GREMLIN Database
BMFP - Membrane fusogenic activity
PFAM: PF04380 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (76)
Sequences: 11357 (5406)
Seq/√Len: 620.1
META: 0.918

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_K69_E2.6681.00
71_R76_E2.6511.00
56_A59_A2.4151.00
58_L61_A2.3371.00
46_V51_F2.0971.00
25_R29_E2.0681.00
55_K59_A1.7451.00
54_Q58_L1.7441.00
61_A65_L1.7401.00
69_E73_A1.7401.00
62_R66_E1.6451.00
59_A63_E1.6121.00
12_K16_D1.5751.00
9_D13_L1.5741.00
57_V61_A1.5401.00
28_L32_F1.5271.00
57_V62_R1.5271.00
70_A74_A1.5251.00
60_R63_E1.4531.00
72_L75_L1.4471.00
52_D55_K1.4421.00
37_E41_A1.4321.00
64_K67_A1.3961.00
73_A77_A1.3841.00
31_N34_A1.3731.00
40_L45_L1.3241.00
5_K8_D1.3041.00
48_R52_D1.2951.00
5_K9_D1.2891.00
19_G22_P1.2761.00
39_A43_L1.2681.00
63_E67_A1.2611.00
14_L32_F1.2511.00
71_R74_A1.2291.00
33_R37_E1.2211.00
51_F54_Q1.1831.00
2_T5_K1.1441.00
51_F55_K1.1441.00
70_A73_A1.1081.00
67_A70_A1.0931.00
36_L40_L1.0881.00
13_L16_D1.0581.00
27_E31_N1.0531.00
68_L72_L1.0081.00
6_F11_A0.9981.00
8_D12_K0.9931.00
54_Q57_V0.9791.00
35_Q39_A0.9711.00
39_A42_K0.9501.00
35_Q38_R0.9251.00
56_A60_R0.9141.00
67_A71_R0.8971.00
65_L69_E0.8951.00
74_A77_A0.8571.00
16_D20_A0.8151.00
4_N8_D0.8051.00
44_D48_R0.8021.00
65_L72_L0.8021.00
38_R42_K0.8011.00
33_R44_D0.7971.00
57_V60_R0.7921.00
11_A15_T0.7781.00
26_R30_K0.7691.00
58_L65_L0.7541.00
16_D19_G0.7541.00
7_L11_A0.7521.00
57_V65_L0.7501.00
26_R29_E0.7411.00
32_F35_Q0.7291.00
73_A76_E0.7221.00
14_L18_L0.7211.00
2_T6_F0.7031.00
61_A64_K0.6991.00
34_A37_E0.6871.00
19_G23_G0.6841.00
53_A57_V0.6771.00
41_A47_T0.6711.00
66_E70_A0.6651.00
65_L68_L0.6471.00
2_T11_A0.6391.00
4_N7_L0.6331.00
20_A23_G0.6311.00
31_N35_Q0.6281.00
6_F9_D0.6091.00
9_D12_K0.6071.00
60_R65_L0.6061.00
28_L31_N0.6041.00
21_A24_L0.6011.00
53_A56_A0.5981.00
17_A24_L0.5981.00
29_E33_R0.5971.00
43_L47_T0.5941.00
58_L62_R0.5921.00
54_Q65_L0.5851.00
32_F39_A0.5851.00
40_L43_L0.5761.00
23_G26_R0.5681.00
36_L43_L0.5661.00
26_R31_N0.5541.00
4_N12_K0.5541.00
63_E66_E0.5511.00
12_K17_A0.5450.99
27_E30_K0.5440.99
60_R67_A0.5280.99
19_G26_R0.5280.99
66_E69_E0.5270.99
9_D16_D0.5210.99
32_F36_L0.5190.99
53_A58_L0.5190.99
67_A74_A0.5160.99
20_A24_L0.5120.99
36_L39_A0.5100.99
10_L39_A0.5060.99
37_E44_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1go4E 4 0.5195 78.1 0.748 Contact Map
1dipA 2 0.4545 37.2 0.807 Contact Map
3ghgA 2 0.9481 35.6 0.809 Contact Map
3qprA 8 0.013 34.7 0.81 Contact Map
3hrnA 3 0.4286 33.4 0.812 Contact Map
2w83C 2 0.6234 31.3 0.815 Contact Map
3vkgA 2 0.8312 30.6 0.816 Contact Map
2yy0A 6 0.6104 29.6 0.817 Contact Map
3c9iA 5 0.974 27.4 0.82 Contact Map
3ljmA 3 0.3636 25.7 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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