GREMLIN Database
DUF485 - Protein of unknown function, DUF485
PFAM: PF04341 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (86)
Sequences: 11315 (5643)
Seq/√Len: 608.5
META: 0.838

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_A41_F2.7871.00
5_E86_E2.7791.00
27_W64_S2.6711.00
8_E12_R2.4651.00
83_L86_E1.8981.00
46_V56_L1.8271.00
41_F53_V1.7491.00
14_R18_W1.7241.00
82_P86_E1.7201.00
67_V71_I1.7061.00
12_R79_E1.6971.00
11_R15_R1.6921.00
78_R82_P1.6841.00
75_R80_F1.6051.00
27_W60_G1.5811.00
18_W22_A1.5491.00
26_V30_G1.5171.00
33_L37_F1.5161.00
8_E83_L1.4871.00
70_G74_R1.4321.00
74_R78_R1.4291.00
75_R79_E1.4171.00
16_F75_R1.3901.00
85_A88_R1.3371.00
41_F44_T1.3371.00
27_W61_Q1.3191.00
24_F68_L1.2761.00
36_A39_P1.2591.00
84_A88_R1.2351.00
12_R83_L1.2211.00
76_A80_F1.2101.00
16_F20_L1.2091.00
34_L57_L1.1921.00
33_L38_A1.1781.00
15_R19_P1.1591.00
34_L38_A1.1571.00
5_E8_E1.1451.00
40_D43_A1.1431.00
22_A26_V1.1211.00
80_F84_A1.1141.00
13_R17_A1.1101.00
25_L29_F1.0991.00
19_P23_A1.0901.00
35_V42_M1.0641.00
79_E83_L1.0631.00
73_V77_N1.0631.00
51_I56_L1.0491.00
79_E82_P1.0381.00
44_T53_V1.0201.00
46_V53_V1.0051.00
4_P8_E1.0031.00
60_G64_S0.9851.00
45_K50_V0.9821.00
20_L71_I0.9791.00
82_P85_A0.9661.00
2_A7_Q0.9611.00
34_L42_M0.9361.00
69_T73_V0.9271.00
67_V70_G0.9211.00
10_V14_R0.9191.00
74_R79_E0.8921.00
63_V67_V0.8901.00
75_R78_R0.8891.00
20_L68_L0.8871.00
21_T24_F0.8841.00
53_V57_L0.8661.00
19_P22_A0.8491.00
7_Q10_V0.8471.00
64_S68_L0.8341.00
28_Y65_T0.8331.00
7_Q11_R0.8281.00
23_A64_S0.8271.00
31_F58_G0.8221.00
47_G50_V0.8171.00
8_E11_R0.7961.00
38_A44_T0.7851.00
4_P7_Q0.7791.00
71_I75_R0.7711.00
42_M57_L0.7691.00
11_R14_R0.7661.00
47_G51_I0.7611.00
24_F65_T0.7561.00
34_L41_F0.7481.00
26_V29_F0.7391.00
70_G73_V0.7351.00
40_D44_T0.7341.00
45_K52_N0.7171.00
3_S7_Q0.7111.00
12_R15_R0.7051.00
30_G57_L0.6981.00
6_F10_V0.6981.00
51_I54_G0.6881.00
39_P43_A0.6821.00
52_N56_L0.6561.00
32_I35_V0.6541.00
30_G34_L0.6531.00
71_I77_N0.6451.00
7_Q14_R0.6421.00
46_V51_I0.6351.00
55_I59_L0.6221.00
23_A27_W0.6181.00
29_F32_I0.6151.00
64_S67_V0.6141.00
16_F71_I0.6111.00
65_T69_T0.6111.00
69_T77_N0.6081.00
43_A52_N0.5861.00
13_R16_F0.5841.00
56_L60_G0.5821.00
61_Q65_T0.5711.00
54_G58_G0.5701.00
9_L83_L0.5691.00
51_I55_I0.5691.00
31_F65_T0.5661.00
55_I58_G0.5661.00
36_A55_I0.5661.00
28_Y31_F0.5581.00
21_T25_L0.5551.00
83_L87_I0.5520.99
3_S6_F0.5470.99
5_E83_L0.5440.99
74_R77_N0.5410.99
47_G56_L0.5380.99
14_R19_P0.5350.99
59_L63_V0.5340.99
35_V54_G0.5340.99
5_E87_I0.5280.99
24_F64_S0.5080.99
35_V39_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hkrA 3 0.9101 31.5 0.848 Contact Map
4ev6A 3 0.8539 17.8 0.865 Contact Map
4i0uA 4 0.8315 16.6 0.867 Contact Map
2onkC 2 0.8202 14.6 0.87 Contact Map
4djkA 2 0.8315 12.4 0.874 Contact Map
4he8M 1 0.9551 12.2 0.875 Contact Map
4he8N 1 0.9551 12 0.875 Contact Map
3rkoN 1 0.9213 11.1 0.877 Contact Map
2m20A 2 0.4831 11.1 0.877 Contact Map
3tx3A 2 0.8427 10.8 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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