GREMLIN Database
DUF434 - Protein of unknown function (DUF434)
PFAM: PF04256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (54)
Sequences: 3430 (2457)
Seq/√Len: 334.4
META: 0.939

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_K28_D4.2711.00
14_S47_D3.1221.00
8_D30_Y2.9961.00
46_S49_A2.1721.00
6_V44_A1.8221.00
18_A21_S1.6121.00
45_C50_A1.5641.00
10_S44_A1.5331.00
47_D51_A1.5071.00
10_S14_S1.4271.00
9_L22_A1.4211.00
11_W15_R1.4111.00
8_D15_R1.4041.00
14_S48_E1.4021.00
9_L23_L1.2811.00
45_C53_R1.2411.00
28_D37_R1.2371.00
48_E52_R1.2291.00
35_R39_A1.2121.00
9_L19_E1.1811.00
51_A55_A1.1181.00
37_R42_R1.1021.00
23_L41_A1.0891.00
38_L41_A1.0831.00
49_A52_R1.0801.00
4_E8_D1.0781.00
21_S25_L1.0661.00
20_K24_K1.0381.00
7_A15_R1.0051.00
4_E7_A1.0021.00
18_A25_L0.9541.00
38_L42_R0.9411.00
52_R55_A0.9271.00
9_L41_A0.9241.00
8_D11_W0.9211.00
36_Q39_A0.9071.00
34_E38_L0.8781.00
6_V10_S0.8771.00
13_L19_E0.8681.00
33_T36_Q0.8541.00
31_Q38_L0.8491.00
22_A25_L0.7951.00
19_E41_A0.7941.00
49_A53_R0.7831.00
30_Y41_A0.7781.00
39_A43_C0.7741.00
9_L26_V0.7501.00
6_V40_L0.7280.99
10_S13_L0.7040.99
14_S46_S0.7040.99
19_E45_C0.6990.99
20_K41_A0.6930.99
7_A11_W0.6880.99
9_L25_L0.6870.99
9_L13_L0.6720.99
25_L29_R0.6650.99
39_A53_R0.6640.99
40_L43_C0.6460.99
11_W17_Y0.6330.98
21_S24_K0.6290.98
10_S47_D0.6290.98
50_A54_R0.6210.98
2_L40_L0.6130.98
24_K34_E0.6090.98
4_E15_R0.6080.98
19_E31_Q0.6030.98
16_G19_E0.5980.98
20_K34_E0.5880.97
9_L44_A0.5770.97
27_G32_L0.5760.97
8_D17_Y0.5630.96
4_E30_Y0.5590.96
51_A54_R0.5570.96
18_A43_C0.5530.96
21_S28_D0.5510.96
26_V40_L0.5360.95
13_L38_L0.5230.95
47_D54_R0.5220.95
32_L40_L0.5160.94
31_Q34_E0.5020.93
28_D31_Q0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3urgA 1 0.3393 38.8 0.824 Contact Map
4ktpA 2 1 11.1 0.864 Contact Map
3wirA 4 1 8.1 0.872 Contact Map
4qmfD 1 0.9286 7.6 0.873 Contact Map
1h54A 2 1 7.5 0.874 Contact Map
3kwpA 2 0 6.9 0.876 Contact Map
4dn7A 2 0.8214 6.6 0.877 Contact Map
2jtvA 1 0.7679 6.1 0.879 Contact Map
3c1dA 2 0.4643 5.5 0.881 Contact Map
1j2zA 3 0.875 4.6 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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