GREMLIN Database
IspA - Intracellular septation protein A
PFAM: PF04279 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (172)
Sequences: 12056 (7241)
Seq/√Len: 552.1
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_W131_A3.5861.00
71_E143_T3.1041.00
102_K113_D2.7811.00
71_E75_K2.7791.00
142_S145_T2.7731.00
114_E118_K2.6971.00
41_W45_R2.6081.00
86_A128_L2.6061.00
39_V43_R2.5441.00
141_F145_T2.5301.00
75_K143_T2.3371.00
90_L124_A2.1451.00
16_A28_V1.9621.00
112_P115_G1.9551.00
91_G95_F1.8821.00
12_L28_V1.8801.00
63_G67_L1.8541.00
137_V141_F1.8451.00
16_A24_V1.8341.00
38_A42_L1.8241.00
83_W87_A1.7801.00
30_I59_V1.7771.00
112_P172_H1.7641.00
23_Y66_L1.7221.00
136_Y141_F1.7221.00
21_G24_V1.7031.00
24_V27_A1.6281.00
135_E139_R1.5861.00
48_P51_P1.5491.00
18_K148_N1.5391.00
130_L154_L1.5371.00
42_L45_R1.5271.00
93_L120_N1.5061.00
37_L55_L1.4971.00
20_A24_V1.4901.00
34_V59_V1.4801.00
41_W47_V1.4781.00
102_K106_G1.4711.00
145_T148_N1.4191.00
93_L117_R1.4131.00
148_N151_L1.4101.00
163_L166_G1.4041.00
29_F58_V1.3971.00
149_F154_L1.3871.00
38_A41_W1.3691.00
37_L47_V1.3541.00
121_L125_L1.3401.00
33_T55_L1.3261.00
128_L132_A1.2951.00
41_W44_T1.2891.00
23_Y69_H1.2851.00
22_I74_I1.2761.00
83_W128_L1.2641.00
132_A136_Y1.2561.00
30_I62_G1.2551.00
99_N102_K1.2541.00
51_P55_L1.2261.00
52_L56_V1.2161.00
88_V91_G1.2121.00
27_A31_V1.2091.00
17_Y143_T1.1991.00
95_F98_K1.1911.00
34_V55_L1.1871.00
148_N152_F1.1831.00
167_P170_S1.1761.00
14_F18_K1.1731.00
100_L103_R1.1611.00
117_R121_L1.1601.00
136_Y140_N1.1591.00
89_L120_N1.1511.00
40_S44_T1.1431.00
115_G118_K1.1411.00
17_Y147_V1.1311.00
166_G170_S1.1251.00
99_N120_N1.1051.00
89_L101_L1.0961.00
153_G156_G1.0941.00
152_F156_G1.0921.00
125_L129_A1.0891.00
26_T62_G1.0831.00
87_A91_G1.0811.00
161_F165_Q1.0791.00
49_K53_V1.0711.00
82_Y154_L1.0611.00
163_L167_P1.0581.00
15_V19_L1.0561.00
115_G168_L1.0541.00
10_L151_L1.0411.00
26_T65_T1.0211.00
64_L68_L1.0201.00
98_K103_R1.0191.00
40_S51_P1.0101.00
75_K138_A0.9991.00
159_L162_A0.9891.00
105_L108_A0.9891.00
47_V52_L0.9841.00
118_K168_L0.9801.00
137_V149_F0.9791.00
12_L32_A0.9761.00
90_L121_L0.9701.00
135_E138_A0.9561.00
113_D117_R0.9521.00
155_L158_T0.9491.00
35_A39_V0.9471.00
92_G100_L0.9411.00
164_A167_P0.9241.00
28_V31_V0.9231.00
76_W139_R0.9221.00
162_A166_G0.9221.00
34_V38_A0.9211.00
118_K121_L0.9151.00
90_L94_L0.9001.00
72_T76_W0.8921.00
54_S58_V0.8861.00
94_L97_G0.8851.00
7_F10_L0.8821.00
86_A90_L0.8731.00
29_F74_I0.8711.00
137_V140_N0.8701.00
39_V42_L0.8681.00
79_T134_N0.8651.00
30_I34_V0.8641.00
90_L125_L0.8601.00
89_L100_L0.8561.00
88_V100_L0.8531.00
168_L172_H0.8521.00
126_F161_F0.8501.00
158_T162_A0.8481.00
99_N103_R0.8431.00
137_V145_T0.8431.00
86_A124_A0.8421.00
144_D148_N0.8411.00
170_S173_L0.8311.00
24_V28_V0.8311.00
53_V57_L0.8261.00
159_L163_L0.8221.00
64_L73_F0.8191.00
122_R165_Q0.8141.00
55_L59_V0.8101.00
151_L155_L0.8101.00
149_F153_G0.8101.00
169_L173_L0.8071.00
133_L157_L0.8041.00
8_G32_A0.8031.00
129_A133_L0.8021.00
15_V18_K0.7961.00
131_A135_E0.7851.00
60_V63_G0.7771.00
40_S47_V0.7761.00
70_D73_F0.7741.00
71_E74_I0.7731.00
105_L109_L0.7701.00
72_T139_R0.7691.00
114_E117_R0.7661.00
107_E110_E0.7621.00
64_L67_L0.7581.00
16_A20_A0.7581.00
121_L124_A0.7581.00
29_F33_T0.7551.00
160_V164_A0.7541.00
52_L55_L0.7531.00
124_A128_L0.7521.00
11_I15_V0.7381.00
112_P118_K0.7271.00
106_G110_E0.7261.00
91_G124_A0.7241.00
138_A142_S0.7171.00
144_D147_V0.7011.00
92_G99_N0.7011.00
130_L133_L0.6991.00
72_T75_K0.6981.00
84_L88_V0.6971.00
56_V60_V0.6961.00
90_L93_L0.6951.00
46_K49_K0.6941.00
41_W52_L0.6841.00
115_G172_H0.6821.00
26_T74_I0.6811.00
33_T40_S0.6741.00
82_Y130_L0.6671.00
33_T58_V0.6661.00
76_W135_E0.6651.00
117_R120_N0.6611.00
162_A169_L0.6581.00
16_A25_A0.6541.00
23_Y26_T0.6481.00
151_L156_G0.6441.00
37_L51_P0.6371.00
18_K144_D0.6321.00
83_W135_E0.6301.00
21_G25_A0.6291.00
85_F89_L0.6271.00
36_Q40_S0.6271.00
167_P171_R0.6251.00
93_L99_N0.6241.00
123_W165_Q0.6191.00
78_P154_L0.6161.00
37_L52_L0.6151.00
93_L121_L0.6131.00
133_L136_Y0.6111.00
156_G160_V0.6111.00
153_G157_L0.6091.00
57_L61_F0.6071.00
81_I85_F0.6041.00
29_F32_A0.6031.00
89_L92_G0.5991.00
27_A66_L0.5981.00
122_R161_F0.5971.00
82_Y158_T0.5971.00
99_N117_R0.5951.00
78_P138_A0.5941.00
119_L165_Q0.5931.00
61_F81_I0.5891.00
54_S81_I0.5861.00
85_F127_F0.5831.00
26_T66_L0.5811.00
17_Y21_G0.5760.99
61_F80_I0.5720.99
93_L97_G0.5710.99
102_K105_L0.5710.99
8_G36_Q0.5700.99
68_L73_F0.5690.99
23_Y65_T0.5690.99
49_K52_L0.5680.99
138_A141_F0.5680.99
23_Y27_A0.5650.99
133_L149_F0.5650.99
98_K102_K0.5610.99
123_W162_A0.5610.99
5_L8_G0.5560.99
14_F151_L0.5540.99
122_R168_L0.5500.99
79_T135_E0.5460.99
126_F157_L0.5450.99
33_T37_L0.5420.99
41_W46_K0.5400.99
133_L137_V0.5370.99
10_L14_F0.5370.99
129_A157_L0.5360.99
31_V35_A0.5360.99
14_F152_F0.5310.99
30_I66_L0.5280.99
30_I33_T0.5280.99
84_L87_A0.5250.99
122_R125_L0.5240.99
89_L124_A0.5240.99
32_A36_Q0.5220.99
2_K48_P0.5220.99
50_M85_F0.5210.99
146_W149_F0.5200.99
130_L157_L0.5190.99
120_N124_A0.5180.99
17_Y144_D0.5170.99
148_N153_G0.5140.99
3_L7_F0.5120.99
79_T132_A0.5090.99
76_W80_I0.5020.99
22_I143_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9034 24.2 0.916 Contact Map
3m73A 3 0.7216 3.8 0.942 Contact Map
3rceA 1 0.8182 3.7 0.943 Contact Map
1pi7A 1 0.108 3.2 0.944 Contact Map
2a65A 2 0.9602 3 0.945 Contact Map
3w4tA 1 0.9432 2.7 0.946 Contact Map
4lz6A 1 0.9545 2.6 0.947 Contact Map
2l2tA 2 0.1989 2.4 0.948 Contact Map
2m20A 2 0.1932 2.4 0.948 Contact Map
3wajA 1 0.9489 2.4 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.