GREMLIN Database
DUF501 - Protein of unknown function (DUF501)
PFAM: PF04417 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (126)
Sequences: 4899 (2310)
Seq/√Len: 205.8
META: 0.868

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_V122_V3.8051.00
3_V11_A3.5691.00
58_R137_E2.8071.00
122_V139_L2.7881.00
32_Y79_E2.4851.00
14_E79_E2.3691.00
57_A61_A2.3391.00
122_V138_V2.3191.00
75_R79_E2.2711.00
36_C39_L2.2261.00
5_C36_C2.0901.00
59_L69_Y2.0411.00
70_A74_E2.0271.00
13_V35_T2.0061.00
51_G54_E1.9741.00
55_M137_E1.9081.00
124_H132_N1.7191.00
68_A136_D1.6861.00
31_L83_L1.6471.00
31_L79_E1.6421.00
58_R65_L1.6221.00
40_V44_S1.6181.00
74_E78_A1.5871.00
18_R84_A1.5761.00
125_A136_D1.5701.00
34_L39_L1.5691.00
5_C9_L1.5681.00
122_V125_A1.5581.00
14_E31_L1.5251.00
75_R124_H1.5241.00
9_L36_C1.4901.00
75_R128_G1.4841.00
125_A139_L1.4831.00
41_A45_R1.4631.00
2_A14_E1.4391.00
11_A36_C1.4301.00
124_H128_G1.3991.00
71_A74_E1.3951.00
55_M134_V1.3291.00
41_A44_S1.3231.00
2_A127_A1.3041.00
65_L134_V1.2941.00
85_P88_G1.2851.00
54_E58_R1.2501.00
42_A45_R1.2461.00
128_G131_V1.2421.00
11_A39_L1.2021.00
39_L122_V1.2011.00
124_H130_G1.1981.00
88_G91_P1.1951.00
38_R42_A1.1811.00
71_A75_R1.1791.00
107_G120_A1.1791.00
58_R62_D1.1771.00
69_Y73_H1.1761.00
74_E77_L1.1651.00
66_A70_A1.1601.00
131_V136_D1.1561.00
34_L43_V1.1551.00
72_A133_P1.1471.00
34_L123_A1.1421.00
68_A71_A1.1131.00
79_E82_A1.1001.00
46_L138_V1.0631.00
22_L26_T1.0451.00
78_A82_A1.0271.00
76_Y124_H1.0041.00
43_V138_V0.9721.00
37_P40_V0.9691.00
79_E128_G0.9631.00
73_H109_M0.9611.00
73_H106_A0.9580.99
60_A113_D0.9430.99
73_H114_R0.9320.99
70_A113_D0.9210.99
134_V137_E0.9170.99
121_H134_V0.9140.99
55_M58_R0.9120.99
64_E67_A0.9100.99
7_C38_R0.9030.99
75_R131_V0.8880.99
63_P67_A0.8730.99
65_L137_E0.8670.99
45_R49_A0.8590.99
68_A133_P0.8550.99
46_L51_G0.8350.99
18_R100_E0.8340.99
38_R41_A0.8160.98
14_E83_L0.8140.98
81_D102_P0.8020.98
29_P44_S0.7970.98
92_V101_I0.7890.98
40_V43_V0.7880.98
3_V12_V0.7880.98
69_Y121_H0.7870.98
109_M120_A0.7820.98
92_V102_P0.7800.98
54_E57_A0.7780.98
125_A128_G0.7630.97
15_T33_Y0.7620.97
22_L25_G0.7520.97
88_G92_V0.7500.97
69_Y115_V0.7480.97
69_Y132_N0.7460.97
87_A91_P0.7420.97
6_P11_A0.7360.97
58_R61_A0.7270.97
5_C38_R0.7270.97
53_R56_E0.7210.96
13_V124_H0.6950.96
73_H105_G0.6950.96
77_L114_R0.6940.96
57_A67_A0.6930.96
67_A70_A0.6910.95
7_C36_C0.6790.95
62_D66_A0.6790.95
55_M115_V0.6780.95
99_P102_P0.6700.95
11_A38_R0.6660.94
114_R121_H0.6650.94
63_P66_A0.6650.94
120_A134_V0.6570.94
51_G55_M0.6550.94
56_E109_M0.6520.94
53_R57_A0.6510.94
16_A88_G0.6420.93
91_P99_P0.6380.93
106_A109_M0.6380.93
76_Y79_E0.6360.93
127_A130_G0.6340.93
6_P38_R0.6290.93
33_Y40_V0.6250.92
33_Y122_V0.6240.92
100_E104_G0.6200.92
75_R78_A0.6190.92
57_A60_A0.6180.92
71_A78_A0.6100.91
15_T76_Y0.6080.91
86_A92_V0.6020.91
62_D68_A0.6020.91
13_V33_Y0.5910.90
85_P91_P0.5810.89
48_A56_E0.5800.89
115_V133_P0.5800.89
55_M65_L0.5790.89
12_V127_A0.5720.89
106_A110_P0.5710.89
49_A54_E0.5710.89
14_E122_V0.5630.88
77_L105_G0.5630.88
36_C43_V0.5630.88
81_D84_A0.5620.88
67_A71_A0.5610.88
3_V6_P0.5550.87
28_F35_T0.5540.87
44_S48_A0.5510.87
61_A64_E0.5500.87
16_A23_P0.5500.87
101_I104_G0.5500.87
136_D139_L0.5490.87
52_M121_H0.5470.86
28_F92_V0.5460.86
16_A83_L0.5460.86
52_M109_M0.5420.86
39_L126_L0.5410.86
43_V50_G0.5400.86
31_L76_Y0.5400.86
132_N135_G0.5400.86
110_P114_R0.5400.86
59_L66_A0.5390.86
32_Y76_Y0.5350.85
25_G91_P0.5300.85
69_Y133_P0.5290.85
69_Y72_A0.5250.84
53_R113_D0.5250.84
72_A124_H0.5240.84
5_C39_L0.5190.83
34_L48_A0.5180.83
109_M121_H0.5180.83
56_E60_A0.5170.83
32_Y124_H0.5140.83
121_H125_A0.5140.83
133_P138_V0.5130.83
86_A89_G0.5110.83
130_G133_P0.5090.82
106_A120_A0.5080.82
13_V22_L0.5070.82
87_A90_G0.5050.82
69_Y109_M0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m0wA 2 0.9643 14 0.942 Contact Map
2bh9A 2 0.8286 12.3 0.943 Contact Map
4lgvA 4 0.7857 11.1 0.944 Contact Map
1xmaA 2 0.55 10.7 0.945 Contact Map
3ruiA 2 0.4357 10.7 0.945 Contact Map
2wyoA 2 0.9429 9.1 0.947 Contact Map
1hsjA 2 0.6357 8.8 0.947 Contact Map
3elkA 3 0.6286 8.7 0.947 Contact Map
2b3wA 1 0.8286 8.6 0.947 Contact Map
1uz3A 2 0.6571 8.4 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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