EutH - PFAM28P - GREMLIN Contacts

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EutH - Ethanolamine utilisation protein, EutH

PFAM:	PF04346	Sequences: INEIIIYIMMIFMVLGAIDKILGNKFGLGEKFEEGFMAMGPLALAMVGIIALAPVLAKLLSPVIVPLYTALGADPAMFATTLLANDMGGYPLAMELAQDPEAGLFAGLILGSMMGATIVFTIPVALGIIEKEDHKYLAKGILAGIITIPIGCLVGGLVAGLSLGMILRNLIPVIIFAVLIALGLWFIPDKMIKGFLVFGKGIVIVITIGLAAAIVEYLTGIVIIPGMAPIEEGLEIVGSIAIVLAGAFPMVYLITKVLKKPLEKLGKKLGMNEVAAAGLLATLANNIPMFGMMKDMDPRGKVINVAFAVSAAFVFGDHLGFTAGVQPEMIFPMIVGKLVGGITAVILALLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	351 (350)
Sequences:	720 (486)
Seq/√Len:	26.0
META:	0.519

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
272_N	297_D	4.824	1.00
28_L	253_L	4.813	1.00
31_K	34_E	4.673	1.00
20_K	33_E	4.583	1.00
17_A	211_A	4.518	1.00
136_Y	298_P	4.006	1.00
133_D	301_K	3.904	1.00
80_T	106_A	3.429	1.00
12_F	253_L	3.336	1.00
39_M	241_A	3.308	1.00
97_A	103_G	3.289	1.00
293_M	305_V	3.182	1.00
90_Y	326_Q	2.958	1.00
85_N	322_T	2.937	1.00
258_L	261_P	2.824	1.00
22_L	26_F	2.748	0.99
68_Y	81_T	2.707	0.99
147_T	150_I	2.624	0.99
285_N	317_D	2.589	0.99
52_L	209_G	2.557	0.99
85_N	108_L	2.510	0.99
161_L	165_M	2.506	0.99
153_L	170_L	2.503	0.99
289_M	304_N	2.503	0.99
130_E	294_K	2.483	0.99
182_L	186_F	2.403	0.99
102_A	161_L	2.372	0.98
254_I	258_L	2.310	0.98
94_M	103_G	2.292	0.98
150_I	343_T	2.276	0.98
154_V	339_V	2.190	0.97
117_T	309_V	2.178	0.97
187_I	190_K	2.160	0.97
102_A	165_M	2.151	0.97
81_T	176_F	2.146	0.97
279_L	345_V	2.082	0.96
113_M	151_G	2.065	0.96
51_A	213_A	2.055	0.96
311_A	317_D	1.963	0.95
61_S	96_L	1.959	0.95
318_H	333_M	1.956	0.95
264_K	267_K	1.948	0.95
179_L	194_G	1.937	0.95
4_I	8_I	1.925	0.94
20_K	207_T	1.898	0.94
191_M	194_G	1.835	0.93
212_A	224_I	1.834	0.93
105_F	152_C	1.833	0.93
108_L	333_M	1.814	0.92
190_K	194_G	1.801	0.92
147_T	344_A	1.798	0.92
84_A	87_M	1.773	0.91
145_I	180_I	1.749	0.91
322_T	333_M	1.725	0.90
252_Y	256_K	1.709	0.90
275_A	300_G	1.708	0.90
135_K	139_K	1.702	0.90
285_N	311_A	1.700	0.90
21_I	312_A	1.697	0.90
14_V	211_A	1.670	0.89
201_G	205_V	1.657	0.88
131_K	134_H	1.645	0.88
175_I	342_I	1.643	0.88
214_I	245_A	1.612	0.87
24_N	29_G	1.597	0.86
21_I	208_I	1.558	0.85
314_V	334_I	1.551	0.85
6_I	243_V	1.543	0.84
271_M	297_D	1.543	0.84
18_I	24_N	1.538	0.84
147_T	310_S	1.513	0.83
33_E	203_V	1.500	0.83
203_V	207_T	1.469	0.81
18_I	22_L	1.463	0.81
56_L	71_L	1.442	0.80
187_I	191_M	1.436	0.80
210_L	245_A	1.436	0.80
213_A	217_Y	1.432	0.80
334_I	338_L	1.429	0.79
312_A	315_F	1.428	0.79
37_M	41_P	1.425	0.79
113_M	148_I	1.421	0.79
12_F	250_M	1.420	0.79
90_Y	219_T	1.403	0.78
142_L	180_I	1.393	0.78
24_N	30_E	1.392	0.78
80_T	107_G	1.387	0.77
281_A	289_M	1.385	0.77
22_L	28_L	1.379	0.77
247_A	251_V	1.379	0.77
307_F	311_A	1.378	0.77
193_K	267_K	1.375	0.77
110_L	180_I	1.372	0.77
71_L	168_R	1.367	0.76
147_T	343_T	1.360	0.76
84_A	119_V	1.358	0.76
268_K	275_A	1.350	0.75
107_G	112_S	1.341	0.75
94_M	100_P	1.319	0.74
80_T	111_G	1.289	0.72
87_M	119_V	1.284	0.72
105_F	170_L	1.273	0.71
42_L	317_D	1.272	0.71
216_E	219_T	1.267	0.71
190_K	193_K	1.265	0.70
282_T	304_N	1.263	0.70
171_I	339_V	1.262	0.70
311_A	314_V	1.261	0.70
253_L	257_V	1.248	0.69
121_T	286_N	1.233	0.68
313_F	317_D	1.229	0.68
310_S	340_G	1.228	0.68
254_I	279_L	1.224	0.68
234_L	238_G	1.223	0.68
90_Y	325_V	1.218	0.67
17_A	32_F	1.211	0.67
104_L	326_Q	1.208	0.67
51_A	227_M	1.197	0.66
183_G	191_M	1.195	0.66
103_G	106_A	1.194	0.66
164_G	168_R	1.189	0.66
141_I	195_F	1.182	0.65
215_V	219_T	1.181	0.65
125_A	137_L	1.171	0.64
74_D	98_Q	1.161	0.64
266_G	270_G	1.157	0.63
278_G	304_N	1.155	0.63
10_M	218_L	1.153	0.63
31_K	252_Y	1.149	0.63
112_S	285_N	1.147	0.63
299_R	303_I	1.146	0.63
315_F	334_I	1.144	0.62
167_L	171_I	1.138	0.62
57_A	65_V	1.138	0.62
7_Y	10_M	1.129	0.61
102_A	159_A	1.128	0.61
303_I	345_V	1.124	0.61
231_E	235_E	1.121	0.61
13_M	245_A	1.121	0.61
183_G	194_G	1.118	0.61
10_M	214_I	1.111	0.60
275_A	299_R	1.109	0.60
155_G	336_G	1.106	0.60
36_F	44_L	1.103	0.60
184_L	240_I	1.096	0.59
13_M	214_I	1.090	0.59
299_R	349_L	1.087	0.58
286_N	313_F	1.081	0.58
247_A	313_F	1.080	0.58
274_V	295_D	1.069	0.57
73_A	169_N	1.061	0.57
238_G	247_A	1.054	0.56
315_F	338_L	1.050	0.56
116_A	152_C	1.043	0.55
7_Y	214_I	1.040	0.55
247_A	281_A	1.033	0.55
214_I	242_I	1.018	0.53
73_A	113_M	1.017	0.53
42_L	285_N	1.012	0.53
108_L	326_Q	1.008	0.53
36_F	245_A	1.005	0.52
113_M	336_G	1.002	0.52
212_A	225_P	0.994	0.52
219_T	222_V	0.993	0.52
307_F	313_F	0.987	0.51
250_M	254_I	0.980	0.51
143_A	303_I	0.974	0.50
76_A	79_A	0.969	0.50
84_A	318_H	0.967	0.50
39_M	43_A	0.964	0.49
44_L	210_L	0.964	0.49
138_A	195_F	0.960	0.49
44_L	49_I	0.953	0.49
51_A	233_G	0.952	0.49
110_L	325_V	0.939	0.48
175_I	208_I	0.938	0.48
114_M	286_N	0.937	0.47
216_E	226_G	0.934	0.47
33_E	43_A	0.934	0.47
108_L	322_T	0.932	0.47
107_G	285_N	0.931	0.47
19_D	25_K	0.927	0.47
188_P	250_M	0.926	0.47
154_V	343_T	0.926	0.47
85_N	112_S	0.925	0.47
36_F	173_V	0.925	0.47
9_M	13_M	0.922	0.46
115_G	337_K	0.920	0.46
67_L	71_L	0.919	0.46
179_L	256_K	0.919	0.46
212_A	223_I	0.916	0.46
90_Y	188_P	0.914	0.46
84_A	309_V	0.913	0.46
281_A	288_P	0.911	0.46
132_E	163_L	0.910	0.45
202_I	206_I	0.906	0.45
210_L	214_I	0.904	0.45
146_I	181_A	0.902	0.45
121_T	125_A	0.898	0.45
53_A	125_A	0.897	0.45
199_G	248_F	0.892	0.44
11_I	215_V	0.891	0.44
159_A	165_M	0.891	0.44
289_M	308_A	0.890	0.44
105_F	256_K	0.880	0.43
228_A	232_E	0.879	0.43
112_S	322_T	0.878	0.43
218_L	242_I	0.877	0.43
310_S	343_T	0.874	0.43
122_I	198_F	0.867	0.42
306_A	348_A	0.866	0.42
241_A	335_V	0.865	0.42
153_L	163_L	0.862	0.42
22_L	25_K	0.858	0.42
198_F	341_G	0.853	0.41
33_E	44_L	0.852	0.41
167_L	303_I	0.851	0.41
19_D	23_G	0.850	0.41
50_I	243_V	0.849	0.41
109_I	173_V	0.849	0.41
53_A	60_L	0.844	0.41
113_M	117_T	0.837	0.40
107_G	173_V	0.834	0.40
47_V	233_G	0.829	0.40
5_I	9_M	0.828	0.40
116_A	313_F	0.825	0.39
180_I	240_I	0.823	0.39
111_G	336_G	0.820	0.39
67_L	99_D	0.819	0.39
166_I	192_I	0.816	0.39
76_A	236_I	0.814	0.39
121_T	311_A	0.809	0.38
249_P	288_P	0.806	0.38
180_I	233_G	0.806	0.38
11_I	18_I	0.805	0.38
194_G	198_F	0.804	0.38
306_A	311_A	0.803	0.38
277_A	340_G	0.798	0.37
212_A	216_E	0.796	0.37
169_N	247_A	0.795	0.37
136_Y	301_K	0.794	0.37
52_L	205_V	0.794	0.37
74_D	101_E	0.792	0.37
54_P	66_P	0.790	0.37
82_L	343_T	0.790	0.37
304_N	308_A	0.787	0.37
49_I	87_M	0.785	0.37
133_D	294_K	0.784	0.36
302_V	336_G	0.777	0.36
212_A	227_M	0.773	0.36
272_N	300_G	0.771	0.36
303_I	314_V	0.767	0.35
141_I	315_F	0.767	0.35
50_I	318_H	0.767	0.35
213_A	227_M	0.767	0.35
9_M	243_V	0.765	0.35
60_L	198_F	0.765	0.35
9_M	124_V	0.764	0.35
116_A	125_A	0.763	0.35
216_E	222_V	0.761	0.35
9_M	211_A	0.759	0.35
44_L	314_V	0.758	0.35
116_A	155_G	0.758	0.35
14_V	215_V	0.757	0.35
50_I	233_G	0.757	0.35
90_Y	110_L	0.752	0.34
244_L	284_A	0.751	0.34
35_G	241_A	0.749	0.34
139_K	302_V	0.745	0.34
82_L	237_V	0.744	0.34
200_K	309_V	0.743	0.34
157_L	164_G	0.743	0.34
176_F	202_I	0.739	0.33
202_I	214_I	0.737	0.33
25_K	235_E	0.734	0.33
171_I	299_R	0.732	0.33
43_A	47_V	0.732	0.33
224_I	230_I	0.731	0.33
37_M	299_R	0.728	0.33
275_A	303_I	0.728	0.33
20_K	27_G	0.727	0.33
289_M	312_A	0.726	0.33
9_M	207_T	0.725	0.33
169_N	316_G	0.720	0.32
112_S	116_A	0.719	0.32
217_Y	231_E	0.718	0.32
55_V	227_M	0.716	0.32
61_S	65_V	0.715	0.32
197_V	204_I	0.711	0.32
77_M	213_A	0.711	0.32
80_T	118_I	0.711	0.32
63_V	96_L	0.709	0.32
240_I	309_V	0.709	0.32
80_T	89_G	0.709	0.32
242_I	279_L	0.704	0.31
12_F	313_F	0.701	0.31
281_A	307_F	0.699	0.31
33_E	46_M	0.698	0.31
11_I	15_L	0.695	0.31
33_E	107_G	0.695	0.31
28_L	252_Y	0.693	0.30
68_Y	331_F	0.692	0.30
282_T	308_A	0.691	0.30
214_I	288_P	0.691	0.30
299_R	335_V	0.690	0.30
82_L	188_P	0.686	0.30
47_V	200_K	0.686	0.30
27_G	72_G	0.686	0.30
34_E	109_I	0.684	0.30
343_T	347_L	0.683	0.30
79_A	92_L	0.681	0.30
163_L	167_L	0.681	0.30
42_L	237_V	0.680	0.30
278_G	296_M	0.680	0.30
8_I	350_L	0.677	0.30
167_L	175_I	0.674	0.29
116_A	312_A	0.673	0.29
47_V	230_I	0.672	0.29
109_I	336_G	0.671	0.29
13_M	243_V	0.669	0.29
49_I	82_L	0.669	0.29
199_G	324_G	0.668	0.29
151_G	340_G	0.664	0.29
339_V	349_L	0.664	0.29
241_A	317_D	0.662	0.29
148_I	180_I	0.661	0.29
335_V	339_V	0.661	0.29
222_V	226_G	0.660	0.28
262_L	276_A	0.660	0.28
56_L	260_K	0.655	0.28
60_L	78_F	0.650	0.28
163_L	166_I	0.649	0.28
109_I	154_V	0.645	0.28
131_K	136_Y	0.643	0.27
7_Y	221_I	0.643	0.27
8_I	67_L	0.640	0.27
16_G	32_F	0.639	0.27
56_L	129_I	0.639	0.27
128_I	287_I	0.638	0.27
61_S	125_A	0.638	0.27
85_N	103_G	0.636	0.27
318_H	337_K	0.636	0.27
90_Y	94_M	0.634	0.27
271_M	275_A	0.634	0.27
109_I	285_N	0.634	0.27
68_Y	77_M	0.633	0.27
122_I	195_F	0.633	0.27
316_G	323_A	0.632	0.27
279_L	304_N	0.632	0.27
281_A	313_F	0.632	0.27
29_G	249_P	0.630	0.27
133_D	136_Y	0.629	0.27
188_P	194_G	0.629	0.27
6_I	222_V	0.629	0.27
70_A	271_M	0.628	0.27
96_L	213_A	0.628	0.27
26_F	56_L	0.627	0.27
276_A	311_A	0.627	0.27
260_K	264_K	0.627	0.27
128_I	291_G	0.627	0.27
19_D	24_N	0.625	0.26
321_F	324_G	0.623	0.26
162_S	165_M	0.623	0.26
99_D	165_M	0.622	0.26
310_S	344_A	0.620	0.26
44_L	267_K	0.620	0.26
20_K	28_L	0.618	0.26
78_F	320_G	0.616	0.26
84_A	147_T	0.616	0.26
334_I	345_V	0.614	0.26
15_L	28_L	0.614	0.26
64_I	171_I	0.613	0.26
110_L	213_A	0.612	0.26
33_E	320_G	0.611	0.26
208_I	212_A	0.610	0.26
154_V	335_V	0.609	0.26
135_K	350_L	0.608	0.25
82_L	176_F	0.606	0.25
7_Y	215_V	0.605	0.25
180_I	308_A	0.605	0.25
216_E	220_G	0.604	0.25
92_L	119_V	0.603	0.25
60_L	96_L	0.602	0.25
226_G	229_P	0.602	0.25
55_V	63_V	0.599	0.25
71_L	335_V	0.598	0.25
112_S	317_D	0.598	0.25
145_I	214_I	0.596	0.25
205_V	209_G	0.594	0.25
76_A	97_A	0.593	0.25
33_E	210_L	0.593	0.25
12_F	28_L	0.593	0.25
77_M	317_D	0.592	0.25
232_E	235_E	0.592	0.25
131_K	135_K	0.591	0.25
38_A	42_L	0.590	0.24
94_M	332_P	0.590	0.24
182_L	189_D	0.590	0.24
6_I	31_K	0.589	0.24
146_I	269_L	0.589	0.24
54_P	220_G	0.589	0.24
47_V	234_L	0.589	0.24
163_L	254_I	0.588	0.24
102_A	168_R	0.585	0.24
9_M	250_M	0.584	0.24
16_G	74_D	0.584	0.24
142_L	319_L	0.583	0.24
25_K	274_V	0.581	0.24
236_I	321_F	0.580	0.24
224_I	227_M	0.579	0.24
199_G	325_V	0.579	0.24
147_T	262_L	0.579	0.24
91_P	108_L	0.578	0.24
243_V	321_F	0.578	0.24
272_N	298_P	0.577	0.24
153_L	250_M	0.576	0.24
55_V	224_I	0.576	0.24
51_A	217_Y	0.576	0.24
22_L	339_V	0.574	0.24
279_L	303_I	0.573	0.24
30_E	154_V	0.573	0.24
121_T	313_F	0.572	0.23
116_A	308_A	0.570	0.23
254_I	273_E	0.570	0.23
67_L	157_L	0.570	0.23
219_T	230_I	0.570	0.23
5_I	152_C	0.570	0.23
209_G	213_A	0.568	0.23
111_G	198_F	0.568	0.23
238_G	244_L	0.568	0.23
9_M	344_A	0.567	0.23
244_L	285_N	0.565	0.23
153_L	211_A	0.565	0.23
106_A	188_P	0.563	0.23
273_E	345_V	0.563	0.23
111_G	116_A	0.563	0.23
339_V	343_T	0.563	0.23
79_A	244_L	0.562	0.23
129_I	137_L	0.562	0.23
171_I	181_A	0.560	0.23
79_A	93_A	0.560	0.23
234_L	258_L	0.559	0.23
15_L	265_L	0.557	0.23
255_T	277_A	0.556	0.23
74_D	100_P	0.554	0.23
178_V	342_I	0.553	0.22
8_I	18_I	0.553	0.22
289_M	313_F	0.552	0.22
137_L	177_A	0.552	0.22
5_I	145_I	0.551	0.22
80_T	91_P	0.551	0.22
179_L	187_I	0.550	0.22
64_I	122_I	0.550	0.22
87_M	117_T	0.550	0.22
73_A	191_M	0.550	0.22
227_M	230_I	0.547	0.22
84_A	151_G	0.546	0.22
129_I	339_V	0.546	0.22
11_I	273_E	0.545	0.22
251_V	281_A	0.545	0.22
143_A	146_I	0.544	0.22
58_K	182_L	0.543	0.22
87_M	151_G	0.541	0.22
6_I	218_L	0.541	0.22
10_M	13_M	0.536	0.22
17_A	216_E	0.535	0.22
93_A	175_I	0.535	0.22
73_A	93_A	0.535	0.22
328_E	332_P	0.535	0.22
98_Q	174_I	0.532	0.21
273_E	350_L	0.532	0.21
71_L	193_K	0.532	0.21
143_A	249_P	0.531	0.21
96_L	101_E	0.531	0.21
162_S	167_L	0.530	0.21
229_P	249_P	0.530	0.21
278_G	289_M	0.530	0.21
102_A	280_L	0.529	0.21
36_F	214_I	0.527	0.21
108_L	207_T	0.527	0.21
162_S	227_M	0.527	0.21
9_M	12_F	0.527	0.21
108_L	329_M	0.526	0.21
52_L	225_P	0.526	0.21
32_F	249_P	0.526	0.21
80_T	116_A	0.525	0.21
143_A	288_P	0.524	0.21
117_T	277_A	0.524	0.21
212_A	270_G	0.524	0.21
135_K	154_V	0.524	0.21
264_K	268_K	0.523	0.21
282_T	286_N	0.520	0.21
145_I	263_E	0.520	0.21
93_A	185_W	0.520	0.21
244_L	247_A	0.519	0.21
125_A	152_C	0.517	0.21
37_M	340_G	0.517	0.21
44_L	204_I	0.517	0.21
163_L	295_D	0.517	0.21
158_V	335_V	0.516	0.21
268_K	271_M	0.515	0.21
166_I	273_E	0.515	0.21
118_I	187_I	0.515	0.21
105_F	156_G	0.514	0.21
287_I	291_G	0.513	0.20
186_F	335_V	0.513	0.20
84_A	117_T	0.511	0.20
122_I	148_I	0.511	0.20
134_H	336_G	0.511	0.20
202_I	205_V	0.510	0.20
248_F	281_A	0.510	0.20
202_I	271_M	0.510	0.20
109_I	203_V	0.509	0.20
121_T	277_A	0.508	0.20
320_G	333_M	0.507	0.20
35_G	285_N	0.505	0.20
307_F	312_A	0.505	0.20
109_I	145_I	0.504	0.20
4_I	267_K	0.503	0.20
247_A	284_A	0.503	0.20
276_A	280_L	0.502	0.20
317_D	330_I	0.501	0.20
122_I	229_P	0.500	0.20
121_T	150_I	0.500	0.20
111_G	315_F	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zuxA	1	0.7778	43.1	0.971	Contact Map
4r0cA	3	0.4986	11.9	0.978	Contact Map
2zy9A	2	0.2365	9.5	0.979	Contact Map
4r1iA	2	0.4929	9.3	0.979	Contact Map
1j4nA	4	0.2764	7.7	0.98	Contact Map
2b6oA	6	0.245	6.9	0.98	Contact Map
4x5mA	2	0.2279	6.5	0.98	Contact Map
4f35D	2	0.4416	6	0.981	Contact Map
4pd6A	3	0.3932	4.7	0.981	Contact Map
4oj2X	3	0.2393	4.7	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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