GREMLIN Database
YdjM - LexA-binding, inner membrane-associated putative hydrolase
PFAM: PF04307 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 173 (154)
Sequences: 23566 (18089)
Seq/√Len: 1457.6
META: 0.862

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_L111_L3.8481.00
113_A121_L3.5961.00
80_A102_F2.6861.00
7_A38_L2.4921.00
107_S111_L2.2031.00
7_A34_A2.0961.00
155_A159_L2.0311.00
150_R153_W2.0041.00
154_L160_V2.0011.00
51_D54_G1.9981.00
95_R99_L1.9851.00
152_A155_A1.9711.00
76_A105_Y1.9201.00
155_A162_Y1.8861.00
52_P55_Y1.7741.00
149_R153_W1.7641.00
120_Q123_W1.7601.00
150_R154_L1.7561.00
69_F123_W1.7341.00
109_L121_L1.7291.00
28_R32_A1.7281.00
29_A33_G1.7141.00
154_L157_V1.7031.00
153_W157_V1.6901.00
3_S38_L1.6811.00
9_L107_S1.6491.00
96_R99_L1.6241.00
85_L89_R1.6241.00
151_W155_A1.6051.00
32_A36_G1.5951.00
84_A88_R1.5871.00
154_L158_L1.5861.00
160_V164_G1.5791.00
156_L160_V1.5621.00
110_L114_L1.5601.00
105_Y109_L1.5441.00
155_A160_V1.4971.00
72_S123_W1.4931.00
155_A158_L1.4851.00
96_R100_L1.4371.00
148_R151_W1.4361.00
39_L42_L1.4311.00
123_W127_D1.3891.00
54_G57_S1.3881.00
122_L130_F1.3851.00
75_F105_Y1.3591.00
157_V161_L1.3581.00
147_R150_R1.3501.00
109_L119_V1.3491.00
37_A107_S1.3281.00
158_L162_Y1.3221.00
8_L12_A1.3151.00
50_G54_G1.2961.00
95_R98_G1.2941.00
45_V48_L1.2531.00
148_R152_A1.2511.00
11_A15_R1.2381.00
29_A32_A1.2341.00
33_G36_G1.2161.00
44_V47_S1.2161.00
76_A109_L1.1941.00
9_L12_A1.1861.00
31_L34_A1.1801.00
149_R152_A1.1721.00
47_S50_G1.1651.00
36_G101_F1.1651.00
40_P105_Y1.1571.00
10_G37_A1.1531.00
106_L109_L1.1481.00
156_L162_Y1.1421.00
154_L159_L1.1381.00
72_S75_F1.1221.00
113_A119_V1.1151.00
76_A106_L1.1141.00
36_G104_G1.1061.00
28_R31_L1.1021.00
120_Q129_R1.1011.00
81_L85_L1.0981.00
151_W154_L1.0881.00
156_L159_L1.0421.00
51_D55_Y1.0411.00
46_L51_D1.0401.00
134_L137_I1.0401.00
90_L93_R1.0381.00
13_L107_S1.0361.00
80_A84_A1.0311.00
77_L80_A1.0251.00
30_L33_G1.0221.00
76_A102_F1.0061.00
115_T118_G1.0031.00
139_V142_L1.0001.00
68_G72_S0.9971.00
33_G37_A0.9911.00
91_G94_R0.9901.00
31_L35_L0.9611.00
48_L52_P0.9601.00
147_R151_W0.9591.00
153_W159_L0.9451.00
150_R155_A0.9411.00
133_D137_I0.9281.00
159_L162_Y0.9271.00
159_L163_L0.9211.00
143_F146_P0.9201.00
55_Y58_G0.9031.00
2_D5_T0.9011.00
15_R19_G0.8911.00
85_L88_R0.8891.00
43_D66_H0.8771.00
74_L77_L0.8711.00
10_G107_S0.8691.00
131_A134_L0.8631.00
157_V162_Y0.8591.00
9_L13_L0.8571.00
46_L50_G0.8541.00
49_L53_L0.8431.00
46_L49_L0.8331.00
47_S51_D0.8261.00
97_L100_L0.8221.00
30_L34_A0.8201.00
132_L136_F0.8161.00
139_V144_T0.8151.00
126_S130_F0.8071.00
36_G79_L0.7911.00
18_L22_T0.7891.00
84_A98_G0.7881.00
10_G14_G0.7871.00
77_L102_F0.7851.00
32_A87_L0.7851.00
87_L91_G0.7841.00
113_A132_L0.7841.00
157_V160_V0.7761.00
79_L105_Y0.7751.00
130_F133_D0.7751.00
81_L98_G0.7711.00
142_L145_L0.7661.00
47_S55_Y0.7651.00
45_V49_L0.7471.00
80_A83_L0.7371.00
42_L70_T0.7361.00
129_R133_D0.7251.00
136_F141_P0.7201.00
131_A137_I0.7191.00
153_W156_L0.7181.00
14_G18_L0.7171.00
162_Y165_L0.7111.00
101_F104_G0.7101.00
98_G102_F0.7061.00
20_R23_G0.7031.00
74_L123_W0.6991.00
45_V50_G0.6991.00
44_V48_L0.6901.00
75_F79_L0.6901.00
151_W156_L0.6811.00
151_W162_Y0.6771.00
76_A80_A0.6741.00
137_I140_D0.6731.00
4_L7_A0.6711.00
6_H37_A0.6691.00
54_G58_G0.6681.00
14_G30_L0.6581.00
153_W160_V0.6571.00
7_A11_A0.6541.00
50_G55_Y0.6531.00
78_L81_L0.6421.00
3_S7_A0.6411.00
5_T8_L0.6371.00
140_D143_F0.6351.00
100_L104_G0.6331.00
131_A136_F0.6331.00
120_Q126_S0.6281.00
153_W161_L0.6191.00
76_A79_L0.6151.00
152_A159_L0.6141.00
148_R154_L0.6131.00
39_L105_Y0.6111.00
155_A161_L0.6091.00
154_L162_Y0.6011.00
46_L55_Y0.5961.00
147_R154_L0.5941.00
136_F139_V0.5871.00
19_G23_G0.5831.00
29_A100_L0.5811.00
122_L126_S0.5771.00
10_G33_G0.5761.00
48_L53_L0.5741.00
139_V143_F0.5741.00
149_R154_L0.5741.00
75_F78_L0.5731.00
132_L137_I0.5731.00
13_L17_V0.5711.00
44_V50_G0.5711.00
12_A15_R0.5681.00
48_L55_Y0.5651.00
68_G120_Q0.5621.00
148_R153_W0.5611.00
161_L165_L0.5601.00
102_F106_L0.5601.00
111_L115_T0.5521.00
142_L146_P0.5521.00
32_A101_F0.5501.00
135_I141_P0.5491.00
135_I140_D0.5491.00
90_L94_R0.5461.00
40_P108_H0.5461.00
35_L38_L0.5451.00
11_A14_G0.5431.00
161_L164_G0.5411.00
86_L90_L0.5401.00
149_R155_A0.5371.00
8_L11_A0.5341.00
15_R30_L0.5341.00
52_P57_S0.5321.00
36_G105_Y0.5291.00
53_L57_S0.5291.00
32_A35_L0.5241.00
69_F72_S0.5221.00
106_L110_L0.5211.00
77_L81_L0.5201.00
33_G104_G0.5181.00
156_L163_L0.5121.00
147_R152_A0.5111.00
88_R91_G0.5111.00
15_R18_L0.5101.00
88_R94_R0.5071.00
152_A156_L0.5051.00
99_L102_F0.5041.00
137_I141_P0.5041.00
79_L83_L0.5041.00
50_G58_G0.5031.00
98_G101_F0.5001.00
131_A135_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d5sA 2 0.3584 8.9 0.911 Contact Map
4p6vB 1 0.3179 1.9 0.936 Contact Map
4d5tA 1 0.3642 1.6 0.939 Contact Map
2mfrA 1 0.2543 1.6 0.939 Contact Map
2k1kA 2 0.2197 1.2 0.943 Contact Map
4b19A 1 0.1734 1.1 0.944 Contact Map
2l6wA 2 0.2023 1.1 0.944 Contact Map
2mofA 1 0.2023 0.9 0.947 Contact Map
3j61A 1 0.3006 0.9 0.948 Contact Map
2jvxA 1 0.1618 0.8 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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