GREMLIN Database
OAD_gamma - Oxaloacetate decarboxylase, gamma chain
PFAM: PF04277 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (73)
Sequences: 12101 (9872)
Seq/√Len: 1155.4
META: 0.903

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_V26_K3.2751.00
26_K30_K3.0791.00
62_D65_L2.7231.00
23_L27_L2.2401.00
70_A74_A2.0251.00
23_L26_K2.0211.00
2_E5_L1.9451.00
66_V70_A1.8761.00
29_S33_N1.8741.00
61_D65_L1.8651.00
4_L8_L1.8601.00
64_E68_A1.8521.00
28_M32_I1.7631.00
19_I23_L1.6711.00
29_S32_I1.6601.00
21_L25_I1.6451.00
7_T11_M1.5691.00
65_L68_A1.5591.00
17_F21_L1.5011.00
26_K29_S1.4681.00
65_L69_I1.4051.00
65_L70_A1.3741.00
71_A75_A1.3691.00
71_A74_A1.3431.00
19_I22_V1.3221.00
7_T10_G1.3161.00
33_N36_A1.2661.00
3_G6_L1.2491.00
30_K34_K1.1501.00
27_L30_K1.1411.00
17_F22_V1.1381.00
25_I28_M1.1031.00
61_D64_E1.1001.00
69_I73_I1.0441.00
30_K33_N1.0381.00
67_A71_A1.0361.00
68_A71_A1.0251.00
16_L19_I1.0221.00
14_V18_L1.0221.00
34_K37_K1.0141.00
32_I35_F0.9621.00
62_D66_V0.9491.00
61_D66_V0.9491.00
22_V25_I0.9451.00
66_V71_A0.9291.00
11_M15_F0.8741.00
9_L12_G0.8711.00
35_F39_K0.8661.00
35_F38_K0.8291.00
20_L24_V0.8291.00
5_L9_L0.8231.00
42_K45_A0.8151.00
13_V16_L0.8021.00
34_K38_K0.7981.00
31_I35_F0.7881.00
63_G66_V0.7761.00
51_A55_A0.7731.00
67_A70_A0.7601.00
70_A76_Y0.7501.00
50_A54_A0.7461.00
16_L20_L0.7401.00
48_A51_A0.7321.00
9_L13_V0.7291.00
15_F19_I0.7141.00
47_A50_A0.7131.00
6_L25_I0.7021.00
16_L23_L0.6961.00
46_A49_A0.6921.00
64_E67_A0.6791.00
21_L29_S0.6731.00
38_K42_K0.6731.00
45_A48_A0.6721.00
13_V25_I0.6661.00
70_A73_I0.6661.00
13_V17_F0.6591.00
10_G17_F0.6551.00
6_L28_M0.6491.00
63_G67_A0.6291.00
19_I26_K0.6231.00
40_A43_A0.6231.00
45_A51_A0.6231.00
36_A39_K0.6201.00
5_L8_L0.6171.00
4_L17_F0.6121.00
38_K41_A0.6051.00
11_M17_F0.5781.00
4_L7_T0.5781.00
40_A44_A0.5751.00
49_A55_A0.5721.00
24_V27_L0.5651.00
68_A72_A0.5641.00
47_A52_A0.5631.00
52_A55_A0.5601.00
24_V28_M0.5581.00
5_L25_I0.5551.00
60_E63_G0.5521.00
10_G13_V0.5501.00
48_A52_A0.5461.00
42_K46_A0.5461.00
42_K50_A0.5421.00
37_K40_A0.5381.00
49_A52_A0.5331.00
58_E61_D0.5301.00
12_G19_I0.5191.00
41_A45_A0.5161.00
59_E62_D0.5111.00
50_A53_A0.5021.00
53_A58_E0.5011.00
2_E6_L0.5001.00
18_L25_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a2fA 1 0 28.4 0.801 Contact Map
4ij3C 1 0 14.6 0.826 Contact Map
2kncA 1 0.5974 14.5 0.826 Contact Map
2kogA 1 0.3377 10.3 0.837 Contact Map
2m3eA 1 0.5455 8.1 0.845 Contact Map
3w9iA 3 0.5325 6.6 0.851 Contact Map
4k0jA 3 0.4935 6.5 0.851 Contact Map
4tphA 2 0.4286 6.2 0.853 Contact Map
4um9B 2 0 6 0.854 Contact Map
4dx5A 3 0.5584 5.9 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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