GREMLIN Database
DUF438 - Family of unknown function (DUF438)
PFAM: PF04282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (66)
Sequences: 3424 (1925)
Seq/√Len: 236.9
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_R20_E5.5531.00
7_R12_E4.0491.00
12_E16_E2.3841.00
47_V51_Q2.0831.00
13_S16_E2.0791.00
49_E52_R2.0691.00
2_K43_E2.0021.00
3_E7_R1.9191.00
6_K43_E1.8811.00
41_I50_I1.8291.00
30_A34_A1.6241.00
38_Q42_A1.6201.00
54_C57_H1.4531.00
12_E17_V1.4291.00
7_R10_E1.3881.00
6_K10_E1.3741.00
22_K59_A1.3051.00
2_K6_K1.2831.00
22_K63_G1.2771.00
1_L36_M1.2711.00
39_E42_A1.2581.00
18_K22_K1.2481.00
47_V50_I1.2231.00
18_K63_G1.1751.00
19_E23_E1.1731.00
59_A62_K1.1461.00
5_I36_M1.1381.00
31_S35_E1.1171.00
9_H49_E1.0751.00
41_I47_V1.0031.00
37_E54_C0.9991.00
62_K65_L0.9981.00
48_E51_Q0.9711.00
16_E20_E0.9631.00
2_K39_E0.9491.00
14_P60_V0.9171.00
18_K59_A0.9101.00
28_V32_E0.9091.00
37_E57_H0.8870.99
62_K66_E0.8620.99
23_E26_G0.8590.99
21_F61_F0.8410.99
33_I61_F0.8360.99
6_K36_M0.8330.99
5_I45_L0.8270.99
3_E10_E0.8240.99
3_E20_E0.8230.99
11_G14_P0.8120.99
30_A33_I0.8000.99
34_A51_Q0.7920.99
21_F33_I0.7680.98
61_F64_S0.7540.98
6_K49_E0.7540.98
47_V58_A0.7510.98
56_V61_F0.7480.98
8_L17_V0.7420.98
4_I28_V0.7390.98
38_Q47_V0.7320.98
16_E19_E0.7150.98
8_L52_R0.7080.97
25_L29_S0.6920.97
12_E20_E0.6680.96
35_E39_E0.6680.96
39_E43_E0.6660.96
20_E23_E0.6580.96
23_E27_D0.6490.96
34_A58_A0.6490.96
26_G29_S0.6470.96
3_E24_L0.6460.96
20_E24_L0.6310.95
45_L49_E0.6270.95
58_A62_K0.6200.95
46_P52_R0.6150.94
58_A63_G0.6130.94
14_P59_A0.6120.94
21_F28_V0.5980.93
61_F65_L0.5790.92
59_A63_G0.5740.92
9_H45_L0.5730.92
19_E22_K0.5670.91
22_K26_G0.5670.91
26_G64_S0.5540.91
38_Q41_I0.5490.90
19_E66_E0.5480.90
9_H33_I0.5470.90
17_V20_E0.5470.90
25_L30_A0.5390.89
6_K45_L0.5360.89
37_E53_L0.5220.88
15_E18_K0.5190.87
28_V33_I0.5150.87
9_H43_E0.5140.87
42_A45_L0.5110.87
38_Q58_A0.5110.87
31_S34_A0.5100.87
4_I60_V0.5040.86
46_P49_E0.5030.86
6_K9_H0.5030.86
29_S36_M0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nufA 2 0.9254 54.2 0.809 Contact Map
4v3iA 2 0.8209 38.2 0.826 Contact Map
4muoA 2 0.9851 35.7 0.829 Contact Map
4gtnA 2 1 30.5 0.835 Contact Map
4giuA 2 1 29.9 0.836 Contact Map
1o17A 2 0.9851 26.6 0.84 Contact Map
1vquA 2 0.9701 26.3 0.84 Contact Map
3u66A 4 0.8806 23.6 0.844 Contact Map
3h5qA 2 1 20.1 0.849 Contact Map
1brwA 2 1 19.8 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0039 seconds.