GREMLIN Database
YihI - Der GTPase activator (YihI)
PFAM: PF04220 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (152)
Sequences: 560 (352)
Seq/√Len: 28.6
META: 0.368

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_R113_E4.8561.00
92_E129_R4.2461.00
130_I134_M3.7231.00
96_L130_I3.0601.00
152_L156_F2.6621.00
135_E139_I2.6441.00
99_D122_Y2.4670.99
124_D127_L2.3370.99
84_K89_P2.2320.98
101_R119_D2.1280.98
127_L130_I2.0890.97
120_Q124_D2.0650.97
18_A21_R2.0610.97
148_S152_L2.0420.97
52_K56_I2.0260.97
103_D106_L1.9830.96
122_Y152_L1.9290.96
17_E21_R1.9280.96
134_M139_I1.9090.95
109_L123_V1.8700.95
153_L156_F1.8410.94
120_Q127_L1.7330.92
90_E94_A1.6970.92
148_S153_L1.6600.91
8_R12_E1.6160.90
8_R20_E1.6010.89
120_Q123_V1.5880.89
71_K74_K1.5730.88
89_P129_R1.4880.85
70_K74_K1.4700.84
152_L155_L1.4630.84
89_P92_E1.4380.83
10_T14_L1.4290.83
117_A121_K1.3520.79
21_R24_K1.3510.79
61_P108_R1.3430.79
15_D27_H1.3430.79
116_S119_D1.3060.77
132_E142_E1.3010.76
149_E152_L1.2970.76
6_G31_K1.2790.75
79_K82_P1.2620.74
100_E119_D1.2460.73
89_P131_D1.2050.71
43_K142_E1.1780.69
11_R14_L1.1730.68
76_K82_P1.1700.68
75_K78_K1.1610.68
148_S154_R1.1510.67
123_V127_L1.1440.66
23_R27_H1.1420.66
38_E149_E1.1400.66
47_G69_K1.1320.66
19_R134_M1.1310.66
59_K124_D1.1170.65
149_E153_L1.1140.64
31_K122_Y1.1110.64
96_L109_L1.1090.64
109_L120_Q1.1060.64
103_D156_F1.1050.64
89_P105_L1.1030.64
24_K27_H1.0830.62
77_K81_K1.0830.62
128_D134_M1.0820.62
27_H30_L1.0770.62
65_V68_A1.0720.61
117_A120_Q1.0710.61
109_L122_Y1.0670.61
25_K118_E1.0660.61
100_E104_A1.0610.60
9_K17_E1.0510.60
110_E123_V1.0400.59
39_A153_L1.0250.58
6_G30_L1.0200.57
19_R30_L1.0170.57
94_A111_N1.0130.57
135_E140_E1.0090.57
88_S150_D1.0050.56
103_D110_E0.9980.56
116_S122_Y0.9900.55
97_E106_L0.9750.54
24_K110_E0.9710.54
11_R15_D0.9610.53
105_L134_M0.9600.53
39_A44_K0.9590.53
29_G33_G0.9570.53
9_K14_L0.9540.52
105_L120_Q0.9530.52
65_V71_K0.9490.52
39_A94_A0.9450.52
32_A42_K0.9370.51
9_K12_E0.9290.50
95_M126_K0.9210.50
109_L139_I0.9150.49
133_L138_G0.9140.49
30_L101_R0.9020.48
19_R25_K0.9010.48
129_R132_E0.8910.47
78_K82_P0.8860.47
10_T13_E0.8860.47
12_E15_D0.8830.47
99_D108_R0.8760.46
50_Q107_D0.8730.46
59_K62_I0.8720.46
36_N119_D0.8700.46
87_L110_E0.8670.46
109_L134_M0.8660.46
75_K80_K0.8640.45
16_Q62_I0.8610.45
101_R122_Y0.8600.45
8_R122_Y0.8600.45
46_N117_A0.8590.45
15_D123_V0.8520.44
43_K46_N0.8320.43
36_N107_D0.8310.43
94_A98_N0.8310.43
34_S84_K0.8240.42
75_K94_A0.8200.42
35_R137_L0.8150.42
92_E98_N0.8140.42
32_A41_K0.8100.41
96_L131_D0.8090.41
44_K146_E0.8010.41
101_R118_E0.7940.40
36_N39_A0.7860.39
108_R119_D0.7800.39
107_D153_L0.7780.39
150_D156_F0.7720.38
126_K139_I0.7690.38
49_K69_K0.7610.38
36_N152_L0.7610.38
111_N132_E0.7530.37
8_R68_A0.7500.37
107_D135_E0.7310.35
78_K81_K0.7280.35
101_R126_K0.7280.35
107_D113_E0.7250.35
45_Q67_E0.7210.35
44_K48_Q0.7050.34
76_K83_K0.7020.33
89_P136_Q0.6990.33
5_K131_D0.6970.33
75_K81_K0.6970.33
43_K104_A0.6970.33
76_K79_K0.6960.33
143_E147_E0.6950.33
7_K18_A0.6940.33
12_E131_D0.6930.33
15_D131_D0.6920.33
10_T16_Q0.6890.33
51_K111_N0.6890.33
36_N96_L0.6870.32
14_L18_A0.6810.32
19_R109_L0.6810.32
10_T15_D0.6790.32
39_A145_E0.6750.32
19_R106_L0.6700.31
63_P66_V0.6680.31
23_R127_L0.6640.31
68_A72_P0.6580.30
75_K83_K0.6570.30
136_Q142_E0.6550.30
111_N135_E0.6540.30
129_R137_L0.6540.30
121_K124_D0.6490.30
37_S118_E0.6460.30
22_K136_Q0.6460.30
28_K98_N0.6410.29
89_P98_N0.6400.29
8_R13_E0.6390.29
17_E22_K0.6320.29
18_A151_D0.6170.28
88_S91_Q0.6160.28
87_L141_D0.6160.28
44_K79_K0.6150.28
71_K82_P0.6150.28
128_D136_Q0.6100.27
14_L140_E0.6100.27
95_M141_D0.6090.27
148_S156_F0.6090.27
7_K154_R0.6030.27
25_K130_I0.6000.27
26_K62_I0.5950.27
47_G148_S0.5940.26
131_D134_M0.5940.26
15_D130_I0.5910.26
67_E72_P0.5890.26
48_Q72_P0.5880.26
15_D18_A0.5880.26
73_K78_K0.5860.26
24_K95_M0.5860.26
134_M138_G0.5860.26
110_E127_L0.5840.26
120_Q134_M0.5810.26
34_S39_A0.5760.25
87_L95_M0.5750.25
128_D132_E0.5730.25
105_L133_L0.5660.25
103_D134_M0.5650.25
141_D148_S0.5600.24
9_K61_P0.5580.24
69_K94_A0.5580.24
28_K150_D0.5570.24
42_K52_K0.5560.24
45_Q144_E0.5550.24
58_S134_M0.5490.24
7_K83_K0.5460.24
50_Q82_P0.5440.24
45_Q142_E0.5440.24
5_K28_K0.5410.23
77_K85_P0.5400.23
62_I73_K0.5400.23
37_S153_L0.5340.23
99_D155_L0.5330.23
107_D125_E0.5310.23
13_E23_R0.5290.23
18_A24_K0.5280.23
6_G52_K0.5250.23
18_A22_K0.5190.22
101_R109_L0.5170.22
22_K103_D0.5160.22
90_E131_D0.5120.22
83_K125_E0.5110.22
37_S58_S0.5090.22
88_S155_L0.5080.22
62_I101_R0.5070.22
20_E142_E0.5000.21
107_D119_D0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k0mA 1 0.5 36.3 0.933 Contact Map
8tfvA 1 0.1346 19 0.942 Contact Map
1vp7A 2 0.4487 16.8 0.943 Contact Map
4gczA 2 0.4038 16.6 0.943 Contact Map
3zrgA 2 0.2885 14.8 0.944 Contact Map
5amrA 1 0.3718 11.9 0.947 Contact Map
2xi5A 5 0.3782 11.5 0.947 Contact Map
4j7qA 2 0.3974 9.2 0.949 Contact Map
4l6yA 2 0.3013 5.3 0.955 Contact Map
2nqbC 2 0.641 5.1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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