GREMLIN Database
DUF490 - Family of unknown function (DUF490)
PFAM: PF04357 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 383 (354)
Sequences: 19913 (15283)
Seq/√Len: 812.3
META: 0.853

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_E208_E3.8951.00
34_T53_D3.6011.00
35_A52_G3.2341.00
206_T229_N3.0401.00
200_N235_D2.9651.00
68_D132_D2.9251.00
241_F252_I2.8801.00
149_E174_R2.7851.00
51_S72_D2.7341.00
32_T55_T2.5701.00
169_R190_T2.5571.00
274_A277_L2.5361.00
210_R225_T2.4741.00
200_N233_T2.4421.00
187_E206_T2.4291.00
208_E225_T2.4071.00
188_R204_D2.3581.00
56_L65_L2.3491.00
282_L285_L2.3321.00
130_D155_R2.3301.00
30_D55_T2.3091.00
55_T66_S2.2951.00
277_L281_A2.2831.00
30_D57_T2.2791.00
176_T183_R2.2771.00
333_L355_Y2.2531.00
70_T134_E2.2531.00
151_G173_V2.2451.00
281_A285_L2.1991.00
285_L289_Q2.1871.00
68_D134_E2.1731.00
93_D97_V2.0941.00
71_V74_G2.0901.00
178_N183_R2.0661.00
231_T240_T2.0631.00
134_E153_D2.0561.00
169_R192_T1.9981.00
206_T227_G1.9821.00
37_N72_D1.9801.00
132_D153_D1.9741.00
64_T128_D1.9631.00
202_T233_T1.9191.00
190_T204_D1.8951.00
132_D155_R1.8891.00
326_G334_Y1.8631.00
13_L38_F1.8571.00
278_A281_A1.8461.00
172_L189_G1.8381.00
204_D231_T1.8251.00
229_N240_T1.8231.00
16_S32_T1.8001.00
208_E227_G1.7981.00
188_R206_T1.7761.00
270_L273_A1.7721.00
229_N242_S1.7471.00
18_T30_D1.7261.00
286_L289_Q1.7211.00
156_L166_L1.7211.00
200_N234_L1.7041.00
300_D327_K1.6811.00
231_T238_E1.6791.00
171_E190_T1.6761.00
227_G242_S1.6651.00
358_T362_S1.6631.00
93_D96_F1.6341.00
358_T361_L1.6261.00
269_Q273_A1.6221.00
142_D147_D1.6121.00
150_G170_Y1.6111.00
328_Y334_Y1.5951.00
39_R42_N1.5901.00
20_D28_R1.5891.00
57_T66_S1.5801.00
15_L33_L1.5771.00
289_Q292_Q1.5711.00
182_K209_Y1.5511.00
135_L152_G1.5421.00
57_T64_T1.5341.00
270_L274_A1.5311.00
354_E364_R1.5301.00
35_A38_F1.5291.00
6_R12_T1.5111.00
261_P265_L1.5041.00
262_L265_L1.4851.00
142_D145_G1.4691.00
54_L67_G1.4521.00
277_L280_S1.4441.00
48_G74_G1.4391.00
157_R165_R1.4351.00
151_G171_E1.4261.00
29_L58_G1.4121.00
147_D176_T1.4071.00
176_T185_T1.4011.00
148_A172_L1.3991.00
56_L63_L1.3911.00
224_V247_L1.3881.00
74_G139_L1.3861.00
303_D306_P1.3811.00
73_R138_D1.3781.00
240_T249_Q1.3771.00
17_G31_L1.3761.00
39_R49_T1.3721.00
93_D98_D1.3661.00
32_T53_D1.3651.00
226_V256_L1.3621.00
273_A277_L1.3581.00
135_L139_L1.3521.00
275_A278_A1.3451.00
225_T244_D1.3371.00
66_S130_D1.3161.00
261_P264_E1.3151.00
274_A278_A1.3101.00
271_A274_A1.3051.00
232_G238_E1.2941.00
14_T34_T1.2891.00
93_D99_P1.2681.00
157_R167_T1.2571.00
204_D229_N1.2561.00
305_D322_R1.2531.00
36_D51_S1.2511.00
5_A13_L1.2461.00
281_A284_G1.2241.00
333_L353_L1.2241.00
275_A279_G1.2231.00
86_L89_S1.2071.00
330_S333_L1.2051.00
95_V98_D1.2011.00
152_G170_Y1.1921.00
306_P309_D1.1911.00
129_L133_V1.1891.00
96_F99_P1.1891.00
192_T202_T1.1771.00
336_T352_T1.1711.00
29_L60_L1.1691.00
140_I149_E1.1651.00
273_A276_S1.1641.00
272_Q275_A1.1621.00
273_A280_S1.1601.00
29_L63_L1.1571.00
23_G26_D1.1571.00
158_G164_P1.1511.00
284_G289_Q1.1511.00
280_S284_G1.1481.00
149_E173_V1.1471.00
234_L237_P1.1401.00
51_S70_T1.1321.00
211_V255_L1.1261.00
9_G50_V1.1241.00
283_S286_L1.1201.00
270_L277_L1.1061.00
16_S34_T1.1051.00
12_T36_D1.1031.00
166_L193_F1.1031.00
334_Y356_R1.1031.00
66_S124_N1.1021.00
125_L129_L1.1001.00
187_E227_G1.0891.00
203_L237_P1.0811.00
279_G282_L1.0771.00
268_A272_Q1.0741.00
248_P252_I1.0681.00
206_T242_S1.0621.00
285_L288_G1.0611.00
96_F100_E1.0581.00
62_A128_D1.0571.00
52_G69_V1.0571.00
270_L281_A1.0561.00
194_T202_T1.0551.00
156_L164_P1.0541.00
22_D26_D1.0531.00
335_V353_L1.0501.00
255_L261_P1.0481.00
276_S280_S1.0461.00
54_L131_L1.0451.00
287_S291_N1.0421.00
28_R59_P1.0351.00
121_L124_N1.0211.00
328_Y331_D1.0181.00
357_L363_L1.0151.00
36_D53_D1.0091.00
301_D304_I1.0081.00
324_T338_G1.0001.00
224_V255_L0.9971.00
226_V252_I0.9961.00
94_V98_D0.9931.00
339_T342_G0.9931.00
37_N49_T0.9901.00
49_T73_R0.9901.00
123_L126_N0.9901.00
247_L255_L0.9831.00
59_P62_A0.9661.00
195_G200_N0.9561.00
122_D125_L0.9551.00
22_D25_K0.9481.00
243_S246_P0.9461.00
305_D308_D0.9451.00
97_V100_E0.9421.00
95_V99_P0.9401.00
332_R355_Y0.9381.00
201_P234_L0.9311.00
269_Q272_Q0.9271.00
323_V327_K0.9251.00
40_L50_V0.9241.00
77_T80_P0.9211.00
342_G345_G0.9161.00
196_D200_N0.9111.00
185_T208_E0.9101.00
308_D311_T0.9091.00
121_L131_L0.9071.00
193_F201_P0.9061.00
301_D326_G0.9061.00
276_S279_G0.8931.00
130_D157_R0.8921.00
21_L24_F0.8911.00
186_I205_I0.8901.00
273_A279_G0.8871.00
273_A278_A0.8871.00
272_Q276_S0.8861.00
211_V222_Q0.8841.00
94_V97_V0.8831.00
293_L296_A0.8781.00
14_T36_D0.8771.00
21_L27_P0.8761.00
11_G37_N0.8701.00
271_A275_A0.8681.00
272_Q277_L0.8671.00
63_L127_L0.8651.00
203_L230_V0.8641.00
288_G291_N0.8631.00
189_G205_I0.8621.00
225_T243_S0.8611.00
268_A271_A0.8601.00
274_A279_G0.8581.00
357_L361_L0.8571.00
75_T142_D0.8561.00
243_S252_I0.8561.00
44_P47_R0.8551.00
283_S287_S0.8551.00
301_D305_D0.8541.00
39_R47_R0.8531.00
43_T48_G0.8511.00
9_G39_R0.8491.00
15_L19_I0.8471.00
287_S290_L0.8441.00
227_G244_D0.8431.00
267_A273_A0.8431.00
45_D143_G0.8431.00
282_L286_L0.8401.00
248_P251_Q0.8391.00
261_P266_S0.8381.00
361_L368_G0.8351.00
15_L18_T0.8311.00
251_Q255_L0.8281.00
350_D366_K0.8241.00
76_I134_E0.8231.00
134_E149_E0.8231.00
361_L377_L0.8221.00
363_L377_L0.8211.00
85_S89_S0.8181.00
368_G371_N0.8161.00
43_T46_L0.8161.00
116_A120_G0.8141.00
273_A281_A0.8141.00
280_S285_L0.8141.00
356_R359_R0.8121.00
269_Q277_L0.8121.00
53_D68_D0.8111.00
114_P117_A0.8101.00
345_G348_Q0.8071.00
8_S42_N0.8021.00
184_F256_L0.8021.00
364_R378_F0.8001.00
140_I147_D0.7961.00
274_A280_S0.7961.00
304_I307_G0.7951.00
251_Q261_P0.7891.00
187_E225_T0.7851.00
184_F209_Y0.7821.00
269_Q278_A0.7731.00
303_D324_T0.7711.00
49_T72_D0.7691.00
352_T366_K0.7691.00
131_L135_L0.7661.00
281_A289_Q0.7651.00
356_R361_L0.7631.00
224_V245_P0.7611.00
281_A287_S0.7601.00
211_V226_V0.7601.00
121_L125_L0.7591.00
311_T314_D0.7561.00
230_V239_I0.7561.00
274_A281_A0.7561.00
285_L292_Q0.7561.00
278_A282_L0.7541.00
148_A186_I0.7531.00
19_I29_L0.7511.00
19_I27_P0.7491.00
35_A51_S0.7481.00
123_L131_L0.7471.00
58_G63_L0.7471.00
89_S93_D0.7471.00
223_D255_L0.7451.00
66_S128_D0.7441.00
58_G62_A0.7421.00
6_R10_G0.7421.00
299_L327_K0.7411.00
75_T140_I0.7401.00
160_P163_D0.7391.00
267_A272_Q0.7311.00
186_I207_A0.7311.00
119_T122_D0.7301.00
338_G352_T0.7291.00
272_Q280_S0.7281.00
166_L199_I0.7281.00
247_L252_I0.7271.00
334_Y354_E0.7241.00
254_S258_F0.7241.00
322_R338_G0.7211.00
120_G123_L0.7201.00
196_D199_I0.7201.00
301_D334_Y0.7191.00
307_G310_G0.7181.00
228_L241_F0.7131.00
209_Y256_L0.7101.00
188_R229_N0.7091.00
371_N374_S0.7061.00
276_S281_A0.7051.00
269_Q274_A0.7041.00
203_L233_T0.7041.00
195_G198_L0.7031.00
254_S262_L0.7031.00
267_A271_A0.7021.00
284_G287_S0.7011.00
159_T163_D0.6981.00
123_L127_L0.6951.00
340_G343_L0.6901.00
15_L31_L0.6891.00
309_D312_G0.6881.00
267_A270_L0.6861.00
262_L266_S0.6821.00
288_G292_Q0.6821.00
360_R381_K0.6811.00
251_Q262_L0.6811.00
130_D133_V0.6811.00
303_D308_D0.6791.00
79_P82_L0.6791.00
33_L54_L0.6771.00
277_L285_L0.6761.00
210_R223_D0.6741.00
54_L65_L0.6731.00
338_G350_D0.6721.00
249_Q252_I0.6721.00
117_A120_G0.6721.00
76_I79_P0.6711.00
94_V99_P0.6711.00
165_R199_I0.6701.00
70_T128_D0.6671.00
42_N47_R0.6671.00
95_V100_E0.6671.00
154_L166_L0.6671.00
270_L280_S0.6651.00
141_V146_L0.6631.00
59_P63_L0.6591.00
15_L21_L0.6581.00
60_L63_L0.6571.00
344_G347_Q0.6561.00
47_R73_R0.6511.00
270_L278_A0.6511.00
263_S266_S0.6491.00
78_L143_G0.6491.00
83_A87_A0.6451.00
154_L201_P0.6441.00
271_A278_A0.6441.00
172_L186_I0.6431.00
301_D324_T0.6431.00
284_G288_G0.6421.00
22_D28_R0.6401.00
272_Q278_A0.6401.00
62_A126_N0.6391.00
269_Q276_S0.6391.00
24_F27_P0.6381.00
356_R362_S0.6361.00
361_L366_K0.6361.00
185_T210_R0.6361.00
138_D149_E0.6351.00
126_N129_L0.6331.00
233_T236_K0.6331.00
268_A280_S0.6331.00
93_D100_E0.6311.00
158_G161_A0.6301.00
29_L33_L0.6291.00
299_L302_L0.6281.00
94_V100_E0.6271.00
341_V344_G0.6271.00
23_G27_P0.6261.00
64_T122_D0.6221.00
354_E380_R0.6211.00
305_D324_T0.6201.00
154_L193_F0.6201.00
138_D147_D0.6191.00
113_E116_A0.6191.00
175_G186_I0.6171.00
281_A286_L0.6141.00
332_R356_R0.6141.00
280_S283_S0.6131.00
279_G285_L0.6111.00
279_G283_S0.6111.00
352_T364_R0.6101.00
211_V224_V0.6091.00
20_D27_P0.6071.00
343_L346_S0.6061.00
83_A86_L0.6051.00
272_Q279_G0.6051.00
303_D307_G0.6041.00
271_A280_S0.6011.00
39_R43_T0.6011.00
227_G243_S0.6001.00
75_T138_D0.6001.00
114_P120_G0.5991.00
278_A284_G0.5971.00
273_A282_L0.5971.00
292_Q296_A0.5961.00
140_I174_R0.5941.00
32_T57_T0.5921.00
305_D310_G0.5921.00
166_L198_L0.5911.00
158_G162_G0.5901.00
184_F207_A0.5891.00
81_L84_S0.5881.00
8_S11_G0.5871.00
251_Q258_F0.5871.00
298_G304_I0.5871.00
129_L135_L0.5861.00
279_G284_G0.5861.00
180_Y257_L0.5841.00
127_L133_V0.5831.00
367_A370_R0.5831.00
367_A373_S0.5821.00
208_E242_S0.5821.00
131_L173_V0.5801.00
357_L377_L0.5801.00
77_T142_D0.5801.00
275_A281_A0.5801.00
148_A175_G0.5791.00
155_R167_T0.5761.00
336_T354_E0.5751.00
46_L76_I0.5741.00
167_T195_G0.5731.00
310_G314_D0.5721.00
277_L289_Q0.5721.00
159_T162_G0.5701.00
306_P311_T0.5701.00
22_D27_P0.5691.00
298_G303_D0.5671.00
354_E362_S0.5661.00
301_D336_T0.5651.00
307_G311_T0.5631.00
270_L276_S0.5621.00
285_L290_L0.5611.00
211_V223_D0.5601.00
189_G206_T0.5601.00
271_A276_S0.5591.00
72_D136_G0.5571.00
40_L43_T0.5561.00
24_F28_R0.5561.00
294_G297_L0.5551.00
329_L335_V0.5521.00
361_L367_A0.5521.00
29_L59_P0.5521.00
211_V256_L0.5511.00
129_L158_G0.5491.00
166_L170_Y0.5481.00
122_D126_N0.5481.00
135_L138_D0.5461.00
299_L304_I0.5431.00
134_E137_D0.5421.00
378_F381_K0.5421.00
330_S334_Y0.5411.00
136_G149_E0.5411.00
270_L285_L0.5401.00
277_L282_L0.5401.00
174_R185_T0.5391.00
339_T343_L0.5371.00
270_L275_A0.5371.00
269_Q280_S0.5361.00
37_N51_S0.5361.00
301_D306_P0.5361.00
324_T327_K0.5351.00
76_I80_P0.5341.00
275_A285_L0.5321.00
268_A273_A0.5311.00
362_S381_K0.5281.00
279_G289_Q0.5281.00
249_Q253_L0.5281.00
64_T130_D0.5271.00
131_L151_G0.5271.00
162_G165_R0.5271.00
37_N73_R0.5261.00
327_K337_Y0.5261.00
23_G28_R0.5231.00
379_Y383_F0.5211.00
203_L231_T0.5211.00
269_Q281_A0.5211.00
224_V252_I0.5201.00
329_L333_L0.5201.00
247_L251_Q0.5191.00
308_D319_T0.5171.00
360_R379_Y0.5161.00
54_L69_V0.5151.00
280_S289_Q0.5151.00
298_G301_D0.5141.00
195_G199_I0.5131.00
267_A280_S0.5131.00
145_G177_Y0.5121.00
65_L131_L0.5111.00
278_A285_L0.5101.00
352_T370_R0.5101.00
321_A324_T0.5101.00
191_I203_L0.5091.00
282_L287_S0.5091.00
270_L279_G0.5091.00
337_Y340_G0.5091.00
68_D126_N0.5071.00
342_G346_S0.5061.00
322_R326_G0.5041.00
5_A11_G0.5041.00
167_T194_T0.5031.00
246_P252_I0.5021.00
269_Q279_G0.5011.00
125_L133_V0.5001.00
251_Q263_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3petA 2 0.2376 11.7 0.956 Contact Map
4opwA 1 0.2402 10.1 0.957 Contact Map
3jx8A 4 0.2402 10.1 0.957 Contact Map
3lycA 2 0.2715 9.3 0.958 Contact Map
3nb3A 2 0.3029 7.8 0.959 Contact Map
4yguA 3 0.2298 7.6 0.96 Contact Map
2jmmA 1 0.1488 5.9 0.962 Contact Map
2wjrA 1 0.282 5.6 0.962 Contact Map
1txyA 2 0.0888 4.5 0.964 Contact Map
4qq0A 1 0.1044 4.4 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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