GREMLIN Database
SpoVR - SpoVR like protein
PFAM: PF04293 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 418 (414)
Sequences: 4525 (2510)
Seq/√Len: 123.4
META: 0.805

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_I242_I4.2261.00
24_D113_K4.1871.00
362_E366_E3.8511.00
85_C109_N3.5901.00
262_M313_F3.3661.00
361_P365_R3.0391.00
27_P83_N3.0301.00
17_I274_I3.0211.00
26_Y124_A2.9351.00
268_S310_F2.9201.00
149_A239_Q2.8821.00
262_M354_F2.8211.00
349_Y358_Y2.7541.00
153_F239_Q2.6811.00
315_D319_R2.6481.00
17_I20_E2.6411.00
312_L363_L2.5391.00
313_F342_I2.5261.00
66_Q72_S2.5231.00
268_S296_V2.4681.00
141_Y241_D2.4301.00
337_S340_E2.3781.00
137_R241_D2.3681.00
83_N125_R2.3601.00
110_D266_W2.3341.00
96_T288_F2.3131.00
178_E181_R2.3001.00
375_D384_I2.2921.00
16_E19_R2.2801.00
317_E339_R2.2641.00
157_C243_L2.2501.00
273_R277_E2.2471.00
318_R366_E2.2471.00
273_R317_E2.2111.00
307_A311_A2.1731.00
33_I41_A2.1721.00
13_E16_E2.1681.00
97_M291_S2.1421.00
334_I341_K2.0831.00
296_V310_F2.0441.00
8_E12_E2.0371.00
15_E19_R2.0331.00
364_I393_V2.0281.00
324_T327_D2.0241.00
20_E277_E1.9981.00
228_I243_L1.9901.00
21_F277_E1.9851.00
315_D360_T1.9661.00
39_L63_L1.9601.00
325_E329_E1.9481.00
154_L246_V1.9391.00
110_D346_R1.9251.00
111_F262_M1.9181.00
341_K344_E1.9111.00
142_E147_R1.9011.00
64_K68_R1.9001.00
149_A152_R1.8791.00
320_W341_K1.8621.00
11_D106_Y1.8601.00
266_W270_W1.8571.00
28_N109_N1.8201.00
16_E20_E1.7901.00
197_R200_P1.7771.00
236_E239_Q1.7761.00
373_E386_D1.7401.00
326_E330_W1.7271.00
178_E182_Q1.7091.00
311_A314_E1.6801.00
11_D15_E1.6701.00
176_E179_E1.6681.00
202_K205_K1.6481.00
363_L366_E1.6371.00
138_I245_I1.6341.00
179_E182_Q1.6171.00
111_F263_N1.6111.00
266_W346_R1.6031.00
141_Y145_Y1.6011.00
273_R314_E1.5941.00
28_N87_A1.5651.00
10_Y14_I1.5451.00
274_I279_D1.5211.00
79_V105_V1.5151.00
362_E365_R1.5051.00
343_F346_R1.4981.00
33_I38_M1.4971.00
229_E244_R1.4861.00
82_S128_I1.4791.00
8_E11_D1.4771.00
337_S341_K1.4691.00
96_T275_M1.4651.00
137_R141_Y1.4531.00
389_G392_K1.4491.00
164_V251_Q1.4461.00
364_I390_Y1.4431.00
363_L367_L1.4411.00
343_F347_E1.4361.00
15_E25_F1.4331.00
18_A25_F1.4271.00
225_L243_L1.4271.00
9_R12_E1.4231.00
15_E106_Y1.4161.00
185_R189_I1.4141.00
103_A274_I1.4071.00
280_L285_M1.4041.00
10_Y13_E1.4041.00
349_Y357_Q1.3941.00
226_Y230_K1.3831.00
261_I355_I1.3791.00
272_Y310_F1.3791.00
19_R25_F1.3721.00
153_F242_I1.3711.00
177_E180_E1.3611.00
411_V414_V1.3581.00
317_E321_E1.3541.00
122_T130_Y1.3501.00
288_F292_H1.3401.00
371_V396_A1.3361.00
272_Y288_F1.3301.00
341_K358_Y1.3171.00
341_K345_V1.3101.00
332_P335_A1.3081.00
311_A367_L1.3061.00
269_Y339_R1.2981.00
134_A245_I1.2951.00
229_E240_R1.2831.00
26_Y109_N1.2801.00
184_E190_N1.2781.00
216_F227_F1.2751.00
269_Y342_I1.2731.00
5_E8_E1.2671.00
322_C331_F1.2661.00
189_I192_Y1.2661.00
195_L199_L1.2651.00
154_L242_I1.2581.00
344_E348_N1.2511.00
10_Y102_I1.2470.99
290_K293_S1.2370.99
307_A367_L1.2360.99
272_Y314_E1.2350.99
315_D366_E1.2340.99
30_F106_Y1.2290.99
216_F231_H1.2260.99
359_L369_L1.2240.99
192_Y195_L1.2240.99
21_F270_W1.2210.99
260_K406_R1.2140.99
280_L284_E1.2070.99
275_M288_F1.2050.99
11_D102_I1.2010.99
190_N194_D1.1980.99
344_E349_Y1.1940.99
313_F354_F1.1940.99
130_Y248_E1.1890.99
181_R184_E1.1890.99
6_E95_L1.1790.99
18_A106_Y1.1770.99
316_I345_V1.1750.99
314_E317_E1.1600.99
324_T362_E1.1570.99
99_K284_E1.1560.99
270_W343_F1.1560.99
28_N106_Y1.1540.99
262_M316_I1.1460.99
326_E329_E1.1380.99
110_D270_W1.1360.99
117_L350_N1.1330.99
196_W200_P1.1200.99
273_R339_R1.1160.99
184_E188_Y1.1130.99
191_P195_L1.1120.99
94_T287_E1.1020.99
17_I279_D1.0990.99
153_F157_C1.0990.99
333_D336_G1.0990.99
190_N195_L1.0920.99
157_C246_V1.0920.99
202_K206_E1.0920.99
392_K395_E1.0910.99
387_E392_K1.0860.99
311_A363_L1.0860.99
46_G78_I1.0830.99
13_E17_I1.0820.99
149_A236_E1.0810.99
349_Y353_S1.0800.99
229_E243_L1.0790.99
37_Q40_D1.0780.99
372_Y381_V1.0760.99
319_R360_T1.0730.98
43_A63_L1.0730.98
9_R13_E1.0640.98
36_E40_D1.0630.98
190_N193_N1.0600.98
116_Y119_R1.0600.98
204_E208_E1.0590.98
215_R412_V1.0570.98
313_F316_I1.0560.98
205_K209_E1.0530.98
59_E62_R1.0510.98
7_L89_L1.0460.98
327_D330_W1.0400.98
162_N406_R1.0390.98
217_P220_P1.0380.98
160_L225_L1.0350.98
185_R190_N1.0330.98
177_E182_Q1.0290.98
311_A366_E1.0230.98
135_A139_R1.0190.98
41_A82_S1.0190.98
52_P135_A1.0150.98
50_R56_F1.0120.98
50_R249_E1.0060.98
6_E9_R1.0000.98
292_H310_F0.9980.98
34_T37_Q0.9950.98
186_E189_I0.9900.97
200_P203_K0.9880.97
315_D318_R0.9840.97
192_Y200_P0.9820.97
247_R251_Q0.9810.97
196_W199_L0.9690.97
21_F274_I0.9670.97
257_R404_G0.9660.97
52_P139_R0.9620.97
175_L178_E0.9600.97
174_S181_R0.9580.97
153_F235_L0.9540.97
204_E207_E0.9530.97
261_I401_Y0.9510.97
148_E152_R0.9500.97
377_D382_E0.9490.97
266_W342_I0.9470.97
364_I370_F0.9440.97
333_D337_S0.9430.97
26_Y85_C0.9430.97
269_Y317_E0.9410.97
10_Y95_L0.9410.97
208_E211_E0.9400.96
7_L102_I0.9390.96
17_I278_L0.9370.96
191_P196_W0.9370.96
194_D197_R0.9370.96
327_D333_D0.9350.96
162_N257_R0.9320.96
14_I274_I0.9310.96
30_F101_V0.9240.96
17_I277_E0.9220.96
207_E211_E0.9210.96
215_R413_D0.9180.96
26_Y113_K0.9130.96
392_K396_A0.9120.96
361_P390_Y0.9090.96
192_Y199_L0.9040.96
323_P327_D0.9040.96
136_R140_R0.9040.96
184_E189_I0.8980.95
218_P221_E0.8980.95
320_W338_G0.8920.95
356_R395_E0.8920.95
22_G343_F0.8910.95
184_E187_E0.8900.95
179_E183_E0.8900.95
206_E209_E0.8900.95
207_E210_E0.8880.95
158_H161_M0.8860.95
25_F109_N0.8810.95
174_S177_E0.8810.95
187_E190_N0.8800.95
186_E192_Y0.8740.95
339_R343_F0.8740.95
78_I260_K0.8720.95
298_P308_L0.8690.95
174_S179_E0.8670.95
266_W313_F0.8660.94
254_Y257_R0.8650.94
126_D129_D0.8600.94
33_I78_I0.8580.94
61_E65_K0.8570.94
170_P258_Q0.8550.94
194_D202_K0.8550.94
65_K69_Y0.8540.94
192_Y198_T0.8530.94
177_E181_R0.8530.94
176_E182_Q0.8510.94
185_R188_Y0.8510.94
226_Y229_E0.8490.94
103_A275_M0.8490.94
356_R363_L0.8400.94
292_H296_V0.8370.93
122_T125_R0.8340.93
253_F256_Q0.8320.93
45_V59_E0.8320.93
38_M78_I0.8310.93
186_E190_N0.8300.93
26_Y125_R0.8290.93
182_Q186_E0.8290.93
33_I90_M0.8290.93
329_E387_E0.8280.93
257_R403_N0.8270.93
206_E210_E0.8260.93
385_H388_R0.8240.93
203_K207_E0.8220.93
174_S178_E0.8210.93
310_F314_E0.8200.93
286_L290_K0.8200.93
20_E278_L0.8190.93
268_S292_H0.8160.93
312_L315_D0.8160.93
334_I337_S0.8160.93
290_K294_G0.8150.92
110_D114_N0.8100.92
25_F113_K0.8050.92
41_A78_I0.8040.92
223_D247_R0.8000.92
24_D114_N0.8000.92
214_K218_P0.7990.92
70_G73_G0.7990.92
272_Y276_N0.7980.92
188_Y191_P0.7950.92
163_H224_L0.7930.91
285_M289_A0.7890.91
182_Q185_R0.7870.91
176_E181_R0.7840.91
192_Y196_W0.7810.91
152_R239_Q0.7810.91
193_N196_W0.7810.91
13_E281_T0.7810.91
221_E226_Y0.7780.91
202_K207_E0.7760.91
175_L181_R0.7750.90
175_L179_E0.7720.90
174_S180_E0.7710.90
275_M278_L0.7690.90
323_P326_E0.7670.90
181_R185_R0.7660.90
244_R248_E0.7640.90
173_L181_R0.7600.90
62_R66_Q0.7600.90
387_E390_Y0.7560.89
192_Y197_R0.7550.89
184_E191_P0.7510.89
394_R398_L0.7490.89
214_K236_E0.7480.89
334_I358_Y0.7440.89
130_Y134_A0.7440.89
13_E279_D0.7420.88
96_T284_E0.7400.88
188_Y193_N0.7400.88
152_R156_A0.7380.88
81_N256_Q0.7360.88
356_R398_L0.7360.88
191_P197_R0.7360.88
79_V109_N0.7360.88
10_Y99_K0.7350.88
118_F256_Q0.7350.88
21_F273_R0.7340.88
110_D343_F0.7330.88
201_K204_E0.7310.88
296_V307_A0.7310.88
72_S75_A0.7280.88
198_T201_K0.7270.87
193_N200_P0.7260.87
371_V382_E0.7260.87
55_S58_K0.7250.87
391_R395_E0.7240.87
276_N285_M0.7240.87
372_Y389_G0.7240.87
33_I40_D0.7220.87
201_K205_K0.7180.87
323_P330_W0.7130.86
225_L228_I0.7120.86
303_I369_L0.7120.86
30_F105_V0.7060.86
185_R192_Y0.7060.86
25_F28_N0.7050.86
120_Q170_P0.7040.86
137_R245_I0.7010.86
173_L180_E0.7010.86
207_E212_K0.7010.86
215_R220_P0.7000.85
66_Q71_L0.6990.85
216_F219_E0.6970.85
320_W360_T0.6950.85
291_S294_G0.6940.85
96_T291_S0.6930.85
319_R331_F0.6910.85
199_L202_K0.6900.85
179_E186_E0.6890.85
399_A405_G0.6880.84
112_F256_Q0.6870.84
209_E212_K0.6870.84
373_E396_A0.6860.84
205_K211_E0.6860.84
213_R236_E0.6850.84
270_W346_R0.6840.84
373_E382_E0.6820.84
352_E398_L0.6810.84
293_S296_V0.6810.84
174_S182_Q0.6800.84
324_T331_F0.6790.84
175_L182_Q0.6790.84
320_W345_V0.6780.84
178_E184_E0.6760.83
344_E358_Y0.6720.83
183_E186_E0.6720.83
205_K210_E0.6700.83
202_K209_E0.6670.83
386_D389_G0.6660.82
403_N406_R0.6650.82
15_E27_P0.6640.82
188_Y192_Y0.6630.82
404_G408_N0.6630.82
122_T126_D0.6630.82
173_L182_Q0.6630.82
261_I305_P0.6620.82
395_E399_A0.6620.82
371_V386_D0.6610.82
193_N198_T0.6590.82
47_M404_G0.6590.82
364_I369_L0.6570.82
62_R68_R0.6570.82
10_Y17_I0.6560.82
257_R260_K0.6540.81
173_L176_E0.6530.81
26_Y83_N0.6520.81
312_L355_I0.6510.81
370_F386_D0.6500.81
16_E279_D0.6480.81
114_N346_R0.6460.81
296_V299_S0.6460.81
359_L390_Y0.6460.81
194_D198_T0.6440.80
126_D133_F0.6430.80
23_L266_W0.6410.80
270_W273_R0.6410.80
323_P332_P0.6400.80
175_L180_E0.6380.80
345_V358_Y0.6380.80
107_G268_S0.6380.80
225_L247_R0.6380.80
266_W343_F0.6380.80
261_I303_I0.6350.79
59_E63_L0.6340.79
275_M280_L0.6320.79
3_T6_E0.6310.79
338_G341_K0.6300.79
373_E393_V0.6290.79
173_L177_E0.6250.78
328_R362_E0.6250.78
63_L72_S0.6230.78
14_I17_I0.6220.78
217_P228_I0.6220.78
4_F32_I0.6210.78
171_R179_E0.6210.78
229_E247_R0.6190.78
37_Q41_A0.6180.78
324_T334_I0.6180.78
67_Y73_G0.6170.77
180_E184_E0.6170.77
206_E212_K0.6160.77
133_F252_Y0.6150.77
224_L411_V0.6150.77
119_R347_E0.6150.77
176_E180_E0.6130.77
76_Y294_G0.6130.77
14_I99_K0.6130.77
226_Y244_R0.6130.77
206_E211_E0.6130.77
328_R335_A0.6100.77
216_F414_V0.6090.77
271_H292_H0.6080.76
191_P199_L0.6060.76
30_F33_I0.6060.76
325_E328_R0.6040.76
184_E192_Y0.6040.76
252_Y256_Q0.6040.76
79_V106_Y0.6030.76
299_S302_G0.6010.76
45_V257_R0.6010.76
99_K102_I0.6000.75
134_A248_E0.6000.75
47_M131_L0.6000.75
116_Y120_Q0.5990.75
260_K313_F0.5970.75
225_L350_N0.5970.75
266_W269_Y0.5950.75
374_D409_I0.5940.75
385_H389_G0.5940.75
172_K175_L0.5930.75
361_P364_I0.5920.75
227_F414_V0.5920.75
318_R332_P0.5910.74
172_K176_E0.5910.74
14_I102_I0.5900.74
312_L345_V0.5900.74
161_M250_A0.5890.74
375_D378_E0.5880.74
11_D28_N0.5850.74
413_D416_Y0.5830.73
340_E344_E0.5830.73
49_T135_A0.5820.73
342_I346_R0.5820.73
312_L316_I0.5810.73
179_E189_I0.5800.73
60_F64_K0.5800.73
177_E189_I0.5800.73
45_V161_M0.5800.73
6_E10_Y0.5780.73
119_R170_P0.5770.73
355_I401_Y0.5750.72
55_S154_L0.5750.72
40_D64_K0.5740.72
194_D200_P0.5730.72
112_F259_T0.5720.72
18_A23_L0.5720.72
262_M266_W0.5720.72
89_L98_Q0.5710.72
171_R174_S0.5710.72
407_P411_V0.5710.72
201_K208_E0.5710.72
200_P204_E0.5700.72
39_L67_Y0.5690.72
216_F220_P0.5690.72
317_E320_W0.5690.72
160_L224_L0.5680.71
176_E187_E0.5660.71
45_V107_G0.5650.71
203_K210_E0.5650.71
217_P231_H0.5650.71
256_Q263_N0.5640.71
88_Y107_G0.5630.71
376_G382_E0.5630.71
143_E147_R0.5620.71
145_Y149_A0.5620.71
281_T284_E0.5590.70
297_S302_G0.5580.70
299_S303_I0.5540.70
81_N112_F0.5530.69
156_A159_A0.5510.69
111_F266_W0.5510.69
67_Y90_M0.5510.69
35_A90_M0.5510.69
275_M291_S0.5510.69
350_N353_S0.5510.69
90_M107_G0.5510.69
303_I308_L0.5500.69
374_D383_A0.5480.69
140_R144_R0.5460.68
202_K210_E0.5460.68
188_Y195_L0.5440.68
272_Y292_H0.5430.68
180_E183_E0.5410.68
127_I252_Y0.5400.68
204_E212_K0.5390.68
256_Q260_K0.5380.67
332_P336_G0.5370.67
38_M66_Q0.5370.67
17_I280_L0.5350.67
184_E194_D0.5340.67
344_E347_E0.5340.67
103_A107_G0.5340.67
117_L348_N0.5330.67
133_F244_R0.5330.67
42_Y74_L0.5330.67
344_E350_N0.5330.67
31_E292_H0.5320.67
25_F106_Y0.5320.67
199_L205_K0.5290.66
284_E287_E0.5280.66
21_F278_L0.5280.66
206_E328_R0.5280.66
343_F356_R0.5270.66
55_S59_E0.5270.66
215_R218_P0.5260.66
225_L233_P0.5260.66
51_Y158_H0.5250.66
28_N33_I0.5250.66
136_R139_R0.5240.65
130_Y230_K0.5230.65
222_E408_N0.5220.65
7_L32_I0.5210.65
165_D168_K0.5210.65
107_G310_F0.5200.65
325_E362_E0.5190.65
361_P391_R0.5190.65
273_R342_I0.5190.65
302_G308_L0.5180.64
181_R188_Y0.5170.64
340_E343_F0.5160.64
194_D214_K0.5150.64
186_E191_P0.5130.64
188_Y194_D0.5130.64
151_E155_D0.5130.64
39_L42_Y0.5120.64
160_L228_I0.5110.63
62_R72_S0.5110.63
268_S272_Y0.5110.63
162_N250_A0.5110.63
354_F358_Y0.5100.63
217_P227_F0.5090.63
375_D382_E0.5090.63
376_G389_G0.5080.63
14_I26_Y0.5070.63
15_E30_F0.5060.63
325_E335_A0.5040.62
13_E20_E0.5040.62
32_I90_M0.5030.62
260_K403_N0.5030.62
204_E211_E0.5030.62
78_I131_L0.5030.62
345_V354_F0.5030.62
79_V85_C0.5030.62
308_L382_E0.5020.62
321_E338_G0.5020.62
259_T263_N0.5020.62
120_Q169_R0.5020.62
365_R386_D0.5010.62
63_L66_Q0.5010.62
183_E190_N0.5010.62
100_L271_H0.5010.62
262_M273_R0.5010.62
117_L167_Y0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cqbA 4 0.2129 49 0.976 Contact Map
4il3A 1 0.4569 47.8 0.976 Contact Map
4qhjA 2 0.2512 19.7 0.98 Contact Map
4j2cA 1 0.1148 11.6 0.982 Contact Map
2r60A 1 0.3349 9.4 0.983 Contact Map
3a5yA 2 0.1746 9 0.983 Contact Map
2jnzA 1 0.134 8.4 0.983 Contact Map
3i4pA 5 0.3612 8.2 0.983 Contact Map
1k0dA 2 0.1627 8.1 0.983 Contact Map
3glvA 2 0.0574 7.8 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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