GREMLIN Database
RseC_MucC - Positive regulator of sigma(E), RseC/MucC
PFAM: PF04246 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (125)
Sequences: 10008 (8298)
Seq/√Len: 742.2
META: 0.875

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_T40_E3.5001.00
80_G102_G3.2951.00
3_S10_W3.2281.00
10_W40_E3.2161.00
2_V12_E2.9171.00
84_G98_G2.7681.00
43_N47_A2.6621.00
12_E36_E2.5941.00
10_W38_E2.3651.00
106_G110_L2.2991.00
77_L99_G2.1931.00
43_N46_G2.1621.00
80_G84_G2.1551.00
76_L106_G2.1371.00
12_E38_E2.1041.00
48_K51_D2.0531.00
4_I49_V1.8431.00
111_R114_R1.8291.00
81_A99_G1.8241.00
76_L102_G1.8141.00
109_I113_F1.7731.00
63_L66_A1.7531.00
5_E10_W1.6621.00
67_L71_L1.6281.00
15_R37_K1.5881.00
108_L112_L1.5361.00
96_A100_L1.5261.00
76_L80_G1.5231.00
62_L66_A1.5191.00
102_G106_G1.5081.00
13_I55_V1.4891.00
3_S49_V1.4761.00
111_R115_R1.4621.00
81_A95_A1.4521.00
2_V38_E1.4171.00
80_G98_G1.4131.00
62_L70_Y1.3751.00
95_A99_G1.3701.00
98_G102_G1.3281.00
59_E63_L1.3211.00
4_I9_A1.2701.00
9_A47_A1.2281.00
1_V47_A1.2171.00
8_T42_P1.2101.00
85_S95_A1.1981.00
114_R118_K1.1801.00
61_A64_K1.1701.00
82_L86_A1.1581.00
84_G88_A1.1101.00
1_V4_I1.0581.00
103_L107_F1.0561.00
103_L106_G1.0451.00
94_L98_G1.0381.00
68_L72_L1.0291.00
7_G42_P1.0131.00
110_L114_R0.9921.00
92_E95_A0.9891.00
9_A43_N0.9801.00
93_L97_L0.9801.00
68_L110_L0.9771.00
5_E8_T0.9741.00
5_E40_E0.9691.00
74_L78_L0.9251.00
15_R18_A0.9241.00
78_L82_L0.9211.00
90_G94_L0.9191.00
91_S94_L0.9001.00
100_L103_L0.8991.00
104_A108_L0.8881.00
84_G90_G0.8821.00
37_K41_V0.8761.00
84_G89_G0.8761.00
95_A98_G0.8731.00
64_K120_K0.8731.00
34_S37_K0.8671.00
92_E96_A0.8671.00
57_I62_L0.8381.00
31_A37_K0.8381.00
31_A35_K0.8371.00
44_P47_A0.8371.00
84_G95_A0.8331.00
63_L67_L0.8311.00
47_A51_D0.8311.00
72_L76_L0.8311.00
108_L111_R0.8291.00
57_I61_A0.8221.00
65_A69_V0.8101.00
117_L120_K0.8041.00
21_S25_K0.8031.00
2_V10_W0.8011.00
66_A70_Y0.7981.00
14_E36_E0.7971.00
93_L96_A0.7861.00
29_K32_S0.7761.00
17_S20_G0.7741.00
77_L103_L0.7691.00
18_A21_S0.7571.00
58_P61_A0.7511.00
32_S37_K0.7461.00
115_R118_K0.7401.00
20_G25_K0.7381.00
89_G94_L0.7371.00
23_A26_G0.7361.00
67_L75_L0.7291.00
57_I70_Y0.7271.00
113_F117_L0.7221.00
32_S35_K0.7221.00
7_G43_N0.7161.00
3_S38_E0.7161.00
23_A27_G0.7141.00
79_A83_L0.6971.00
24_A27_G0.6941.00
83_L87_L0.6911.00
56_G59_E0.6871.00
79_A82_L0.6851.00
100_L104_A0.6811.00
112_L116_R0.6791.00
116_R119_K0.6781.00
17_S21_S0.6771.00
107_F110_L0.6731.00
67_L72_L0.6641.00
109_I112_L0.6611.00
9_A45_L0.6601.00
84_G94_L0.6551.00
107_F111_R0.6501.00
68_L113_F0.6491.00
64_K122_R0.6491.00
112_L115_R0.6491.00
21_S24_A0.6461.00
9_A41_V0.6431.00
84_G102_G0.6431.00
42_P124_Q0.6391.00
60_S122_R0.6361.00
114_R117_L0.6291.00
10_W13_I0.6271.00
71_L75_L0.6231.00
116_R120_K0.6141.00
60_S64_K0.6101.00
113_F116_R0.6051.00
20_G23_A0.6041.00
27_G31_A0.6031.00
99_G103_L0.6011.00
11_V55_V0.5981.00
76_L110_L0.5981.00
74_L81_A0.5971.00
69_V107_F0.5971.00
66_A74_L0.5931.00
85_S92_E0.5911.00
24_A70_Y0.5851.00
66_A69_V0.5851.00
47_A53_V0.5841.00
56_G61_A0.5841.00
72_L109_I0.5791.00
14_E52_R0.5791.00
71_L74_L0.5781.00
15_R57_I0.5761.00
4_I7_G0.5711.00
63_L71_L0.5711.00
88_A94_L0.5681.00
105_L109_I0.5641.00
9_A125_P0.5631.00
33_G37_K0.5601.00
121_F124_Q0.5591.00
122_R125_P0.5561.00
85_S91_S0.5531.00
92_E99_G0.5501.00
101_L104_A0.5491.00
69_V110_L0.5461.00
13_I62_L0.5451.00
13_I37_K0.5281.00
69_V73_P0.5271.00
72_L106_G0.5251.00
89_G98_G0.5251.00
105_L108_L0.5251.00
21_S26_G0.5241.00
90_G93_L0.5221.00
17_S23_A0.5211.00
62_L81_A0.5211.00
70_Y78_L0.5201.00
41_V45_L0.5201.00
104_A107_F0.5181.00
88_A92_E0.5181.00
77_L81_A0.5151.00
81_A96_A0.5081.00
30_L34_S0.5041.00
102_G105_L0.5001.00
41_V53_V0.5001.00
17_S33_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vehA 1 0.4186 13.9 0.897 Contact Map
1kg2A 1 0.3411 12.1 0.899 Contact Map
2m5oA 1 0.4031 9.8 0.903 Contact Map
4ql5A 4 0.4574 9.2 0.904 Contact Map
3i4oA 1 0.4574 8.1 0.907 Contact Map
4toiA 2 0.3488 7.9 0.907 Contact Map
1xhjA 1 0.4419 7.3 0.909 Contact Map
2d9rA 1 0.4574 7.1 0.909 Contact Map
1oruA 2 0.4264 6.4 0.911 Contact Map
3pjyA 1 0.4109 6.3 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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