HemX - PFAM28P - GREMLIN Contacts

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HemX - HemX

PFAM:	PF04375	Sequences: DEPAKPATPAPPAAPAPPKAKRSGLGLALLALLLALAALAAGYWQGWQQRQQLQAELQRLAQQLAALEQQLAAARQAQELARELQAKLALLEARLAELQSQQAQLEALYQSLSRLSGRSRDDWLLAEAEYLLRLANQQLQLAGDVEAALAALQAADARLARLDDPRLLPVRRAIARDIAALKAVPVVDVAGLALRLDALIAQVDSLPLANAARPAAPAAAAAAAASASASDWWQRLARSVWSELRSLVRVRRIDQPEAPLLAPEQAFFLRENLKLRLLNARLALLRRDQALYRADLAAAQAWLERYFDTDSPAVQAALAELKQLAAQPIAPELPDISESLAALRALLARRERRLLAQPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	359 (337)
Sequences:	4742 (3737)
Seq/√Len:	203.6
META:	0.764

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
43_Y	47_W	5.071	1.00
149_L	178_I	4.479	1.00
199_L	317_A	3.433	1.00
296_L	321_L	3.194	1.00
156_D	171_R	3.087	1.00
63_Q	68_E	3.074	1.00
300_Q	318_L	3.063	1.00
46_G	50_R	2.973	1.00
153_Q	182_K	2.960	1.00
42_G	45_Q	2.689	1.00
289_Q	293_R	2.556	1.00
43_Y	46_G	2.480	1.00
42_G	46_G	2.459	1.00
304_E	318_L	2.451	1.00
59_R	64_L	2.357	1.00
129_E	344_R	2.294	1.00
288_D	291_L	2.266	1.00
37_A	41_A	2.220	1.00
54_Q	57_L	2.170	1.00
300_Q	322_K	2.163	1.00
138_Q	144_D	2.160	1.00
188_D	191_G	2.098	1.00
300_Q	325_A	2.096	1.00
59_R	63_Q	2.081	1.00
41_A	45_Q	2.049	1.00
35_A	38_A	2.047	1.00
44_W	47_W	2.037	1.00
303_L	318_L	2.013	1.00
104_Q	109_Y	2.002	1.00
176_R	338_E	1.997	1.00
177_D	339_S	1.985	1.00
59_R	62_Q	1.977	1.00
204_D	274_K	1.966	1.00
32_L	35_A	1.962	1.00
64_L	71_L	1.944	1.00
271_E	274_K	1.941	1.00
64_L	68_E	1.925	1.00
45_Q	49_Q	1.920	1.00
311_S	314_V	1.913	1.00
195_R	320_E	1.904	1.00
58_Q	62_Q	1.898	1.00
233_W	237_A	1.896	1.00
68_E	72_A	1.876	1.00
303_L	317_A	1.873	1.00
292_Y	324_L	1.867	1.00
240_V	243_E	1.854	1.00
46_G	49_Q	1.828	1.00
297_A	325_A	1.813	1.00
268_F	272_N	1.775	1.00
64_L	67_L	1.751	1.00
237_A	241_W	1.745	1.00
45_Q	50_R	1.679	1.00
266_A	270_R	1.674	1.00
31_A	35_A	1.670	1.00
45_Q	48_Q	1.669	1.00
168_L	194_L	1.669	1.00
124_L	128_A	1.666	1.00
101_Q	105_L	1.648	1.00
53_L	56_E	1.639	1.00
272_N	302_W	1.628	1.00
138_Q	142_A	1.604	1.00
59_R	71_L	1.601	1.00
60_L	67_L	1.590	1.00
47_W	50_R	1.585	1.00
192_L	327_Q	1.584	1.00
28_A	32_L	1.582	1.00
53_L	57_L	1.556	1.00
249_R	252_R	1.532	1.00
51_Q	54_Q	1.517	1.00
58_Q	61_A	1.510	1.00
28_A	35_A	1.502	1.00
299_A	321_L	1.501	1.00
259_P	302_W	1.495	1.00
68_E	71_L	1.466	1.00
241_W	245_R	1.464	1.00
156_D	175_A	1.463	1.00
63_Q	67_L	1.459	1.00
320_E	323_Q	1.452	1.00
61_A	65_A	1.442	1.00
300_Q	304_E	1.439	1.00
63_Q	71_L	1.434	1.00
62_Q	66_A	1.420	1.00
63_Q	66_A	1.419	1.00
193_A	281_R	1.418	1.00
65_A	68_E	1.407	1.00
44_W	48_Q	1.403	1.00
70_Q	73_A	1.402	1.00
322_K	325_A	1.400	1.00
43_Y	50_R	1.398	1.00
101_Q	104_Q	1.394	1.00
173_A	177_D	1.393	1.00
149_L	182_K	1.382	1.00
56_E	59_R	1.381	1.00
80_L	84_L	1.380	1.00
25_L	29_L	1.368	1.00
38_A	41_A	1.365	1.00
94_R	97_E	1.354	1.00
44_W	49_Q	1.354	1.00
63_Q	69_Q	1.353	1.00
60_L	68_E	1.347	1.00
232_W	235_R	1.339	1.00
191_G	194_L	1.334	1.00
152_L	336_I	1.323	1.00
174_I	178_I	1.321	1.00
277_L	299_A	1.316	1.00
327_Q	331_P	1.311	1.00
173_A	342_A	1.303	1.00
83_E	87_K	1.299	1.00
269_L	272_N	1.297	1.00
263_P	272_N	1.294	1.00
129_E	340_L	1.293	1.00
67_L	70_Q	1.281	1.00
301_A	305_R	1.267	1.00
32_L	41_A	1.260	1.00
34_L	38_A	1.259	1.00
69_Q	73_A	1.255	1.00
43_Y	49_Q	1.249	1.00
75_R	79_E	1.236	1.00
60_L	66_A	1.233	1.00
81_A	85_Q	1.232	1.00
43_Y	48_Q	1.227	1.00
124_L	162_L	1.221	1.00
132_L	177_D	1.220	1.00
156_D	191_G	1.214	1.00
328_P	331_P	1.208	1.00
292_Y	327_Q	1.203	1.00
66_A	70_Q	1.193	1.00
271_E	278_L	1.190	1.00
231_D	234_Q	1.189	1.00
52_Q	56_E	1.187	1.00
60_L	63_Q	1.186	1.00
173_A	176_R	1.170	1.00
74_A	77_A	1.166	1.00
42_G	49_Q	1.164	1.00
49_Q	52_Q	1.163	1.00
26_G	29_L	1.162	1.00
69_Q	72_A	1.157	1.00
92_E	96_A	1.157	1.00
195_R	323_Q	1.149	1.00
126_A	130_Y	1.148	1.00
164_D	167_L	1.145	1.00
178_I	182_K	1.136	1.00
123_W	127_E	1.129	1.00
31_A	38_A	1.128	1.00
76_Q	79_E	1.127	1.00
60_L	64_L	1.122	1.00
152_L	174_I	1.122	1.00
35_A	39_L	1.120	1.00
106_E	109_Y	1.120	1.00
231_D	235_R	1.119	1.00
309_T	318_L	1.115	1.00
132_L	174_I	1.114	1.00
42_G	47_W	1.112	1.00
276_R	298_A	1.111	1.00
235_R	238_R	1.105	1.00
52_Q	55_A	1.101	1.00
207_P	311_S	1.096	1.00
262_A	267_F	1.092	1.00
96_A	100_S	1.083	1.00
88_L	92_E	1.081	1.00
206_L	317_A	1.076	1.00
83_E	86_A	1.065	1.00
101_Q	109_Y	1.063	1.00
32_L	36_L	1.050	1.00
94_R	98_L	1.044	1.00
29_L	32_L	1.041	1.00
155_A	174_I	1.033	1.00
50_R	54_Q	1.026	1.00
319_A	323_Q	1.025	1.00
308_D	314_V	1.016	1.00
293_R	325_A	1.015	1.00
105_L	109_Y	1.013	1.00
270_R	307_F	1.011	1.00
151_A	281_R	0.997	1.00
64_L	70_Q	0.996	1.00
27_L	35_A	0.993	1.00
46_G	53_L	0.992	1.00
49_Q	53_L	0.992	1.00
102_Q	106_E	0.987	1.00
272_N	306_Y	0.984	1.00
92_E	95_L	0.983	1.00
62_Q	68_E	0.982	1.00
342_A	345_A	0.976	1.00
314_V	317_A	0.973	1.00
233_W	236_L	0.971	1.00
137_Q	177_D	0.964	0.99
235_R	239_S	0.959	0.99
170_V	343_L	0.959	0.99
47_W	51_Q	0.958	0.99
101_Q	108_L	0.954	0.99
66_A	72_A	0.949	0.99
263_P	269_L	0.940	0.99
232_W	237_A	0.938	0.99
283_A	291_L	0.932	0.99
214_P	217_P	0.930	0.99
97_E	100_S	0.928	0.99
59_R	68_E	0.925	0.99
139_L	145_V	0.925	0.99
32_L	39_L	0.922	0.99
42_G	50_R	0.919	0.99
60_L	70_Q	0.913	0.99
138_Q	147_A	0.905	0.99
244_L	248_V	0.904	0.99
50_R	53_L	0.898	0.99
132_L	339_S	0.895	0.99
232_W	236_L	0.893	0.99
105_L	108_L	0.889	0.99
132_L	170_V	0.889	0.99
123_W	126_A	0.884	0.99
27_L	31_A	0.884	0.99
276_R	302_W	0.881	0.99
156_D	160_A	0.880	0.99
303_L	314_V	0.880	0.99
145_V	333_L	0.879	0.99
62_Q	71_L	0.875	0.99
292_Y	296_L	0.875	0.99
61_A	68_E	0.872	0.99
28_A	31_A	0.871	0.99
170_V	346_L	0.871	0.99
95_L	99_Q	0.868	0.99
66_A	69_Q	0.867	0.99
91_L	94_R	0.866	0.99
79_E	82_R	0.863	0.99
34_L	37_A	0.859	0.99
203_V	317_A	0.858	0.99
120_R	124_L	0.858	0.99
58_Q	63_Q	0.854	0.99
46_G	51_Q	0.853	0.99
119_S	122_D	0.846	0.99
151_A	155_A	0.845	0.99
68_E	73_A	0.844	0.99
335_D	338_E	0.844	0.99
31_A	34_L	0.844	0.99
66_A	73_A	0.842	0.99
26_G	30_L	0.839	0.99
81_A	84_L	0.836	0.99
339_S	343_L	0.836	0.99
62_Q	73_A	0.834	0.99
144_D	147_A	0.834	0.99
128_A	159_L	0.827	0.98
57_L	61_A	0.820	0.98
237_A	240_V	0.817	0.98
112_L	116_S	0.814	0.98
60_L	71_L	0.813	0.98
38_A	42_G	0.812	0.98
25_L	31_A	0.808	0.98
267_F	272_N	0.807	0.98
48_Q	51_Q	0.804	0.98
276_R	279_N	0.803	0.98
273_L	302_W	0.802	0.98
108_L	113_S	0.800	0.98
57_L	60_L	0.799	0.98
13_A	16_A	0.798	0.98
304_E	309_T	0.789	0.98
111_S	114_R	0.788	0.98
267_F	271_E	0.786	0.98
318_L	322_K	0.786	0.98
189_V	192_L	0.782	0.98
207_P	308_D	0.779	0.98
67_L	72_A	0.778	0.98
177_D	342_A	0.773	0.98
36_L	40_A	0.772	0.98
202_Q	320_E	0.771	0.98
62_Q	67_L	0.771	0.98
153_Q	178_I	0.770	0.98
95_L	98_L	0.766	0.97
241_W	244_L	0.766	0.97
276_R	281_R	0.765	0.97
33_L	36_L	0.759	0.97
90_L	95_L	0.758	0.97
25_L	36_L	0.758	0.97
79_E	83_E	0.757	0.97
200_I	274_K	0.755	0.97
273_L	299_A	0.754	0.97
177_D	180_A	0.753	0.97
27_L	32_L	0.751	0.97
14_A	17_P	0.749	0.97
151_A	279_N	0.749	0.97
33_L	37_A	0.744	0.97
289_Q	328_P	0.744	0.97
59_R	72_A	0.743	0.97
135_A	152_L	0.740	0.97
260_L	272_N	0.735	0.97
168_L	190_A	0.734	0.97
192_L	284_L	0.732	0.97
263_P	268_F	0.730	0.97
104_Q	111_S	0.726	0.96
62_Q	69_Q	0.723	0.96
18_P	21_K	0.723	0.96
162_L	167_L	0.722	0.96
49_Q	54_Q	0.722	0.96
109_Y	115_L	0.720	0.96
99_Q	104_Q	0.720	0.96
38_A	43_Y	0.720	0.96
77_A	80_L	0.717	0.96
48_Q	52_Q	0.715	0.96
58_Q	65_A	0.715	0.96
39_L	42_G	0.713	0.96
108_L	111_S	0.712	0.96
260_L	263_P	0.711	0.96
132_L	343_L	0.708	0.96
130_Y	134_L	0.708	0.96
67_L	71_L	0.707	0.96
276_R	295_D	0.704	0.96
87_K	90_L	0.702	0.96
55_A	58_Q	0.702	0.96
61_A	70_Q	0.701	0.96
59_R	67_L	0.701	0.96
52_Q	57_L	0.700	0.96
196_L	200_I	0.697	0.96
176_R	201_A	0.697	0.96
101_Q	111_S	0.693	0.95
77_A	81_A	0.693	0.95
319_A	322_K	0.693	0.95
74_A	78_Q	0.690	0.95
130_Y	133_R	0.690	0.95
193_A	295_D	0.688	0.95
335_D	339_S	0.688	0.95
39_L	43_Y	0.687	0.95
57_L	63_Q	0.686	0.95
93_A	97_E	0.683	0.95
159_L	174_I	0.682	0.95
33_L	43_Y	0.682	0.95
234_Q	237_A	0.681	0.95
136_N	340_L	0.680	0.95
60_L	72_A	0.677	0.95
114_R	118_R	0.677	0.95
46_G	54_Q	0.677	0.95
233_W	240_V	0.675	0.95
94_R	102_Q	0.674	0.95
230_S	233_W	0.672	0.95
51_Q	55_A	0.671	0.95
261_L	265_Q	0.671	0.95
225_A	229_A	0.670	0.95
31_A	41_A	0.669	0.94
202_Q	313_A	0.669	0.94
225_A	228_S	0.669	0.94
110_Q	114_R	0.669	0.94
106_E	110_Q	0.667	0.94
99_Q	103_A	0.666	0.94
136_N	337_S	0.666	0.94
61_A	67_L	0.665	0.94
65_A	69_Q	0.661	0.94
309_T	314_V	0.660	0.94
236_L	240_V	0.660	0.94
280_A	299_A	0.660	0.94
44_W	50_R	0.659	0.94
98_L	102_Q	0.658	0.94
190_A	194_L	0.656	0.94
206_L	314_V	0.656	0.94
213_R	217_P	0.655	0.94
128_A	132_L	0.655	0.94
33_L	40_A	0.652	0.94
134_L	151_A	0.651	0.94
30_L	33_L	0.651	0.94
47_W	53_L	0.651	0.94
25_L	28_A	0.650	0.94
21_K	24_G	0.650	0.94
45_Q	52_Q	0.649	0.94
131_L	155_A	0.648	0.93
24_G	32_L	0.648	0.93
58_Q	71_L	0.647	0.93
145_V	184_V	0.644	0.93
193_A	284_L	0.643	0.93
12_P	16_A	0.643	0.93
338_E	342_A	0.643	0.93
24_G	27_L	0.642	0.93
98_L	101_Q	0.641	0.93
64_L	73_A	0.641	0.93
58_Q	70_Q	0.641	0.93
228_S	235_R	0.637	0.93
130_Y	142_A	0.635	0.93
282_L	286_R	0.632	0.93
289_Q	292_Y	0.631	0.93
127_E	133_R	0.631	0.93
262_A	268_F	0.629	0.92
207_P	314_V	0.627	0.92
296_L	324_L	0.624	0.92
65_A	71_L	0.623	0.92
304_E	322_K	0.622	0.92
66_A	71_L	0.621	0.92
22_R	25_L	0.621	0.92
27_L	30_L	0.619	0.92
133_R	344_R	0.618	0.92
263_P	302_W	0.617	0.92
171_R	194_L	0.616	0.92
65_A	72_A	0.616	0.92
143_G	287_R	0.615	0.92
179_A	183_A	0.615	0.92
208_L	266_A	0.614	0.92
271_E	275_L	0.614	0.92
300_Q	321_L	0.613	0.91
101_Q	112_L	0.613	0.91
35_A	41_A	0.612	0.91
289_Q	330_A	0.611	0.91
168_L	172_R	0.611	0.91
30_L	37_A	0.611	0.91
269_L	306_Y	0.611	0.91
97_E	105_L	0.609	0.91
206_L	273_L	0.608	0.91
200_I	204_D	0.608	0.91
101_Q	106_E	0.607	0.91
234_Q	238_R	0.605	0.91
24_G	29_L	0.604	0.91
58_Q	72_A	0.603	0.91
108_L	112_L	0.603	0.91
78_Q	82_R	0.601	0.91
187_V	331_P	0.600	0.91
125_L	129_E	0.599	0.91
294_A	297_A	0.598	0.90
136_N	177_D	0.598	0.90
158_R	281_R	0.597	0.90
128_A	131_L	0.595	0.90
199_L	203_V	0.593	0.90
102_Q	109_Y	0.589	0.90
60_L	69_Q	0.589	0.90
35_A	45_Q	0.588	0.90
56_E	73_A	0.586	0.90
67_L	73_A	0.583	0.89
64_L	72_A	0.582	0.89
297_A	300_Q	0.581	0.89
60_L	65_A	0.580	0.89
90_L	93_A	0.580	0.89
199_L	320_E	0.577	0.89
84_L	87_K	0.576	0.89
26_G	31_A	0.574	0.89
56_E	61_A	0.573	0.89
132_L	336_I	0.572	0.88
203_V	307_F	0.572	0.88
85_Q	88_L	0.571	0.88
322_K	326_A	0.571	0.88
101_Q	113_S	0.571	0.88
19_K	23_S	0.569	0.88
109_Y	112_L	0.568	0.88
12_P	18_P	0.568	0.88
58_Q	69_Q	0.568	0.88
16_A	19_K	0.566	0.88
30_L	38_A	0.566	0.88
15_P	19_K	0.565	0.88
202_Q	205_S	0.563	0.88
308_D	311_S	0.563	0.88
312_P	315_Q	0.562	0.88
218_A	221_A	0.561	0.87
19_K	22_R	0.561	0.87
25_L	32_L	0.561	0.87
50_R	56_E	0.559	0.87
238_R	242_S	0.559	0.87
33_L	38_A	0.559	0.87
242_S	246_S	0.556	0.87
126_A	150_A	0.554	0.87
171_R	191_G	0.553	0.87
194_L	198_A	0.553	0.87
61_A	71_L	0.552	0.87
75_R	78_Q	0.552	0.87
158_R	193_A	0.552	0.87
125_L	128_A	0.551	0.87
123_W	130_Y	0.551	0.87
82_R	85_Q	0.551	0.87
148_A	181_L	0.550	0.86
325_A	328_P	0.549	0.86
149_L	153_Q	0.549	0.86
108_L	115_L	0.549	0.86
187_V	329_I	0.547	0.86
20_A	24_G	0.547	0.86
126_A	154_A	0.546	0.86
21_K	25_L	0.545	0.86
156_D	174_I	0.542	0.86
128_A	167_L	0.540	0.85
89_A	93_A	0.538	0.85
28_A	39_L	0.534	0.85
193_A	291_L	0.534	0.85
196_L	277_L	0.534	0.85
151_A	193_A	0.533	0.85
289_Q	329_I	0.530	0.84
204_D	270_R	0.529	0.84
48_Q	54_Q	0.527	0.84
62_Q	65_A	0.527	0.84
229_A	234_Q	0.526	0.84
81_A	87_K	0.525	0.84
141_L	158_R	0.522	0.83
87_K	94_R	0.522	0.83
97_E	110_Q	0.522	0.83
340_L	344_R	0.522	0.83
123_W	191_G	0.521	0.83
77_A	84_L	0.514	0.83
41_A	47_W	0.512	0.82
139_L	148_A	0.512	0.82
272_N	276_R	0.511	0.82
297_A	301_A	0.511	0.82
172_R	176_R	0.510	0.82
314_V	318_L	0.509	0.82
62_Q	72_A	0.508	0.82
141_L	165_P	0.508	0.82
15_P	20_A	0.507	0.82
230_S	234_Q	0.507	0.82
274_K	278_L	0.506	0.82
310_D	315_Q	0.505	0.81
154_A	157_A	0.505	0.81
167_L	343_L	0.505	0.81
125_L	347_L	0.503	0.81
139_L	144_D	0.503	0.81
167_L	346_L	0.503	0.81
212_A	215_A	0.503	0.81
337_S	340_L	0.502	0.81
150_A	154_A	0.501	0.81
159_L	171_R	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j6da	3	0.0084	41.9	0.948	Contact Map
3fymA	1	0.0279	34.9	0.951	Contact Map
4n78F	1	0.2479	34.1	0.951	Contact Map
4v3iA	2	0.0139	26.4	0.953	Contact Map
1scfA	4	0	23.2	0.955	Contact Map
2m8rA	1	0.1253	20.8	0.956	Contact Map
5a2fA	1	0	19	0.956	Contact Map
3r2pA	2	0.1811	11.5	0.961	Contact Map
2rpaA	1	0.1922	11.4	0.961	Contact Map
2mi2A	1	0.2897	11.1	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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