GREMLIN Database
NA37 - 37-kD nucleoid-associated bacterial protein
PFAM: PF04245 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 312 (302)
Sequences: 4260 (3181)
Seq/√Len: 183.1
META: 0.666

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_K251_Q5.1311.00
1_I70_V4.4361.00
54_V76_I4.0141.00
247_K250_F3.7741.00
95_L110_I3.7181.00
236_A239_V3.6061.00
99_Y106_D3.1591.00
70_V74_K3.0801.00
49_H52_D2.7521.00
231_F235_V2.7511.00
77_A95_L2.7451.00
237_E240_F2.6251.00
121_K128_E2.5391.00
68_D71_E2.5111.00
240_F243_E2.4491.00
230_I235_V2.4271.00
59_S146_K2.3681.00
248_D251_Q2.3591.00
49_H53_L2.3301.00
73_S97_V2.3071.00
63_E146_K2.3041.00
156_V178_C2.2731.00
249_F253_E2.2421.00
61_I99_Y2.1851.00
140_L143_N2.1711.00
218_D222_E2.1431.00
223_N234_E2.0841.00
236_A240_F2.0661.00
281_I286_N2.0071.00
61_I72_F1.9741.00
80_L175_F1.9741.00
101_E106_D1.9701.00
250_F253_E1.9401.00
75_N78_K1.9281.00
105_V143_N1.8551.00
72_F75_N1.8401.00
283_L286_N1.8371.00
277_I285_I1.8221.00
48_E51_E1.8021.00
100_F109_G1.8011.00
243_E246_A1.7541.00
74_K78_K1.7411.00
249_F252_E1.7021.00
282_N286_N1.6801.00
248_D252_E1.6601.00
76_I95_L1.6111.00
281_I285_I1.6061.00
64_D68_D1.5891.00
280_D285_I1.5861.00
277_I280_D1.5611.00
204_L209_Q1.5601.00
57_Y75_N1.5331.00
275_R286_N1.5281.00
125_I130_G1.5151.00
275_R280_D1.5091.00
275_R281_I1.4821.00
281_I284_S1.4821.00
57_Y72_F1.4731.00
237_E243_E1.4541.00
277_I281_I1.4431.00
28_L32_F1.4421.00
279_L282_N1.4381.00
279_L287_F1.4191.00
228_E232_L1.4101.00
273_Q279_L1.4061.00
196_K213_L1.4011.00
239_V243_E1.3991.00
48_E52_D1.3871.00
226_F231_F1.3841.00
158_F172_F1.3751.00
9_S12_E1.3741.00
226_F230_I1.3661.00
58_L108_I1.3581.00
238_E242_D1.3551.00
16_E74_K1.3461.00
112_K138_K1.3431.00
47_S179_K1.3431.00
282_N285_I1.3271.00
240_F244_P1.3221.00
275_R279_L1.3091.00
191_L195_C1.3071.00
83_Q174_D1.3071.00
139_C142_I1.3021.00
139_C143_N1.2901.00
295_Y299_T1.2901.00
65_P69_F1.2641.00
277_I287_F1.2601.00
60_E72_F1.2541.00
279_L284_S1.2511.00
279_L283_L1.2431.00
283_L288_D1.2411.00
45_R48_E1.2381.00
238_E243_E1.2261.00
56_N60_E1.2261.00
10_D13_V1.2201.00
283_L287_F1.2131.00
78_K82_E1.2131.00
12_E15_S1.2021.00
60_E75_N1.1941.00
275_R282_N1.1891.00
304_I307_I1.1831.00
239_V242_D1.1811.00
273_Q280_D1.1811.00
273_Q281_I1.1801.00
145_E181_R1.1771.00
282_N287_F1.1741.00
242_D245_E1.1651.00
271_K274_K1.1641.00
17_L20_L1.1581.00
280_D283_L1.1541.00
192_L217_V1.1481.00
279_L285_I1.1471.00
280_D286_N1.1471.00
158_F178_C1.1461.00
279_L286_N1.1451.00
71_E75_N1.1371.00
275_R287_F1.1331.00
219_Y223_N1.1231.00
275_R284_S1.1201.00
270_L279_L1.1131.00
223_N230_I1.1101.00
275_R283_L1.1061.00
270_L273_Q1.0991.00
280_D284_S1.0971.00
59_S63_E1.0941.00
1_I69_F1.0931.00
106_D143_N1.0921.00
76_I97_V1.0871.00
236_A243_E1.0871.00
96_Y113_S1.0861.00
195_C199_V1.0831.00
284_S287_F1.0821.00
76_I110_I1.0781.00
61_I108_I1.0731.00
169_S172_F1.0711.00
194_A197_D1.0711.00
61_I64_D1.0711.00
284_S288_D1.0651.00
17_L21_D1.0621.00
281_I296_D1.0551.00
294_I297_D1.0551.00
216_S219_Y1.0521.00
278_K283_L1.0291.00
282_N288_D1.0291.00
242_D246_A1.0251.00
239_V244_P1.0251.00
277_I286_N1.0241.00
273_Q285_I1.0221.00
68_D72_F1.0190.99
57_Y79_H1.0150.99
213_L216_S1.0150.99
133_I136_L1.0150.99
27_L31_Y1.0140.99
187_Q190_N1.0140.99
79_H83_Q1.0090.99
48_E53_L1.0040.99
171_W175_F1.0010.99
55_Y59_S1.0010.99
226_F235_V0.9990.99
189_K193_K0.9910.99
295_Y300_D0.9910.99
65_P68_D0.9900.99
277_I282_N0.9870.99
183_D186_E0.9800.99
275_R278_K0.9780.99
9_S15_S0.9720.99
60_E65_P0.9710.99
280_D287_F0.9700.99
237_E242_D0.9690.99
235_V240_F0.9650.99
241_E244_P0.9650.99
72_F76_I0.9610.99
182_E187_Q0.9610.99
79_H82_E0.9520.99
76_I175_F0.9450.99
279_L289_A0.9440.99
46_F156_V0.9430.99
28_L96_Y0.9410.99
224_D230_I0.9350.99
231_F261_E0.9280.99
158_F162_R0.9240.99
90_I171_W0.9200.99
98_A109_G0.9180.99
145_E152_E0.9170.99
28_L35_P0.9160.99
103_C142_I0.9070.99
10_D15_S0.9050.99
277_I283_L0.9030.99
262_F265_S0.9030.99
254_E257_E0.9020.99
97_V110_I0.9010.99
269_A275_R0.8980.99
285_I302_L0.8960.99
152_E155_Y0.8950.99
50_S53_L0.8950.99
168_A172_F0.8940.99
270_L287_F0.8890.99
211_D215_R0.8890.99
164_K167_D0.8890.99
191_L239_V0.8820.99
253_E256_Y0.8790.99
7_N14_L0.8730.98
59_S147_E0.8720.98
71_E74_K0.8710.98
229_E261_E0.8700.98
184_S265_S0.8680.98
114_E138_K0.8640.98
51_E57_Y0.8630.98
272_K286_N0.8630.98
296_D299_T0.8620.98
251_Q254_E0.8610.98
9_S13_V0.8590.98
113_S133_I0.8560.98
64_D99_Y0.8530.98
273_Q284_S0.8530.98
281_I287_F0.8460.98
270_L280_D0.8430.98
58_L141_I0.8410.98
236_A241_E0.8310.98
281_I288_D0.8290.98
269_A272_K0.8260.98
18_E70_V0.8200.98
208_E211_D0.8180.98
235_V243_E0.8120.97
228_E235_V0.8110.97
160_D168_A0.8100.97
225_E263_P0.8080.97
207_A210_I0.8000.97
274_K277_I0.8000.97
73_S77_A0.8000.97
138_K160_D0.8000.97
46_F49_H0.7920.97
247_K252_E0.7900.97
278_K284_S0.7870.97
272_K283_L0.7840.97
274_K284_S0.7830.97
202_E205_E0.7810.97
26_E30_K0.7800.97
278_K286_N0.7770.97
70_V73_S0.7770.97
154_Y160_D0.7750.97
57_Y60_E0.7720.97
14_L77_A0.7690.97
269_A287_F0.7650.96
103_C107_A0.7630.96
199_V212_L0.7620.96
81_Y85_N0.7610.96
32_F109_G0.7600.96
138_K175_F0.7590.96
172_F178_C0.7590.96
274_K280_D0.7590.96
59_S154_Y0.7590.96
6_G12_E0.7530.96
93_G112_K0.7530.96
23_E26_E0.7510.96
293_I298_G0.7490.96
239_V246_A0.7490.96
247_K253_E0.7490.96
224_D231_F0.7480.96
162_R166_E0.7430.96
207_A211_D0.7400.96
194_A256_Y0.7390.96
210_I214_N0.7350.96
214_N218_D0.7330.95
293_I303_I0.7320.95
80_L84_S0.7310.95
169_S173_D0.7280.95
94_E113_S0.7280.95
137_D140_L0.7280.95
278_K281_I0.7270.95
275_R285_I0.7260.95
191_L228_E0.7240.95
190_N193_K0.7210.95
269_A283_L0.7160.95
272_K281_I0.7140.95
286_N289_A0.7130.95
126_E129_K0.7120.95
215_R218_D0.7100.95
47_S53_L0.7090.95
43_Y157_S0.7080.95
276_V281_I0.7080.95
269_A284_S0.7020.94
261_E265_S0.7020.94
192_L220_F0.7020.94
272_K284_S0.7010.94
286_N290_Y0.7000.94
142_I157_S0.6920.94
227_D230_I0.6920.94
91_K171_W0.6890.94
8_K82_E0.6890.94
273_Q278_K0.6870.94
116_K119_F0.6870.94
114_E137_D0.6860.94
133_I137_D0.6840.93
295_Y302_L0.6840.93
232_L258_L0.6840.93
270_L284_S0.6830.93
5_V14_L0.6810.93
299_T303_I0.6800.93
8_K13_V0.6790.93
269_A281_I0.6780.93
84_S87_P0.6780.93
193_K197_D0.6730.93
267_K273_Q0.6710.93
274_K286_N0.6700.93
233_E247_K0.6690.93
191_L194_A0.6670.93
272_K287_F0.6660.93
25_V29_L0.6650.92
231_F240_F0.6640.92
94_E121_K0.6610.92
9_S14_L0.6590.92
80_L95_L0.6570.92
184_S263_P0.6560.92
195_C212_L0.6540.92
4_K38_S0.6540.92
69_F73_S0.6530.92
195_C250_F0.6510.92
147_E152_E0.6490.92
269_A273_Q0.6480.92
278_K288_D0.6480.92
11_E14_L0.6460.91
12_E81_Y0.6450.91
299_T302_L0.6440.91
47_S50_S0.6420.91
129_K132_N0.6410.91
187_Q259_P0.6410.91
283_L290_Y0.6410.91
83_Q86_H0.6400.91
237_E241_E0.6390.91
227_D261_E0.6370.91
283_L289_A0.6370.91
230_I233_E0.6360.91
211_D214_N0.6350.91
45_R49_H0.6330.91
237_E247_K0.6330.91
270_L281_I0.6280.90
273_Q286_N0.6270.90
197_D201_E0.6270.90
143_N153_G0.6270.90
229_E232_L0.6250.90
236_A244_P0.6230.90
182_E186_E0.6220.90
3_H73_S0.6180.89
30_K34_K0.6150.89
292_R306_G0.6140.89
298_G302_L0.6090.89
276_V287_F0.6060.89
16_E19_L0.6050.88
190_N258_L0.6040.88
293_I296_D0.6030.88
182_E257_E0.5960.88
273_Q288_D0.5950.88
94_E116_K0.5930.87
157_S160_D0.5920.87
11_E15_S0.5910.87
138_K170_Y0.5910.87
206_K209_Q0.5910.87
219_Y224_D0.5900.87
58_L61_I0.5900.87
87_P90_I0.5890.87
46_F53_L0.5890.87
139_C144_L0.5890.87
136_L159_I0.5880.87
96_Y136_L0.5870.87
268_K285_I0.5840.87
273_Q283_L0.5830.87
293_I301_S0.5820.87
300_D304_I0.5790.86
223_N227_D0.5770.86
240_F246_A0.5760.86
269_A274_K0.5760.86
227_D231_F0.5750.86
231_F234_E0.5740.86
117_E132_N0.5730.86
21_D24_L0.5730.86
112_K160_D0.5710.85
197_D256_Y0.5710.85
54_V110_I0.5690.85
302_L307_I0.5690.85
144_L155_Y0.5680.85
276_V286_N0.5680.85
142_I145_E0.5680.85
167_D172_F0.5670.85
62_F144_L0.5650.85
278_K287_F0.5640.85
20_L23_E0.5640.85
276_V283_L0.5630.85
7_N90_I0.5620.85
297_D302_L0.5620.85
45_R181_R0.5620.85
256_Y260_D0.5610.84
186_E190_N0.5610.84
301_S306_G0.5610.84
69_F177_G0.5610.84
155_Y160_D0.5600.84
1_I5_V0.5590.84
281_I289_A0.5580.84
297_D300_D0.5580.84
276_V280_D0.5570.84
276_V284_S0.5570.84
4_K13_V0.5550.84
57_Y78_K0.5550.84
234_E237_E0.5540.84
75_N82_E0.5530.84
85_N174_D0.5510.83
91_K178_C0.5500.83
223_N226_F0.5480.83
298_G305_K0.5460.83
236_A242_D0.5460.83
220_F223_N0.5450.83
220_F230_I0.5440.83
293_I297_D0.5440.83
214_N217_V0.5390.82
109_G178_C0.5390.82
187_Q262_F0.5390.82
270_L275_R0.5370.82
60_E66_D0.5370.82
269_A285_I0.5350.82
246_A250_F0.5330.81
300_D306_G0.5320.81
128_E132_N0.5320.81
140_L176_L0.5300.81
125_I128_E0.5290.81
116_K130_G0.5270.81
235_V246_A0.5270.81
54_V57_Y0.5250.80
5_V77_A0.5250.80
277_I284_S0.5240.80
269_A282_N0.5220.80
298_G303_I0.5220.80
294_I305_K0.5210.80
269_A279_L0.5210.80
143_N146_K0.5210.80
300_D307_I0.5210.80
300_D305_K0.5200.80
47_S52_D0.5200.80
65_P99_Y0.5190.80
217_V223_N0.5180.80
79_H177_G0.5170.79
8_K11_E0.5170.79
270_L286_N0.5120.79
134_N161_K0.5110.79
273_Q287_F0.5090.78
296_D301_S0.5080.78
299_T307_I0.5070.78
159_I163_N0.5050.78
191_L220_F0.5030.78
58_L142_I0.5020.77
197_D254_E0.5020.77
279_L306_G0.5020.77
285_I297_D0.5010.77
156_V160_D0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h6qA 1 0.3077 4.6 0.961 Contact Map
1ucrA 2 0.2276 4.4 0.961 Contact Map
1yz1A 1 0.3013 3.9 0.962 Contact Map
1txjA 1 0.3077 3.7 0.963 Contact Map
1bazA 4 0.0513 2.1 0.967 Contact Map
3k7cA 2 0.3237 1.9 0.968 Contact Map
2a4hA 1 0.1987 1.9 0.968 Contact Map
2fu4A 2 0.2404 1.8 0.968 Contact Map
4x86A 1 0.1635 1.8 0.968 Contact Map
3b34A 1 0.2404 1.8 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0095 seconds.