704	0.37
207_I	214_E	0.704	0.37
60_A	102_V	0.704	0.37
288_S	293_P	0.702	0.37
288_S	314_P	0.700	0.37
31_G	56_V	0.698	0.37
323_G	328_S	0.697	0.37
279_P	292_T	0.696	0.37
268_R	273_A	0.695	0.36
196_E	243_K	0.691	0.36
75_I	158_E	0.691	0.36
231_E	237_K	0.689	0.36
293_P	311_P	0.688	0.36
8_N	82_C	0.688	0.36
313_T	329_D	0.687	0.36
34_V	60_A	0.685	0.36
294_G	313_T	0.685	0.36
130_E	133_N	0.684	0.36
73_T	96_K	0.684	0.36
2_G	5_K	0.679	0.35
109_N	113_E	0.678	0.35
95_P	100_Y	0.678	0.35
1_M	7_L	0.675	0.35
275_S	278_S	0.672	0.35
289_K	296_A	0.669	0.35
291_S	294_G	0.667	0.34
121_E	128_E	0.666	0.34
283_K	289_K	0.666	0.34
285_T	292_T	0.665	0.34
222_L	225_G	0.663	0.34
128_E	132_E	0.662	0.34
71_L	96_K	0.661	0.34
43_I	56_V	0.659	0.34
282_K	296_A	0.658	0.34
95_P	109_N	0.658	0.34
162_L	166_Q	0.658	0.34
311_P	329_D	0.656	0.34
53_Y	99_D	0.656	0.34
136_M	155_R	0.654	0.33
6_V	20_I	0.653	0.33
21_P	24_R	0.652	0.33
2_G	18_S	0.652	0.33
279_P	286_E	0.648	0.33
208_R	212_E	0.647	0.33
170_D	173_A	0.646	0.33
297_P	310_A	0.646	0.33
37_F	80_M	0.641	0.32
52_I	89_I	0.641	0.32
124_E	132_E	0.640	0.32
219_R	223_V	0.640	0.32
37_F	178_R	0.639	0.32
31_G	43_I	0.639	0.32
129_E	133_N	0.639	0.32
178_R	185_K	0.638	0.32
31_G	66_G	0.637	0.32
181_F	185_K	0.636	0.32
50_E	192_E	0.636	0.32
293_P	310_A	0.635	0.32
149_E	160_K	0.633	0.32
171_Y	178_R	0.632	0.32
219_R	222_L	0.630	0.32
57_K	73_T	0.628	0.32
113_E	116_E	0.627	0.31
230_F	237_K	0.627	0.31
74_P	171_Y	0.627	0.31
217_E	220_A	0.626	0.31
157_E	162_L	0.626	0.31
80_M	141_N	0.625	0.31
280_S	293_P	0.624	0.31
38_M	73_T	0.621	0.31
274_S	285_T	0.621	0.31
146_S	158_E	0.621	0.31
50_E	56_V	0.620	0.31
249_S	255_L	0.620	0.31
313_T	317_S	0.620	0.31
281_K	291_S	0.618	0.31
86_S	113_E	0.611	0.30
268_R	272_K	0.610	0.30
285_T	291_S	0.609	0.30
32_Q	61_R	0.608	0.30
116_E	120_E	0.606	0.30
284_T	311_P	0.605	0.30
11_Y	15_F	0.605	0.30
291_S	314_P	0.603	0.30
39_M	56_V	0.602	0.30
280_S	296_A	0.601	0.30
321_L	327_D	0.600	0.30
42_N	51_Y	0.600	0.30
317_S	320_S	0.596	0.29
233_S	241_S	0.595	0.29
236_P	241_S	0.595	0.29
279_P	283_K	0.593	0.29
60_A	80_M	0.592	0.29
209_L	212_E	0.592	0.29
285_T	293_P	0.592	0.29
280_S	310_A	0.588	0.29
209_L	214_E	0.587	0.29
200_A	203_S	0.585	0.29
21_P	28_R	0.584	0.28
27_A	32_Q	0.581	0.28
234_S	267_V	0.581	0.28
287_S	296_A	0.580	0.28
311_P	316_S	0.580	0.28
216_D	219_R	0.579	0.28
257_K	260_G	0.579	0.28
278_S	283_K	0.578	0.28
264_R	267_V	0.577	0.28
72_G	107_T	0.577	0.28
216_D	220_A	0.577	0.28
42_N	111_E	0.576	0.28
250_S	262_L	0.576	0.28
20_I	54_K	0.575	0.28
290_T	296_A	0.574	0.28
282_K	292_T	0.573	0.28
141_N	145_D	0.572	0.28
21_P	142_R	0.570	0.28
109_N	118_E	0.569	0.27
297_P	312_A	0.569	0.27
291_S	310_A	0.569	0.27
278_S	282_K	0.569	0.27
171_Y	185_K	0.569	0.27
285_T	289_K	0.567	0.27
37_F	57_K	0.566	0.27
82_C	87_A	0.566	0.27
273_A	293_P	0.565	0.27
287_S	295_S	0.563	0.27
234_S	260_G	0.561	0.27
237_K	242_P	0.561	0.27
296_A	315_G	0.559	0.27
290_T	311_P	0.558	0.27
320_S	326_S	0.556	0.27
283_K	292_T	0.556	0.27
292_T	314_P	0.555	0.27
278_S	288_S	0.551	0.26
252_K	257_K	0.549	0.26
266_V	270_K	0.547	0.26
233_S	245_T	0.546	0.26
294_G	316_S	0.545	0.26
280_S	287_S	0.543	0.26
277_S	281_K	0.543	0.26
82_C	85_C	0.541	0.26
277_S	284_T	0.540	0.26
46_K	96_K	0.537	0.25
278_S	290_T	0.535	0.25
42_N	112_A	0.534	0.25
142_R	155_R	0.533	0.25
204_L	207_I	0.532	0.25
232_S	236_P	0.530	0.25
178_R	182_R	0.530	0.25
278_S	285_T	0.528	0.25
254_S	261_S	0.528	0.25
50_E	58_F	0.527	0.25
215_E	219_R	0.527	0.25
58_F	89_I	0.527	0.25
218_E	222_L	0.527	0.25
63_E	103_E	0.525	0.25
286_E	293_P	0.523	0.25
224_K	227_S	0.521	0.24
80_M	138_K	0.518	0.24
1_M	6_V	0.516	0.24
280_S	290_T	0.513	0.24
271_K	283_K	0.508	0.24
61_R	88_E	0.507	0.24
310_A	316_S	0.506	0.24
233_S	237_K	0.506	0.24
2_G	15_F	0.505	0.23
296_A	314_P	0.505	0.23
33_L	56_V	0.502	0.23
2_G	39_M	0.501	0.23
253_E	262_L	0.500	0.23
15_F	19_K	0.500	0.23
268_R	292_T	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4iloA	3	0.2212	72.9	0.958	Contact Map
3na7A	1	0.2273	63.9	0.961	Contact Map
4qiwP	1	0.1273	37.1	0.967	Contact Map
2k2dA	1	0.1424	30.1	0.968	Contact Map
5aunA	1	0.2818	26.4	0.969	Contact Map
3m7kA	2	0.3212	25.4	0.97	Contact Map
1wiiA	1	0.2515	24.5	0.97	Contact Map
1vd4A	1	0.1727	21.3	0.971	Contact Map
3wwlA	1	0.1606	19.6	0.971	Contact Map
2kdxA	1	0.2394	17.9	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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