GREMLIN Database
DUF565 - Protein of unknown function (DUF565)
PFAM: PF04483 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (57)
Sequences: 1136 (731)
Seq/√Len: 96.9
META: 0.734

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_E57_K5.7201.00
21_S44_K3.7631.00
41_N44_K2.5191.00
25_Y44_K1.8981.00
16_F20_I1.8461.00
4_D8_V1.8461.00
24_R41_N1.8261.00
6_D52_F1.7341.00
19_L23_L1.6761.00
13_L47_L1.5671.00
5_W8_V1.5031.00
21_S41_N1.4271.00
25_Y41_N1.3540.99
45_I49_Y1.3040.99
21_S24_R1.2940.99
27_L33_R1.2930.99
10_A51_L1.2920.99
33_R36_L1.2900.99
26_R30_R1.2300.99
11_L14_V1.2210.99
49_Y59_G1.2180.99
25_Y34_S1.1630.98
6_D9_A1.1380.98
4_D7_P1.0980.97
27_L34_S1.0850.97
35_L40_L1.0850.97
7_P58_L1.0590.96
33_R38_L1.0240.96
26_R32_K1.0240.96
24_R44_K0.9730.94
56_F59_G0.9150.92
28_R39_L0.9090.92
21_S54_E0.8870.91
21_S25_Y0.8870.91
16_F31_S0.8840.91
47_L51_L0.8830.91
32_K39_L0.8720.90
52_F55_A0.8370.88
33_R40_L0.8300.88
29_R32_K0.8010.86
28_R40_L0.7850.85
10_A49_Y0.7690.84
23_L29_R0.7630.83
22_R54_E0.7630.83
19_L39_L0.7410.81
10_A15_L0.7370.81
31_S36_L0.7250.80
14_V57_K0.7200.79
10_A37_L0.7170.79
5_W9_A0.7130.79
56_F60_S0.7040.78
19_L36_L0.7020.78
20_I40_L0.7020.78
12_L37_L0.6950.77
21_S43_L0.6910.77
7_P10_A0.6750.75
20_I28_R0.6690.74
49_Y56_F0.6660.74
17_I52_F0.6370.71
20_I31_S0.6360.70
30_R36_L0.6230.69
27_L37_L0.6080.67
6_D10_A0.6030.66
29_R40_L0.5940.65
8_V33_R0.5910.65
39_L50_G0.5900.65
16_F29_R0.5870.64
49_Y54_E0.5860.64
34_S42_N0.5820.64
37_L43_L0.5790.63
11_L26_R0.5780.63
39_L47_L0.5760.63
20_I24_R0.5760.63
27_L38_L0.5750.63
20_I38_L0.5740.63
17_I42_N0.5660.62
5_W50_G0.5550.60
9_A55_A0.5440.59
8_V15_L0.5300.57
20_I27_L0.5280.56
4_D16_F0.5260.56
16_F47_L0.5170.55
4_D9_A0.5140.54
14_V56_F0.5070.53
13_L51_L0.5060.53
27_L32_K0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rmfA 2 0.85 3.4 0.898 Contact Map
4wj4A 2 0.85 2.9 0.901 Contact Map
3a74A 4 0.9167 2.8 0.902 Contact Map
1c0aA 1 0.85 2.5 0.904 Contact Map
4up7A 2 0.9167 2.5 0.905 Contact Map
1l0wA 2 0.85 2.2 0.907 Contact Map
4pg3A 2 0.7333 2.2 0.908 Contact Map
3iykG 3 0 1.8 0.912 Contact Map
1fftA 1 0.35 1.6 0.915 Contact Map
4hw4A 2 0.2833 1.4 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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