GREMLIN Database
PTPLA - Protein tyrosine phosphatase-like protein, PTPLA
PFAM: PF04387 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (161)
Sequences: 1111 (825)
Seq/√Len: 65.0
META: 0.291

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_I155_L4.7201.00
85_L89_L4.3431.00
98_I147_F4.2771.00
2_T35_W4.0061.00
57_A96_L3.9781.00
124_N127_N3.4741.00
53_L100_S3.3041.00
61_T89_L3.2391.00
88_T162_L2.9901.00
64_I89_L2.7921.00
102_L140_L2.6631.00
148_P152_T2.5091.00
9_L13_L2.4231.00
5_V31_L2.2921.00
6_L10_H2.1381.00
50_G103_L2.0741.00
116_G121_S2.0591.00
123_P127_N2.0571.00
11_A20_V1.9861.00
33_V54_L1.9151.00
38_L54_L1.9071.00
151_Y155_L1.7631.00
19_P153_H1.7621.00
152_T155_L1.7431.00
8_V28_A1.7070.99
4_A7_E1.6400.99
68_F83_T1.6130.99
122_L127_N1.5630.99
153_H157_Q1.5580.99
141_L144_I1.5550.99
124_N130_F1.5520.99
88_T91_I1.5490.99
26_Q94_Y1.4990.99
127_N130_F1.4850.98
109_L137_I1.4820.98
61_T64_I1.4430.98
105_I136_L1.4280.98
8_V24_L1.4060.98
54_L100_S1.4000.98
36_G132_Y1.3750.97
29_S98_I1.3360.97
5_V8_V1.3320.97
84_W88_T1.3130.97
83_T162_L1.3050.96
98_I150_L1.2950.96
56_L59_S1.2800.96
137_I141_L1.2770.96
24_L28_A1.2710.96
132_Y136_L1.2630.96
19_P22_T1.2450.95
11_A19_P1.2390.95
140_L144_I1.2130.95
86_R97_G1.1950.94
14_G17_R1.1940.94
50_G100_S1.1940.94
21_L25_M1.1780.94
12_L20_V1.1600.93
90_F151_Y1.1570.93
133_Y137_I1.1420.93
18_S69_Y1.1140.92
47_S50_G1.1020.91
11_A23_T1.0690.90
69_Y73_L1.0580.90
80_Y88_T1.0480.89
25_M150_L1.0460.89
135_F139_L1.0420.89
75_L78_V1.0360.89
141_L145_P1.0140.88
98_I143_Y1.0060.87
134_Y138_A1.0040.87
5_V24_L0.9770.85
103_L107_A0.9610.85
150_L154_M0.9490.84
124_N128_F0.9360.83
152_T156_K0.9280.82
69_Y87_Y0.9270.82
144_I148_P0.9190.82
87_Y97_G0.9170.82
53_L96_L0.9130.81
51_V55_L0.9070.81
62_E67_S0.9060.81
69_Y72_N0.9020.81
71_L75_L0.8950.80
100_S104_L0.8800.79
32_F136_L0.8670.78
60_I63_V0.8670.78
63_V70_A0.8590.77
123_P130_F0.8560.77
62_E97_G0.8530.77
29_S99_S0.8520.77
38_L104_L0.8390.76
116_G119_S0.8380.75
156_K159_K0.8350.75
88_T163_G0.8340.75
95_P101_E0.8330.75
37_I136_L0.8270.75
7_E10_H0.8190.74
109_L140_L0.8170.74
90_F94_Y0.8150.73
153_H156_K0.8080.73
32_F135_F0.8030.72
18_S23_T0.8010.72
116_G131_S0.8010.72
81_W162_L0.7920.71
44_V47_S0.7830.70
50_G53_L0.7730.69
68_F72_N0.7700.69
147_F151_Y0.7700.69
113_K133_Y0.7670.69
10_H84_W0.7650.69
29_S143_Y0.7630.68
120_I124_N0.7620.68
23_T29_S0.7610.68
102_L106_Y0.7590.68
123_P126_W0.7520.67
41_F112_A0.7500.67
123_P131_S0.7490.67
71_L78_V0.7480.67
4_A16_V0.7480.67
20_V24_L0.7480.67
59_S63_V0.7430.66
35_W39_Y0.7420.66
159_K163_G0.7410.66
154_M158_R0.7410.66
108_A112_A0.7380.66
63_V67_S0.7320.65
5_V12_L0.7310.65
77_K82_L0.7270.65
57_A93_L0.7270.65
79_P82_L0.7240.64
144_I147_F0.7240.64
8_V11_A0.7210.64
139_L144_I0.7200.64
97_G101_E0.7160.64
57_A100_S0.7150.63
112_A132_Y0.7140.63
124_N131_S0.7110.63
109_L133_Y0.7100.63
61_T155_L0.7100.63
86_R101_E0.7020.62
69_Y97_G0.6950.61
88_T151_Y0.6950.61
140_L143_Y0.6890.61
123_P129_S0.6860.60
64_I85_L0.6840.60
99_S103_L0.6820.60
102_L144_I0.6790.59
90_F95_P0.6750.59
28_A31_L0.6700.58
68_F161_V0.6690.58
83_T161_V0.6690.58
12_L45_Q0.6680.58
93_L154_M0.6670.58
34_V61_T0.6670.58
58_W101_E0.6630.58
67_S81_W0.6610.57
29_S62_E0.6590.57
52_F55_L0.6540.57
71_L77_K0.6540.57
60_I99_S0.6520.56
147_F150_L0.6510.56
1_Q7_E0.6480.56
26_Q29_S0.6390.55
41_F104_L0.6390.55
116_G122_L0.6380.55
71_L134_Y0.6360.54
90_F143_Y0.6340.54
13_L20_V0.6330.54
9_L77_K0.6320.54
37_I105_I0.6280.54
1_Q4_A0.6270.53
100_S103_L0.6260.53
66_Y69_Y0.6230.53
123_P128_F0.6220.53
120_I126_W0.6200.53
111_Y114_E0.6200.53
156_K160_K0.6150.52
16_V27_V0.6120.52
15_L24_L0.6110.52
134_Y137_I0.6100.51
100_S145_P0.6080.51
16_V62_E0.6060.51
29_S154_M0.6060.51
18_S30_R0.6040.51
57_A61_T0.6010.50
119_S125_K0.5990.50
87_Y101_E0.5930.49
116_G137_I0.5870.49
8_V20_V0.5860.49
98_I102_L0.5840.48
34_V51_V0.5840.48
35_W41_F0.5780.48
29_S61_T0.5780.48
38_L51_V0.5760.47
93_L97_G0.5750.47
76_G135_F0.5750.47
67_S72_N0.5720.47
103_L135_F0.5710.47
120_I125_K0.5670.46
113_K137_I0.5630.46
64_I150_L0.5620.46
17_R46_S0.5610.46
9_L129_S0.5600.46
41_F117_L0.5580.45
140_L148_P0.5560.45
37_I41_F0.5560.45
72_N99_S0.5560.45
89_L92_V0.5550.45
50_G104_L0.5530.45
112_A136_L0.5530.45
19_P23_T0.5470.44
26_Q90_F0.5460.44
10_H15_L0.5460.44
112_A133_Y0.5410.43
2_T39_Y0.5380.43
139_L143_Y0.5380.43
85_L98_I0.5340.43
157_Q162_L0.5330.43
1_Q26_Q0.5320.42
120_I123_P0.5310.42
56_L60_I0.5310.42
47_S70_A0.5300.42
114_E117_L0.5290.42
4_A23_T0.5290.42
127_N131_S0.5280.42
79_P90_F0.5270.42
115_T118_Y0.5270.42
1_Q58_W0.5240.41
79_P83_T0.5220.41
91_I151_Y0.5190.41
110_P113_K0.5130.40
9_L21_L0.5130.40
87_Y90_F0.5090.40
73_L145_P0.5080.40
117_L146_G0.5070.40
34_V161_V0.5060.39
33_V105_I0.5060.39
90_F155_L0.5050.39
55_L161_V0.5050.39
131_S134_Y0.5040.39
139_L142_L0.5030.39
149_V152_T0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tz1B 1 0.0732 6.1 0.953 Contact Map
4b19A 1 0.1829 3.3 0.959 Contact Map
2rddB 1 0.2012 2 0.963 Contact Map
2kpaA 1 0.1159 1.9 0.964 Contact Map
2maeA 1 0.061 1.9 0.964 Contact Map
2mw3A 1 0.128 1.5 0.966 Contact Map
1jb0I 1 0.2317 1.3 0.967 Contact Map
4r1dB 1 0.3537 1.2 0.967 Contact Map
2ja2A 1 0.2561 1.1 0.968 Contact Map
4he8A 1 0.1829 1.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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