GREMLIN Database
FAINT - Domain of unknown function, DUF529
PFAM: PF04385 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 78 (72)
Sequences: 1539 (1409)
Seq/√Len: 166.1
META: 0.001

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_V47_K3.0051.00
54_C57_V2.7131.00
29_P35_F2.6381.00
37_K47_K2.4581.00
12_F15_Y2.2751.00
37_K44_V2.2201.00
55_S58_V2.0451.00
8_D11_D1.9501.00
71_L74_T1.6371.00
9_S13_F1.6251.00
48_A54_C1.5381.00
68_F74_T1.4991.00
69_L74_T1.4891.00
56_L59_V1.4841.00
68_F73_L1.3861.00
57_V60_Y1.3811.00
9_S14_V1.3711.00
63_D66_K1.3491.00
8_D13_F1.3331.00
68_F72_L1.3311.00
35_F55_S1.2541.00
20_D24_V1.2471.00
54_C61_Y1.2391.00
13_F16_E1.2351.00
39_V44_V1.2191.00
8_D14_V1.2121.00
39_V45_I1.1841.00
50_D53_E1.1681.00
7_P12_F1.1611.00
8_D12_F1.1571.00
8_D16_E1.1561.00
7_P13_F1.1381.00
59_V62_K1.1361.00
25_K28_T1.1081.00
7_P10_S1.1041.00
5_S40_D1.0901.00
9_S16_E1.0851.00
46_W59_V1.0520.99
3_D6_K1.0450.99
29_P34_K1.0390.99
48_A51_D1.0040.99
57_V61_Y0.9970.99
52_E55_S0.9830.99
70_V73_L0.9820.99
10_S15_Y0.9500.99
54_C59_V0.9480.99
60_Y66_K0.9260.99
57_V63_D0.9240.99
39_V43_K0.9000.98
10_S14_V0.8970.98
69_L72_L0.8970.98
52_E65_K0.8670.98
23_N27_Y0.8650.98
9_S12_F0.8380.97
58_V61_Y0.8230.97
40_D45_I0.8200.97
61_Y66_K0.8070.96
13_F30_K0.7920.96
17_Y24_V0.7910.96
24_V45_I0.7900.96
8_D15_Y0.7620.95
6_K12_F0.7610.95
6_K10_S0.7560.95
27_Y38_V0.7460.95
69_L73_L0.7450.95
47_K52_E0.7440.95
64_G70_V0.7410.94
52_E57_V0.7390.94
36_T48_A0.7350.94
45_I74_T0.7350.94
11_D16_E0.7210.94
29_P48_A0.7160.93
24_V42_D0.7150.93
11_D15_Y0.7080.93
23_N68_F0.6960.92
25_K40_D0.6890.92
59_V63_D0.6840.92
21_G25_K0.6810.91
7_P11_D0.6790.91
27_Y59_V0.6760.91
23_N26_T0.6710.91
24_V65_K0.6610.90
35_F40_D0.6500.89
10_S13_F0.6400.89
55_S60_Y0.6240.88
11_D14_V0.6190.87
29_P33_Y0.6180.87
40_D43_K0.6120.87
49_K56_L0.6100.86
16_E23_N0.5930.85
51_D55_S0.5910.85
43_K72_L0.5900.84
54_C58_V0.5790.83
19_S22_V0.5780.83
2_L74_T0.5700.82
31_D44_V0.5620.82
48_A52_E0.5600.81
29_P38_V0.5500.80
31_D36_T0.5370.79
17_Y28_T0.5340.78
8_D32_G0.5240.77
43_K50_D0.5190.76
44_V51_D0.5160.76
20_D23_N0.5060.74
13_F22_V0.5030.74
27_Y44_V0.5010.74
51_D54_C0.5000.74
62_K66_K0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ic8A 3 0.4872 2.9 0.843 Contact Map
1gqpA 2 0.9487 2.8 0.844 Contact Map
3izxB 7 0.9359 1.9 0.857 Contact Map
1h7zA 3 0.4615 1.6 0.863 Contact Map
4lo0C 1 0.6923 1.1 0.876 Contact Map
3v42A 2 0.8462 1.1 0.877 Contact Map
1k7hA 2 0.5 1.1 0.877 Contact Map
1kqrA 1 0.9744 1 0.878 Contact Map
2hzdA 1 0.5256 1 0.878 Contact Map
2nykA 1 0.8205 0.9 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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