GREMLIN Database
EutH - Ethanolamine utilisation protein, EutH
PFAM: PF04346 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 351 (350)
Sequences: 720 (486)
Seq/√Len: 26.0
META: 0.519

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_N297_D4.8241.00
28_L253_L4.8131.00
31_K34_E4.6731.00
20_K33_E4.5831.00
17_A211_A4.5181.00
136_Y298_P4.0061.00
133_D301_K3.9041.00
80_T106_A3.4291.00
12_F253_L3.3361.00
39_M241_A3.3081.00
97_A103_G3.2891.00
293_M305_V3.1821.00
90_Y326_Q2.9581.00
85_N322_T2.9371.00
258_L261_P2.8241.00
22_L26_F2.7480.99
68_Y81_T2.7070.99
147_T150_I2.6240.99
285_N317_D2.5890.99
52_L209_G2.5570.99
85_N108_L2.5100.99
161_L165_M2.5060.99
153_L170_L2.5030.99
289_M304_N2.5030.99
130_E294_K2.4830.99
182_L186_F2.4030.99
102_A161_L2.3720.98
254_I258_L2.3100.98
94_M103_G2.2920.98
150_I343_T2.2760.98
154_V339_V2.1900.97
117_T309_V2.1780.97
187_I190_K2.1600.97
102_A165_M2.1510.97
81_T176_F2.1460.97
279_L345_V2.0820.96
113_M151_G2.0650.96
51_A213_A2.0550.96
311_A317_D1.9630.95
61_S96_L1.9590.95
318_H333_M1.9560.95
264_K267_K1.9480.95
179_L194_G1.9370.95
4_I8_I1.9250.94
20_K207_T1.8980.94
191_M194_G1.8350.93
212_A224_I1.8340.93
105_F152_C1.8330.93
108_L333_M1.8140.92
190_K194_G1.8010.92
147_T344_A1.7980.92
84_A87_M1.7730.91
145_I180_I1.7490.91
322_T333_M1.7250.90
252_Y256_K1.7090.90
275_A300_G1.7080.90
135_K139_K1.7020.90
285_N311_A1.7000.90
21_I312_A1.6970.90
14_V211_A1.6700.89
201_G205_V1.6570.88
131_K134_H1.6450.88
175_I342_I1.6430.88
214_I245_A1.6120.87
24_N29_G1.5970.86
21_I208_I1.5580.85
314_V334_I1.5510.85
6_I243_V1.5430.84
271_M297_D1.5430.84
18_I24_N1.5380.84
147_T310_S1.5130.83
33_E203_V1.5000.83
203_V207_T1.4690.81
18_I22_L1.4630.81
56_L71_L1.4420.80
187_I191_M1.4360.80
210_L245_A1.4360.80
213_A217_Y1.4320.80
334_I338_L1.4290.79
312_A315_F1.4280.79
37_M41_P1.4250.79
113_M148_I1.4210.79
12_F250_M1.4200.79
90_Y219_T1.4030.78
142_L180_I1.3930.78
24_N30_E1.3920.78
80_T107_G1.3870.77
281_A289_M1.3850.77
22_L28_L1.3790.77
247_A251_V1.3790.77
307_F311_A1.3780.77
193_K267_K1.3750.77
110_L180_I1.3720.77
71_L168_R1.3670.76
147_T343_T1.3600.76
84_A119_V1.3580.76
268_K275_A1.3500.75
107_G112_S1.3410.75
94_M100_P1.3190.74
80_T111_G1.2890.72
87_M119_V1.2840.72
105_F170_L1.2730.71
42_L317_D1.2720.71
216_E219_T1.2670.71
190_K193_K1.2650.70
282_T304_N1.2630.70
171_I339_V1.2620.70
311_A314_V1.2610.70
253_L257_V1.2480.69
121_T286_N1.2330.68
313_F317_D1.2290.68
310_S340_G1.2280.68
254_I279_L1.2240.68
234_L238_G1.2230.68
90_Y325_V1.2180.67
17_A32_F1.2110.67
104_L326_Q1.2080.67
51_A227_M1.1970.66
183_G191_M1.1950.66
103_G106_A1.1940.66
164_G168_R1.1890.66
141_I195_F1.1820.65
215_V219_T1.1810.65
125_A137_L1.1710.64
74_D98_Q1.1610.64
266_G270_G1.1570.63
278_G304_N1.1550.63
10_M218_L1.1530.63
31_K252_Y1.1490.63
112_S285_N1.1470.63
299_R303_I1.1460.63
315_F334_I1.1440.62
167_L171_I1.1380.62
57_A65_V1.1380.62
7_Y10_M1.1290.61
102_A159_A1.1280.61
303_I345_V1.1240.61
231_E235_E1.1210.61
13_M245_A1.1210.61
183_G194_G1.1180.61
10_M214_I1.1110.60
275_A299_R1.1090.60
155_G336_G1.1060.60
36_F44_L1.1030.60
184_L240_I1.0960.59
13_M214_I1.0900.59
299_R349_L1.0870.58
286_N313_F1.0810.58
247_A313_F1.0800.58
274_V295_D1.0690.57
73_A169_N1.0610.57
238_G247_A1.0540.56
315_F338_L1.0500.56
116_A152_C1.0430.55
7_Y214_I1.0400.55
247_A281_A1.0330.55
214_I242_I1.0180.53
73_A113_M1.0170.53
42_L285_N1.0120.53
108_L326_Q1.0080.53
36_F245_A1.0050.52
113_M336_G1.0020.52
212_A225_P0.9940.52
219_T222_V0.9930.52
307_F313_F0.9870.51
250_M254_I0.9800.51
143_A303_I0.9740.50
76_A79_A0.9690.50
84_A318_H0.9670.50
39_M43_A0.9640.49
44_L210_L0.9640.49
138_A195_F0.9600.49
44_L49_I0.9530.49
51_A233_G0.9520.49
110_L325_V0.9390.48
175_I208_I0.9380.48
114_M286_N0.9370.47
216_E226_G0.9340.47
33_E43_A0.9340.47
108_L322_T0.9320.47
107_G285_N0.9310.47
19_D25_K0.9270.47
188_P250_M0.9260.47
154_V343_T0.9260.47
85_N112_S0.9250.47
36_F173_V0.9250.47
9_M13_M0.9220.46
115_G337_K0.9200.46
67_L71_L0.9190.46
179_L256_K0.9190.46
212_A223_I0.9160.46
90_Y188_P0.9140.46
84_A309_V0.9130.46
281_A288_P0.9110.46
132_E163_L0.9100.45
202_I206_I0.9060.45
210_L214_I0.9040.45
146_I181_A0.9020.45
121_T125_A0.8980.45
53_A125_A0.8970.45
199_G248_F0.8920.44
11_I215_V0.8910.44
159_A165_M0.8910.44
289_M308_A0.8900.44
105_F256_K0.8800.43
228_A232_E0.8790.43
112_S322_T0.8780.43
218_L242_I0.8770.43
310_S343_T0.8740.43
122_I198_F0.8670.42
306_A348_A0.8660.42
241_A335_V0.8650.42
153_L163_L0.8620.42
22_L25_K0.8580.42
198_F341_G0.8530.41
33_E44_L0.8520.41
167_L303_I0.8510.41
19_D23_G0.8500.41
50_I243_V0.8490.41
109_I173_V0.8490.41
53_A60_L0.8440.41
113_M117_T0.8370.40
107_G173_V0.8340.40
47_V233_G0.8290.40
5_I9_M0.8280.40
116_A313_F0.8250.39
180_I240_I0.8230.39
111_G336_G0.8200.39
67_L99_D0.8190.39
166_I192_I0.8160.39
76_A236_I0.8140.39
121_T311_A0.8090.38
249_P288_P0.8060.38
180_I233_G0.8060.38
11_I18_I0.8050.38
194_G198_F0.8040.38
306_A311_A0.8030.38
277_A340_G0.7980.37
212_A216_E0.7960.37
169_N247_A0.7950.37
136_Y301_K0.7940.37
52_L205_V0.7940.37
74_D101_E0.7920.37
54_P66_P0.7900.37
82_L343_T0.7900.37
304_N308_A0.7870.37
49_I87_M0.7850.37
133_D294_K0.7840.36
302_V336_G0.7770.36
212_A227_M0.7730.36
272_N300_G0.7710.36
303_I314_V0.7670.35
141_I315_F0.7670.35
50_I318_H0.7670.35
213_A227_M0.7670.35
9_M243_V0.7650.35
60_L198_F0.7650.35
9_M124_V0.7640.35
116_A125_A0.7630.35
216_E222_V0.7610.35
9_M211_A0.7590.35
44_L314_V0.7580.35
116_A155_G0.7580.35
14_V215_V0.7570.35
50_I233_G0.7570.35
90_Y110_L0.7520.34
244_L284_A0.7510.34
35_G241_A0.7490.34
139_K302_V0.7450.34
82_L237_V0.7440.34
200_K309_V0.7430.34
157_L164_G0.7430.34
176_F202_I0.7390.33
202_I214_I0.7370.33
25_K235_E0.7340.33
171_I299_R0.7320.33
43_A47_V0.7320.33
224_I230_I0.7310.33
37_M299_R0.7280.33
275_A303_I0.7280.33
20_K27_G0.7270.33
289_M312_A0.7260.33
9_M207_T0.7250.33
169_N316_G0.7200.32
112_S116_A0.7190.32
217_Y231_E0.7180.32
55_V227_M0.7160.32
61_S65_V0.7150.32
197_V204_I0.7110.32
77_M213_A0.7110.32
80_T118_I0.7110.32
63_V96_L0.7090.32
240_I309_V0.7090.32
80_T89_G0.7090.32
242_I279_L0.7040.31
12_F313_F0.7010.31
281_A307_F0.6990.31
33_E46_M0.6980.31
11_I15_L0.6950.31
33_E107_G0.6950.31
28_L252_Y0.6930.30
68_Y331_F0.6920.30
282_T308_A0.6910.30
214_I288_P0.6910.30
299_R335_V0.6900.30
82_L188_P0.6860.30
47_V200_K0.6860.30
27_G72_G0.6860.30
34_E109_I0.6840.30
343_T347_L0.6830.30
79_A92_L0.6810.30
163_L167_L0.6810.30
42_L237_V0.6800.30
278_G296_M0.6800.30
8_I350_L0.6770.30
167_L175_I0.6740.29
116_A312_A0.6730.29
47_V230_I0.6720.29
109_I336_G0.6710.29
13_M243_V0.6690.29
49_I82_L0.6690.29
199_G324_G0.6680.29
151_G340_G0.6640.29
339_V349_L0.6640.29
241_A317_D0.6620.29
148_I180_I0.6610.29
335_V339_V0.6610.29
222_V226_G0.6600.28
262_L276_A0.6600.28
56_L260_K0.6550.28
60_L78_F0.6500.28
163_L166_I0.6490.28
109_I154_V0.6450.28
131_K136_Y0.6430.27
7_Y221_I0.6430.27
8_I67_L0.6400.27
16_G32_F0.6390.27
56_L129_I0.6390.27
128_I287_I0.6380.27
61_S125_A0.6380.27
85_N103_G0.6360.27
318_H337_K0.6360.27
90_Y94_M0.6340.27
271_M275_A0.6340.27
109_I285_N0.6340.27
68_Y77_M0.6330.27
122_I195_F0.6330.27
316_G323_A0.6320.27
279_L304_N0.6320.27
281_A313_F0.6320.27
29_G249_P0.6300.27
133_D136_Y0.6290.27
188_P194_G0.6290.27
6_I222_V0.6290.27
70_A271_M0.6280.27
96_L213_A0.6280.27
26_F56_L0.6270.27
276_A311_A0.6270.27
260_K264_K0.6270.27
128_I291_G0.6270.27
19_D24_N0.6250.26
321_F324_G0.6230.26
162_S165_M0.6230.26
99_D165_M0.6220.26
310_S344_A0.6200.26
44_L267_K0.6200.26
20_K28_L0.6180.26
78_F320_G0.6160.26
84_A147_T0.6160.26
334_I345_V0.6140.26
15_L28_L0.6140.26
64_I171_I0.6130.26
110_L213_A0.6120.26
33_E320_G0.6110.26
208_I212_A0.6100.26
154_V335_V0.6090.26
135_K350_L0.6080.25
82_L176_F0.6060.25
7_Y215_V0.6050.25
180_I308_A0.6050.25
216_E220_G0.6040.25
92_L119_V0.6030.25
60_L96_L0.6020.25
226_G229_P0.6020.25
55_V63_V0.5990.25
71_L335_V0.5980.25
112_S317_D0.5980.25
145_I214_I0.5960.25
205_V209_G0.5940.25
76_A97_A0.5930.25
33_E210_L0.5930.25
12_F28_L0.5930.25
77_M317_D0.5920.25
232_E235_E0.5920.25
131_K135_K0.5910.25
38_A42_L0.5900.24
94_M332_P0.5900.24
182_L189_D0.5900.24
6_I31_K0.5890.24
146_I269_L0.5890.24
54_P220_G0.5890.24
47_V234_L0.5890.24
163_L254_I0.5880.24
102_A168_R0.5850.24
9_M250_M0.5840.24
16_G74_D0.5840.24
142_L319_L0.5830.24
25_K274_V0.5810.24
236_I321_F0.5800.24
224_I227_M0.5790.24
199_G325_V0.5790.24
147_T262_L0.5790.24
91_P108_L0.5780.24
243_V321_F0.5780.24
272_N298_P0.5770.24
153_L250_M0.5760.24
55_V224_I0.5760.24
51_A217_Y0.5760.24
22_L339_V0.5740.24
279_L303_I0.5730.24
30_E154_V0.5730.24
121_T313_F0.5720.23
116_A308_A0.5700.23
254_I273_E0.5700.23
67_L157_L0.5700.23
219_T230_I0.5700.23
5_I152_C0.5700.23
209_G213_A0.5680.23
111_G198_F0.5680.23
238_G244_L0.5680.23
9_M344_A0.5670.23
244_L285_N0.5650.23
153_L211_A0.5650.23
106_A188_P0.5630.23
273_E345_V0.5630.23
111_G116_A0.5630.23
339_V343_T0.5630.23
79_A244_L0.5620.23
129_I137_L0.5620.23
171_I181_A0.5600.23
79_A93_A0.5600.23
234_L258_L0.5590.23
15_L265_L0.5570.23
255_T277_A0.5560.23
74_D100_P0.5540.23
178_V342_I0.5530.22
8_I18_I0.5530.22
289_M313_F0.5520.22
137_L177_A0.5520.22
5_I145_I0.5510.22
80_T91_P0.5510.22
179_L187_I0.5500.22
64_I122_I0.5500.22
87_M117_T0.5500.22
73_A191_M0.5500.22
227_M230_I0.5470.22
84_A151_G0.5460.22
129_I339_V0.5460.22
11_I273_E0.5450.22
251_V281_A0.5450.22
143_A146_I0.5440.22
58_K182_L0.5430.22
87_M151_G0.5410.22
6_I218_L0.5410.22
10_M13_M0.5360.22
17_A216_E0.5350.22
93_A175_I0.5350.22
73_A93_A0.5350.22
328_E332_P0.5350.22
98_Q174_I0.5320.21
273_E350_L0.5320.21
71_L193_K0.5320.21
143_A249_P0.5310.21
96_L101_E0.5310.21
162_S167_L0.5300.21
229_P249_P0.5300.21
278_G289_M0.5300.21
102_A280_L0.5290.21
36_F214_I0.5270.21
108_L207_T0.5270.21
162_S227_M0.5270.21
9_M12_F0.5270.21
108_L329_M0.5260.21
52_L225_P0.5260.21
32_F249_P0.5260.21
80_T116_A0.5250.21
143_A288_P0.5240.21
117_T277_A0.5240.21
212_A270_G0.5240.21
135_K154_V0.5240.21
264_K268_K0.5230.21
282_T286_N0.5200.21
145_I263_E0.5200.21
93_A185_W0.5200.21
244_L247_A0.5190.21
125_A152_C0.5170.21
37_M340_G0.5170.21
44_L204_I0.5170.21
163_L295_D0.5170.21
158_V335_V0.5160.21
268_K271_M0.5150.21
166_I273_E0.5150.21
118_I187_I0.5150.21
105_F156_G0.5140.21
287_I291_G0.5130.20
186_F335_V0.5130.20
84_A117_T0.5110.20
122_I148_I0.5110.20
134_H336_G0.5110.20
202_I205_V0.5100.20
248_F281_A0.5100.20
202_I271_M0.5100.20
109_I203_V0.5090.20
121_T277_A0.5080.20
320_G333_M0.5070.20
35_G285_N0.5050.20
307_F312_A0.5050.20
109_I145_I0.5040.20
4_I267_K0.5030.20
247_A284_A0.5030.20
276_A280_L0.5020.20
317_D330_I0.5010.20
122_I229_P0.5000.20
121_T150_I0.5000.20
111_G315_F0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.7778 43.1 0.971 Contact Map
4r0cA 3 0.4986 11.9 0.978 Contact Map
2zy9A 2 0.2365 9.5 0.979 Contact Map
4r1iA 2 0.4929 9.3 0.979 Contact Map
1j4nA 4 0.2764 7.7 0.98 Contact Map
2b6oA 6 0.245 6.9 0.98 Contact Map
4x5mA 2 0.2279 6.5 0.98 Contact Map
4f35D 2 0.4416 6 0.981 Contact Map
4pd6A 3 0.3932 4.7 0.981 Contact Map
4oj2X 3 0.2393 4.7 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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