GREMLIN Database
DUF418 - Protein of unknown function (DUF418)
PFAM: PF04235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 163 (161)
Sequences: 14065 (10810)
Seq/√Len: 851.9
META: 0.809

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_N140_S3.6781.00
99_L152_L3.3581.00
9_D12_R3.1621.00
86_P89_A2.7701.00
106_T112_Y2.7581.00
21_A70_L2.7241.00
89_A141_R2.5171.00
142_W146_R2.3721.00
141_R145_R2.3031.00
149_F154_W2.2951.00
5_G8_T2.2761.00
26_G30_P2.2681.00
25_L67_Y2.1201.00
108_I116_L2.0611.00
101_Q136_Q2.0041.00
15_R19_R1.9171.00
14_R76_R1.9101.00
137_L141_R1.8911.00
90_V97_N1.8871.00
107_L114_L1.8751.00
105_C132_I1.8661.00
93_M144_L1.8581.00
92_R144_L1.8071.00
104_I132_I1.7371.00
14_R18_R1.7251.00
96_T100_L1.7171.00
154_W158_S1.7131.00
12_R16_L1.6511.00
86_P141_R1.5961.00
100_L139_F1.5721.00
6_V16_L1.5161.00
100_L136_Q1.4891.00
106_T110_Y1.4731.00
95_L152_L1.4531.00
121_G124_Q1.4221.00
27_I30_P1.4121.00
19_R23_I1.3921.00
116_L120_L1.3781.00
9_D13_H1.3761.00
124_Q127_L1.3621.00
21_A66_G1.3511.00
90_V137_L1.3411.00
20_L69_A1.3341.00
120_L124_Q1.3231.00
13_H16_L1.3191.00
77_R80_G1.3121.00
97_N136_Q1.2961.00
21_A69_A1.2871.00
90_V133_W1.2861.00
80_G83_L1.2801.00
16_L20_L1.2721.00
138_L141_R1.2661.00
10_G13_H1.2571.00
71_I75_Y1.2541.00
23_I26_G1.2541.00
30_P34_L1.2441.00
127_L131_A1.2421.00
22_L26_G1.2301.00
25_L66_G1.2161.00
63_L67_Y1.2141.00
120_L128_I1.2001.00
107_L112_Y1.1861.00
24_G69_A1.1821.00
116_L119_R1.1801.00
120_L125_L1.1711.00
138_L142_W1.1631.00
16_L19_R1.1481.00
158_S162_G1.1321.00
102_S106_T1.1271.00
135_L139_F1.1211.00
72_V76_R1.1201.00
18_R73_L1.1121.00
20_L24_G1.0941.00
123_A127_L1.0921.00
134_A138_L1.0841.00
148_R154_W1.0831.00
56_Y60_R1.0741.00
30_P33_L1.0571.00
85_R88_A1.0571.00
18_R22_L1.0541.00
62_L66_G1.0421.00
142_W145_R1.0421.00
149_F158_S1.0401.00
149_F157_R1.0331.00
81_R85_R1.0191.00
32_N59_G1.0171.00
93_M143_W1.0071.00
78_G81_R1.0041.00
82_R86_P1.0041.00
93_M140_S0.9971.00
40_A43_F0.9911.00
14_R73_L0.9891.00
21_A25_L0.9851.00
28_G32_N0.9851.00
111_G115_G0.9731.00
74_L84_L0.9721.00
13_H17_Y0.9691.00
83_L86_P0.9671.00
100_L104_I0.9671.00
159_L162_G0.9491.00
18_R21_A0.9231.00
11_E76_R0.9201.00
17_Y69_A0.9031.00
149_F161_Y0.8881.00
70_L74_L0.8841.00
37_L40_A0.8801.00
5_G9_D0.8771.00
45_P48_L0.8721.00
68_A72_V0.8691.00
99_L102_S0.8651.00
108_I128_I0.8481.00
86_P137_L0.8481.00
103_L152_L0.8461.00
81_R84_L0.8431.00
28_G66_G0.8351.00
156_W159_L0.8341.00
2_G8_T0.8301.00
105_C109_F0.8301.00
93_M139_F0.8281.00
37_L41_A0.8281.00
69_A73_L0.8261.00
136_Q139_F0.8261.00
128_I132_I0.8211.00
66_G70_L0.8121.00
66_G69_A0.8091.00
135_L138_L0.8081.00
94_A97_N0.8081.00
32_N35_G0.8001.00
27_I62_L0.7991.00
70_L73_L0.7981.00
20_L23_I0.7971.00
79_A82_R0.7961.00
122_R125_L0.7941.00
21_A73_L0.7891.00
4_S7_L0.7871.00
39_L43_F0.7851.00
15_R18_R0.7851.00
41_A44_P0.7821.00
143_W147_F0.7671.00
104_I135_L0.7551.00
133_W137_L0.7401.00
31_L59_G0.7311.00
57_Y60_R0.7291.00
39_L44_P0.7191.00
129_A133_W0.7181.00
64_A68_A0.7161.00
87_L137_L0.7091.00
104_I107_L0.7061.00
26_G66_G0.7001.00
29_L32_N0.6951.00
46_P50_L0.6921.00
125_L129_A0.6851.00
54_L58_L0.6841.00
148_R158_S0.6831.00
130_L134_A0.6831.00
6_V17_Y0.6811.00
63_L66_G0.6751.00
6_V12_R0.6711.00
141_R144_L0.6671.00
109_F117_F0.6631.00
15_R22_L0.6571.00
90_V93_M0.6571.00
10_G76_R0.6561.00
110_Y113_G0.6561.00
144_L148_R0.6481.00
40_A44_P0.6461.00
4_S8_T0.6441.00
44_P47_L0.6441.00
67_Y71_I0.6431.00
29_L33_L0.6401.00
75_Y78_G0.6391.00
74_L80_G0.6381.00
38_L41_A0.6311.00
80_G84_L0.6281.00
97_N139_F0.6281.00
85_R89_A0.6231.00
93_M96_T0.6211.00
132_I136_Q0.6191.00
97_N100_L0.6171.00
24_G66_G0.6131.00
82_R85_R0.6101.00
31_L35_G0.6101.00
47_L50_L0.6081.00
119_R122_R0.6061.00
8_T12_R0.6051.00
65_L69_A0.6041.00
21_A24_G0.6041.00
73_L77_R0.6041.00
25_L30_P0.6001.00
104_I108_I0.5971.00
24_G62_L0.5931.00
147_F154_W0.5931.00
76_R80_G0.5931.00
131_A134_A0.5921.00
6_V20_L0.5881.00
60_R64_A0.5831.00
32_N56_Y0.5791.00
44_P48_L0.5791.00
56_Y59_G0.5791.00
38_L43_F0.5791.00
10_G72_V0.5781.00
43_F48_L0.5761.00
28_G63_L0.5711.00
45_P50_L0.5711.00
2_G7_L0.5651.00
155_L158_S0.5651.00
57_Y61_L0.5631.00
21_A26_G0.5611.00
17_Y21_A0.5601.00
47_L51_L0.5581.00
26_G29_L0.5561.00
81_R86_P0.5551.00
17_Y20_L0.5491.00
38_L42_G0.5471.00
58_L61_L0.5451.00
108_I114_L0.5441.00
126_L129_A0.5431.00
11_E14_R0.5421.00
39_L42_G0.5421.00
144_L147_F0.5401.00
22_L25_L0.5401.00
2_G5_G0.5391.00
53_L56_Y0.5381.00
33_L36_A0.5371.00
86_P138_L0.5371.00
101_Q132_I0.5351.00
28_G31_L0.5341.00
155_L159_L0.5291.00
86_P90_V0.5291.00
107_L110_Y0.5231.00
49_G52_G0.5211.00
31_L62_L0.5181.00
78_G84_L0.5171.00
112_Y117_F0.5171.00
42_G45_P0.5171.00
64_A67_Y0.5101.00
96_T139_F0.5051.00
23_I27_I0.5021.00
40_A45_P0.5011.00
43_F47_L0.5011.00
58_L62_L0.5011.00
85_R141_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9202 7.1 0.923 Contact Map
3l1lA 2 0.8037 6.8 0.924 Contact Map
4lz6A 1 0.8773 4.8 0.929 Contact Map
4i0uA 4 0.4417 4.4 0.931 Contact Map
4humA 1 0.9141 3.9 0.932 Contact Map
4ev6A 3 0.454 3.9 0.932 Contact Map
3giaA 1 0.8221 2.7 0.937 Contact Map
2a65A 2 0.5092 2.5 0.939 Contact Map
4ryoA 1 0.816 2.3 0.94 Contact Map
4uc1A 3 0.8221 2.2 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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