GREMLIN Database
HtaA - Htaa
PFAM: PF04213 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (162)
Sequences: 1595 (1283)
Seq/√Len: 100.8
META: 0.438

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_A156_L3.9331.00
66_R75_D3.7061.00
136_A159_V3.3781.00
30_S64_S3.3381.00
117_L134_A3.1641.00
80_D111_R3.0861.00
91_T113_P2.9061.00
70_H74_L2.6511.00
9_G15_R2.6281.00
83_V117_L2.5061.00
117_L136_A2.4551.00
94_A114_L2.3071.00
95_D111_R2.2871.00
6_L61_F2.2741.00
12_E16_S2.2631.00
113_P141_A2.1331.00
51_D54_T2.0451.00
82_R111_R2.0211.00
9_G157_D2.0071.00
139_T142_G2.0031.00
93_T111_R1.8781.00
115_A136_A1.8081.00
69_G72_G1.7751.00
10_V67_F1.7731.00
84_E93_T1.7601.00
7_D42_R1.7531.00
22_I69_G1.7531.00
131_L161_L1.7461.00
151_P154_T1.7391.00
50_Y54_T1.7251.00
69_G74_L1.7221.00
99_K106_P1.7161.00
93_T113_P1.7001.00
12_E157_D1.6801.00
15_R157_D1.6681.00
23_A69_G1.5751.00
27_I41_F1.5691.00
81_P94_A1.5141.00
118_D135_P1.5061.00
19_T35_R1.4911.00
4_G46_G1.4871.00
83_V161_L1.4771.00
68_T72_G1.4741.00
15_R67_F1.4271.00
97_T108_T1.4021.00
81_P111_R1.3831.00
50_Y57_G1.3740.99
13_S17_Y1.3100.99
11_K154_T1.3100.99
57_G85_V1.3000.99
68_T75_D1.2980.99
35_R38_G1.2840.99
140_A152_A1.2780.99
78_L94_A1.2680.99
20_G23_A1.2660.99
4_G44_P1.2480.99
76_L98_S1.2140.99
117_L159_V1.1930.99
130_T160_T1.1870.98
47_S60_A1.1540.98
28_T66_R1.1510.98
64_S79_S1.1320.98
32_G64_S1.1240.98
35_R39_G1.1070.98
138_L143_A1.1050.98
82_R93_T1.1030.98
24_K69_G1.0960.97
70_H73_A1.0730.97
146_F150_Y1.0690.97
46_G62_G1.0650.97
18_V67_F1.0590.97
136_A156_L1.0520.97
91_T116_T1.0360.96
36_A40_A1.0220.96
131_L134_A1.0220.96
14_F67_F1.0210.96
58_T84_E1.0070.96
60_A82_R1.0060.96
11_K17_Y1.0060.96
31_G64_S1.0010.96
78_L81_P0.9940.95
139_T143_A0.9910.95
113_P116_T0.9830.95
61_F81_P0.9630.95
64_S77_T0.9620.94
41_F67_F0.9440.94
10_V15_R0.9420.94
43_F46_G0.9390.94
90_G117_L0.9380.94
35_R41_F0.9370.94
118_D121_G0.9260.93
118_D122_A0.9190.93
137_T155_A0.9190.93
14_F74_L0.9120.93
24_K71_G0.9060.93
80_D95_D0.9050.92
33_A43_F0.8990.92
80_D110_D0.8880.92
140_A143_A0.8730.91
138_L146_F0.8700.91
17_Y70_H0.8700.91
100_D107_V0.8640.91
59_V161_L0.8630.91
116_T137_T0.8410.89
109_G112_V0.8360.89
130_T162_S0.8350.89
138_L142_G0.8200.88
143_A146_F0.8190.88
44_P62_G0.8090.88
112_V141_A0.8090.88
90_G119_L0.7930.87
96_V145_A0.7920.86
143_A153_G0.7900.86
21_P24_K0.7890.86
38_G94_A0.7840.86
62_G81_P0.7830.86
58_T82_R0.7760.85
95_D112_V0.7680.85
119_L135_P0.7660.85
29_L35_R0.7550.84
51_D55_G0.7520.83
18_V25_G0.7520.83
27_I67_F0.7520.83
12_E162_S0.7460.83
63_G80_D0.7420.83
17_Y74_L0.7400.83
117_L122_A0.7370.82
37_G40_A0.7190.81
122_A134_A0.7170.80
143_A148_G0.7170.80
14_F76_L0.7170.80
137_T140_A0.7160.80
138_L156_L0.7120.80
141_A144_A0.7050.79
73_A100_D0.7040.79
48_G145_A0.7020.79
43_F65_V0.7010.79
49_T60_A0.6940.78
143_A151_P0.6940.78
129_V163_V0.6890.78
140_A144_A0.6850.77
34_T42_R0.6830.77
134_A159_V0.6800.77
31_G120_S0.6780.77
59_V163_V0.6770.77
25_G69_G0.6740.76
3_G7_D0.6720.76
121_G124_V0.6660.75
2_T53_D0.6620.75
97_T106_P0.6610.75
98_S109_G0.6600.75
81_P92_L0.6590.75
11_K150_Y0.6560.74
85_V119_L0.6470.73
27_I35_R0.6400.72
72_G103_G0.6400.72
57_G72_G0.6390.72
38_G42_R0.6330.72
128_T162_S0.6310.71
80_D93_T0.6300.71
118_D137_T0.6300.71
89_T125_A0.6270.71
43_F81_P0.6270.71
81_P85_V0.6240.71
27_I149_F0.6240.71
35_R40_A0.6230.70
135_P158_P0.6210.70
84_E91_T0.6190.70
2_T128_T0.6180.70
119_L122_A0.6110.69
149_F156_L0.6100.69
44_P63_G0.6100.69
9_G12_E0.6050.68
15_R27_I0.6050.68
91_T114_L0.6010.68
99_K104_G0.6000.68
11_K157_D0.5940.67
80_D92_L0.5890.66
113_P139_T0.5890.66
101_M105_A0.5860.66
88_G119_L0.5830.65
18_V27_I0.5810.65
98_S147_G0.5800.65
2_T49_T0.5760.64
33_A65_V0.5740.64
29_L41_F0.5700.64
15_R41_F0.5700.64
3_G46_G0.5690.64
125_A128_T0.5680.63
13_S150_Y0.5680.63
78_L114_L0.5670.63
12_E37_G0.5660.63
20_G69_G0.5660.63
6_L45_A0.5630.63
28_T124_V0.5620.63
33_A42_R0.5610.62
94_A112_V0.5600.62
100_D103_G0.5600.62
44_P83_V0.5590.62
51_D56_T0.5570.62
119_L134_A0.5570.62
118_D134_A0.5570.62
11_K15_R0.5550.62
2_T99_K0.5530.61
43_F57_G0.5510.61
100_D105_A0.5470.61
109_G127_G0.5470.61
12_E39_G0.5450.60
25_G67_F0.5450.60
23_A70_H0.5430.60
87_G90_G0.5430.60
11_K16_S0.5420.60
5_T45_A0.5380.59
29_L33_A0.5330.59
2_T163_V0.5320.58
4_G61_F0.5310.58
47_S144_A0.5300.58
103_G106_P0.5280.58
127_G131_L0.5280.58
69_G73_A0.5240.57
57_G63_G0.5210.57
26_S68_T0.5200.57
10_V156_L0.5190.57
138_L154_T0.5180.56
68_T98_S0.5180.56
114_L156_L0.5180.56
30_S66_R0.5180.56
39_G65_V0.5130.56
79_S94_A0.5100.55
12_E19_T0.5080.55
19_T27_I0.5070.55
92_L159_V0.5070.55
98_S107_V0.5060.55
143_A152_A0.5060.55
146_F149_F0.5060.55
65_V81_P0.5050.55
76_L149_F0.5040.54
142_G156_L0.5030.54
13_S115_A0.5020.54
2_T5_T0.5020.54
14_F145_A0.5000.54
52_P126_G0.5000.54
143_A149_F0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3us9A 1 0.4512 6.6 0.941 Contact Map
2pb9A 3 0.3293 6.1 0.941 Contact Map
4tshB 1 0.3354 4.5 0.945 Contact Map
3qv0A 3 0.3293 3 0.95 Contact Map
2q2kA 3 0.1341 2.6 0.951 Contact Map
2lt9A 1 0.4634 2.5 0.952 Contact Map
3szeA 1 0.811 2.5 0.952 Contact Map
2hyxA 2 0.7805 2.4 0.952 Contact Map
3ht4A 4 0.2439 2.3 0.953 Contact Map
1yqfA 3 0.3293 2.2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.