GREMLIN Database
DUF502 - Protein of unknown function (DUF502)
PFAM: PF04367 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (103)
Sequences: 25528 (15157)
Seq/√Len: 1493.4
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_E72_W2.8751.00
62_V75_G2.4611.00
62_V77_V2.3801.00
98_T101_N2.3671.00
8_L12_L2.2781.00
68_R71_I2.2741.00
72_W91_L2.1931.00
27_E44_K2.0451.00
65_E68_R2.0141.00
98_T103_T1.9741.00
21_R25_L1.9401.00
21_R24_R1.9291.00
65_E70_G1.8851.00
77_V92_V1.8631.00
31_E41_S1.7891.00
65_E69_K1.7801.00
64_V96_V1.7631.00
16_N19_G1.7381.00
87_T91_L1.7311.00
6_L10_V1.7231.00
28_R32_R1.6071.00
44_K48_E1.6061.00
79_G93_A1.5971.00
64_V75_G1.5631.00
60_K80_E1.5491.00
12_L16_N1.5391.00
75_G94_V1.4721.00
83_G86_G1.4111.00
47_V51_F1.3931.00
58_F76_F1.3691.00
26_G29_L1.3611.00
73_S98_T1.3531.00
25_L29_L1.3171.00
66_Y69_K1.3001.00
98_T102_P1.2831.00
26_G30_L1.2831.00
81_D93_A1.2761.00
25_L28_R1.2521.00
27_E31_E1.2451.00
3_T7_I1.2271.00
11_G15_S1.2041.00
66_Y71_I1.1841.00
73_S96_V1.1821.00
75_G96_V1.1821.00
60_K77_V1.1331.00
14_A23_L1.1081.00
88_G91_L1.0851.00
95_F103_T1.0631.00
24_R28_R1.0521.00
35_L38_S1.0521.00
38_S41_S1.0411.00
62_V94_V1.0311.00
87_T90_D1.0281.00
34_P39_I1.0241.00
54_S57_S0.9891.00
67_P73_S0.9771.00
82_L90_D0.9651.00
99_T103_T0.9351.00
61_V74_I0.9221.00
31_E37_R0.9201.00
66_Y73_S0.9201.00
2_L5_L0.9171.00
82_L85_V0.8931.00
67_P70_G0.8911.00
4_L8_L0.8871.00
86_G91_L0.8761.00
17_F21_R0.8701.00
20_R24_R0.8681.00
97_P100_P0.8611.00
43_V47_V0.8591.00
23_L27_E0.8561.00
80_E90_D0.8491.00
82_L86_G0.8461.00
73_S102_P0.8421.00
49_T58_F0.8411.00
16_N21_R0.8401.00
69_K72_W0.8241.00
2_L6_L0.8231.00
45_Q48_E0.8191.00
29_L32_R0.8031.00
80_E92_V0.7881.00
63_L72_W0.7871.00
42_S49_T0.7751.00
38_S42_S0.7711.00
66_Y70_G0.7671.00
31_E44_K0.7661.00
1_L4_L0.7641.00
5_L9_L0.7621.00
84_E87_T0.7531.00
52_G55_K0.7451.00
10_V14_A0.7291.00
28_R31_E0.7191.00
49_T52_G0.7161.00
63_L74_I0.7151.00
18_I21_R0.7121.00
23_L26_G0.7061.00
59_K80_E0.7061.00
64_V71_I0.7031.00
95_F100_P0.6931.00
5_L8_L0.6911.00
37_R41_S0.6901.00
67_P71_I0.6861.00
100_P103_T0.6831.00
83_G87_T0.6781.00
27_E40_Y0.6771.00
42_S46_L0.6731.00
61_V76_F0.6711.00
8_L11_G0.6711.00
36_V40_Y0.6611.00
12_L15_S0.6571.00
77_V94_V0.6561.00
15_S19_G0.6561.00
17_F20_R0.6551.00
33_I36_V0.6421.00
23_L44_K0.6401.00
16_N20_R0.6391.00
9_L12_L0.6311.00
29_L34_P0.6281.00
83_G89_E0.6251.00
81_D85_V0.6241.00
82_L93_A0.6231.00
57_S79_G0.6181.00
39_I42_S0.6181.00
37_R42_S0.6111.00
7_I11_G0.5901.00
41_S49_T0.5891.00
85_V91_L0.5891.00
6_L9_L0.5871.00
99_T102_P0.5821.00
53_D56_K0.5771.00
81_D90_D0.5771.00
37_R51_F0.5721.00
14_A49_T0.5651.00
20_R27_E0.5621.00
84_E88_G0.5621.00
85_V88_G0.5551.00
25_L32_R0.5461.00
51_F58_F0.5451.00
11_G14_A0.5431.00
95_F101_N0.5431.00
78_T95_F0.5401.00
78_T99_T0.5391.00
3_T6_L0.5361.00
21_R26_G0.5341.00
9_L13_L0.5301.00
56_K59_K0.5181.00
58_F77_V0.5161.00
35_L39_I0.5161.00
78_T93_A0.5101.00
81_D86_G0.5081.00
21_R28_R0.5071.00
22_L25_L0.5061.00
32_R35_L0.5041.00
40_Y44_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fokA 1 0.3077 4.8 0.911 Contact Map
4cq4A 4 0.5962 3.7 0.916 Contact Map
3o3mB 1 0.5769 3.4 0.918 Contact Map
3tqoA 1 0.3558 3.1 0.919 Contact Map
3x2dB 3 0.6827 2.9 0.92 Contact Map
4k0mC 1 0.4712 2.8 0.921 Contact Map
2fyuK 1 0.2596 2.6 0.922 Contact Map
3f6dA 2 0.4808 2.4 0.924 Contact Map
1scfA 4 0 2.4 0.924 Contact Map
4gycB 2 0.1827 2.1 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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