GREMLIN Database
VanW - VanW like protein
PFAM: PF04294 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (128)
Sequences: 16322 (10241)
Seq/√Len: 905.2
META: 0.879

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_V53_G2.8851.00
77_V107_K2.5481.00
4_H40_K2.3961.00
34_T37_K2.3071.00
69_A106_F2.2451.00
16_T29_T2.2391.00
75_E107_K2.2071.00
80_H102_V2.1751.00
19_A113_P2.1471.00
19_A22_E2.0901.00
23_T77_V2.0771.00
25_S103_D2.0501.00
35_A54_V2.0341.00
118_A127_V1.9141.00
23_T107_K1.8861.00
12_K37_K1.8601.00
23_T105_K1.8121.00
119_Y128_E1.7731.00
12_K39_Y1.7691.00
43_P52_P1.7411.00
14_N117_Q1.7331.00
117_Q128_E1.7281.00
10_A118_A1.7051.00
75_E109_D1.6581.00
67_N93_R1.6511.00
69_A104_L1.6061.00
74_L114_I1.5831.00
41_E52_P1.5731.00
8_L12_K1.5681.00
43_P50_L1.5271.00
9_A61_V1.5131.00
46_V51_V1.5111.00
35_A41_E1.5061.00
9_A58_V1.4861.00
69_A76_I1.4821.00
63_T89_Y1.4691.00
4_H7_R1.4461.00
78_E105_K1.4381.00
41_E54_V1.4351.00
71_F93_R1.4211.00
119_Y126_T1.3871.00
8_L11_S1.3851.00
4_H8_L1.3761.00
7_R11_S1.3581.00
26_F97_V1.3281.00
27_N33_R1.3111.00
20_P113_P1.3081.00
17_V113_P1.2861.00
98_S101_Y1.2331.00
60_Q64_T1.2331.00
96_T102_V1.2121.00
45_I50_L1.2071.00
98_S102_V1.1761.00
50_L84_Y1.1641.00
67_N71_F1.1511.00
13_I24_F1.1181.00
69_A74_L1.1171.00
121_D124_S1.1101.00
77_V105_K1.1041.00
26_F62_S1.1011.00
3_V7_R1.0921.00
59_C82_H1.0811.00
17_V115_L1.0751.00
3_V123_G1.0611.00
46_V53_G1.0601.00
32_P99_Y1.0571.00
85_P91_P1.0511.00
30_V33_R1.0351.00
13_I61_V1.0101.00
10_A125_L0.9871.00
16_T24_F0.9791.00
13_I16_T0.9661.00
9_A30_V0.9621.00
33_R58_V0.9501.00
62_S104_L0.9481.00
7_R120_V0.9431.00
67_N89_Y0.9391.00
8_L37_K0.9291.00
76_I79_R0.9291.00
121_D126_T0.9271.00
24_F29_T0.9111.00
66_Y104_L0.8991.00
20_P111_D0.8931.00
26_F30_V0.8931.00
24_F106_F0.8831.00
45_I86_V0.8651.00
68_A129_I0.8641.00
14_N118_A0.8591.00
45_I84_Y0.8571.00
15_G117_Q0.8541.00
66_Y70_L0.8511.00
27_N99_Y0.8471.00
68_A127_V0.8421.00
74_L109_D0.8351.00
74_L106_F0.8261.00
44_V51_V0.8241.00
10_A61_V0.8171.00
21_G111_D0.8151.00
18_I22_E0.8081.00
8_L39_Y0.8081.00
33_R99_Y0.8011.00
31_G38_G0.7941.00
70_L93_R0.7931.00
62_S97_V0.7911.00
72_A129_I0.7841.00
8_L40_K0.7811.00
32_P37_K0.7611.00
65_L118_A0.7541.00
65_L116_I0.7521.00
3_V120_V0.7521.00
63_T67_N0.7441.00
15_G115_L0.7431.00
50_L86_V0.7301.00
13_I29_T0.7281.00
26_F61_V0.7251.00
64_T127_V0.7241.00
65_L127_V0.7121.00
44_V98_S0.7111.00
116_I129_I0.7101.00
34_T54_V0.7061.00
45_I83_S0.6991.00
9_A26_F0.6881.00
59_C94_D0.6771.00
27_N97_V0.6771.00
90_P93_R0.6751.00
34_T38_G0.6741.00
59_C96_T0.6731.00
67_N90_P0.6721.00
68_A72_A0.6701.00
85_P90_P0.6661.00
18_I106_F0.6651.00
2_R6_I0.6561.00
32_P36_E0.6441.00
65_L106_F0.6431.00
74_L110_T0.6401.00
64_T68_A0.6391.00
53_G98_S0.6391.00
76_I104_L0.6351.00
65_L69_A0.6341.00
10_A120_V0.6331.00
46_V49_E0.6331.00
66_Y76_I0.6311.00
82_H96_T0.6271.00
112_Y115_L0.6261.00
3_V6_I0.6201.00
79_R95_A0.6171.00
78_E101_Y0.6141.00
84_Y87_S0.6091.00
30_V39_Y0.6051.00
120_V123_G0.6011.00
69_A129_I0.6001.00
106_F114_I0.5911.00
13_I30_V0.5891.00
31_G37_K0.5831.00
85_P89_Y0.5821.00
120_V125_L0.5801.00
61_V125_L0.5761.00
66_Y79_R0.5711.00
106_F116_I0.5711.00
7_R122_G0.5701.00
27_N101_Y0.5661.00
11_S14_N0.5641.00
12_K16_T0.5641.00
55_G59_C0.5621.00
13_I26_F0.5471.00
33_R55_G0.5461.00
27_N31_G0.5451.00
78_E102_V0.5391.00
66_Y92_G0.5361.00
68_A116_I0.5351.00
21_G107_K0.5341.00
25_S28_K0.5331.00
59_C79_R0.5311.00
18_I24_F0.5311.00
31_G99_Y0.5311.00
110_T113_P0.5301.00
42_A52_P0.5281.00
66_Y89_Y0.5261.00
66_Y95_A0.5231.00
27_N100_P0.5221.00
110_T114_I0.5211.00
9_A13_I0.5201.00
80_H96_T0.5171.00
80_H83_S0.5161.00
81_N84_Y0.5151.00
73_G89_Y0.5081.00
41_E53_G0.5081.00
58_V61_V0.5071.00
27_N58_V0.5061.00
79_R94_D0.5041.00
10_A127_V0.5011.00
6_I60_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p8rA 1 0.9538 33.4 0.913 Contact Map
1m1sA 1 0.3692 26.4 0.917 Contact Map
2f8aA 3 0.2538 23.5 0.919 Contact Map
4f82A 2 0.3769 14.5 0.926 Contact Map
2og4A 1 0.9538 11.7 0.929 Contact Map
4aslA 2 0.2 11.2 0.93 Contact Map
2co7B 1 0.3923 9.6 0.932 Contact Map
4o94A 1 0.2385 9.3 0.933 Contact Map
4pbqA 1 0.2308 9.2 0.933 Contact Map
1rowA 1 0.3462 7 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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