GREMLIN Database
DUF411 - Protein of unknown function, DUF
PFAM: PF04214 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (69)
Sequences: 11726 (6779)
Seq/√Len: 816.1
META: 0.902

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_L29_V3.2311.00
35_I47_L2.5731.00
14_A23_A2.5121.00
46_R50_E2.2481.00
47_L54_A2.1711.00
13_K36_E2.0971.00
6_T9_L1.9851.00
9_L13_K1.8781.00
45_K49_A1.7531.00
27_T36_E1.6761.00
35_I57_L1.5721.00
8_D11_A1.5621.00
19_P22_L1.5471.00
35_I39_V1.4921.00
12_I16_L1.4811.00
20_A23_A1.4761.00
33_Y52_P1.4171.00
43_D46_R1.4041.00
41_A45_K1.3781.00
11_A15_R1.3511.00
13_K23_A1.3261.00
13_K27_T1.3181.00
30_V35_I1.2811.00
41_A67_P1.2671.00
59_V64_V1.2261.00
59_V65_G1.2191.00
39_V59_V1.2151.00
9_L12_I1.2021.00
33_Y47_L1.2011.00
14_A20_A1.1821.00
28_A59_V1.1641.00
32_G51_R1.1611.00
59_V66_S1.1601.00
31_G51_R1.1241.00
38_H66_S1.0731.00
6_T12_I1.0711.00
15_R29_V1.0081.00
24_S58_A0.9971.00
12_I15_R0.9941.00
47_L51_R0.9861.00
10_A23_A0.9761.00
22_L58_A0.9551.00
25_C62_M0.9371.00
17_G55_A0.9201.00
6_T11_A0.9081.00
16_L34_V0.9041.00
35_I44_I0.8771.00
29_V32_G0.8711.00
18_V34_V0.8701.00
33_Y53_D0.8601.00
24_S67_P0.8541.00
24_S36_E0.8411.00
43_D47_L0.8401.00
10_A14_A0.8391.00
36_E58_A0.8341.00
13_K24_S0.7701.00
34_V55_A0.7701.00
35_I67_P0.7581.00
24_S38_H0.7571.00
29_V34_V0.7551.00
26_H62_M0.7481.00
19_P23_A0.7471.00
6_T10_A0.7381.00
43_D57_L0.7321.00
43_D59_V0.7281.00
10_A20_A0.7121.00
30_V44_I0.7031.00
7_D11_A0.6981.00
30_V48_L0.6921.00
61_G64_V0.6871.00
63_P66_S0.6721.00
40_P66_S0.6571.00
44_I47_L0.6551.00
33_Y50_E0.6431.00
41_A44_I0.6401.00
25_C69_M0.6261.00
42_A45_K0.6201.00
31_G48_L0.6131.00
24_S40_P0.6131.00
33_Y56_G0.6091.00
22_L55_A0.6001.00
54_A57_L0.5981.00
62_M69_M0.5971.00
13_K18_V0.5881.00
26_H38_H0.5851.00
33_Y57_L0.5841.00
18_V23_A0.5831.00
12_I27_T0.5751.00
7_D10_A0.5751.00
61_G66_S0.5721.00
9_L23_A0.5701.00
55_A59_V0.5631.00
11_A14_A0.5591.00
2_T7_D0.5571.00
4_H7_D0.5551.00
57_L63_P0.5501.00
3_V6_T0.5421.00
33_Y54_A0.5401.00
39_V57_L0.5301.00
24_S28_A0.5261.00
21_E49_A0.5251.00
59_V63_P0.5171.00
30_V43_D0.5011.00
18_V27_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ttzA 1 0.6812 37.2 0.876 Contact Map
1z6mA 1 0.7246 23.8 0.888 Contact Map
1s4zC 1 0.4348 23 0.889 Contact Map
3ic4A 1 0.6522 16.4 0.896 Contact Map
4ml1A 4 0.6522 15.6 0.897 Contact Map
3fz5A 2 0.7681 14.5 0.898 Contact Map
1t3bA 2 0.6812 13.5 0.9 Contact Map
4c1lA 4 0.8406 13 0.9 Contact Map
4nv5A 1 0.7391 10.1 0.905 Contact Map
1vs1A 4 0.8261 9.8 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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