GREMLIN Database
DUF551 - Protein of unknown function (DUF551)
PFAM: PF04448 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (65)
Sequences: 8538 (7982)
Seq/√Len: 990.0
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_S7_D3.8391.00
3_I8_R3.1781.00
60_H68_P2.7841.00
5_V9_L2.7071.00
19_Y67_P2.4721.00
62_M65_P2.3311.00
18_V58_V2.1371.00
1_E62_M2.0851.00
65_P68_P1.9701.00
14_E63_P1.8591.00
17_L62_M1.7281.00
53_G56_D1.5701.00
8_R11_E1.5001.00
19_Y68_P1.4981.00
4_S60_H1.4841.00
31_F34_G1.4361.00
34_G37_G1.4281.00
17_L64_L1.4051.00
11_E14_E1.3471.00
19_Y60_H1.3001.00
8_R63_P1.2421.00
32_G36_Y1.2231.00
13_G16_V1.2171.00
35_V38_Y1.2071.00
48_E51_D1.1251.00
29_G33_G1.1251.00
2_W10_P1.1071.00
35_V39_Y1.0691.00
26_D29_G1.0661.00
27_Y30_D1.0221.00
19_Y59_T1.0101.00
64_L67_P1.0101.00
55_D58_V0.9571.00
33_G36_Y0.9501.00
60_H66_E0.9491.00
41_G44_G0.8981.00
12_D16_V0.8651.00
25_G30_D0.8491.00
39_Y45_W0.8431.00
32_G35_V0.8351.00
28_V31_F0.8341.00
38_Y41_G0.8131.00
22_D26_D0.8071.00
3_I7_D0.8021.00
50_G53_G0.7961.00
42_G45_W0.7901.00
25_G32_G0.7871.00
30_D33_G0.7761.00
22_D25_G0.7691.00
28_V32_G0.7651.00
17_L65_P0.7631.00
52_G55_D0.7531.00
5_V58_V0.7371.00
1_E4_S0.7351.00
50_G54_E0.7291.00
47_D50_G0.7281.00
33_G40_F0.7161.00
1_E5_V0.7161.00
31_F35_V0.7051.00
22_D27_Y0.7041.00
36_Y39_Y0.6871.00
3_I63_P0.6731.00
51_D55_D0.6681.00
29_G32_G0.6661.00
15_D51_D0.6661.00
37_G40_F0.6551.00
24_G28_V0.6481.00
38_Y43_G0.6401.00
26_D30_D0.6371.00
33_G37_G0.6301.00
59_T68_P0.6251.00
30_D35_V0.6251.00
29_G34_G0.6191.00
2_W61_W0.6061.00
30_D34_G0.6031.00
63_P66_E0.6011.00
23_G30_D0.5911.00
23_G26_D0.5881.00
5_V8_R0.5811.00
24_G27_Y0.5791.00
24_G29_G0.5721.00
39_Y42_G0.5711.00
15_D47_D0.5641.00
51_D54_E0.5601.00
5_V60_H0.5481.00
25_G28_V0.5431.00
53_G57_E0.5411.00
33_G38_Y0.5361.00
10_P13_G0.5281.00
49_G55_D0.5271.00
36_Y40_F0.5141.00
34_G38_Y0.5111.00
31_F36_Y0.5101.00
32_G37_G0.5091.00
37_G45_W0.5091.00
23_G29_G0.5081.00
49_G52_G0.5071.00
51_D56_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qxpA 1 1 6.9 0.85 Contact Map
3bowA 1 1 6.6 0.851 Contact Map
2r9fA 1 1 6.4 0.852 Contact Map
2nqaA 3 1 5.8 0.855 Contact Map
1zivA 1 1 3.3 0.872 Contact Map
4qbbA 1 0.3623 2.1 0.885 Contact Map
4upuB 1 0.2754 1.7 0.89 Contact Map
1t6sA 4 0.4348 1.5 0.894 Contact Map
1u2eA 2 0.8841 1.3 0.897 Contact Map
4bl9A 1 0.8986 1.2 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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