GREMLIN Database
DUF441 - Protein of unknown function (DUF441)
PFAM: PF04284 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (139)
Sequences: 1013 (590)
Seq/√Len: 50.1
META: 0.494

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_L23_A3.3741.00
3_L61_A3.2081.00
15_N90_A2.9581.00
93_N130_I2.8951.00
47_I51_I2.5051.00
11_L14_K2.4781.00
116_I121_F2.1141.00
39_L47_I2.0761.00
74_F132_A2.0381.00
49_L93_N2.0111.00
13_G18_V1.9961.00
83_I112_I1.9290.99
126_V129_L1.8750.99
97_V137_L1.8060.99
40_L58_V1.7960.99
85_G93_N1.7400.99
76_S79_G1.7310.99
81_L138_L1.6960.98
33_L38_P1.6920.98
114_T118_V1.6830.98
69_D72_E1.6750.98
56_V111_V1.6710.98
18_V53_T1.6580.98
7_L26_L1.5900.98
116_I120_F1.5710.97
85_G135_A1.5200.97
89_V118_V1.5140.97
24_V54_I1.4820.96
58_V62_S1.4800.96
22_A57_L1.4110.95
43_R46_N1.4090.95
12_I138_L1.4070.95
117_G131_A1.3900.95
119_A124_V1.3720.94
11_L16_N1.3450.94
26_L60_I1.3310.93
27_L75_K1.3200.93
56_V129_L1.3060.93
85_G89_V1.3030.93
10_G18_V1.2880.92
81_L135_A1.2850.92
95_R136_A1.2810.92
60_I108_V1.2700.92
28_L37_F1.2610.91
130_I135_A1.2600.91
28_L40_L1.2570.91
43_R49_L1.2520.91
66_G69_D1.2440.91
15_N118_V1.2340.90
40_L54_I1.2330.90
49_L85_G1.2240.90
57_L111_V1.2180.90
124_V130_I1.2180.90
60_I120_F1.2060.89
4_L26_L1.2050.89
20_I100_L1.1970.89
6_L25_L1.1970.89
81_L84_A1.1890.89
4_L8_A1.1880.89
1_L5_I1.1710.88
49_L97_V1.1560.87
5_I75_K1.1450.87
43_R85_G1.1040.85
30_L61_A1.0930.84
31_L87_I1.0830.84
13_G139_L1.0760.83
18_V129_L1.0650.83
5_I74_F1.0600.82
17_S60_I1.0580.82
115_I119_A1.0540.82
67_F70_L1.0520.82
92_L101_K1.0470.81
56_V66_G1.0440.81
2_F8_A1.0350.81
136_A139_L1.0340.81
66_G80_L1.0320.81
13_G30_L1.0300.80
34_D83_I1.0210.80
28_L58_V1.0170.80
14_K27_L0.9970.78
111_V126_V0.9930.78
67_F71_L0.9700.76
114_T130_I0.9700.76
19_A22_A0.9670.76
118_V130_I0.9490.75
83_I117_G0.9470.74
23_A54_I0.9450.74
75_K139_L0.9380.74
84_A88_L0.9380.74
66_G115_I0.9370.74
6_L132_A0.9300.73
11_L23_A0.9230.73
19_A23_A0.9150.72
86_G104_P0.9040.71
78_K139_L0.8970.70
89_V93_N0.8930.70
57_L76_S0.8880.70
89_V130_I0.8790.69
49_L130_I0.8770.69
1_L12_I0.8550.67
52_L107_V0.8540.67
15_N93_N0.8520.66
25_L29_K0.8460.66
123_G127_G0.8330.65
20_I31_L0.8310.64
7_L22_A0.8300.64
18_V29_K0.8290.64
86_G99_L0.8290.64
45_L104_P0.8190.63
89_V114_T0.8130.63
127_G133_G0.8110.63
15_N130_I0.8030.62
50_I55_A0.8020.62
15_N119_A0.8020.62
126_V133_G0.8010.62
20_I24_V0.7990.61
33_L36_Y0.7970.61
114_T122_K0.7940.61
7_L106_I0.7910.61
114_T117_G0.7880.60
114_T125_P0.7820.60
35_R121_F0.7710.59
49_L89_V0.7700.59
37_F82_A0.7610.58
25_L129_L0.7510.57
90_A114_T0.7420.56
72_E75_K0.7340.55
28_L34_D0.7310.55
94_G103_D0.7280.54
72_E105_E0.7230.54
90_A93_N0.7220.54
57_L79_G0.7190.53
25_L125_P0.7170.53
72_E98_T0.7150.53
46_N50_I0.7120.53
6_L21_A0.7070.52
4_L7_L0.7070.52
62_S80_L0.6990.51
41_E64_K0.6990.51
46_N136_A0.6980.51
90_A119_A0.6970.51
5_I8_A0.6890.50
106_I122_K0.6890.50
46_N89_V0.6870.50
4_L121_F0.6840.50
1_L120_F0.6810.49
49_L55_A0.6800.49
109_G125_P0.6760.49
11_L63_G0.6730.49
53_T90_A0.6700.48
6_L31_L0.6660.48
75_K107_V0.6650.48
2_F106_I0.6610.47
16_N40_L0.6580.47
109_G136_A0.6520.47
46_N121_F0.6470.46
35_R42_K0.6460.46
88_L92_L0.6410.45
23_A27_L0.6400.45
130_I133_G0.6370.45
74_F92_L0.6250.44
15_N114_T0.6230.44
41_E117_G0.6230.44
13_G120_F0.6120.42
63_G66_G0.6110.42
57_L115_I0.6090.42
21_A74_F0.6080.42
9_L18_V0.5950.41
83_I87_I0.5920.40
64_K81_L0.5910.40
56_V104_P0.5880.40
37_F58_V0.5860.40
100_L111_V0.5830.40
2_F112_I0.5820.39
85_G91_Y0.5810.39
126_V134_I0.5760.39
45_L55_A0.5710.38
90_A97_V0.5710.38
33_L66_G0.5710.38
31_L39_L0.5690.38
52_L126_V0.5660.38
16_N122_K0.5660.38
68_K72_E0.5660.38
13_G100_L0.5630.38
9_L67_F0.5510.36
82_A106_I0.5510.36
8_A12_I0.5460.36
69_D111_V0.5430.36
92_L106_I0.5430.36
91_Y136_A0.5420.36
53_T101_K0.5410.36
61_A98_T0.5400.35
71_L84_A0.5370.35
108_V135_A0.5360.35
16_N19_A0.5360.35
13_G79_G0.5330.35
25_L56_V0.5250.34
5_I84_A0.5240.34
95_R124_V0.5230.34
10_G84_A0.5210.34
17_S130_I0.5200.34
93_N129_L0.5190.33
93_N126_V0.5140.33
112_I120_F0.5100.33
5_I14_K0.5060.32
87_I121_F0.5050.32
91_Y94_G0.5010.32
80_L84_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.7842 12.8 0.937 Contact Map
1i5pA 1 0.5612 5 0.948 Contact Map
4o93B 1 0.8417 4.8 0.948 Contact Map
4o9uB 2 0.8201 4.3 0.949 Contact Map
1gntA 1 0.5971 3.1 0.952 Contact Map
2nq2A 2 0.705 2.7 0.954 Contact Map
1gnlA 1 0.5755 2.7 0.954 Contact Map
2zy9A 2 0.9065 2.3 0.956 Contact Map
2l9uA 2 0.1151 2.3 0.956 Contact Map
3wajA 1 0.8633 1.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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