GREMLIN Database
Ysc84 - Las17-binding protein actin regulator
PFAM: PF04366 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (121)
Sequences: 17735 (8758)
Seq/√Len: 796.2
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_D27_D3.2811.00
18_L65_I3.0761.00
93_E99_K3.0701.00
88_D91_A2.8011.00
20_V25_G2.4771.00
118_R122_A2.4101.00
24_R27_D2.2881.00
24_R64_E2.2721.00
107_S110_V2.1111.00
101_T104_D2.0861.00
115_A118_R1.9661.00
37_L43_V1.8761.00
103_R107_S1.8631.00
92_N105_I1.8421.00
22_N25_G1.7821.00
113_P121_L1.7231.00
20_V65_I1.7121.00
118_R121_L1.6741.00
57_T60_K1.6381.00
62_R72_R1.6031.00
15_D70_R1.5941.00
104_D109_K1.5891.00
117_A121_L1.5721.00
119_P123_A1.5051.00
24_R28_S1.4871.00
104_D107_S1.4861.00
100_V104_D1.4801.00
57_T61_M1.4411.00
22_N64_E1.4351.00
119_P122_A1.4121.00
91_A94_A1.4051.00
53_S67_S1.3791.00
27_D103_R1.3571.00
21_M66_L1.3511.00
31_S60_K1.3431.00
95_L116_A1.3211.00
20_V26_V1.3161.00
87_P102_A1.2991.00
28_S62_R1.2971.00
31_S103_R1.2971.00
19_L66_L1.2641.00
58_D61_M1.2351.00
107_S111_P1.2301.00
92_N102_A1.2271.00
28_S60_K1.1761.00
12_Q44_A1.1641.00
13_A72_R1.1551.00
36_K81_E1.1541.00
122_A125_N1.1481.00
28_S31_S1.1451.00
12_Q42_S1.1331.00
104_D108_G1.1221.00
121_L125_N1.1201.00
19_L68_Y1.0731.00
113_P118_R1.0721.00
4_S79_S1.0681.00
8_Q75_F1.0471.00
27_D31_S1.0461.00
100_V110_V1.0341.00
116_A119_P1.0341.00
98_K104_D1.0291.00
121_L124_L1.0271.00
18_L67_S1.0181.00
89_D99_K1.0171.00
114_P117_A1.0161.00
55_A81_E1.0071.00
108_G111_P1.0051.00
87_P92_N0.9791.00
43_V67_S0.9611.00
90_D94_A0.9591.00
120_L123_A0.9471.00
2_G83_A0.9451.00
4_S8_Q0.9411.00
34_K86_R0.9371.00
7_L78_V0.9201.00
59_A63_A0.9101.00
44_A71_S0.9071.00
27_D30_L0.9011.00
14_T71_S0.8931.00
89_D101_T0.8921.00
46_G68_Y0.8891.00
60_K63_A0.8771.00
115_A119_P0.8621.00
32_S89_D0.8571.00
47_P68_Y0.8501.00
57_T63_A0.8451.00
90_D93_E0.8431.00
29_L85_L0.8421.00
89_D93_E0.8391.00
113_P117_A0.8291.00
37_L65_I0.8281.00
47_P66_L0.8191.00
9_I76_A0.8151.00
28_S64_E0.8081.00
32_S60_K0.7951.00
42_S71_S0.7861.00
59_A62_R0.7831.00
110_V113_P0.7831.00
38_G81_E0.7771.00
100_V105_I0.7711.00
7_L79_S0.7571.00
114_P118_R0.7551.00
75_F79_S0.7551.00
28_S40_D0.7551.00
20_V87_P0.7521.00
99_K104_D0.7521.00
34_K84_V0.7341.00
43_V76_A0.7331.00
41_A52_A0.7281.00
95_L117_A0.7261.00
92_N100_V0.7251.00
95_L99_K0.7251.00
95_L120_L0.7241.00
93_E98_K0.7231.00
8_Q77_G0.7201.00
35_F41_A0.7181.00
42_S51_T0.7171.00
41_A78_V0.7141.00
47_P70_R0.7121.00
32_S87_P0.7081.00
95_L114_P0.7071.00
118_R125_N0.7051.00
16_L80_L0.6991.00
34_K87_P0.6851.00
100_V111_P0.6801.00
4_S81_E0.6801.00
91_A95_L0.6771.00
20_V29_L0.6751.00
109_K125_N0.6751.00
111_P114_P0.6721.00
58_D62_R0.6641.00
6_G10_G0.6621.00
36_K83_A0.6531.00
39_A54_A0.6531.00
89_D102_A0.6491.00
16_L69_S0.6471.00
50_R54_A0.6391.00
95_L98_K0.6381.00
44_A49_G0.6371.00
23_D26_V0.6271.00
30_L102_A0.6261.00
98_K110_V0.6261.00
2_G11_G0.6231.00
3_G11_G0.6211.00
7_L76_A0.6191.00
36_K55_A0.6161.00
5_F8_Q0.6121.00
31_S34_K0.6091.00
40_D81_E0.6051.00
26_V84_V0.6031.00
18_L80_L0.6001.00
58_D64_E0.5991.00
37_L85_L0.5991.00
89_D100_V0.5971.00
2_G50_R0.5931.00
84_V88_D0.5911.00
57_T62_R0.5871.00
100_V109_K0.5861.00
2_G6_G0.5821.00
67_S79_S0.5721.00
111_P115_A0.5711.00
52_A68_Y0.5681.00
9_I74_L0.5631.00
21_M25_G0.5611.00
42_S64_E0.5601.00
47_P67_S0.5561.00
21_M29_L0.5511.00
14_T69_S0.5481.00
45_A77_G0.5371.00
8_Q79_S0.5371.00
102_A106_L0.5341.00
73_G77_G0.5241.00
55_A60_K0.5231.00
26_V30_L0.5201.00
120_L124_L0.5161.00
32_S86_R0.5151.00
38_G55_A0.5121.00
79_S120_L0.5041.00
79_S83_A0.5031.00
43_V48_V0.5021.00
12_Q71_S0.5011.00
111_P118_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d1zA 1 0.5238 7 0.914 Contact Map
1xkmA 2 0.1429 3.7 0.925 Contact Map
3h5nA 3 0.5397 3.6 0.925 Contact Map
1v0lA 1 0.5159 3.6 0.925 Contact Map
4pmxA 1 0.4921 3.4 0.926 Contact Map
1i1wA 1 0.5317 3.2 0.927 Contact Map
1qw2A 3 0.7302 2.8 0.929 Contact Map
3bboW 1 0 2.8 0.929 Contact Map
2gkpA 1 0.4762 2.6 0.93 Contact Map
3ds4A 2 0.2222 2.4 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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