GREMLIN Database
DUF479 - Protein of unknown function, DUF479
PFAM: PF04336 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (104)
Sequences: 8948 (6983)
Seq/√Len: 684.7
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_L86_E2.8301.00
29_E47_I2.7911.00
50_N53_Y2.7891.00
32_Y40_Q2.3391.00
93_E97_R2.1521.00
88_H91_E2.0471.00
62_E66_E2.0411.00
11_R97_R1.9731.00
1_Y95_D1.9341.00
12_Y97_R1.8991.00
8_N97_R1.8661.00
77_P80_E1.8531.00
15_E23_R1.8451.00
3_H89_Y1.7591.00
8_N11_R1.7581.00
21_T53_Y1.7381.00
8_N93_E1.7301.00
63_R67_G1.6941.00
62_E82_I1.6341.00
18_E53_Y1.6231.00
31_N34_L1.6131.00
25_Y50_N1.6071.00
64_A67_G1.5331.00
91_E95_D1.4981.00
4_F89_Y1.4951.00
57_T60_G1.4791.00
6_A17_L1.4741.00
67_G70_R1.4161.00
43_L47_I1.4131.00
7_K93_E1.3621.00
69_S79_A1.3611.00
17_L21_T1.3231.00
72_T76_S1.3101.00
18_E22_Q1.2841.00
69_S76_S1.2551.00
53_Y56_A1.2361.00
45_Y49_Q1.1941.00
94_E98_E1.1911.00
16_P19_D1.1751.00
58_L89_Y1.1621.00
89_Y93_E1.1381.00
20_F24_V1.1351.00
7_K89_Y1.1301.00
83_E87_E1.1291.00
58_L82_I1.1241.00
96_F100_F1.1171.00
92_L95_D1.1111.00
42_M51_W1.0821.00
41_R45_Y1.0731.00
91_E94_E1.0571.00
3_H7_K1.0461.00
18_E50_N1.0381.00
90_D93_E1.0331.00
6_A56_A1.0211.00
101_P104_I1.0101.00
21_T50_N0.9881.00
29_E43_L0.9841.00
27_L31_N0.9801.00
64_A68_M0.9801.00
24_V28_L0.9761.00
80_E83_E0.9741.00
39_L44_P0.9711.00
44_P48_E0.9521.00
37_E41_R0.9481.00
23_R27_L0.9401.00
97_R101_P0.9391.00
88_H92_L0.9371.00
72_T75_P0.9371.00
84_E88_H0.9321.00
82_I86_E0.9311.00
29_E32_Y0.9081.00
26_A30_E0.9011.00
65_L81_A0.9011.00
69_S78_L0.8991.00
35_L43_L0.8811.00
21_T25_Y0.8671.00
100_F103_L0.8601.00
98_E101_P0.8531.00
55_Y64_A0.8511.00
39_L42_M0.8411.00
46_M51_W0.8411.00
18_E21_T0.8191.00
83_E86_E0.8021.00
6_A21_T0.7921.00
54_S57_T0.7891.00
51_W67_G0.7881.00
58_L62_E0.7871.00
98_E102_E0.7791.00
9_W12_Y0.7781.00
60_G64_A0.7731.00
32_Y35_L0.7691.00
19_D23_R0.7591.00
21_T52_L0.7561.00
4_F93_E0.7561.00
59_E62_E0.7361.00
66_E69_S0.7291.00
84_E87_E0.7221.00
90_D94_E0.7171.00
28_L43_L0.7121.00
15_E19_D0.7111.00
37_E40_Q0.7101.00
61_I65_L0.7071.00
51_W64_A0.7021.00
24_V27_L0.7001.00
58_L85_L0.6931.00
69_S73_K0.6921.00
39_L43_L0.6781.00
27_L30_E0.6761.00
85_L89_Y0.6731.00
13_S100_F0.6721.00
8_N12_Y0.6671.00
40_Q44_P0.6651.00
66_E79_A0.6651.00
74_R77_P0.6621.00
73_K76_S0.6551.00
46_M52_L0.6501.00
82_I85_L0.6401.00
49_Q67_G0.6371.00
45_Y48_E0.6361.00
54_S64_A0.6321.00
42_M45_Y0.6281.00
66_E70_R0.6201.00
35_L39_L0.6131.00
4_F8_N0.6051.00
42_M46_M0.6031.00
99_F102_E0.6021.00
3_H6_A0.5991.00
63_R66_E0.5971.00
66_E80_E0.5951.00
21_T24_V0.5891.00
12_Y17_L0.5871.00
28_L35_L0.5841.00
88_H95_D0.5801.00
75_P79_A0.5741.00
45_Y67_G0.5681.00
86_E89_Y0.5671.00
38_R42_M0.5651.00
78_L84_E0.5631.00
25_Y47_I0.5621.00
55_Y68_M0.5551.00
58_L61_I0.5541.00
54_S63_R0.5531.00
94_E97_R0.5511.00
45_Y51_W0.5481.00
100_F104_I0.5471.00
4_F85_L0.5461.00
95_D98_E0.5431.00
23_R26_A0.5391.00
32_Y44_P0.5311.00
12_Y100_F0.5221.00
69_S75_P0.5160.99
99_F103_L0.5080.99
62_E86_E0.5080.99
18_E56_A0.5010.99
38_R41_R0.5000.99
4_F92_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wa5C 1 1 13.3 0.896 Contact Map
4hpqC 2 0.9619 6.3 0.91 Contact Map
1h2vC 1 0.4095 5.5 0.913 Contact Map
3zqeA 1 0.9143 5.2 0.914 Contact Map
3gjxA 1 0.9524 4.7 0.916 Contact Map
4ow8A 2 0.7333 4.7 0.916 Contact Map
4fgvA 1 0.9524 4.4 0.917 Contact Map
3a6pA 1 0.9524 4.2 0.918 Contact Map
1g1eB 1 0.8476 4.1 0.918 Contact Map
4po5B 3 0.6381 4 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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