GREMLIN Database
PSP1 - PSP1 C-terminal conserved region
PFAM: PF04468 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (85)
Sequences: 24140 (13978)
Seq/√Len: 1516.1
META: 0.939

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_I76_E2.9101.00
36_L72_D2.5281.00
21_K51_G2.2761.00
32_K35_E2.2721.00
32_K72_D2.2521.00
15_L19_R2.1821.00
29_C42_L2.0331.00
28_I32_K1.9951.00
28_I31_E1.9521.00
33_I42_L1.8951.00
29_C56_F1.8731.00
25_A47_Y1.8721.00
47_Y54_L1.7901.00
36_L68_E1.6111.00
9_E13_E1.5481.00
19_R22_E1.4931.00
48_Q55_T1.4481.00
31_E35_E1.4291.00
35_E72_D1.4231.00
26_L30_R1.4071.00
48_Q52_S1.4051.00
14_K17_E1.4011.00
13_E17_E1.3811.00
26_L42_L1.3691.00
28_I77_F1.3481.00
26_L45_V1.3381.00
21_K24_E1.3161.00
18_N51_G1.2881.00
24_E28_I1.2851.00
43_V86_I1.2781.00
13_E16_E1.2711.00
5_R11_D1.2701.00
10_E13_E1.2611.00
27_E31_E1.2361.00
17_E20_E1.2141.00
54_L79_T1.1771.00
17_E21_K1.1671.00
9_E12_L1.1341.00
10_E14_K1.1131.00
32_K76_E1.1091.00
30_R34_R1.0921.00
25_A56_F1.0881.00
14_K51_G1.0771.00
12_L15_L1.0711.00
23_K27_E1.0631.00
68_E72_D1.0421.00
7_A12_L1.0241.00
20_E24_E0.9971.00
12_L16_E0.9781.00
46_E57_Y0.9771.00
54_L77_F0.9701.00
21_K47_Y0.9631.00
27_E30_R0.9601.00
16_E20_E0.9421.00
14_K18_N0.9301.00
43_V59_T0.9251.00
33_I40_M0.9151.00
72_D75_S0.8821.00
24_E27_E0.8771.00
16_E19_R0.8641.00
22_E25_A0.8641.00
31_E34_R0.8521.00
66_F70_V0.8381.00
23_K26_L0.8351.00
70_V83_L0.8271.00
29_C73_L0.8261.00
7_A15_L0.8231.00
29_C33_I0.8201.00
68_E71_K0.8181.00
18_N49_F0.8171.00
48_Q57_Y0.8071.00
74_A82_E0.8071.00
39_P62_G0.8041.00
40_M66_F0.8021.00
47_Y79_T0.7941.00
15_L18_N0.7911.00
26_L29_C0.7661.00
40_M64_V0.7521.00
31_E76_E0.7491.00
25_A54_L0.7401.00
22_E44_D0.7261.00
17_E51_G0.7201.00
45_V54_L0.7161.00
72_D76_E0.7151.00
20_E23_K0.7121.00
33_I69_L0.7051.00
58_F83_L0.7011.00
53_K82_E0.7001.00
5_R8_T0.6941.00
34_R37_G0.6921.00
32_K36_L0.6761.00
24_E76_E0.6741.00
48_Q53_K0.6741.00
60_A63_R0.6661.00
45_V56_F0.6621.00
44_D57_Y0.6541.00
57_Y84_R0.6321.00
40_M60_A0.6291.00
25_A77_F0.6281.00
47_Y51_G0.6251.00
58_F66_F0.6081.00
66_F83_L0.6071.00
18_N47_Y0.5991.00
26_L44_D0.5751.00
18_N21_K0.5741.00
44_D47_Y0.5691.00
58_F85_Q0.5631.00
3_V6_K0.5551.00
4_L74_A0.5471.00
55_T82_E0.5461.00
29_C45_V0.5421.00
38_L69_L0.5361.00
75_S79_T0.5351.00
63_R85_Q0.5331.00
5_R49_F0.5321.00
33_I36_L0.5231.00
57_Y62_G0.5221.00
62_G74_A0.5211.00
22_E45_V0.5191.00
63_R66_F0.5161.00
11_D48_Q0.5161.00
66_F71_K0.5121.00
25_A45_V0.5081.00
39_P61_E0.5081.00
77_F81_I0.5071.00
67_R85_Q0.5061.00
40_M58_F0.5001.00
41_K59_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3af5A 1 0.7093 23.6 0.865 Contact Map
2ycbA 2 0.7326 22.5 0.867 Contact Map
2xr1A 2 0.7558 15.6 0.876 Contact Map
2dyjA 1 0.8256 13.4 0.88 Contact Map
1pa4A 1 0.7907 11.5 0.883 Contact Map
2kzfA 1 0.9186 11 0.884 Contact Map
3cfxA 1 0.4186 10 0.886 Contact Map
3cijA 1 0.407 9.8 0.887 Contact Map
1mh3A 1 0.4535 9.8 0.887 Contact Map
4qq0A 1 0.9651 9.6 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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