GREMLIN Database
MlaA - MlaA lipoprotein
PFAM: PF04333 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 194 (193)
Sequences: 16097 (10628)
Seq/√Len: 765.0
META: 0.892

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_F12_M3.6471.00
100_E104_Q2.7901.00
20_D163_R2.6151.00
56_F72_L2.4331.00
60_L68_A2.4021.00
58_N105_T2.3991.00
148_D152_Y2.3161.00
126_T189_L2.2961.00
25_K29_K2.2701.00
37_E40_R2.1891.00
111_V114_G2.1481.00
6_E10_R2.0271.00
35_V39_V1.9481.00
42_G45_N1.9361.00
46_F86_L1.9291.00
119_L130_A1.9031.00
32_R40_R1.8631.00
13_F180_P1.8351.00
48_S97_K1.7501.00
18_A22_A1.7021.00
44_S161_D1.6771.00
38_P42_G1.6711.00
147_D150_V1.6671.00
149_A153_G1.6471.00
56_F71_D1.6301.00
103_G129_D1.6211.00
161_D165_R1.6121.00
77_I93_M1.5841.00
52_E56_F1.5711.00
101_D104_Q1.5681.00
64_K100_E1.5441.00
67_R98_H1.5441.00
170_E174_E1.5421.00
113_P126_T1.5381.00
11_A14_A1.5361.00
42_G86_L1.5291.00
83_L87_F1.5121.00
102_F135_V1.4981.00
70_S98_H1.4591.00
131_V134_V1.4481.00
113_P193_R1.4411.00
59_N71_D1.4231.00
59_N67_R1.4211.00
56_F68_A1.4201.00
5_L8_F1.4131.00
72_L76_L1.4081.00
16_N118_V1.3991.00
127_V130_A1.3681.00
49_N79_S1.3671.00
54_V139_L1.3351.00
53_P75_F1.3331.00
32_R164_A1.3301.00
59_N98_H1.3271.00
30_G33_A1.3231.00
64_K67_R1.3221.00
170_E173_L1.3211.00
152_Y156_A1.3141.00
52_E75_F1.3121.00
73_G95_L1.3121.00
39_V42_G1.3111.00
101_D192_R1.2981.00
42_G87_F1.2961.00
125_S129_D1.2961.00
17_D180_P1.2441.00
74_R88_D1.2411.00
55_T59_N1.2371.00
63_G108_V1.2281.00
129_D192_R1.2241.00
37_E41_T1.2211.00
104_Q108_V1.2131.00
52_E71_D1.2111.00
55_T71_D1.2071.00
166_L169_A1.1971.00
70_S95_L1.1901.00
52_E55_T1.1851.00
153_G156_A1.1851.00
80_T84_G1.1831.00
57_V139_L1.1781.00
113_P189_L1.1771.00
150_V153_G1.1761.00
17_D21_R1.1711.00
73_G76_L1.1421.00
8_F11_A1.1401.00
5_L115_P1.1391.00
64_K108_V1.1381.00
44_S165_R1.1351.00
8_F117_L1.1331.00
19_L23_V1.1201.00
149_A152_Y1.1181.00
12_M118_V1.1181.00
131_V135_V1.0981.00
29_K33_A1.0891.00
106_L135_V1.0881.00
58_N102_F1.0851.00
115_P127_V1.0851.00
81_V93_M1.0811.00
65_F69_G1.0771.00
146_D150_V1.0681.00
59_N100_E1.0641.00
77_I81_V1.0611.00
153_G157_L1.0601.00
27_V30_G1.0441.00
19_L121_L1.0381.00
69_G73_G1.0291.00
156_A159_A1.0291.00
182_A185_R1.0231.00
56_F75_F1.0221.00
24_L159_A1.0181.00
55_T99_D1.0081.00
186_D190_Q1.0061.00
5_L11_A1.0011.00
130_A134_V0.9971.00
162_T166_L0.9931.00
30_G34_V0.9851.00
71_D98_H0.9821.00
140_D154_L0.9811.00
81_V89_V0.9801.00
66_K70_S0.9771.00
52_E97_K0.9751.00
106_L111_V0.9711.00
89_V93_M0.9691.00
18_A21_R0.9671.00
7_P11_A0.9611.00
32_R168_D0.9611.00
17_D174_E0.9581.00
80_T83_L0.9561.00
81_V84_G0.9491.00
125_S130_A0.9461.00
111_V115_P0.9431.00
19_L24_L0.9421.00
182_A186_D0.9411.00
130_A133_L0.9331.00
76_L80_T0.9241.00
107_G128_R0.9151.00
13_F118_V0.9091.00
4_P115_P0.9051.00
167_L170_E0.9051.00
11_A15_F0.9041.00
25_K170_E0.8881.00
174_E180_P0.8861.00
35_V40_R0.8831.00
88_D91_S0.8831.00
56_F59_N0.8751.00
119_L125_S0.8751.00
180_P184_V0.8751.00
12_M15_F0.8611.00
55_T98_H0.8571.00
14_A18_A0.8531.00
102_F136_D0.8531.00
19_L22_A0.8521.00
127_V131_V0.8441.00
12_M16_N0.8401.00
15_F118_V0.8371.00
28_A167_L0.8361.00
183_F187_A0.8351.00
54_V136_D0.8341.00
169_A172_L0.8341.00
155_T159_A0.8321.00
38_P87_F0.8291.00
63_G109_W0.8241.00
100_E107_G0.8241.00
87_F92_E0.8161.00
44_S48_S0.8161.00
5_L127_V0.8121.00
138_F141_P0.8121.00
18_A23_V0.8091.00
161_D164_A0.8071.00
53_P57_V0.8061.00
40_R164_A0.8021.00
144_Y147_D0.8021.00
171_D175_E0.8021.00
62_Q100_E0.8011.00
29_K167_L0.7961.00
77_I80_T0.7961.00
68_A72_L0.7911.00
13_F184_V0.7881.00
117_L130_A0.7851.00
60_L65_F0.7851.00
170_E180_P0.7831.00
61_L105_T0.7761.00
14_A17_D0.7641.00
57_V61_L0.7611.00
155_T158_D0.7601.00
89_V92_E0.7581.00
77_I90_A0.7551.00
25_K167_L0.7411.00
132_G136_D0.7411.00
56_F60_L0.7371.00
15_F19_L0.7361.00
21_R174_E0.7291.00
40_R165_R0.7291.00
73_G77_I0.7181.00
135_V138_F0.7171.00
74_R90_A0.7141.00
125_S133_L0.7131.00
51_G55_T0.7071.00
3_D9_N0.7071.00
35_V38_P0.7061.00
29_K32_R0.7051.00
102_F106_L0.6991.00
122_L133_L0.6981.00
191_R194_A0.6981.00
140_D158_D0.6931.00
152_Y155_T0.6911.00
150_V154_L0.6901.00
65_F68_A0.6891.00
52_E72_L0.6871.00
13_F17_D0.6871.00
36_P39_V0.6851.00
134_V138_F0.6801.00
106_L132_G0.6721.00
46_F49_N0.6721.00
101_D129_D0.6701.00
118_V184_V0.6671.00
103_G192_R0.6671.00
2_N189_L0.6671.00
121_L159_A0.6601.00
27_V160_V0.6571.00
77_I95_L0.6551.00
148_D151_R0.6551.00
158_D162_T0.6541.00
41_T45_N0.6521.00
47_F154_L0.6501.00
107_G113_P0.6481.00
43_V46_F0.6461.00
160_V163_R0.6451.00
28_A164_A0.6411.00
5_L117_L0.6391.00
62_Q104_Q0.6351.00
164_A167_L0.6331.00
66_K69_G0.6291.00
163_R167_L0.6241.00
173_L184_V0.6221.00
142_V145_I0.6211.00
102_F105_T0.6161.00
55_T100_E0.6151.00
59_N63_G0.6131.00
32_R167_L0.6121.00
55_T97_K0.6121.00
100_E108_V0.6101.00
21_R25_K0.6081.00
172_L176_A0.6061.00
31_Y43_V0.6031.00
116_Y126_T0.6011.00
58_N62_Q0.5971.00
25_K171_D0.5951.00
172_L175_E0.5951.00
135_V139_L0.5931.00
126_T129_D0.5921.00
12_M119_L0.5911.00
142_V146_D0.5891.00
43_V157_L0.5881.00
59_N64_K0.5881.00
28_A32_R0.5841.00
134_V137_S0.5821.00
69_G72_L0.5811.00
65_F72_L0.5801.00
159_A162_T0.5771.00
83_L86_L0.5771.00
112_G115_P0.5771.00
111_V131_V0.5771.00
157_L161_D0.5721.00
145_I150_V0.5661.00
22_A30_G0.5641.00
179_D182_A0.5631.00
189_L193_R0.5621.00
84_G87_F0.5611.00
48_S52_E0.5601.00
176_A183_F0.5591.00
57_V60_L0.5521.00
51_G54_V0.5511.00
70_S73_G0.5501.00
62_Q105_T0.5491.00
177_S180_P0.5441.00
79_S83_L0.5361.00
173_L180_P0.5351.00
105_T109_W0.5331.00
162_T165_R0.5251.00
61_L109_W0.5251.00
50_L53_P0.5211.00
170_E184_V0.5201.00
40_R161_D0.5171.00
90_A95_L0.5151.00
49_N80_T0.5121.00
8_F13_F0.5121.00
17_D118_V0.5101.00
40_R44_S0.5061.00
102_F139_L0.5061.00
58_N136_D0.5051.00
133_L137_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aqnA 2 0.5155 42.7 0.945 Contact Map
3s88J 3 0.3918 31.8 0.949 Contact Map
2d7eA 4 0.2062 11 0.958 Contact Map
1vw41 1 0.3093 4.3 0.966 Contact Map
3zkvA 1 0.4124 4 0.966 Contact Map
1y2kA 2 0.299 3.4 0.967 Contact Map
3hdeA 2 0.4845 3.3 0.967 Contact Map
4e97A 1 0.5258 3 0.968 Contact Map
3hdfA 1 0.5103 3 0.968 Contact Map
1wjnA 1 0.3814 2.9 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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