GREMLIN Database
ERF - ERF superfamily
PFAM: PF04404 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 151 (134)
Sequences: 21815 (17330)
Seq/√Len: 1497.1
META: 0.958

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_G30_S3.2531.00
11_E44_K3.2501.00
7_K45_H3.1171.00
11_E45_H2.8661.00
97_G106_Y2.8411.00
20_K27_K2.6581.00
97_G102_Y2.3851.00
18_D33_D2.3761.00
42_L112_F2.2941.00
34_I109_L2.2921.00
8_A12_L2.2461.00
18_D30_S2.0871.00
10_A43_A1.9681.00
49_L108_L1.9511.00
9_Q39_R1.9491.00
109_L116_T1.8521.00
30_S33_D1.8211.00
19_G33_D1.8151.00
11_E41_L1.7921.00
20_K25_K1.7611.00
8_A41_L1.7471.00
40_P44_K1.7221.00
4_A72_H1.6771.00
21_N24_F1.6731.00
35_L39_R1.5341.00
52_S69_T1.5291.00
7_K11_E1.4991.00
8_A47_L1.4961.00
7_K10_A1.4891.00
104_R110_A1.4581.00
104_R113_G1.4541.00
38_V108_L1.4511.00
41_L44_K1.4391.00
22_P25_K1.4351.00
69_T79_E1.4311.00
51_Q107_A1.3841.00
38_V112_F1.3681.00
6_A48_S1.3451.00
72_H75_G1.3291.00
46_G73_S1.3231.00
92_A95_A1.3201.00
100_I110_A1.2961.00
65_K84_G1.2811.00
88_D91_D1.2681.00
53_T100_I1.2601.00
52_S67_T1.2581.00
14_K36_E1.2461.00
8_A45_H1.2381.00
125_N128_S1.2361.00
67_T79_E1.2031.00
50_T71_I1.1841.00
41_L45_H1.1751.00
91_D95_A1.1431.00
88_D92_A1.1351.00
6_A10_A1.1311.00
35_L49_L1.0841.00
69_T78_I1.0711.00
17_K32_E1.0651.00
99_A103_A1.0631.00
20_K23_F1.0601.00
51_Q68_T1.0501.00
35_L115_A1.0461.00
35_L108_L1.0391.00
60_D63_Y1.0381.00
31_L104_R1.0331.00
33_D37_A1.0311.00
2_A71_I1.0171.00
15_I29_A1.0061.00
57_G60_D0.9971.00
29_A116_T0.9751.00
14_K117_E0.9691.00
122_D126_A0.9661.00
8_A112_F0.9601.00
120_D123_D0.9541.00
6_A43_A0.9541.00
95_A98_S0.9491.00
68_T107_A0.9461.00
3_K73_S0.9141.00
3_K7_K0.9141.00
93_P103_A0.9101.00
69_T77_E0.8931.00
49_L113_G0.8921.00
23_F26_Y0.8901.00
42_L49_L0.8871.00
88_D95_A0.8811.00
33_D36_E0.8771.00
65_K82_T0.8761.00
48_S71_I0.8701.00
39_R43_A0.8671.00
89_K95_A0.8621.00
22_P26_Y0.8601.00
52_S80_S0.8421.00
122_D127_A0.8371.00
4_A47_L0.8321.00
86_P90_K0.8121.00
46_G74_S0.8091.00
52_S111_L0.8071.00
70_L73_S0.8061.00
79_E82_T0.8041.00
104_R109_L0.8021.00
59_G63_Y0.7991.00
8_A42_L0.7971.00
69_T80_S0.7891.00
21_N25_K0.7811.00
13_P40_P0.7811.00
122_D125_N0.7801.00
87_A90_K0.7771.00
82_T85_A0.7771.00
96_T100_I0.7671.00
32_E115_A0.7651.00
9_Q43_A0.7641.00
38_V41_L0.7581.00
38_V114_I0.7561.00
6_A73_S0.7521.00
118_D123_D0.7451.00
49_L112_F0.7441.00
15_I37_A0.7421.00
90_K95_A0.7401.00
93_P99_A0.7291.00
16_K33_D0.7271.00
3_K46_G0.7251.00
34_I114_I0.7231.00
14_K115_A0.7201.00
29_A34_I0.7181.00
70_L74_S0.7161.00
73_S76_G0.7141.00
5_L48_S0.7121.00
85_A89_K0.7101.00
57_G62_G0.7061.00
85_A103_A0.7011.00
81_S84_G0.6991.00
4_A46_G0.6961.00
17_K116_T0.6931.00
89_K92_A0.6881.00
123_D126_A0.6871.00
63_Y84_G0.6841.00
100_I104_R0.6801.00
58_V65_K0.6801.00
52_S79_E0.6751.00
10_A44_K0.6711.00
120_D124_G0.6701.00
37_A40_P0.6671.00
9_Q113_G0.6591.00
86_P91_D0.6591.00
47_L70_L0.6551.00
2_A48_S0.6511.00
20_K24_F0.6501.00
67_T82_T0.6461.00
126_A129_G0.6411.00
87_A91_D0.6371.00
107_A111_L0.6341.00
124_G127_A0.6331.00
95_A99_A0.6311.00
16_K117_E0.6231.00
7_K46_G0.6221.00
86_P89_K0.6181.00
100_I106_Y0.6081.00
132_K136_P0.6061.00
31_L35_L0.6051.00
109_L114_I0.5941.00
39_R49_L0.5921.00
134_A137_K0.5901.00
21_N26_Y0.5901.00
13_P37_A0.5851.00
12_L41_L0.5831.00
119_D122_D0.5831.00
108_L113_G0.5801.00
56_G60_D0.5791.00
83_A86_P0.5771.00
29_A109_L0.5741.00
15_I33_D0.5671.00
128_S131_P0.5641.00
35_L113_G0.5581.00
119_D123_D0.5571.00
59_G62_G0.5561.00
38_V42_L0.5501.00
19_G28_Y0.5481.00
96_T103_A0.5461.00
127_A130_K0.5441.00
35_L38_V0.5441.00
65_K81_S0.5421.00
53_T110_A0.5371.00
93_P98_S0.5341.00
4_A74_S0.5341.00
9_Q48_S0.5341.00
52_S81_S0.5281.00
53_T66_V0.5241.00
72_H76_G0.5241.00
66_V103_A0.5221.00
85_A90_K0.5221.00
5_L47_L0.5171.00
51_Q104_R0.5161.00
29_A33_D0.5151.00
50_T79_E0.5151.00
31_L108_L0.5141.00
3_K74_S0.5131.00
124_G128_S0.5121.00
84_G87_A0.5071.00
69_T73_S0.5021.00
62_G66_V0.5011.00
133_K136_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nlyA 1 0.8477 9.8 0.912 Contact Map
3epzA 1 0.6225 5 0.923 Contact Map
1vw4E 1 0.543 4.6 0.925 Contact Map
4kqtA 1 0.5629 4.5 0.925 Contact Map
3gnlA 1 0.298 3.8 0.928 Contact Map
4g0dW 1 0.1258 3.7 0.928 Contact Map
3crvA 1 0.3377 3.5 0.929 Contact Map
1r7aA 2 0.543 3.4 0.929 Contact Map
3hdqA 4 0.3046 3.3 0.93 Contact Map
2azeB 1 0.5364 2.9 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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