GREMLIN Database
DUF507 - Protein of unknown function (DUF507)
PFAM: PF04368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 182 (181)
Sequences: 1368 (724)
Seq/√Len: 53.8
META: 0.937

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_L85_L6.0991.00
34_V116_V4.6431.00
16_V34_V3.8931.00
24_D128_K3.5811.00
121_D124_E3.1951.00
159_I162_T3.1911.00
78_F82_K3.0031.00
144_D169_Y2.8471.00
39_E43_E2.4041.00
35_A39_E2.3791.00
43_E47_R2.3491.00
55_E89_R2.2731.00
38_I106_I2.1651.00
13_R35_A2.1141.00
170_R174_E2.0511.00
45_Y102_I2.0281.00
27_T31_P2.0091.00
158_L168_L1.9781.00
41_V109_M1.9691.00
175_E179_K1.9020.99
84_K88_E1.8060.99
110_L116_V1.8000.99
101_D105_Q1.7920.99
153_N158_L1.7810.99
111_M118_V1.7700.99
154_Y158_L1.7480.99
8_I46_L1.6990.99
17_R21_N1.6970.99
173_Y176_E1.6890.99
144_D148_R1.6320.98
107_L125_V1.6130.98
176_E179_K1.6130.98
154_Y157_E1.5890.98
52_L56_V1.5090.97
154_Y172_Y1.5000.97
85_L88_E1.4920.97
158_L164_E1.4700.97
50_D57_R1.4640.97
12_A15_I1.4570.97
172_Y175_E1.4490.97
56_V78_F1.4380.96
22_S128_K1.4380.96
44_E47_R1.4290.96
37_D40_A1.3910.96
34_V110_L1.3770.95
97_D104_H1.3470.95
173_Y177_L1.3410.95
29_D34_V1.3380.95
57_R166_D1.3290.94
59_I85_L1.3240.94
148_R160_E1.3120.94
100_N103_S1.3040.94
158_L175_E1.3030.94
29_D32_E1.2920.94
45_Y98_R1.2880.94
162_T169_Y1.2330.92
49_E53_N1.2290.92
49_E98_R1.2210.92
116_V122_D1.2040.91
5_R50_D1.1990.91
47_R53_N1.1890.90
20_V31_P1.1800.90
2_R5_R1.1750.90
11_I15_I1.1740.90
168_L172_Y1.1680.90
55_E147_V1.1570.89
125_V128_K1.1480.89
16_V116_V1.1450.89
122_D153_N1.1420.89
59_I81_I1.1310.88
85_L108_E1.1100.87
10_Y13_R1.0990.87
33_E37_D1.0860.86
159_I164_E1.0850.86
53_N78_F1.0580.84
47_R51_E1.0580.84
80_R151_I1.0560.84
41_V106_I1.0460.84
155_K163_E1.0420.84
76_E80_R1.0270.83
48_V92_I1.0260.83
138_A162_T1.0230.82
42_L46_L1.0230.82
55_E88_E1.0150.82
18_D22_S1.0140.82
69_R72_V1.0070.81
67_M71_G1.0050.81
51_E89_R0.9850.80
60_L81_I0.9840.80
8_I12_A0.9780.79
7_K136_H0.9720.79
109_M124_E0.9620.78
52_L91_V0.9460.77
151_I169_Y0.9370.76
143_I147_V0.9360.76
88_E177_L0.9350.76
58_D61_E0.9320.76
25_I132_I0.9280.76
24_D124_E0.9230.75
22_S120_V0.9170.75
178_R182_L0.9120.74
163_E174_E0.9090.74
123_N127_L0.9040.74
144_D151_I0.9000.73
67_M72_V0.8970.73
163_E167_I0.8950.73
96_E134_T0.8940.73
110_L115_L0.8870.72
59_I84_K0.8800.72
111_M117_E0.8740.71
100_N130_V0.8730.71
4_Y8_I0.8730.71
52_L90_G0.8710.71
98_R102_I0.8600.70
170_R175_E0.8470.69
143_I173_Y0.8460.69
157_E162_T0.8450.69
145_R149_E0.8380.68
46_L78_F0.8370.68
52_L84_K0.8340.68
60_L78_F0.8320.67
151_I172_Y0.8310.67
76_E114_R0.8240.67
51_E55_E0.8200.66
144_D147_V0.8190.66
15_I129_I0.8180.66
4_Y7_K0.8030.65
24_D120_V0.8020.65
161_G166_D0.7990.64
2_R7_K0.7960.64
144_D172_Y0.7920.64
9_P39_E0.7900.63
89_R102_I0.7800.62
28_E119_F0.7740.62
97_D170_R0.7740.62
147_V169_Y0.7700.61
100_N104_H0.7670.61
104_H123_N0.7640.61
108_E119_F0.7630.61
5_R13_R0.7600.60
7_K11_I0.7550.60
21_N24_D0.7550.60
91_V171_R0.7530.60
106_I180_R0.7520.60
138_A142_E0.7480.59
24_D41_V0.7410.58
176_E180_R0.7410.58
109_M112_K0.7400.58
28_E58_D0.7390.58
37_D118_V0.7360.58
25_I110_L0.7350.58
168_L175_E0.7350.58
7_K10_Y0.7350.58
92_I100_N0.7310.57
32_E35_A0.7300.57
20_V35_A0.7280.57
2_R53_N0.7280.57
93_L131_K0.7250.57
8_I139_V0.7230.57
80_R127_L0.7210.56
115_L147_V0.7190.56
28_E81_I0.7170.56
98_R137_L0.7130.56
54_E57_R0.7070.55
100_N129_I0.7070.55
60_L82_K0.7060.55
172_Y176_E0.7040.55
105_Q113_S0.7030.55
119_F122_D0.6960.54
107_L123_N0.6950.54
42_L140_E0.6860.53
12_A58_D0.6790.52
58_D166_D0.6770.52
72_V108_E0.6740.51
32_E39_E0.6700.51
139_V143_I0.6660.51
45_Y48_V0.6610.50
170_R173_Y0.6590.50
10_Y82_K0.6580.50
56_V65_E0.6550.49
25_I128_K0.6540.49
8_I42_L0.6520.49
124_E131_K0.6510.49
20_V27_T0.6500.49
8_I57_R0.6500.49
73_D76_E0.6450.48
50_D132_I0.6450.48
41_V113_S0.6450.48
44_E48_V0.6450.48
174_E180_R0.6440.48
86_A93_L0.6440.48
17_R33_E0.6440.48
39_E102_I0.6430.48
153_N168_L0.6420.48
159_I163_E0.6390.48
46_L154_Y0.6370.47
167_I179_K0.6330.47
67_M74_Y0.6330.47
60_L137_L0.6330.47
55_E58_D0.6320.47
78_F164_E0.6310.47
132_I136_H0.6300.47
88_E145_R0.6300.47
61_E136_H0.6280.47
151_I154_Y0.6280.47
50_D54_E0.6280.47
105_Q146_E0.6270.46
41_V105_Q0.6260.46
126_R160_E0.6230.46
37_D122_D0.6220.46
77_M90_G0.6210.46
168_L171_R0.6170.45
86_A106_I0.6150.45
36_E40_A0.6140.45
3_L137_L0.6130.45
65_E176_E0.6060.44
151_I157_E0.6060.44
67_M77_M0.6030.44
43_E158_L0.6000.44
133_L169_Y0.6000.44
72_V113_S0.5970.43
137_L140_E0.5930.43
42_L137_L0.5920.43
43_E100_N0.5910.43
44_E51_E0.5890.42
50_D147_V0.5880.42
37_D113_S0.5840.42
13_R17_R0.5800.42
46_L53_N0.5730.41
77_M80_R0.5690.40
107_L118_V0.5680.40
58_D78_F0.5650.40
55_E66_Y0.5650.40
149_E152_K0.5620.40
86_A122_D0.5560.39
147_V173_Y0.5550.39
71_G165_W0.5540.39
152_K157_E0.5530.39
6_E17_R0.5510.39
102_I106_I0.5510.39
103_S129_I0.5490.38
72_V94_A0.5480.38
173_Y181_G0.5440.38
45_Y134_T0.5430.38
61_E84_K0.5430.38
74_Y152_K0.5410.38
85_L90_G0.5390.37
158_L161_G0.5390.37
52_L92_I0.5380.37
49_E90_G0.5370.37
70_E157_E0.5330.37
24_D125_V0.5330.37
128_K132_I0.5320.37
107_L178_R0.5310.37
8_I11_I0.5280.36
141_E173_Y0.5250.36
104_H130_V0.5190.35
155_K168_L0.5190.35
60_L97_D0.5170.35
125_V162_T0.5170.35
3_L15_I0.5160.35
113_S162_T0.5160.35
101_D119_F0.5150.35
119_F124_E0.5130.35
98_R150_K0.5110.35
71_G74_Y0.5070.34
103_S171_R0.5070.34
76_E108_E0.5060.34
129_I133_L0.5030.34
152_K172_Y0.5020.34
75_Q78_F0.5020.34
16_V20_V0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h0lB 1 0.2253 23.2 0.942 Contact Map
3n8iA 1 0.3462 18.7 0.944 Contact Map
4yvqA 2 0.4341 17.5 0.945 Contact Map
2hz7A 1 0 17 0.945 Contact Map
3rofA 1 0.3626 13.8 0.947 Contact Map
1q1vA 1 0.3791 12.9 0.948 Contact Map
3ip4B 1 0.6099 12.3 0.949 Contact Map
1ileA 1 0.3516 12 0.949 Contact Map
3al0B 1 0.5714 11.6 0.949 Contact Map
2gi4A 1 0.3407 10.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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