GREMLIN Database
HemX - HemX
PFAM: PF04375 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 359 (337)
Sequences: 4742 (3737)
Seq/√Len: 203.6
META: 0.764

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_Y47_W5.0711.00
149_L178_I4.4791.00
199_L317_A3.4331.00
296_L321_L3.1941.00
156_D171_R3.0871.00
63_Q68_E3.0741.00
300_Q318_L3.0631.00
46_G50_R2.9731.00
153_Q182_K2.9601.00
42_G45_Q2.6891.00
289_Q293_R2.5561.00
43_Y46_G2.4801.00
42_G46_G2.4591.00
304_E318_L2.4511.00
59_R64_L2.3571.00
129_E344_R2.2941.00
288_D291_L2.2661.00
37_A41_A2.2201.00
54_Q57_L2.1701.00
300_Q322_K2.1631.00
138_Q144_D2.1601.00
188_D191_G2.0981.00
300_Q325_A2.0961.00
59_R63_Q2.0811.00
41_A45_Q2.0491.00
35_A38_A2.0471.00
44_W47_W2.0371.00
303_L318_L2.0131.00
104_Q109_Y2.0021.00
176_R338_E1.9971.00
177_D339_S1.9851.00
59_R62_Q1.9771.00
204_D274_K1.9661.00
32_L35_A1.9621.00
64_L71_L1.9441.00
271_E274_K1.9411.00
64_L68_E1.9251.00
45_Q49_Q1.9201.00
311_S314_V1.9131.00
195_R320_E1.9041.00
58_Q62_Q1.8981.00
233_W237_A1.8961.00
68_E72_A1.8761.00
303_L317_A1.8731.00
292_Y324_L1.8671.00
240_V243_E1.8541.00
46_G49_Q1.8281.00
297_A325_A1.8131.00
268_F272_N1.7751.00
64_L67_L1.7511.00
237_A241_W1.7451.00
45_Q50_R1.6791.00
266_A270_R1.6741.00
31_A35_A1.6701.00
45_Q48_Q1.6691.00
168_L194_L1.6691.00
124_L128_A1.6661.00
101_Q105_L1.6481.00
53_L56_E1.6391.00
272_N302_W1.6281.00
138_Q142_A1.6041.00
59_R71_L1.6011.00
60_L67_L1.5901.00
47_W50_R1.5851.00
192_L327_Q1.5841.00
28_A32_L1.5821.00
53_L57_L1.5561.00
249_R252_R1.5321.00
51_Q54_Q1.5171.00
58_Q61_A1.5101.00
28_A35_A1.5021.00
299_A321_L1.5011.00
259_P302_W1.4951.00
68_E71_L1.4661.00
241_W245_R1.4641.00
156_D175_A1.4631.00
63_Q67_L1.4591.00
320_E323_Q1.4521.00
61_A65_A1.4421.00
300_Q304_E1.4391.00
63_Q71_L1.4341.00
62_Q66_A1.4201.00
63_Q66_A1.4191.00
193_A281_R1.4181.00
65_A68_E1.4071.00
44_W48_Q1.4031.00
70_Q73_A1.4021.00
322_K325_A1.4001.00
43_Y50_R1.3981.00
101_Q104_Q1.3941.00
173_A177_D1.3931.00
149_L182_K1.3821.00
56_E59_R1.3811.00
80_L84_L1.3801.00
25_L29_L1.3681.00
38_A41_A1.3651.00
94_R97_E1.3541.00
44_W49_Q1.3541.00
63_Q69_Q1.3531.00
60_L68_E1.3471.00
232_W235_R1.3391.00
191_G194_L1.3341.00
152_L336_I1.3231.00
174_I178_I1.3211.00
277_L299_A1.3161.00
327_Q331_P1.3111.00
173_A342_A1.3031.00
83_E87_K1.2991.00
269_L272_N1.2971.00
263_P272_N1.2941.00
129_E340_L1.2931.00
67_L70_Q1.2811.00
301_A305_R1.2671.00
32_L41_A1.2601.00
34_L38_A1.2591.00
69_Q73_A1.2551.00
43_Y49_Q1.2491.00
75_R79_E1.2361.00
60_L66_A1.2331.00
81_A85_Q1.2321.00
43_Y48_Q1.2271.00
124_L162_L1.2211.00
132_L177_D1.2201.00
156_D191_G1.2141.00
328_P331_P1.2081.00
292_Y327_Q1.2031.00
66_A70_Q1.1931.00
271_E278_L1.1901.00
231_D234_Q1.1891.00
52_Q56_E1.1871.00
60_L63_Q1.1861.00
173_A176_R1.1701.00
74_A77_A1.1661.00
42_G49_Q1.1641.00
49_Q52_Q1.1631.00
26_G29_L1.1621.00
69_Q72_A1.1571.00
92_E96_A1.1571.00
195_R323_Q1.1491.00
126_A130_Y1.1481.00
164_D167_L1.1451.00
178_I182_K1.1361.00
123_W127_E1.1291.00
31_A38_A1.1281.00
76_Q79_E1.1271.00
60_L64_L1.1221.00
152_L174_I1.1221.00
35_A39_L1.1201.00
106_E109_Y1.1201.00
231_D235_R1.1191.00
309_T318_L1.1151.00
132_L174_I1.1141.00
42_G47_W1.1121.00
276_R298_A1.1111.00
235_R238_R1.1051.00
52_Q55_A1.1011.00
207_P311_S1.0961.00
262_A267_F1.0921.00
96_A100_S1.0831.00
88_L92_E1.0811.00
206_L317_A1.0761.00
83_E86_A1.0651.00
101_Q109_Y1.0631.00
32_L36_L1.0501.00
94_R98_L1.0441.00
29_L32_L1.0411.00
155_A174_I1.0331.00
50_R54_Q1.0261.00
319_A323_Q1.0251.00
308_D314_V1.0161.00
293_R325_A1.0151.00
105_L109_Y1.0131.00
270_R307_F1.0111.00
151_A281_R0.9971.00
64_L70_Q0.9961.00
27_L35_A0.9931.00
46_G53_L0.9921.00
49_Q53_L0.9921.00
102_Q106_E0.9871.00
272_N306_Y0.9841.00
92_E95_L0.9831.00
62_Q68_E0.9821.00
342_A345_A0.9761.00
314_V317_A0.9731.00
233_W236_L0.9711.00
137_Q177_D0.9640.99
235_R239_S0.9590.99
170_V343_L0.9590.99
47_W51_Q0.9580.99
101_Q108_L0.9540.99
66_A72_A0.9490.99
263_P269_L0.9400.99
232_W237_A0.9380.99
283_A291_L0.9320.99
214_P217_P0.9300.99
97_E100_S0.9280.99
59_R68_E0.9250.99
139_L145_V0.9250.99
32_L39_L0.9220.99
42_G50_R0.9190.99
60_L70_Q0.9130.99
138_Q147_A0.9050.99
244_L248_V0.9040.99
50_R53_L0.8980.99
132_L339_S0.8950.99
232_W236_L0.8930.99
105_L108_L0.8890.99
132_L170_V0.8890.99
123_W126_A0.8840.99
27_L31_A0.8840.99
276_R302_W0.8810.99
156_D160_A0.8800.99
303_L314_V0.8800.99
145_V333_L0.8790.99
62_Q71_L0.8750.99
292_Y296_L0.8750.99
61_A68_E0.8720.99
28_A31_A0.8710.99
170_V346_L0.8710.99
95_L99_Q0.8680.99
66_A69_Q0.8670.99
91_L94_R0.8660.99
79_E82_R0.8630.99
34_L37_A0.8590.99
203_V317_A0.8580.99
120_R124_L0.8580.99
58_Q63_Q0.8540.99
46_G51_Q0.8530.99
119_S122_D0.8460.99
151_A155_A0.8450.99
68_E73_A0.8440.99
335_D338_E0.8440.99
31_A34_L0.8440.99
66_A73_A0.8420.99
26_G30_L0.8390.99
81_A84_L0.8360.99
339_S343_L0.8360.99
62_Q73_A0.8340.99
144_D147_A0.8340.99
128_A159_L0.8270.98
57_L61_A0.8200.98
237_A240_V0.8170.98
112_L116_S0.8140.98
60_L71_L0.8130.98
38_A42_G0.8120.98
25_L31_A0.8080.98
267_F272_N0.8070.98
48_Q51_Q0.8040.98
276_R279_N0.8030.98
273_L302_W0.8020.98
108_L113_S0.8000.98
57_L60_L0.7990.98
13_A16_A0.7980.98
304_E309_T0.7890.98
111_S114_R0.7880.98
267_F271_E0.7860.98
318_L322_K0.7860.98
189_V192_L0.7820.98
207_P308_D0.7790.98
67_L72_A0.7780.98
177_D342_A0.7730.98
36_L40_A0.7720.98
202_Q320_E0.7710.98
62_Q67_L0.7710.98
153_Q178_I0.7700.98
95_L98_L0.7660.97
241_W244_L0.7660.97
276_R281_R0.7650.97
33_L36_L0.7590.97
90_L95_L0.7580.97
25_L36_L0.7580.97
79_E83_E0.7570.97
200_I274_K0.7550.97
273_L299_A0.7540.97
177_D180_A0.7530.97
27_L32_L0.7510.97
14_A17_P0.7490.97
151_A279_N0.7490.97
33_L37_A0.7440.97
289_Q328_P0.7440.97
59_R72_A0.7430.97
135_A152_L0.7400.97
260_L272_N0.7350.97
168_L190_A0.7340.97
192_L284_L0.7320.97
263_P268_F0.7300.97
104_Q111_S0.7260.96
62_Q69_Q0.7230.96
18_P21_K0.7230.96
162_L167_L0.7220.96
49_Q54_Q0.7220.96
109_Y115_L0.7200.96
99_Q104_Q0.7200.96
38_A43_Y0.7200.96
77_A80_L0.7170.96
48_Q52_Q0.7150.96
58_Q65_A0.7150.96
39_L42_G0.7130.96
108_L111_S0.7120.96
260_L263_P0.7110.96
132_L343_L0.7080.96
130_Y134_L0.7080.96
67_L71_L0.7070.96
276_R295_D0.7040.96
87_K90_L0.7020.96
55_A58_Q0.7020.96
61_A70_Q0.7010.96
59_R67_L0.7010.96
52_Q57_L0.7000.96
196_L200_I0.6970.96
176_R201_A0.6970.96
101_Q111_S0.6930.95
77_A81_A0.6930.95
319_A322_K0.6930.95
74_A78_Q0.6900.95
130_Y133_R0.6900.95
193_A295_D0.6880.95
335_D339_S0.6880.95
39_L43_Y0.6870.95
57_L63_Q0.6860.95
93_A97_E0.6830.95
159_L174_I0.6820.95
33_L43_Y0.6820.95
234_Q237_A0.6810.95
136_N340_L0.6800.95
60_L72_A0.6770.95
114_R118_R0.6770.95
46_G54_Q0.6770.95
233_W240_V0.6750.95
94_R102_Q0.6740.95
230_S233_W0.6720.95
51_Q55_A0.6710.95
261_L265_Q0.6710.95
225_A229_A0.6700.95
31_A41_A0.6690.94
202_Q313_A0.6690.94
225_A228_S0.6690.94
110_Q114_R0.6690.94
106_E110_Q0.6670.94
99_Q103_A0.6660.94
136_N337_S0.6660.94
61_A67_L0.6650.94
65_A69_Q0.6610.94
309_T314_V0.6600.94
236_L240_V0.6600.94
280_A299_A0.6600.94
44_W50_R0.6590.94
98_L102_Q0.6580.94
190_A194_L0.6560.94
206_L314_V0.6560.94
213_R217_P0.6550.94
128_A132_L0.6550.94
33_L40_A0.6520.94
134_L151_A0.6510.94
30_L33_L0.6510.94
47_W53_L0.6510.94
25_L28_A0.6500.94
21_K24_G0.6500.94
45_Q52_Q0.6490.94
131_L155_A0.6480.93
24_G32_L0.6480.93
58_Q71_L0.6470.93
145_V184_V0.6440.93
193_A284_L0.6430.93
12_P16_A0.6430.93
338_E342_A0.6430.93
24_G27_L0.6420.93
98_L101_Q0.6410.93
64_L73_A0.6410.93
58_Q70_Q0.6410.93
228_S235_R0.6370.93
130_Y142_A0.6350.93
282_L286_R0.6320.93
289_Q292_Y0.6310.93
127_E133_R0.6310.93
262_A268_F0.6290.92
207_P314_V0.6270.92
296_L324_L0.6240.92
65_A71_L0.6230.92
304_E322_K0.6220.92
66_A71_L0.6210.92
22_R25_L0.6210.92
27_L30_L0.6190.92
133_R344_R0.6180.92
263_P302_W0.6170.92
171_R194_L0.6160.92
65_A72_A0.6160.92
143_G287_R0.6150.92
179_A183_A0.6150.92
208_L266_A0.6140.92
271_E275_L0.6140.92
300_Q321_L0.6130.91
101_Q112_L0.6130.91
35_A41_A0.6120.91
289_Q330_A0.6110.91
168_L172_R0.6110.91
30_L37_A0.6110.91
269_L306_Y0.6110.91
97_E105_L0.6090.91
206_L273_L0.6080.91
200_I204_D0.6080.91
101_Q106_E0.6070.91
234_Q238_R0.6050.91
24_G29_L0.6040.91
58_Q72_A0.6030.91
108_L112_L0.6030.91
78_Q82_R0.6010.91
187_V331_P0.6000.91
125_L129_E0.5990.91
294_A297_A0.5980.90
136_N177_D0.5980.90
158_R281_R0.5970.90
128_A131_L0.5950.90
199_L203_V0.5930.90
102_Q109_Y0.5890.90
60_L69_Q0.5890.90
35_A45_Q0.5880.90
56_E73_A0.5860.90
67_L73_A0.5830.89
64_L72_A0.5820.89
297_A300_Q0.5810.89
60_L65_A0.5800.89
90_L93_A0.5800.89
199_L320_E0.5770.89
84_L87_K0.5760.89
26_G31_A0.5740.89
56_E61_A0.5730.89
132_L336_I0.5720.88
203_V307_F0.5720.88
85_Q88_L0.5710.88
322_K326_A0.5710.88
101_Q113_S0.5710.88
19_K23_S0.5690.88
109_Y112_L0.5680.88
12_P18_P0.5680.88
58_Q69_Q0.5680.88
16_A19_K0.5660.88
30_L38_A0.5660.88
15_P19_K0.5650.88
202_Q205_S0.5630.88
308_D311_S0.5630.88
312_P315_Q0.5620.88
218_A221_A0.5610.87
19_K22_R0.5610.87
25_L32_L0.5610.87
50_R56_E0.5590.87
238_R242_S0.5590.87
33_L38_A0.5590.87
242_S246_S0.5560.87
126_A150_A0.5540.87
171_R191_G0.5530.87
194_L198_A0.5530.87
61_A71_L0.5520.87
75_R78_Q0.5520.87
158_R193_A0.5520.87
125_L128_A0.5510.87
123_W130_Y0.5510.87
82_R85_Q0.5510.87
148_A181_L0.5500.86
325_A328_P0.5490.86
149_L153_Q0.5490.86
108_L115_L0.5490.86
187_V329_I0.5470.86
20_A24_G0.5470.86
126_A154_A0.5460.86
21_K25_L0.5450.86
156_D174_I0.5420.86
128_A167_L0.5400.85
89_A93_A0.5380.85
28_A39_L0.5340.85
193_A291_L0.5340.85
196_L277_L0.5340.85
151_A193_A0.5330.85
289_Q329_I0.5300.84
204_D270_R0.5290.84
48_Q54_Q0.5270.84
62_Q65_A0.5270.84
229_A234_Q0.5260.84
81_A87_K0.5250.84
141_L158_R0.5220.83
87_K94_R0.5220.83
97_E110_Q0.5220.83
340_L344_R0.5220.83
123_W191_G0.5210.83
77_A84_L0.5140.83
41_A47_W0.5120.82
139_L148_A0.5120.82
272_N276_R0.5110.82
297_A301_A0.5110.82
172_R176_R0.5100.82
314_V318_L0.5090.82
62_Q72_A0.5080.82
141_L165_P0.5080.82
15_P20_A0.5070.82
230_S234_Q0.5070.82
274_K278_L0.5060.82
310_D315_Q0.5050.81
154_A157_A0.5050.81
167_L343_L0.5050.81
125_L347_L0.5030.81
139_L144_D0.5030.81
167_L346_L0.5030.81
212_A215_A0.5030.81
337_S340_L0.5020.81
150_A154_A0.5010.81
159_L171_R0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j6da 3 0.0084 41.9 0.948 Contact Map
3fymA 1 0.0279 34.9 0.951 Contact Map
4n78F 1 0.2479 34.1 0.951 Contact Map
4v3iA 2 0.0139 26.4 0.953 Contact Map
1scfA 4 0 23.2 0.955 Contact Map
2m8rA 1 0.1253 20.8 0.956 Contact Map
5a2fA 1 0 19 0.956 Contact Map
3r2pA 2 0.1811 11.5 0.961 Contact Map
2rpaA 1 0.1922 11.4 0.961 Contact Map
2mi2A 1 0.2897 11.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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