GREMLIN Database
DctQ - Tripartite ATP-independent periplasmic transporters, DctQ component
PFAM: PF04290 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 132 (128)
Sequences: 87979 (57446)
Seq/√Len: 5077.5
META: 0.867

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_F122_L2.5371.00
7_A19_L2.4971.00
58_P61_A2.4791.00
32_W110_A2.4671.00
61_A64_V2.1941.00
45_G125_E2.1731.00
78_A82_W2.1211.00
121_Q124_A1.9631.00
41_A46_G1.9371.00
87_V91_L1.9301.00
5_V26_A1.8421.00
57_L61_A1.7931.00
7_A11_L1.7671.00
74_L119_A1.7541.00
70_D129_L1.7261.00
51_D55_D1.6871.00
42_L122_L1.6551.00
77_C118_L1.6501.00
40_Y44_R1.6361.00
43_R121_Q1.6241.00
81_A116_A1.6011.00
42_L118_L1.5971.00
42_L125_E1.5751.00
54_Y62_R1.5651.00
60_R64_V1.5531.00
57_L65_L1.5501.00
103_P106_P1.4851.00
11_L15_F1.4761.00
77_C119_A1.4591.00
54_Y66_D1.4421.00
88_L92_G1.4201.00
67_L126_L1.4161.00
23_E27_R1.4091.00
70_D125_E1.3941.00
11_L17_S1.3681.00
78_A119_A1.3401.00
38_A118_L1.3331.00
39_A117_L1.3151.00
70_D126_L1.3131.00
10_V14_V1.3031.00
11_L19_L1.2941.00
93_G105_W1.2931.00
77_C115_F1.2851.00
30_F34_V1.2741.00
63_R129_L1.2701.00
81_A119_A1.2441.00
86_F90_L1.2431.00
59_P63_R1.2401.00
81_A85_W1.2331.00
66_D129_L1.2321.00
125_E129_L1.2261.00
59_P62_R1.2111.00
88_L91_L1.2061.00
39_A121_Q1.1661.00
8_Q23_E1.1561.00
121_Q125_E1.1531.00
85_W112_P1.1511.00
125_E128_R1.1351.00
81_A115_F1.1341.00
90_L94_G1.1281.00
97_S100_L1.1171.00
65_L69_G1.1151.00
80_L115_F1.0931.00
90_L93_G1.0881.00
60_R63_R1.0871.00
77_C122_L1.0691.00
124_A128_R1.0591.00
89_S93_G1.0571.00
79_L83_Y1.0551.00
74_L126_L1.0361.00
6_F10_V1.0301.00
62_R66_D1.0281.00
87_V90_L1.0281.00
10_V15_F1.0231.00
8_Q22_A1.0091.00
28_Y107_V0.9931.00
3_L7_A0.9831.00
28_Y97_S0.9721.00
64_V68_L0.9661.00
4_L29_L0.9501.00
97_S101_G0.9491.00
96_S101_G0.9451.00
66_D70_D0.9221.00
106_P110_A0.9181.00
89_S92_G0.9101.00
109_L112_P0.9071.00
49_R66_D0.9051.00
84_G115_F0.8991.00
73_F77_C0.8911.00
8_Q19_L0.8901.00
72_L75_A0.8841.00
74_L123_L0.8771.00
43_R124_A0.8751.00
64_V67_L0.8741.00
110_A114_G0.8721.00
63_R67_L0.8621.00
38_A42_L0.8571.00
70_D122_L0.8561.00
67_L129_L0.8351.00
75_A78_A0.8341.00
4_L22_A0.8311.00
95_Q104_L0.8301.00
104_L108_Y0.8281.00
19_L22_A0.8261.00
74_L122_L0.8261.00
45_G49_R0.8201.00
2_V6_F0.8191.00
84_G111_I0.8181.00
61_A65_L0.8051.00
105_W109_L0.8021.00
11_L14_V0.7931.00
91_L95_Q0.7891.00
81_A112_P0.7881.00
41_A47_H0.7861.00
122_L125_E0.7811.00
45_G66_D0.7741.00
105_W108_Y0.7621.00
102_I107_V0.7561.00
104_L107_V0.7491.00
25_L100_L0.7481.00
84_G112_P0.7381.00
39_A114_G0.7381.00
32_W36_L0.7341.00
106_P109_L0.7321.00
71_L126_L0.7291.00
71_L75_A0.7261.00
113_V117_L0.7221.00
98_P101_G0.7181.00
114_G118_L0.7151.00
25_L102_I0.7141.00
31_V34_V0.7131.00
21_W25_L0.7071.00
63_R66_D0.7071.00
52_L56_R0.7001.00
49_R54_Y0.6981.00
35_F111_I0.6971.00
62_R65_L0.6971.00
82_W85_W0.6941.00
74_L78_A0.6901.00
109_L113_V0.6791.00
123_L127_I0.6751.00
8_Q18_P0.6711.00
8_Q11_L0.6681.00
45_G129_L0.6661.00
4_L25_L0.6651.00
54_Y65_L0.6601.00
116_A120_L0.6581.00
93_G96_S0.6561.00
91_L94_G0.6501.00
42_L47_H0.6441.00
37_G41_A0.6361.00
124_A127_I0.6321.00
92_G95_Q0.6261.00
53_L56_R0.6211.00
86_F89_S0.6201.00
120_L124_A0.6161.00
89_S105_W0.6161.00
96_S100_L0.6141.00
68_L72_L0.6141.00
86_F93_G0.6111.00
10_V13_Y0.6091.00
55_D62_R0.6061.00
40_Y43_R0.6031.00
112_P116_A0.6001.00
54_Y69_G0.5951.00
6_F9_V0.5931.00
27_R31_V0.5921.00
4_L26_A0.5861.00
11_L18_P0.5851.00
45_G70_D0.5791.00
9_V13_Y0.5791.00
30_F33_L0.5791.00
59_P64_V0.5731.00
119_A122_L0.5721.00
25_L29_L0.5671.00
66_D69_G0.5651.00
69_G73_F0.5581.00
38_A47_H0.5521.00
82_W87_V0.5481.00
67_L71_L0.5451.00
46_G49_R0.5411.00
42_L70_D0.5411.00
87_V94_G0.5391.00
5_V8_Q0.5371.00
88_L93_G0.5311.00
7_A17_S0.5241.00
114_G117_L0.5221.00
22_A26_A0.5191.00
35_F115_F0.5131.00
87_V92_G0.5101.00
107_V110_A0.5031.00
23_E26_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wswA 3 0.6212 4.8 0.911 Contact Map
2a65A 2 0.9242 4.5 0.912 Contact Map
4humA 1 0.9773 4.1 0.914 Contact Map
2ov2I 1 0.2424 3.5 0.917 Contact Map
2odbB 1 0.2424 3.3 0.918 Contact Map
3mktA 1 0.9773 3.1 0.92 Contact Map
4xp4A 1 0.9545 2.9 0.921 Contact Map
4c7rA 3 0.9924 2.8 0.921 Contact Map
4lz6A 1 0.9848 2.8 0.922 Contact Map
2qmeI 1 0.1591 1.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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